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Development of a portable reflectance confocal microscope and its application in the noninvasive in vivo evaluation of mesenchymal stem cell-promoted cutaneous wound healing

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Bio-Design and manufacturing 2023年第3期6卷 268-283页

作者： Lixing Zhang Xin Miao Meijia Wang Aihua Shi Jingwen Wang zhonglin ma Yunhai Zhang Jingzhong Zhang Shuang Yu Suzhou Institute of Biomedical Engineering and Technology(SIBET) Chinese Academy of SciencesSuzhou 215163China Department of Biomedical Engineering School of Medical ImagingXuzhou Medical UniversityXuzhou 221004China Zhengzhou Zhongke Institute of Biomedical Engineering and Technology Affiliated with SIBET Zhengzhou 450001China School of Biomedical Engineering(Suzhou) Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China School of Radiation Medicine and Protection Soochow UniversitySuzhou 215123China

The process of wound healing is routinely evaluated by histological evaluation in the clinic,which may cause scarring and secondary *** confocal microscopy(RCM)represents a noninvasive,real-time imaging technique that allows in vivo evaluation of the *** RCM was wide-probe-based,which limited its application on uneven and covered *** this study,we report the development of a portable reflectance confocal microscope(PRCM)in which all components were assembled in a handheld *** the size and weight of the PRCM were reduced based on the use of a microelectromechanical system,the resolution was kept at 0.91μm,and the field of view of the system was 343μm×532μ*** used in vivo,the PRCM was able to visualize cellular and nuclear morphology for both mouse and human *** evaluations were then performed on wounds after topically applied mesenchymal stem cells(MSCs)or saline *** PRCM allowed visualization of the formation of collagen bundles,re-epithelization from the wound edge to the wound bed,and hair follicle regeneration,which were consistent with histological ***,we offer new insights into monitoring the effects of topically applied MSCs on the process of wound healing by using *** study illustrates that the newly developed PRCM represents a promising device for real-time,noninvasive monitoring of the dynamic process of wound healing,which demonstrates its potential to diagnose,monitor,or predict disease in clinical wound therapy.

关键词： Portable reflectance confocal microscope Wound healing Noninvasive optical imaging Real-time in vivo visualization

Novel pneumatically assisted atomization device for living cell delivery:application of sprayed mesenchymal stem cells for skin regeneration

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Bio-Design and manufacturing 2022年第1期5卷 220-232页

作者： Lixing Zhang Xintao Yan Li An Meijia Wang Xi Xu zhonglin ma Mengting Nie Fangzhou Du Jingzhong Zhang Shuang Yu Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of SciencesSuzhou 215163China Zhengzhou Institute of Engineering and Technology Affiliated with SIBET Zhengzhou 450001China Xuzhou Medical University Xuzhou 221004China Academy for Engineering and Technology Fudan UniversityShanghai 200433China

Large cutaneous wounds pose a severe medical problem and may be deadly in cases when regeneration is ***,topical stem cell therapy has been realized as a promising strategy for wound healing and skin ***,stem cells must be administrated uniformly to the wound area,otherwise treatment will be ineffective,which has been a limitation of current administration ***,the delivery pressure and nozzle features of most clinical cell spray devices are unknown,which may significantly affect the viability of sprayed cells and their capacity for ***,we developed a novel pneumatically assisted atomization device(PAAD)in which cell suspensions were uniformly atomized at a low delivery *** optimized the applied fluidic pressure and air pressure to maximize cell survival and function for the application of multiple cell types,while ensuring uniform dispersal across the wound ***,we found that the application of sprayed umbilical cord-derived mesenchymal stem cells to wound sites significantly accelerated wound healing and promoted appendage regeneration on an excisional cutaneous wound ***,the novel PAAD system delivered living cells uniformly and maintained the viability and differentiation of sprayed cells,strongly suggesting its potential for application in clinical cell therapy,especially for large,irregular,and severe skin wounds.

关键词： Cell delivery Skin wound Wound healing Spray application Cell-spray autografting Stem cell therapy

Flexible interdigitated layered framework with multiple accessible active sites for high-performance CH_(3)I capture

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Science China Chemistry 2024年第5期67卷 1569-1577页

作者： Bo Tai Baoyu Li Linwei He zhonglin ma Shujing Lin Mingxing Zhang Junchang Chen Fuqi Wu Long Chen Xing Dai Fuyin ma Zhifang Chai Shuao Wang State Key Laboratory of Radiation Medicine and Protection School for Radiological and interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou 215123China

