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Dual-ratiometric magnetic resonance tunable nanoprobe with acidic-microenvironment-responsive property to enhance the visualization of early tumor pathological changes

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Nano Research 2023年第7期16卷 10034-10046页

作者： Rong Cao Ning Tang Yi Zhu An Chen Yumeng Li Renbin Ge Yuan Li Zhongyi Huang Jiajing Guo Jiali Deng Hongwei Lu Ziwei Lu Helen Forgham Thomas PDavis Ruirui Qiao zhongling wang Department of Radiology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China School of food science Nanjing Xiaozhuang UniversityNanjing 211171China School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Neurology School of MedicineNew York UniversityNew York 10016USA Department of Biomedical Engineering College of EngineeringShantou UniversityShantou 515063China Department of Radiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbane QLD 4072Australia

The development of microenvironment-responsive nanoprobes has shown great promise for use in magnetic resonance imaging(MRI),with the advantage of significantly improved specificity and good biocompatibility.However,the clinical application of responsive probes is hampered by a lack of biological sensitivity for early molecular diagnostics and visualizing microenvionment of metabolism reprogramming in tumor progression.Here,we report on a dual-ratiometric magnetic resonance tunable(DMRT)nanoprobe designed by crosslinking different ratios of transferrin chelating gadolinium and superparamagnetic nanoparticles,complexed to a pH responsive biocompatible polymer.This dually activatable nanoprobe enables pH-dependent tumor microenvironment visualization,providing exceptional quantitative pathophysiological information in vitro and in vivo.When used in combination with dual-contrast enhancement triple subtraction imaging technique(DETSI),this smart nanoprobe guarantees the diagnosis of early-stage diseases.We envisage that this novel integrated nanoplatform will provide a new paradigm for the clinical translation of robust DMRT nanoprobes for early disease detection and staging,as well as microenvironment visualization and disease progression monitoring.

关键词： ratiometric nanoprobe dually activatable microenvironment visualization early diagnosis pathological changes

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A novel clustered SPIO nanoplatform with enhanced magnetic resonance T2 relaxation rate for micro-tumor detection and photothermal synergistic therapy

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Nano Research 2020年第8期13卷 2216-2225页

作者： Hongwei Lu Yongjing Xu Ruirui Qiao Ziwei Lu Pin wang Xindan Zhang An Chen Liming Zou zhongling wang Department of Radiology Shanghai General HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai200080China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai201620China ARC Centre of Excellence in Convergent Bio-Nano Science and Technology Monash Institute of Pharmaceutical SciencesMonash University381 Royal ParadeParkvilleVIC3052Australia Department of Radiology The First Affiliated Hospital of Soochow UniversitySuzhou215006China Department of Gastroenterology Nanjing Drum Tower HospitalAffiliated Hospital of Nanjing University Medical SchoolNanjing210029China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen518055China

Construction of micro tumor sensitive theranostic nanoagents that can increase the accuracy of imaging diagnosis and boost the therapeutic efficacy has been demonstrated for a promising approach for diagnosis and treatment of cancer.Herein,we reported a novel super-paramagnetic iron oxide(SPIO)based nanoplatform that possess significantly enhanced magnetic resonance property and photothermal effect for tumor theranostic purpose.This polyethylene glycol with four phenylboronic acid(PEG-B4)/CNTs@porphyrin(ph)/SPIO(BCPS)nanoplatform was simply prepared via integrated SPIO,ph,and a novel dendrimer with PEG liner and four PBA groups(PEG-B4)on the surface of carbon nanotubes(CNTs).Subsequently,a significant T2 relaxation rate enhanced can be achieved by the reduced accessibility of water to SPIO clustering.Moreover,the synergetic enhanced photothermal from BCPS nanoplatform contributed to better photothermal effect for cancer therapy.Furthermore,the targeting ability to sialic acid overexpressed tumor was further introduced from phenylboronic acid from PEG-B4.We showed that BCPS nanoplatform could not only selectively identify solid tumors and detect micro-sized metastatic tumor(1 mm)in the liver,but also effectively ablate tumors in a xenograft model,thereby achieving a complete cure rate of 100%at low laser dose.Our results highlight the potential of BCPS nanoplatform for accurate micro-tumor diagnosis and effective tumor therapy.

