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mRNA medicine:Recent progresses in chemical modification,design,and engineering

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Nano Research 2024年第10期17卷 9015-9030页

作者： Xiaowen hou Jinjun Shi Yuling Xiao Department of Cardiology Zhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Center for Nanomedicine and Department of Anesthesiology Perioperative and Pain MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA

Messenger RNA(mRNA)is a type of RNA that carries genetic information from DNA to the ribosome,where it is translated into *** has emerged as a powerful platform for development of new types of medicine,especially after the clinical approval of COVID-19 mRNA *** modification and nanoparticle delivery have contributed to this success significantly by improving mRNA stability,reducing its immunogenicity,protecting it from enzymatic degradation,and enhancing cellular uptake and endosomal ***,substantial progresses have been made in new modification chemistries,sequence design,and structural engineering to generate more stable and efficient next-generation *** innovations could further facilitate the clinical translation of mRNA therapies and *** that numerous review articles have been published on mRNA nanoparticle delivery and biomedical applications over the last few years,we herein focus on overviewing recent advances in mRNA chemical modification,mRNA sequence optimization,and mRNA engineering(e.g.,circular RNA and multitailed mRNA),with the aim of providing new perspectives on the development of more effective and safer mRNA medicines.

关键词： mRNA self-amplifying RNA circular RNA multitailed mRNA chemical modification machine learning

Numerical study on the use of soft material walls to enhance seismic performance of an existing tunnel

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Underground Space 2024年第2期15卷 90-112页

作者： Qiangqiang Sun Menghao hou Daniel Dias Institute of Geotechnical Engineering College of Civil Engineering and ArchitectureHebei UniversityBaoding 071002China Laboratory 3SR CNRS UMR 5521Grenoble Alpes UniversityGrenoble 38000France

Seismic risk is one of the biggest challenges for tunnel safety,and several mitigation techniques have been proposed to enhance the seismic performance of existing *** paper aims to investigate the effectiveness of an innovative approach for reducing the seismic risk of existing tunnels by using soft material walls(SMW)symmetrically installed in the surrounding *** investigation is performed with a two-dimensional numerical model and the effectiveness of SMW in mitigating the seismic-induced lining forces is quantitatively evaluated by reduction *** influences of nonlinear properties of soil,SMW and tunnel lining on the isolation effectiveness are also *** parametric studies show that the computed reduction ratio is strongly affected by the modulus ratio between the SMW and the soil,the wall geometric parameter,and the flexibility *** is more effective for the thick and soft isolation walls that are inserted near a stiff tunnel in the soft *** tunnel seismic response can be reduced by up to 50%for the scenarios ***,the parametric study identifies an optimum normalized depth of SMW and recommends a relation between the maximum isolation effect and the flexibility ***,simple charts are suggested in this work for estimating the isolation effect in specific conditions of the soil and the *** these lines,the results of this work may be used in the seismic retrofitting of an existing tunnel,aiding the preliminary design of the isolation walls.

关键词： Tunnels Earthquakes Seismic analysis Isolation walls Soft material

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基于数据驱动方法的控制器设计及其参数整定

系统科学与数学 2010年第6期30卷 792-805页

作者：王卫红侯忠生霍海波金尚泰北京航空航天大学机械工程及自动化学院北京100191 北京交通大学先进控制系统研究所电子与信息工程学院北京100044 上海海洋大学电气工程系上海201306

以一般离散时间非线性系统为研究对象,提出一类基于数据驱动的控制器设计及其参数整定方法.方法首先依据非参数时变动态线性化定理提出3种控制器结构,再采用迭代反馈整定方法(IFT)优化其控制器参数,从根本上解决了IFT方法给定控制器结... 详细信息

以一般离散时间非线性系统为研究对象,提出一类基于数据驱动的控制器设计及其参数整定方法.方法首先依据非参数时变动态线性化定理提出3种控制器结构,再采用迭代反馈整定方法(IFT)优化其控制器参数,从根本上解决了IFT方法给定控制器结构时存在的盲目性.最后将该方法与另外两种数据驱动控制方法—无模型自适应控制(MFAC)和IFT方法进行比较研究,结果表明方法是有效的.

