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第十三届全国免疫学学术大会

作者： Lixin Wang Wenbin Wu Xiaowen Zhu Wanyi Huang Chenyuan Gong Chao Yao zhongya ni Shiguo Zhu Shanghai University of Traditional Chinese Medicine

Background: The tumor microenvironment(TME) has a deep influence on cancer progression and has become into a new target for cancer treatment. In our previous study, we found that Yu-Ping-Feng(YPF), an ancient Chinese herbal decoction, significantly inhibited the Lewis lung cancer tumor growth in a subcutaneous xenograft tumor model, and prolonged the survival of tumor-bearing mice. But the regulation of YPF on TME is ***: To investigate the inhibitory effect and TME regulation of YPF on the non-small cell lung cancer in an orthotopic lewis lung cancer tumor ***: To access the effect of YPF on non-small cell lung cancer(NSCLC), an orthotopic luciferase stably expressed LLC(LLC-Luc) tumor model was established, and then the survival and the tumor growth were evaluated. To address the TME immune regulation, the percentages of CD4+ T cells, CD8+ T cells, NK cells, regulatory T cells, macrophages, and myeloid-derived suppressor cells in spleens and tumor tissues, the macrophage polarization and CD4+ T cell cytotocixity were analyzed by flow cytometry, biophotonic cell killing activity assay, real-time PCR and ***: YPF significantly prolonged orthotopic lung tumor-bearing mouse survival, and increased the percentages of CD4+ T cell and M1 macrophages and the cytotoxicity of CD4+ T cells. YPF significantly enhanced macrophage-mediated lysis of LLC in a dose-dependent manner, and had no effect on CD4+ T cell-mediated lysis of LLC, but significantly increased CD4+ T cell-mediated lysis after co-incubated with macrophages. In addition, YPF induced M1 macrophage polarization through promoting the phosphorylation of ***: YPF induced M1 macrophages polarization, and then activated CD4+ T lymphocytes, resulting in killing of LLC cells. YPF was a potent regulator of M1 macrophage polarization and might have a promising application in tumor immunotherapy.

关键词： Non-small cell lung cancer Yu-Ping-Feng Macrophages CD4+ T cells Tumor microenvironment

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基于网络药理学及实验研究探讨臭椿皮散治疗结直肠癌的潜在机制

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南京医科大学学报（自然科学版） 2024年第2期44卷 170-177,184页

作者：石诺林倪中亚袁富文上海中医药大学中西医结合研究院上海201203 捷思英达医药技术有限公司上海201318

目的:基于网络药理学和细胞实验探讨中药复方臭椿皮散(Chouchunpi San,CCPS)治疗结直肠癌的潜在机制。方法:通过网络药理学筛选臭椿皮散作用靶点和结直肠癌靶点,构建蛋白质互作(protein⁃protein interaction networks,PPI)网络,预测臭... 详细信息

目的:基于网络药理学和细胞实验探讨中药复方臭椿皮散(Chouchunpi San,CCPS)治疗结直肠癌的潜在机制。方法:通过网络药理学筛选臭椿皮散作用靶点和结直肠癌靶点,构建蛋白质互作(protein⁃protein interaction networks,PPI)网络,预测臭椿皮散可能的作用靶点,通过富集分析预测臭椿皮散抗结直肠癌的作用途径;CCK⁃8法检测臭椿皮散对结直肠癌细胞活性的影响;使用不同浓度臭椿皮散处理结直肠癌细胞,流式实验检测细胞凋亡情况;划痕实验检测结直肠癌细胞迁移能力;Western blot检测STAT3蛋白的表达。结果:通过多个数据库检索到臭椿皮散的117个活性成分,920个潜在靶点,787个药物与疾病交集靶点。PPI网络分析得到STAT3、MAPK1、AKT1、MYC等核心靶点,GO功能富集和KEGG通路分析结果显示臭椿皮散主要参与对细胞凋亡、氧化应激反应等生物学过程,参与的通路涉及癌症通路,如AGE⁃RAGE信号通路、PI3K⁃Akt信号通路等。分子对接结果显示STAT3与其对应的化合物licochalcone A有较好的结合能力。细胞实验显示臭椿皮散抑制结直肠癌细胞活性,降低细胞迁移能力,促进结直肠癌细胞凋亡。Western blot结果显示,经不同浓度臭椿皮散处理后,细胞中STAT3蛋白表达显著下降,且呈浓度依赖性。结论:臭椿皮散治疗结直肠癌具有多成分、多靶点、多通路的作用机制,臭椿皮散明显抑制结直肠癌细胞的活性及迁移能力,其作用机制可能与靶向降低STAT3蛋白水平有关。