关键词： theranostic agent clustered SPIO nanoplatform T2 MRI micro-tumor detection photothermal therapy synergetic effect

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Excipient-free porphyrin/SN-38 based nanotheranostics for drug delivery and cell imaging

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Nano Research 2020年第2期13卷 503-510页

作者： Ye Yuan Ruonan Bo Di Jing Zhao Ma zhongling wang Tzu-yin Lin Lijie Dong Xiangdong Xue Yuanpei Li Center for Smart Materials and Devices State Key Laboratory of Advanced Technology for Materials Synthesis and ProcessingWuhan University of TechnologyWuhan 430070China Department of Biochemistry and Molecular Medicine UC Davis Comprehensive Cancer CenterUniversity of California DavisSacramento 95817USA School of Veterinary Medicine Yangzhou UniversityYangzhou 225009Chino Department of Oncolog) Xiangya HospitalCentral South UniversityChangsha 410008China Department of Radiology Shanghai General HospitalShanghai jiao Tong University School of MedicineShanghai 200080China Division of Hematology/Oncology Department of Internal MedicineUniversity of California DavisSacramento 95817USA College of Life Sciences Northwest UniversityXian 710069China

Nanotheranostics with comprehensive diagnostic and therapeutic capabilities show exciting cancer treatment potentials.Here,we develop an excipient-free drug delivery system for cancer diagnosis as well as therapy,in which a near infra-red photosensitizer and a chemotherapeutic drug can be self-delivered without any carriers.The building block of the drug delivery system was synthesized by covalently conjugating four anticancer drugs(7-ethyl-10-hydroxy-camptothecin,SN-38)with a photosensitizer(porphyrin)via hydrolyzable ester linkage,which endows the drug delivery system with 100%active pharmaceutical ingredients,excellent imaging,and therapeutic functionalities.The conjugates can readily self-assemble into nanosheets(PS NSs)and remain stable for at least 20 days in aqueous solution.In PS NSs,fluorescence resonance energy transfer(FRET)dominates the fluorescence of SN-38 and enables to monitor the drug release fluorescentiy.The PS NSs also show excellent anticancer activity in vitro,due to the increased cell uptake with the synergistic effect of photodynamic therapy and chemotherapy.

关键词： porphyrin 7-ethyl-10-hydroxy-camptothecin(SN-38) drug delivery self-indication nanotheranostics photodynamic therapy

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一种钹型直线式压电电动机的设计

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机械工程师 2024年第5期 77-81页

作者：龙昊王忠岭闫明孙自强沈阳工业大学辽宁省冲击防护与损伤评估技术工程研究中心沈阳110870 辽宁中蓝光电科技有限公司辽宁盘锦124013

针对高端精密机械领域对响应快、大行程、运动速度快的压电直线电动机的设计需求,设计了一种基于惯性驱动压电陶瓷的新型直线压电直线电动机。通过对压电电动机工作原理及压电电动机应用环境的分析,设计了新的电动机结构,并制作了原理... 详细信息

针对高端精密机械领域对响应快、大行程、运动速度快的压电直线电动机的设计需求,设计了一种基于惯性驱动压电陶瓷的新型直线压电直线电动机。通过对压电电动机工作原理及压电电动机应用环境的分析,设计了新的电动机结构,并制作了原理样机。通过试验数据分析后得知:在一定频率范围内,该款压电定子可以保持纵振幅度足够大且稳定,最大幅值可达740 nm;电动机最大无负载速度为8.56 mm/s,最大负载能力1.5 g。这种电动机结构简单,容易实现小型化。钹形振子更容易放大压电陶瓷的振幅,使该电动机更易于实用化,适合用于物体精密定位、精细物料输送或振动切割工具。

关键词：直线电动机压电振子惯性驱动长行程结构设计

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Climate change filtered out resource-acquisitive plants in a temperate grassland in Inner Mongolia,China

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Science China(Life Sciences) 2024年第2期67卷 403-413页

作者： Heying Jing Xingshuo Xiong Feng Jiang Xucai Pu Wenhong Ma Daijiang Li zhongling Liu Zhiheng wang Institute of Ecology and Key Laboratory for Earth Surface Processes of the Ministry of Education College of Urban and Environmental SciencesPeking UniversityBeijing 100871China Ministry of Education Key Laboratory of Ecology and Resource Use of the Mongolian Plateau School of Ecology and EnvironmentInner Mongolia UniversityHohhot 010021China Department of Biological Sciences Louisiana State UniversityBaton RougeLA 70803USA

