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BLT1 in dendritic cells promotes Th1/Th17 differentiation and its deficiency ameliorates TNBS-induced colitis

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Cellular & Molecular Immunology 2018年第12期15卷 1047-1056页

作者： Jinfeng Zhou Weiming Lai Wanjie Yang Juping Pan Hu Shen Yingying Cai Cuixia Yang Ningjia ma Yue Zhang Ru Zhang Xin Xie zhongjun Dong Yuan Gao Changsheng Du Putuo District People’s Hospital Shanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Tongji Hospital of Tongji University branch Tongji UniversityShanghai 200092China CAS Key Laboratory of Receptor Research National Center for Drug ScreeningShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Institute for Immunology and School of Medicine Tsinghua UniversityBeijing 100086China

Leukotriene B4(LTB4)synthesis is enhanced in the colonic mucosa in patients with inflammatory bowel disease(IBD).BLT1,a highaffinity receptor for LTB4,exhibits no effect on the progression of dextran sodium sulfate(DSS)-induced colitis,which mostly relies on innate ***,we reported that BLT1 regulates trinitrobenzene sulfonic acid(TNBS)-induced colitis,which reflects CD4+T-cell-dependent adaptive immune mechanisms of *** found that BLT1 signaling enhanced the progression of colitis through controlling the production of proinflammatory cytokines by dendritic cells(DCs)and modulating the differentiation of Th1 and ***1−/−mice displayed an alleviated severity of TNBS-induced colitis with reduced body weight loss and infiltrating cells in the lamina ***1 deficiency in DCs led to reduced production of proinflammatory cytokines,including IL-6,TNF-α,and IL-12,and these results were further confirmed via treatment with a BLT1 *** impaired cytokine production by BLT1−/−DCs subsequently led to reduced Th1 and Th17 differentiation both in vitro and in *** further performed a conditional DC reconstitution experiment to assess whether BLT1 in DCs plays a major role in regulating the pathogenesis of TNBS-induced colitis,and the results indicate that BLT1 deficiency in DCs also significantly reduces disease *** mechanistic study demonstrated that BLT1-regulated proinflammatory cytokine production through the Gαiβγsubunit-phospholipase Cβ(PLCβ)-PKC ***,we found that treatment with the BLT1 antagonist also reduced the production of proinflammatory cytokines by human peripheral blood *** findings reveal the critical role of BLT1 in regulating adaptive immunity and TNBS-induced colitis,which further supports BLT1 as a potential drug target for adaptive immunity-mediated IBD.

关键词： Th17 colitis immunity

超声辅助微注塑成型中熔体壁面滑移行为的研究

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应用基础与工程科学学报 2017年第5期25卷 1057-1064页

作者：高山仇中军马壮天津大学精密测试技术及仪器国家重点实验室天津300072

壁面滑移在聚合物熔体注塑成型过程对熔体充模流动行为具有显著的影响.本文基于对超声辅助微注塑加工机理的研究,分析了超声振动对微尺度型腔中熔体壁面滑移的作用方式.结合聚合物熔体壁面滑移方程和超声对熔体壁面滑移的影响机理,阐明... 详细信息

壁面滑移在聚合物熔体注塑成型过程对熔体充模流动行为具有显著的影响.本文基于对超声辅助微注塑加工机理的研究,分析了超声振动对微尺度型腔中熔体壁面滑移的作用方式.结合聚合物熔体壁面滑移方程和超声对熔体壁面滑移的影响机理,阐明了不同情况下的壁面滑移理论模型.采用毛细管流变仪研究了超声振动作用下的聚合物熔体的壁面滑移行为,通过分析壁面滑移的临界剪切应力变化,明确了超声振动作用下的熔体壁面滑移行为对微尺度型腔充模情况的影响.研究结果表明,超声辅助微注塑过程中,超声作用下的微尺度型腔中熔体壁面滑移的临界剪切应力降低或变为零,壁面滑移速度随剪切应力增加而增加,不同剪切速率时超声作用下的熔体黏度均明显降低,进而提升了熔体对微尺度型腔的充模能力并改善了微塑件的成型质量.