关键词：臭椿皮散结直肠癌网络药理学细胞增殖 STAT3

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Grid-Connected/Islanded Switching Control Strategy for Photovoltaic Storage Hybrid Inverters Based on Modified Chimpanzee Optimization Algorithm

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Energy Engineering 2025年第1期122卷 265-284页

作者： Chao Zhou NarisuWang Fuyin ni Wenchao Zhang School of Electrical and Information Engineering Jiangsu University of TechnologyChangzhou213001China Jiangsu Key Laboratory of Power Transmission&Distribution Equipment Technology Jiangsu University of TechnologyChangzhou213001China

Uneven power distribution,transient voltage,and frequency deviations are observed in the photovoltaic storage hybrid inverter during the switching between grid-connected and island *** response to these issues,this paper proposes a grid-connected/island switching control strategy for photovoltaic storage hybrid inverters based on the modified chimpanzee optimization *** proposed strategy incorporates coupling compensation and power differentiation elements based on the traditional droop ***,it combines the angular frequency and voltage amplitude adjustments provided by the phase-locked loop-free pre-synchronization control *** pre-synchronization is achieved by regulating the virtual current to zero and aligning the photovoltaic storage hybrid inverter with the grid ***,two novel operators,learning and emotional behaviors are introduced to enhance the optimization precision of the chimpanzee *** operators ensure high-precision and high-reliability optimization of the droop control parameters for photovoltaic storage hybrid inverters.A Simulink model was constructed for simulation analysis,which validated the optimized control strategy’s ability to evenly distribute power under load *** strategy effectively mitigated transient voltage and current surges during mode ***,seamless and efficient switching between gridconnected and island modes was achieved for the photovoltaic storage hybrid *** enhanced energy utilization efficiency,in turn,offers robust technical support for grid stability.

关键词： Photovoltaic storage hybrid inverters modified chimpanzee optimization algorithm droop control seamless switching

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Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma Yang Qu Jiaxin Ren Yingying Sun Zhen-ni Guo Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

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Nano high-entropy oxide cathode with enhanced stability for direct borohydride fuel cells

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Journal of Energy Chemistry 2025年第1期100卷 309-316页

作者： Lei Zhang Lingfeng Kuang Lianke Zhang Wen Chu Haiying Qin Jing Zhang Junjing He Hualiang ni Hongzhong Chi New Energy Materials Research Center College of Materials and Environmental Engineering Hangzhou Dianzi University School of Materials Science and Engineering Zhejiang University Key Laboratory of MEMS of Ministry of Education School of Integrated Circuits Southeast University

High-entropy materials have become high-activity electrocatalysis owing to their high-entropy effect and multiple active ***,we synthesize a series of carbon-supported nano high-entropy oxides（HEOs/C）,specifically （PtFeConiCu）O/C,using a carbothermal shock （CTS） method for application as a cathode catalyst in direct borohydride fuel cells （DBFCs）.The microstructure of the prepared catalysts was characterized by X-ray photoelectron spectroscopy,X-ray absorption fine structure,and transmission electron *** prepared （PtFeConiCu）O/C,with particle sizes ranging from 2 to 4 nm,demonstrates 3.94 transferred electrons towards the oxygen reduction reaction in an alkaline environment,resulting in a minimal H2O2yield of 2.6%.Additionally,it exhibits a Tafel slope of 61 mV dec-1,surpassing that of commercial Pt/C (82 mV dec-1).Furthermore,after 40,000 cycles of cyclic voltammetry（CV） testing,the half-wave potential of （PtFeConiCu）O/C shows a positive shift of 3 mV,with no notable decline in the limiting current *** （PtFeConiCu）O/C is used as a cathode catalyst in DBFCs,the DBFC achieves a maximum power density of 441 mW cm-2at 60°C and sustains a cell voltage of approximately 0.73 V after 52 h at 30°*** findings confirm that HEO/C is a promising cathode catalyst for DBFCs.