Global climate change has led to the decline of species and functional diversity in ecosystems,changing community composition and ecosystem functions.However,we still know little about how species with different resource-use strategies(different types of resource usage and plant growth of plants as indicated by the spectrum of plant economic traits,including acquisitive resource-use strategy and conservative resource-use strategy)would change in response to climate change,and how the changes in the diversity of species with different resource-use strategies may influence community-level productivity.Here,using long-term(1982–2017)observatory data in a temperate grassland in Inner Mongolia,we investigated how climate change had affected the species richness(SR)and functional richness(FRic)for the whole community and for species with different resource-use strategies.Specifically,based on data for four traits representing leaf economics spectrum(leaf carbon concentration,leaf nitrogen concentration,leaf phosphorus concentration,and specific leaf area),we divided 81 plant species appearing in the grassland community into three plant functional types representing resource-acquisitive,medium,and resource-conservative species.We then analyzed the changes in community-level productivity in response to the decline of SR and FRic at the community level and for different resource-use strategies.We found that community-level SR and FRic decreased with drying climate,which was largely driven by the decline of diversity for resource-acquisitive species.However,community-level productivity remained stable because resource-conservative species dominating this grassland were barely affected by climate change.Our study revealed distinctive responses of species with different resource-use strategies to climate change and provided a new approach based on species functional traits for predicting the magnitude and direction of climate change effects on ecosystem functions.

关键词： biodiversity ecological strategy functional diversity functional trait long-term change species diversity

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Ti_(3)C_(2)T_(x)MXene wrapped,carbon-coated porous Si sheets for improved lithium storage performance

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Chinese Chemical Letters 2024年第2期35卷 617-621页

作者： Hui Cheng Yueming Liu zhongling Cheng Xianying wang Na Huang Haijiao Zhang Institute of Nanochemistry and Nanobiology School of Environmental and Chemical EngineeringShanghai UniversityShanghai 200444China Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China Energy Materials Research Center AG Hydrogen Materials & Devices CAS Key Laboratory of Materials for Energy ConversionShanghai Institute of CeramicsChinese Academy of Sciences (SICCAS)Shanghai 200050China

Si-based materials have shown great potential as lithium-ion batteries(LIBs)anodes due to their natural reserves and high theoretical capacity.However,the large volume changes during cycles and poor conductivity of Si lead to rapid capacity decay and poor cycling stability,ultimately limiting their commercial applications.Herein,we have skillfully utilized the microporous MCM-22 zeolite as the unique silicon source to produce porous Si(pSi)sheets by a simple magnesiothermic reduction,followed by a carbon coating and further Ti_(3)C_(2)T_(x)MXene assembly,obtaining the ternary pSi@NC@TNSs composite.In the design,porous Si sheets provide more active sites and shorten Li-ion transport paths for electrochemical reactions.The N-doped carbon(NC)layer serves as a bonding layer to couple pSi and Ti_(3)C_(2)T_(x).The conductive network formed by 2D Ti_(3)C_(2)T_(x)and medium NC layer effectively enhances the overall charge transport of the electrode material,and helps to stabilize the electrode structure.Therefore,the as-made pSi@NC@TNSs anode delivers an improved lithium storage performance,exhibiting a high reversible capacity of 925 mAh/g at 0.5 A/g after 100 cycles.This present strategy provides an effective way towards high-performance Si-based anodes for LIBs.

关键词： Si anodes Ti_(3)C_(2)Ti_(x)MXene Porous structure Interfacial assembly Lithium-ion batteries

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Construction and Application Exploration of Smart Agriculture Based on Big Data Technology

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Journal of Electronic Research and Application 2024年第3期8卷 72-77页

作者： zhongling Li Hairui wang Liaoning Institute of Science and Engineering Jinzhou 121000China

Big data finds extensive application and many fields.It brings new opportunities for the development of agriculture.Using big data technology to promote the development of smart agriculture can greatly improve the effect of agricultural planting,reduce the input of manpower and material resources,and lay a solid foundation for the realization of agricultural modernization.In this regard,this paper briefly analyzes the construction and application of smart agriculture based on big data technology,hoping to provide some valuable insights for readers.

关键词： Big data technology Smart agriculture Construction Apply

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Finite Element Simulations of the Localized Failure and Fracture Propagation in Cohesive Materials with Friction

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 997-1015页

作者： Chengbao Hu Shilin Gong Bin Chen zhongling Zong Xingwang Bao Xiaojian Ru Department of Civil Engineering Hangzhou City UniversityHangzhou310015China Zhejiang Engineering Research Center of Intelligent Urban Infrastructure Hangzhou310015China Key Laboratory of Safe Construction and Intelligent Maintenance for Urban Shield Tunnels of Zhejiang Province Hangzhou310015China School of Civil and Ocean Engineering Jiangsu Ocean UniversityLianyungang222005China Institute of Municipal Engineering Hangzhou Shangcheng District Municipal Engineering Group Co.Ltd.Hangzhou310016China