The development of adsorbent materials for effective capture of radioactive iodomethane(CH_(3)I) from the off-gas of used nuclear fuel reprocessing, remains a significant and challenging line of research because currently state-of-art adsorbents still suffer from low binding affinity with CH_(3)I. Here, we proposed a brand-new adsorption topological structure by developing a 2D interdigitated layered framework, named SCU-20, featuring slide-like channel with multiple active sites for CH_(3)I capture. The responsive rotating-adaptive aperture of SCU-20 enables the optimal utilization of all active sites within the pore for highly selective recognition and capture of CH_(3)I. A record-breaking CH_(3)I uptake capacity of 1.84 g/g was achieved under static sorption conditions with saturated CH_(3)I vapor. Both experimental and theoretical findings demonstrated that the exceptional uptake of SCU-20 towards CH_(3)I can be attributed to the confined physical electrostatic adsorption of F sites, coupled with the chemical nitrogen methylation reaction with uncoordinated N atoms of pyrazine. Moreover, dynamic CH_(3)I uptake capacity potentially allows for the capture of CH_(3)I in simulated real-world off gas reprocessing conditions. This study highlights the potential of SCU-20 as a promising candidate for efficient capture of iodine species and contributes to the development of effective solutions for radioactive iodine remediation.

关键词： 2D interdigitated layered framework iodomethane dual-sites electrostatic interaction physisorption and chemisorption

Synergy of first-and second-sphere interactions in a covalent organic framework boosts highly selective platinum uptake

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Science China Chemistry 2023年第3期66卷 783-790页

作者： Linwei He Baoyu Li zhonglin ma Lixi Chen Shicheng Gong Mingxing Zhang Yaoyao Bai Qi Guo Fuqi Wu Fuqiang Zhao Jie Li Duo Zhang Daopeng Sheng Xing Dai Long Chen Jie Shu Zhifang Chai Shuao Wang State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou 215123China Analysis and Testing Center Soochow UniversitySuzhou 215123China

Platinum recovery from waste electrical and electronic equipment(WEEE) in highly acidic solutions is significant to the electronics industry and environmental remediation. However, the lack of ingenious design and synergetic coordination gives rise to unsatisfied PtCl_(4)^(2-)extraction capacities and selectivities in most previously reported adsorbents(e.g., polymeric and inorganic materials). Herein, we proposed a synergistic strategy that realizes highly selective PtCl_(4)^(2-)uptake through first-and second-sphere coordinations. The proof-of-concept imine-linked covalent organic framework(SCU-COF-3) was found to chelate Pt Cl42-via the direct N…Pt coordination and the synergistically interlaminar N–H…Cl hydrogen bonds, which was disclosed by the comprehensive analysis of extended X-ray adsorption fine structure(EXAFS) characterizations and density functional theory(DFT) calculations. The unique adsorption mechanism imparts a superior adsorption capacity(168.4 mg g-1)and extraordinary Pt(II) selectivity to SCU-COF-3 under static conditions. In addition, SCU-COF-3 exhibits an upgraded distribution coefficient of 1.62 × 10^(5)mL· g^(-1), one order of magnitude higher than those of reported natural adsorbents. Specifically, SCU-COF-3 can extract PtCl_(4)^(2- )quantitatively from a simulated acidic waste solution coexisting with other 12 competitive ions, suggesting its promising application in practical scenarios.

关键词： covalent organic frameworks platinum hydrogen bond adsorption

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主被动锁模Nd∶YLF激光器

中国激光 2000年第3期27卷 200-202页

作者：王春陈绍和马忠林许世忠中国科学院上海光机所上海201800

在脉冲抽运主动锁模Nd∶YLF激光器中 ,用倍频晶体CLBO和双色镜构成的非线性镜取代输出镜 ,实现了主被动锁模 ,与纯主动锁模相比 ,脉冲宽度压缩了 8倍 ,获得了

关键词：固体激光器双色镜主被动锁模 Nd:YLF激光器

自拟扶正祛邪化瘀汤配合针刺治疗类风湿关节炎的临床观察

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中国医药导刊 2018年第7期20卷 393-396页

作者：马仲林兰州中医骨伤科医院甘肃兰州730030

目的:观察自拟扶正祛邪化瘀汤配合针刺治疗类风湿关节炎(RA)的临床疗效。方法:RA患者80例随机分为观察组和对照组,每组各40例。对照组给予西药常规治疗,观察组在对照组基础上配合自拟扶正祛邪化瘀汤配合针刺治疗,两组均每日1次,连续治疗... 详细信息