关键词： Direct borohydride fuel cells (DBFC)

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基于NK细胞的肿瘤免疫逃逸及中医药对NK的免疫调节作用

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中国医药导报 2019年第28期16卷 52-55页

作者：孙御芳倪中亚王莉新朱诗国上海中医药大学基础医学院免疫学与病原生物学教研室

恶性肿瘤是当今世界发病率和致死率最高的疾病之一。近年来,肿瘤免疫治疗作为一种靶向治疗方法,其利用自身免疫系统诱导抗肿瘤效应,现备受关注。自然杀伤(NK)细胞是具有多种免疫功能的淋巴细胞,是天然免疫中的重要一员。NK细胞可以通过... 详细信息

恶性肿瘤是当今世界发病率和致死率最高的疾病之一。近年来,肿瘤免疫治疗作为一种靶向治疗方法,其利用自身免疫系统诱导抗肿瘤效应,现备受关注。自然杀伤(NK)细胞是具有多种免疫功能的淋巴细胞,是天然免疫中的重要一员。NK细胞可以通过细胞毒作用及免疫调节直接或间接杀伤肿瘤细胞,在肿瘤免疫监视中发挥着重要作用。但恶性肿瘤中存在着多种机制来逃避NK细胞的识别及杀伤,导致肿瘤免疫逃逸。因此,如何恢复和增强NK细胞的抗肿瘤作用尤为重要。在恶性肿瘤的治疗中,中医药可以调节包括NK细胞在内的多种免疫细胞功能。本文就肿瘤细胞如何逃逸NK细胞免疫监视及中医药对NK细胞的调节作用进行综述。

关键词：自然杀伤细胞免疫监视肿瘤免疫逃逸中医药

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Formation and evolution of supercritical geofluid

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Science China Earth Sciences 2025年第1期68卷 39-51页

作者： Huaiwei ni Yilin XIAO Xiaolin XIONG Xiandong LIU Chunxiao GAO Yi-Xiang CHEN Yunguo LI Wan-Cai LI Xuan GUO Yang-Yang WANG Dong-Bo TAN Li ZHANG State Key Laboratory of Lithospheric and Environmental Coevolution University of Science and Technology of China Deep Space Exploration Laboratory/School of Earth and Space Sciences University of Science and Technology of China Guangzhou Institute of Geochemistry Chinese Academy of Sciences School of Earth Sciences and Engineering Nanjing University State Key Lab of Superhard Materials Jilin University

In this work, we provide a comprehensive review on the formation, evolution, properties, and effects of supercritical geofluid. In Earth's interior, enhanced miscibility between H2O and silicate by the addition of special components or by the increase of pressure and temperature gives rise to supercritical geofluid with a significant amount of both H2O and silicate *** formation of supercritical geofluid in magmatic-hydrothermal systems, typified by pegmatite system, is governed by meltfluid critical curve. The formation of supercritical geofluid in metamorphic systems, typified by subducted slab, is governed by the second critical end point. Experimental results suggest that the presence of boron and fluorine in pegmatite system makes it possible to form supercritical geofluid at crustal depths, but the release of supercritical geofluid from subducted slab is withheld until almost 100 km depth. A major presence of both H2O and depolymerized structural units（monomers, dimers, etc.） endows supercritical geofluid with unique physical properties including low density, low elastic moduli, low viscosity, high diffusivity,and high electrical conductivity. Supercritical geofluid can effectively mobilize a variety of elements even including high field strength elements and heavy rare earth elements. The chemical signatures of supercritical geofluid can be inherited by metasomatized mantle and mantle-derived melts, and this could give an explanation of the oxidation of arc magmas. Phase separation of supercritical geofluid through the mechanism of spinodal decomposition leads to formation of a melt network. Multiphase fluid inclusions recovered from subduction zone rocks and pegmatites are possible relics of supercritical geofluid. Supercritical geofluid can cause electrical anomaly and low seismic velocity near the top of subducted slab, and can be linked with intermediate-focus earthquakes. Supercritical geofluid may have played a crucial role in the formation of pe