Strain localization frequently occurs in cohesive materials with friction(e.g.,composites,soils,rocks)and is widely recognized as a fundamental cause of progressive structural failure.Nonetheless,achieving high-fidelity simulation for this issue,particularly concerning strong discontinuities and tension-compression-shear behaviors within localized zones,remains significantly constrained.In response,this study introduces an integrated algorithmwithin the finite element framework,merging a coupled cohesive zone model(CZM)with the nonlinear augmented finite elementmethod(N-AFEM).The coupledCZMcomprehensively describes tension-compression and compressionshear failure behaviors in cohesive,frictional materials,while the N-AFEM allows nonlinear coupled intraelement discontinuities without necessitating extra nodes or nodal DoFs.Following CZM validation using existing experimental data,this integrated algorithm was utilized to analyze soil slope failure mechanisms involving a specific tensile strength and to assess the impact of mechanical parameters(e.g.,tensile strength,weighting factor,modulus)in soils.

关键词： FEM analysis strong discontinuity nonlinear soil rupture cohesive zone model tension-compression-shear coupling

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Two H3K36 methyltransferases differentially associate with transcriptional activity and enrichment of facultative heterochromatin in rice blast fungus

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aBIOTECH 2024年第1期5卷 1-16页

作者： Mengting Xu Ziyue Sun Huanbin Shi Jiangnan Yue Xiaohui Xiong zhongling Wu Yanjun Kou Zeng Tao Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects Institute of BiotechnologyZhejiang UniversityHangzhou 310058China State Key Lab of Rice Biology and Breeding China National Rice Research InstituteHangzhou 310021China

Di-and tri-methylation of lysine 36 on histone H3(H3K36me2/3)is catalysed by histone methyltransferase Set2,which plays an essential role in transcriptional regulation.Although there is a single H3K36 methyltransferase in yeast and higher eukaryotes,two H3K36 methyltransferases,Ash1 and Set2,were present in many filamentous fungi.However,their roles in H3K36 methylation and transcriptional regulation remained unclear.Combined with methods of RNA-seq and ChIP-seq,we revealed that both Ash1 and Set2 are redundantly required for the full H3K36me2/3 activity in Magnaporthe oryzae,which causes the devastating worldwide rice blast disease.Ash1 and Set2 distinguish genomic H3K36me2/3-marked regions and are differentially associated with repressed and activated transcription,respectively.Furthermore,Ash1-catalysed H3K36me2 was co-localized with H3K27me3 at the chromatin,and Ash1 was required for the enrichment and transcriptional silencing of H3K27me3-occupied genes.With the different roles of Ash1 and Set2,in H3K36me2/3 enrichment and transcriptional regulation on the stress-responsive genes,they differentially respond to various stresses in M.oryzae.Overall,we reveal a novel mechanism by which two H3K36 methyltransferases catalyze H3K36me2/3 that differentially associate with transcriptional activities and contribute to enrichment of facultative heterochromatin in eukaryotes.

关键词： Ash1 Facultative heterochromatin H3K36me2/3 Magnaporthe oryzae Set2 Transcriptional regulation

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湖北省水资源压力与经济发展脱钩的时空演化

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水资源保护 2023年第3期39卷 134-141页

作者：陈述汪钟铃颜克胜吕文芳三峡大学水电工程施工与管理湖北省重点实验室湖北宜昌443002 三峡大学水利与环境学院湖北宜昌443002

以水资源压力指数为指标,采用Mann-Kendall检验分析2011—2020年湖北省水资源压力的变化趋势及突变点,并利用Tapio脱钩模型揭示水资源压力与经济发展脱钩关系的时空演化规律。结果表明:除2016年与2020年外,湖北省水资源压力整体偏大,空... 详细信息

以水资源压力指数为指标,采用Mann-Kendall检验分析2011—2020年湖北省水资源压力的变化趋势及突变点,并利用Tapio脱钩模型揭示水资源压力与经济发展脱钩关系的时空演化规律。结果表明:除2016年与2020年外,湖北省水资源压力整体偏大,空间上呈现鄂西最大、鄂东居中、鄂中最小的态势;湖北省水资源压力整体呈下降趋势,突变点在2012年与2019年前后;全省水资源压力与经济发展之间的脱钩关系因水文特征波动,在时序上从2012—2016年的强脱钩发展到2017—2019年的扩张负脱钩,再到2020年的衰退脱钩;因自然气候及发展战略差异,在空间上各区域的平均脱钩率从2012—2016年鄂西最低、鄂东居中、鄂中最高,发展到2017—2019年鄂东最低、鄂中居中、鄂西最高,2020年趋于平衡。为此,湖北省未来应重视制定基于水文波动的水资源压力变化应对预案,并对鄂东和鄂中地区实施产业结构调整。

关键词：水资源压力经济发展脱钩分析时空演化湖北省

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