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A nitroreductase-responsive nanoprobe with homogeneous composition and high loading for preoperative non-invasive tumor imaging and intraoperative guidance

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Chinese Chemical Letters 2024年第7期35卷 313-318页

作者： Jingqi Xin Shupeng Han Meichen Zheng Chenfeng Xu zhongxi huang Bin Wang Changmin Yu Feifei An Yu Ren Institute of Medical Engineering Department of BiophysicsSchool of Basic Medical ScienceHealth Science CenterXi'an Jiaotong UniversityXi'an 710061China School of Public Health Health Science CenterXi'an Jiaotong UniversityXi'an 710061China Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech UniversityNanjing 211816China Department of Breast Surgery the First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061China

Tumor microenvironment(TME)-activatable probes have been proven to effectively increase signal-tobackground ratios(SBRs)and improve the success rate of complete tumor ***,many fluorescence probes have to be loaded into a nanocarrier for tumor targeted delivery,which consequently encounters poor drug loading,heterogeneous composition and non-encapsulated drug aggregates occurred during nanoformulation ***,a nitroreductase(NTR)-activated“OFF-ON”near-infrared fluorescence nanoprobe,named Nano Bodipy,was synthesized by the spontaneous self-assembling of NTRresponsive dye-polyethylene glycol(PEG)amphiphilic polymer in *** NTR-responsive dye acted as the hydrophobic segment in the amphiphilic polymer,yielding a homogeneous composition and a high loading of 12.2 wt%(according to calculation)in the synthesized Nano *** synthesized Nano Bodipy can efficiently accumulate in tumors via the enhanced permeability and retention(EPR)effect,enabling non-invasive tumor-targeted fluorescence imaging and guiding complete tumor *** the synthesized Nano Bodipy entered the tumor cells,they dissociated and were activated by overexpressed *** the real-time fluorescence guide of Nano Bodipy,complete tumor resection surgery was performed successfully.

关键词： Nitroreductase Tumor diagnosis Intraoperative guidance Self-assembly Nanoprobe

Ultrasensitive detection of IgE levels based on magnetic nanocapturer linked immunosensor assay for early diagnosis of cancer

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Chinese Chemical Letters 2022年第4期33卷 1855-1860页

作者： Yongxin Liu Mengda Cao zhongxi huang Changmin Yu Naidi Yang Qiong Wu Liang Shi Wenjie Duan Yi Zhu Jifu Wei Lin Li Wei huang Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)Nanjing 211816China Research Division of Clinical Pharmacology&Clinical Allergy Center the First Affiliated Hospital of Nanjing Medical UniversityDepartment of PharmacyJiangsu Institute of Cancer Research&the Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Pharmacy Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210044China State Key Laboratory of Coordination Chemistry Nanjing UniversityNanjing 210023China Shaanxi Institute of Flexible Electronics(SIFE) Northwestern Polytechnical University(NPU)Xi’an 710072China The First Affiliated Hospital of USTC Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China

Rapid and accurate detection of immunoglobulin E(Ig E) in serum and reduction of serum dosage are of great significance for clinical detection. Herein, we described a rapid magnetic separation of Ig E from patient serum based on Fe3 O4@Si O2-NTA@026 sdab as the capture probe and multiple horseradish peroxidase(HRP)-labeled antibodies linked gold nanoparticles(Au NPs) as chemiluminescence(CL) signal amplifier for ultrasensitive detection of total Ig E. Results showed that the limit of detection of our immunosensor system in serum samples was 0.03 k U/L, which is lowest in comparison with current methods, and far lower than that of Immuno CAP for Ig E detection(0.1 k U/L). Furthermore, our immunosensor possessed satisfied repeatability and accuracy, as well as good stability. In comparison with the Immuno CAP for the quantitative detection of Ig E, highly consistent results were achieved in 20 serum samples. Specially, this method was also successfully utilized for assessing the Ig E traces in breast cancer patients,which provides a new idea for the diagnosis of early cancer. Therefore, we believe that such versatile immunosensor will offer an alternative method for the on-site monitoring and determination of various Ig E-related diseases.

关键词： Gold nanoparticles Magnetic nanocapturer IgE detection Ultrasensitive immunosensor Cancer

Glutathione depletion based Pt(Ⅳ) hybrid mesoporous organosilica delivery system to conquer cisplatin chemoresistance: A “one stone three birds” strategy

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Chinese Chemical Letters 2024年第10期35卷 278-285页

作者： Linjie Ju zhongxi huang Qian Shen Chan Fu Shuanghe Li Wenjie Duan Chenfeng Xu Weizhen An Zhiqiang Zhai Jifu Wei Changmin Yu Guoren Zhou Department of Pharmacy Jiangsu Cancer HospitalThe Affiliated Cancer Hospital of Nanjing Medical UniversityJiangsu Institute of Cancer ResearchNanjing210009China Key Laboratory of Flexible Electronics(KLOFE) School of Flexible Electronics(Future Technologies)&Institute of Advanced Materials(IAM)Nanjing Tech University(NanjingTech)Nanjing211816China Department of Oncology Jiangsu Cancer HospitalThe Affiliated Cancer Hospital of Nanjing Medical UniversityJiangsu Institute of Cancer ResearchNanjing 210009China Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization College of Resources and Environmental SciencesNanjing AgriculturalUniversityNanjing210095China