关键词：数据驱动非参数时变动态线性化无模型自适应控制迭代反馈整定

A Statistical Analysis of Model Free Adaptive Control with Measurement Disturbance

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A Statistical Analysis of Model Free Adaptive Control with M...

Bioinspired nanofluidic iontronics for brain-like computing

第二十九届中国控制会议

作者： BU Xuhui,hou zhongsheng,JIN Shangtai Advanced Control Systems Lab.,Beijing Jiaotong University,Beijing 100044,P.R.China

This work is considered with the robustness of model free adaptive control（MFAC）systems with measurement *** using statistical analysis,it is possible to investigate the influence of the measurement disturbance with statistical *** to suppress the measurement disturbance,a modified MFAC algorithm with a decreasing gain is also *** rigorous analysis,it is shown that the modified algorithm has better robustness to measurement *** analysis is supported by simulations.

关键词： Model Free Adaptive Control Measurement Disturbance Statistical Analysis Robustness

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Nano Research 2024年第2期17卷 503-514页

作者： Lejian Yu Xipeng Li Chunyi Luo Zhenkang Lei Yilan Wang Yaqi hou Miao Wang Xu hou State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Institute of Artificial Intelligence Xiamen UniversityXiamen 361005China Department of Physics Research Institute for Biomimetics and Soft MatterFujian Provincial Key Laboratory for Soft Functional Materials ResearchJiujiang Research InstituteCollege of Physical Science and TechnologyXiamen UniversityXiamen 361005China The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province Department of BiomaterialsResearch Center of Biomedical Engineering of XiamenCollege of MaterialsXiamen UniversityXiamen 361005China The Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamen 361005China Binzhou Institute of Technology Binzhou 256600China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361102China Engineering Research Center of Electrochemical Technologies of Ministry of Education Xiamen UniversityXiamen 361005China

The human brain performs computations via a highly interconnected network of *** inspiration from the information delivery and processing mechanism of the human brain in central nervous systems,bioinspired nanofluidic iontronics has been proposed and gradually engineered to overcome the limitations of the conventional electron-based von Neumann architecture,which shows the promising potential to enable efficient brain-like *** and tunable nanofluidic ion transport behaviors and spatial confinement show promising controllability of charge carriers,and a wide range of structural and chemical modification paves new ways for realizing brain-like ***,a comprehensive framework of mechanisms and design strategy is summarized to enable the rational design of nanofluidic systems and facilitate the further development of bioinspired nanofluidic *** review provides recent advances and prospects of the bioinspired nanofluidic iontronics,including ion-based brain computing,comprehension of intrinsic mechanisms,design of artificial nanochannels,and the latest artificial neuromorphic functions ***,the challenges and opportunities of bioinspired nanofluidic iontronics in the pioneering and interdisciplinary research fields are proposed,including brain–computer interfaces and artificial neurons.

关键词： human brain ion transport nanofluidics brain-like computing memristive effect

Friendship Inference Based on Interest Trajectory Similarity and Co-occurrence

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Chinese Journal of Electronics 2024年第3期33卷 708-720页

作者： Junfeng TIAN Zhengqi hou School of Cyber Security and Computer Hebei University Hebei Key Laboratory of High Confidence Information Systems Hebei University

Most of the current research on user friendship speculation in location-based social networks is based on the co-occurrence characteristics of users,however,statistics find that co-occurrence is not common among all users;meanwhile,most of the existing work focuses on mining more features to improve the accuracy but ignoring the time complexity in practical *** this basis,a friendship inference model named ITSIC is proposed based on the similarity of user interest tracks and joint user location *** utilizing MeanShift clustering algorithm,ITSIC clustered and filtered user check-ins and divided the dataset into interesting,abnormal,and noise *** interest trajectories were constructed from user interest check-in data,which allows ITSIC to work efficiently even for users without *** the same time,by application of clustering,the single-moment multi-interest trajectory was further proposed,which increased the richness of the meaning of the trajectory *** extensive experiments on two real online social network datasets show that ITSIC outperforms existing methods in terms of AUC score and time efficiency compared to existing methods.