关键词： Supercritical geofluid Miscibility Subduction zone Pegmatite

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补肾解毒散结方对脱氧胆酸诱导的TGR5活性及人结肠癌细胞侵袭转移的影响

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上海中医药大学学报 2020年第2期34卷 48-53页

作者：贾茹邵诗芸倪中亚张影茹冯媛媛王炎李琦上海中医药大学附属曙光医院肿瘤科上海201203 上海中医药大学附属曙光医院肿瘤研究所上海201203 上海中医药大学中西医结合研究院上海201203

目的:探讨补肾解毒散结方对脱氧胆酸(DCA)诱导的TGR5活性和人结肠癌细胞侵袭转移的影响及其可能机制。方法:分别以TGR5稳转HEK293细胞和人结肠癌HCT-116细胞为对象进行实验。将细胞分为对照组和DCA组、DCA+中药低剂量组、DCA+中药高剂... 详细信息

目的:探讨补肾解毒散结方对脱氧胆酸(DCA)诱导的TGR5活性和人结肠癌细胞侵袭转移的影响及其可能机制。方法:分别以TGR5稳转HEK293细胞和人结肠癌HCT-116细胞为对象进行实验。将细胞分为对照组和DCA组、DCA+中药低剂量组、DCA+中药高剂量组。除对照组外,其他各组均先给予DCA(30μmol/L)干预;DCA+中药低剂量组和DCA+中药高剂量组再分别给予20μg/ml和60μg/ml补肾解毒散结方醇提液;对照组仅给予等体积的培养基。细胞培养24 h后,双荧光素酶报告基因检测HEK293细胞中TGR5转录活性;划痕实验观察0、12、24 h各组HCT-116细胞的迁移情况,计算细胞迁移率;Western blot检测各组HCT-116细胞表皮生长因子受体(EGFR)、基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶-9(MMP-9)的蛋白表达;ELISA检测各组HCT-116细胞血管内皮生长因子(VEGF)表达。结果:①双荧光素酶报告基因检测显示,DCA组细胞TGR5转录活性较对照组显著上调(P<0.01);高、低剂量补肾解毒散结方作用后均可显著抑制DCA诱导的TGR5过表达(P<0.01),且DCA+中药高剂量组细胞的TGR5活性明显低于DCA+中药低剂量组(P<0.01)。②细胞划痕实验显示,DCA组细胞12、24 h时迁移率较对照组明显升高(P<0.01);高、低剂量补肾解毒散结方作用后均可显著抑制DCA诱导的HCT-116细胞的迁移,细胞迁移率较DCA组显著降低(P<0.01),且DCA+中药高剂量组的细胞迁移率明显低于DCA+中药低剂量组(P<0.05)。③蛋白表达检测显示,DCA组细胞MMP-2、MMP-9、EGFR蛋白表达和VEGF含量较对照组显著上调(P<0.05,P<0.01);与DCA组相比,高、低剂量补肾解毒散结方作用后均可显著下调MMP-2、MMP-9、EGFR蛋白表达,降低VEGF含量(P<0.01),且DCA+中药高剂量组细胞的MMP-9、EGFR蛋白表达水平和VEGF含量明显低于DCA+中药低剂量组(P<0.05,P<0.01)。结论:补肾解毒散结方可下调DCA诱导的TGR5过表达,并抑制DCA诱导的人结肠癌细胞侵袭转移。

关键词：补肾解毒散结方大肠癌脱氧胆酸 TGR5 侵袭转移

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Effects of Ti-and Nb-based transition element from single to multiple compound oxides and carbon-based composite additives on Mg-MgH2 hydrogen storage material