The occurrence of acquired resistance to cisplatin(DDP)that induces the toxic drug effects has always been a huge challenge and urgently needs to be resolved in the cancer *** combination of anticancer drugs with different mechanisms can remarkably improve the chemotherapeutic *** that glutathione(GSH)plays as the driving factors in the resistance of DDP,here we have firstly proposed a“three birds,one stone”based nanoplatform to achieve triple synergetic effects simultaneously addressing DDP resistance in non-small cell lung cancer(NSCLC).Specifically,we initially designed and synthesized a DDP prodrug[Pt(Ⅳ)]bridged silsesquioxane precursor(Pt-Si).Then Pt-Si and bis[3-(triethoxysilyl)propyl]diselenide(BTESe PD)were integrated into the framework of mesoporous organosilica nanoparticles(MONs)to obtain a nanocarrier MONPt/*** loading with norcantharidin(NCTD)and modifying with the aptamer AS1411 based G-quadruplex(Apt),the Apt@NCTD@MONPt/Seexhibit impressive tumor homing *** being endocytosed,(Ⅰ)the diselenide and-O-Pt(Ⅳ)-O-rich scaffold can be reduced by the excessive GSH,followed by(Ⅱ)breaking the redox homeostasis via GSH depletion and precise release of the ***,the encapsulated NCTD is also released along with the degradation of the nanocarriers thereby(Ⅲ)achieving the GSH depletion and synergistic anti-tumor effect of NCTD and *** together,we believe this“one stone,three birds”strategy may be a promising paradigm to conquer drug resistance for clinical care.

关键词： MON_(ptse) NSCLC Glutathione depletion Responsive biodegradation Traditional Chinese medicines Synergistictherapy

基于表达谱分析识别鼻咽癌血管生成及淋巴管生成的调控通路

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南方医科大学学报 2012年第11期32卷 1553-1558页

作者：马佳怡黄坤黄仲曦南方医科大学第一临床医学院2006级八年制广东广州510515 南方医科大学肿瘤研究所广东广州510515

目的探讨鼻咽癌是通过调节哪些靶基因的表达影响血管生成和淋巴管生成。方法以Sengupta等通过基因芯片数据(其中含10例正常鼻咽组织,31例鼻咽癌组织)分析所得的831个鼻咽癌与正常鼻咽组织差异表达基因为基础,根据最新的基因组信息以及... 详细信息

目的探讨鼻咽癌是通过调节哪些靶基因的表达影响血管生成和淋巴管生成。方法以Sengupta等通过基因芯片数据(其中含10例正常鼻咽组织,31例鼻咽癌组织)分析所得的831个鼻咽癌与正常鼻咽组织差异表达基因为基础,根据最新的基因组信息以及设定差异表达值的最小阈值260,筛选出246个有效基因。对这246个基因进行基于文献挖掘的基因功能分析和网络构建,最后进行通路分析。结果 246个基因与鼻咽癌、EB病毒、转移、血管生成、淋巴管生成、侵袭等关键词特异相关。其中,52个基因已知与血管生成相关(P=0.00001),19个基因构成了血管生成基因网络(P=0.0042);21个基因已知与淋巴管生成相关(P=0.00001),6个基因构成了与淋巴管生成相关基因网络(P=0.0226)。包含PTGS2在内的8个基因参与NFκB信号通路已知在小细胞肺癌中与血管生成密切相关(P=7.87E-07)。包含STAT1及CXCL10等在内的5个基因参与了Toll样受体通路(P=0.00176)。结论 PTGS2和NFκB共同调控鼻咽癌血管生成,Toll样受体信号通路可能与淋巴管生成密切相关。它们的相互作用方式值得进一步研究。

关键词：鼻咽癌基因芯片数据挖掘信号通路血管生成淋巴管生成

中国古典文学海外英译荟萃——读《含英咀华集》

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国外外语教学 2004年第1期 62-64页

作者：黄中习广州金融高等专科学校

一、编者简介Classical Chinese Literature(《含英咀华集》)(第一卷)是闵福德(John Minford)教授和刘绍铭(Joseph ***)教授合编的中国古典文学英译选集.