目的:观察自拟扶正祛邪化瘀汤配合针刺治疗类风湿关节炎(RA)的临床疗效。方法:RA患者80例随机分为观察组和对照组,每组各40例。对照组给予西药常规治疗,观察组在对照组基础上配合自拟扶正祛邪化瘀汤配合针刺治疗,两组均每日1次,连续治疗4周。治疗结束后观察比较两组治疗前后临床症状、实验室指标[包括类风湿因子(rheumatoid factor,RF)、C-反应蛋白(C-reactive protein,CRP)、血沉(erythrocyte sedimentation rate,ESR)、抗环瓜氨酸肽抗体(A-CCP)水平]以及疾病活动度(DAS28评分)。结果:观察组临床总有效率为90.0%,高于对照组的77.5%,差异有统计学意义(P<0.05);治疗后,两组患者晨僵时间、休息痛、压痛个数、肿胀个数、双手握力和健康状况问卷均较治疗前明显改善(P<0.05),观察组优于对照组(P<0.05);两组患者治疗后RF、CRP、ESR、A-CCP指标均较治疗前降低(P<0.05);观察组较对照组改善明显(P<0.05);两组患者治疗后DAS28评分均较治疗前下降(P<0.05),观察组DAS28评分均低于对照组(P<0.05)。结论 :自拟扶正祛邪化瘀汤配合针刺治疗RA疗效稳定,可改善RA患者的症状,RF、CRP、ESR、A-CCP指标等实验室指标以及RA疾病的活动度。

关键词：扶正祛邪化瘀汤针刺类风湿关节炎类风湿因子

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前馈环与反馈环的动力学行为研究进展

山西大学学报(自然科学版) 2024年第4期47卷 717-726页

作者：祁宏马中琳曹旭清山西大学复杂系统研究所

模体是网络中频繁出现的局部连接模式，是组成网络的基础构件。前馈环和反馈环是生物网络中最常见的两种模体，研究者们针对它们分别做了大量研究。虽然很多证据表明生物网络中有前馈环和反馈环共存的实例，但目前尚缺乏对这种耦合网络... 详细信息

模体是网络中频繁出现的局部连接模式，是组成网络的基础构件。前馈环和反馈环是生物网络中最常见的两种模体，研究者们针对它们分别做了大量研究。虽然很多证据表明生物网络中有前馈环和反馈环共存的实例，但目前尚缺乏对这种耦合网络动力学行为的研究。本综述首先介绍了前馈环的结构与功能；然后总结了反馈环的结构与动力学行为，着重阐述了多稳态和振荡这两种动力学行为的研究现状；最后列举了一些既包含前馈环又包含反馈环结构的生物学实例，强调了研究此类耦合网络动力学行为的重要性。

关键词：模体前馈环反馈环多稳态振荡

来源：博看期刊

桂西北微细浸染型金矿中铂族元素的发现及其找矿意义

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地质找矿论丛 2019年第1期34卷 10-14页

作者：马忠林辽宁省第九地质大队辽宁铁岭112000

本文基于辽宁第九地质大队2015—2017年间在桂西北尾腊沟金矿勘查过程中的新发现而撰写。桂西北尾腊沟金矿体主要赋存于中三叠统兰木组二段第3亚段的压碎泥岩、粉砂岩、细砂岩中;而铂族元素矿则是在兰木组二段第1、2、3亚段地层中,均存... 详细信息

本文基于辽宁第九地质大队2015—2017年间在桂西北尾腊沟金矿勘查过程中的新发现而撰写。桂西北尾腊沟金矿体主要赋存于中三叠统兰木组二段第3亚段的压碎泥岩、粉砂岩、细砂岩中;而铂族元素矿则是在兰木组二段第1、2、3亚段地层中,均存在不同程度的铂(族)矿化。区内的铂族元素不单纯局限在金矿体内,在其围岩中也同样存在,找矿潜力乐观。本次在桂西北中三叠统砂岩、泥岩中发现高品位的铂族元素,突破了我国在川黔滇围绕寒武系黑色页岩中寻找铂族元素矿的束缚,无疑对今后铂族元素的找矿方向拓宽了新的思路,也为研究铂族元素的成矿机制提供了新的线索。

关键词：微细浸染型金矿铂族元素黑色岩系铂族矿床桂西北地区

EVA生产工艺及性能影响因素——以陕西延长中煤榆林能源化工股份有限公司生产线为例

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生物化工 2024年第4期10卷 145-147页

作者：马帅马忠林陕西延长中煤榆林能源化工股份有限公司陕西榆林718500

乙烯-醋酸乙烯共聚树脂(Ethylene-Vinyl Acetate resin,EVA)是继高密度聚乙烯、低密度聚乙烯和线性低密度聚乙烯之后的第四大乙烯系列聚合物,广泛应用于塑料制品、橡胶制品等领域,在新产能的不断投放下,EVA的总产量稳步增长。本文以陕... 详细信息

乙烯-醋酸乙烯共聚树脂(Ethylene-Vinyl Acetate resin,EVA)是继高密度聚乙烯、低密度聚乙烯和线性低密度聚乙烯之后的第四大乙烯系列聚合物,广泛应用于塑料制品、橡胶制品等领域,在新产能的不断投放下,EVA的总产量稳步增长。本文以陕西延长中煤榆林能源化工股份有限公司生产线为例,论述EVA的生产流程及工艺装置主要单元,分析了影响其性能的主要因素,旨在加强对EVA生产工艺的认知,助力EVA化工产业的高质量发展。

关键词： EVA 生产工艺性能影响因素熔融指数