关键词： Data privacy Social networking (online) Noise Clustering algorithms Prediction algorithms Inference algorithms Data models

Current progress in glass-based nanochannels

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International Journal of Smart and Nano Materials 2024年第1期15卷 222-237页

作者： Yixin Ling Xuelian Yang Lei Zhou Zhenkang Lei Yaqi hou Xu hou state Key Laboratory of Physical Chemistry of Solid Surfaces and Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamenChina Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamenChina Institute of Artificial Intelligence Xiamen UniversityXiamenChina Department of Physics Research Institute for Biomimetics and Soft MatterFujian Provincial Key Laboratory for Soft Materials ResearchJiujiang Research InstituteCollege of Physical Science and TechnologyXiamen UniversityXiamenChina

Glass-based nanochannels have become powerful tools for chemi-cal and biological sensing due to their advantages of easy prepara-tion,flexible modification,and high ***,research on ion transport behaviors in glass-based nanochannels and their applications in nanofluidic iontronics has gradually become a focus,including various ion transport behaviors such as resistive-pulse,ion rectification,ionic current memory,*** this review,we summarize the progress of manufacturing methods for glass-based nanochannels and discuss several typical ion transport behaviors of glass-based nanochannels,as well as the main application scenarios of glass-based nanochannels in terms of biosensing,detection,and neuromorphic *** enormous assistance of artificial intel-ligence in the standardized manufacturing process of glass-based nanochannels was anticipated,and the potential development of glass-based nanochannels in achieving neuromorphic functions was expected.

关键词： Glass-based nanochannels biosensing ionic rectification ionic memristive effect nanofluidic neuromorphic functions

A Data-Driven Adaptive Iterative Learning Predictive Control for a Class of Discrete-time Nonlinear Systems

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A Data-Driven Adaptive Iterative Learning Predictive Control...

Palladium(Ⅱ)-Catalyzed Markovnikov Hydroalkynylation of Unactivated Terminal Alkenes

第二十九届中国控制会议

作者： SUN Heqing,hou zhongsheng Advanced Control Systems Laboratory,School of Electronics and Information Engineering,Beijing Jiaotong University,Beijing 100044,P.R.China

On the basis of dynamic linearization method along the iteration axis,a novel data-driven adaptive iterative learning predictive control（AILPC）is presented for a class of general repeatable discrete-time nonlinear *** highlight of the algorithm is that the controller design only depends on the I/O data of the dynamical system without using any priori knowledge of the *** monotonic convergence and effectiveness of the AILPC algorithm are proven and verified through rigorous analyses,numerical example and freeway traffic flow control application.

关键词： Data-driven Control Iterative Learning Control Predictive Control Model Free Adaptive Control

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Chinese Journal of Chemistry 2024年第1期42卷 29-34页

作者： Chuanqi hou Pinhong Chen Guosheng Liu Sstate Key Laboratory of Organometallic Chemistry and Shanghai Hongkong Joint Laboratory in Chemical SynthesisCenter for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032China Chang-Kung Chuang Institute East China Normal UniversityShanghai 200062China

Alkynes are versatile synthons in organic synthesis,as well as important structural moieties in bioactive ***,transition metal-catalyzed hydroalkynylation of alkenes has been developed with reactive alkenes and alkenes bearing directing ***,the regioselective hydroalkynylation of simple alkenes is still ***,we have developed a palladium-catalyzed Markovnikov hydroalkynylation of unactivated terminal alkenes,which provides an efficient approach for the synthesis of branched alkynyl compounds under mild *** reaction features excellent functional group tolerance,good reaction yields and excellent ***,the asymmetric hydroalkynylation reaction has also been achieved with moderate enantioselectivity by introducing a sterically bulky chiral Pyox ligand.

关键词： Palladium catalysis Alkynylpalladation Unactivated terminal alkenes Markovnikov hydroalkynylation