关键词：中国古典文学《含英咀华集》英语翻译书评

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加强民族典籍的英译，弘扬民族优秀文化

广西民族研究 2008年第4期 164-165页

作者：汪榕培黄中习中国英汉对比研究会典籍英译学科委员会苏州大学大连理工大学苏州大学外国语学院广东金融学院副教授苏州215006

将我国民族文化典籍翻译成世界上使用最广泛的语言——英语,让海内国外读者了解我国少数民族的文化典籍,使之走向世界,普及民众,是我国翻译工作者义不容辞的责任。

关键词：民族典籍英译

基于差异性表达谱分析挖掘不同亚型鼻咽癌的保护性转录因子

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南方医科大学学报 2013年第11期33卷 1565-1570页

作者：黄春月林沛汪佳宏黄仲曦南方医科大学第一临床医学院2007级八年制南方医科大学肿瘤研究所广东广州510515

目的探究41例鼻咽组织活检样本中差异基因表达谱所显示的失调基因及挖掘调控这些基因的转录因子。方法利用EXCEL及生物信息学方法分析Ⅰ、Ⅱ型鼻咽癌(NPC)患者鼻咽组织活检样本中差异表达基因谱,挖掘出同时符合以下条件的转录因子:(1)... 详细信息

目的探究41例鼻咽组织活检样本中差异基因表达谱所显示的失调基因及挖掘调控这些基因的转录因子。方法利用EXCEL及生物信息学方法分析Ⅰ、Ⅱ型鼻咽癌(NPC)患者鼻咽组织活检样本中差异表达基因谱,挖掘出同时符合以下条件的转录因子:(1)在两组差异表达基因的结合位点具有统计学意义;(2)鼻咽组织中转录因子与基因的表达存在相关性;(3)相关基因的表达至少有40%是受转录因子影响的。结果在Ⅰ型NPC较Ⅱ型NPC上调的差异表达基因谱("Ⅰ_Ⅱ_Up")中,找到对应的符合条件的转录因子有80个。其中RUNX3、GATA3、NR3C1、NRF1、RXRA、SMAD7、TBP、ZBTB6等8个正调节因子和HLF、MTF1等2个负调节因子,它们调控与T细胞受体信号通路相关的基因。然而在Ⅰ型NPC较Ⅱ型NPC下调的差异表达基因谱("Ⅰ_Ⅱ_Down")中,未找到符合条件的转录因子。结论通过分析Ⅰ、Ⅱ型NPC患者鼻咽组织活检样本的差异表达基因谱发现,Ⅰ型NPC(NPC_Ⅰ)患者的差异表达基因主要与机体免疫反应相关,利用EXCEL及生物信息学方法,挖掘出8个正调节因子和2个负调节因子,主要调控与T细胞受体信号通路相关的基因。预测到的这10个转录因子有可能成为药物研发的新靶点,通过增强机体免疫防御能力,有望提高NPC患者的生存率。但研究中未能发现与"Ⅰ_Ⅱ_Down"基因谱明显相关的转录因子,这可能与NPC_Ⅱ患者差异表达基因受转录因子、DNA修饰、磷酸化、染色体变异、环境等多因素影响有关。

关键词：鼻咽癌免疫防御保护性转录因子生存率

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正确把握中华文化多元一体的内在特征

孔学堂 2017年第4期4卷 87-89页

作者：索晓霞 huang zhongxi Hong Xiyao 贵州省社会科学院 the School of Foreign Languages and Cultures at Guangdong University of Finance

中华文化是中华民族的重要特征,是中华儿女共同缔造的精神家园,是中华民族凝聚力、生命力、创造力的重要源泉.中华文化博大精深、多彩绚丽,每一个民族不论大小,都对中华民族的形成和发展做出了独特贡献;每一个民族的优秀文化,都是中华... 详细信息

中华文化是中华民族的重要特征,是中华儿女共同缔造的精神家园,是中华民族凝聚力、生命力、创造力的重要源泉.中华文化博大精深、多彩绚丽,每一个民族不论大小,都对中华民族的形成和发展做出了独特贡献;每一个民族的优秀文化,都是中华民族的共有精神财富,丰富多彩的多民族文化是中华文化的基本构成.但是,在这个问题上,

关键词：中华文化内在特征多元一体中华民族凝聚力多民族文化精神家园优秀文化精神财富

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历史悠久,内涵丰富:中国汉字魅力无限

孔学堂 2017年第4期 64-68+78-85页

作者：李运富 huang zhongxi Chen Shukun 北京师范大学文学院郑州大学汉字文明研究中心教育部 the School of Foreign Languages and Cultures at Guangdong University of Finance

习近平总书记说:"汉字是中华文明的重要标志,也是传承中华文明的重要载体。在长期使用汉字的过程中,中华民族发明了造纸术、活字印刷术。这两项重大发明既使历史悠久、博大精深的中华文化得到广泛传承,又使其得到交流,并向世界传播。";... 详细信息

习近平总书记说:"汉字是中华文明的重要标志,也是传承中华文明的重要载体。在长期使用汉字的过程中,中华民族发明了造纸术、活字印刷术。这两项重大发明既使历史悠久、博大精深的中华文化得到广泛传承,又使其得到交流,并向世界传播。";这段话明确指出汉字不仅是中华文明的重要元素,而且是传承中华文明和传播中华文化的重要符号。汉字历史悠久,内涵丰富,并且与时俱进,至今魅力无穷。汉字具有的生命力、创造力、表现力、凝聚力和影响力铸就了中国人的文化自信。

关键词：文化解释民族凝聚力内涵丰富历史悠久