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Tungsten 2025年第1期7卷 32-49页

作者： Li-Rong Xiao Chen Chen Shuo Wang Zi-Yin Dai Hideo Kimura Cui ni Chuan-Xin Hou Xue-Qin Sun Si-Jie Guo Wei Du Xiu-Bo Xie School of Environmental and Material Engineering Yantai University Bosch HUAYU Steering Systems (Yantai) Co. Ltd.Ytp/MFE University of Tennessee Knoxville Shandong Key Laboratory of Eco-Environmental Science for the Yellow River Delta Shandong University of Aeronautics

MgH2is considered as a promising hydrogen storage material for its high hydrogen storage capacity,low cost and abundant resource ***,the low kinetics and high enthalpy formation of MgH2limit its wide *** the perspective of adding catalysts to enhance the hydrogen storage properties of Mg-MgH2,this article elaborated the main catalysts based on Ti and Nb transition elements,including single oxide catalysts,binary oxides catalysts（combined with ni,Na,Sr,V,etc.）,multiple catalysts bound to carbon,and composite catalysts with Ti and Nb elements combined with MXene ***,the main pathways of various catalysts to reduce the reaction activity and broaden the hydrogen desorption channel were also *** Ti-based catalysts can enhance the reactive sites of the matrix by forming multivalent states,while Nb-based catalysts broaden the hydrogen reaction channels by forming tiny *** improving the size structure and enhancing the grain size stability,combined with carbon materials should be the future considerations.

关键词： Catalysts Mg-based hydrogen storage alloys Solid hydrogen storage Transition metal elements

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Pyrite Geochemistry and S-Hg Isotopes Reveal the Ore Genesis of the Hydrothermal Vein-type Cuiluan Ag-Pb-Zn Deposit in NE China

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Journal of Earth Science 2025年

作者： Lidong Zhang Changzhou Deng Yao Tang Xinran ni Bizheng Yang Shanshan Liang Weipeng Liu Jishuang Ding Xiaohui Zeng Heilongjiang Institute of Natural Resources Survey State Key Laboratory of Ore Deposit Geochemistry， Institute of Geochemistry， Chinese Academy of Sciences College of Earth and Planetary Sciences， Chengdu University of Technology

The Xing'an-Mongolian orogenic belt is an important Ag-Pb-Zn metallogenic province in China. The study on the genesis of the newly discovered Cuiluan hydrothermal vein-type Ag-Pb-Zn deposit located in the Lesser Xing'an Range， within the eastern of Xing'an-Mongolian orogenic belt， is pivotal in understanding the metallogenic mechanism and regularity of Ag-Pb-Zn deposits in this region. This study utilizes pyrite trace elements and sulfur isotopic geochemistry， and mercury isotope of rocks and ores to constrain the genesis of the Cuiluan deposit. Pyrite geochemical data show that Ag exists in the form of galena inclusions (Ag++(Bi3+， Sb3+) ? Pb2+) in the polymetallic sulfide stage， and independent Ag-bearing minerals （matildite and gustavite） precipitate during the main mineralization stage. The small varied δ34S values （3.24‰ - 4.94‰） of pyrites from four hydrothermal stages are within the range of magmatic S isotopes， indicating that the ore-forming fluid of the Cuiluan deposit mainly originated from the magma. The Δ199Hg values of the ores are close to 0‰， which are consistent with the Δ199Hg values of mantle， further indicating that the ore-forming materials came from the lithospheric mantle. Combined with the regional tectonic evolution， we conclude that the plate subduction of Paleo-oceans in NE China triggered the partial melting of metasomatized mantle. The mantle-derived magma rose along the deep fractures and evolved ore-forming fluids， and finally caused the formation of Cuiluan quartz vein-type Ag-Pb-Zn deposit in the shallow crust. Accompany with previous documents， we infer that the fractures in the large-scale “Granite Sea” in the Lesser Xing'an Range may have significant potential for vein-type Ag-Pb-Zn exploration.

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