关键词：超声微注塑壁面滑移熔体流动毛细管流变仪

特大铁路钢梁桥调平垫片用Q235钢的C-N-O-S多元共渗及组织性能演变

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金属热处理 2024年第5期49卷 260-266页

作者：张敏敏王殿堂李江涛王忠军张纪兵张强魏胜民张琪李建国中国铁路济南局集团有限公司科学技术研究所山东济南250001 中国铁路济南局集团有限公司工务部山东济南250001 中国铁路济南局集团有限公司科信部山东济南250001 中国铁路济南局集团有限公司聊城工务段山东聊城252004 中国铁道科学研究院集团有限公司铁道科学技术研究发展中心北京100081

为有效延长钢梁桥Q235钢调平垫片的服役寿命,采用C-N-O-S多元共渗技术进行改性处理,研究了不同参数耦合对改性层组织、硬度、耐磨性及耐候性的影响。结果表明,改性层多层结构与共渗温度有关,在640℃与650℃之间存在临界值,临界温度以下... 详细信息

为有效延长钢梁桥Q235钢调平垫片的服役寿命,采用C-N-O-S多元共渗技术进行改性处理,研究了不同参数耦合对改性层组织、硬度、耐磨性及耐候性的影响。结果表明,改性层多层结构与共渗温度有关,在640℃与650℃之间存在临界值,临界温度以下由化合物层、扩散层及氧化层组成,当超过临界温度时,由化合物层和氧化层组成。改性层厚度受共渗温度、氨气及催渗剂影响机制不同,共渗温度及氨气流量对渗层各层结构均有影响,扩散层受催渗剂流量作用明显;改性层硬度是基材的2~3倍,三层结构渗层硬度由表层向基材不断降低;两层结构化合物层的硬度均匀,在界面区硬度陡降。改性层摩擦因数最低为0.2468,约为基材的1/3。改性层自腐蚀电位最高达-0.4845 V,自腐蚀电流密度最低为1.187×10-6 ma/cm2,较基体降低2个数量级。

关键词：铁路钢梁桥调平钢垫片服役寿命多元共渗组织性能

Two-dimensional tin diselenide nanosheets pretreated with an alkaloid for near-and mid-infrared ultrafast photonics

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Photonics Research 2020年第11期8卷 1687-1696页

作者： Zhenhong Wang Bin Zhang Bing Hu zhongjun Li Chunyang ma Yu Chen Yufeng Song Han Zhang Jun Liu Guohui Nie Shenzhen Engineering Laboratory of Phosphorene and Optoelectronics Institute of Translational MedicineDepartment of OtolaryngologyShenzhen Second People's HospitalThe First Affiliated Hospital of Shenzhen UniversityHealth Science CenterInternational Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of EducationCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China

Two-dimensional(2D)tin diselenide(SnSe2),a novel layered material with excellent optical and electronic properties,has been extensively investigated in various promising applications,including photodetectors,optical switching,and ultrafast *** this work,SnSe2 nanosheets have been obtained after pretreatment in an alkaloid,exhibiting high optical absorption and electron-enriched ***,the performances of the prepared SnSe2 in near-infrared(NIR)and mid-infrared(MIR)ultrafast photonics are ***,by employing the SnSe2-deposited microfiber device as a saturable absorber(SA)exhibiting typical nonlinear optical absorption properties,stable ultrashort pulses and rogue waves are realized in an erbium-doped fiber ***,the SnSe2-deposited SA device is also applied to a thulium-doped fiber laser to achieve stable ultrashort *** study indicates that SnSe2 is expected to be a suitable candidate for ultrafast fiber lasers in the NIR and MIR regions.

关键词： SnSe2 fiber ultrashort

Fabrication of ulcer-adhesive oral keratin hydrogel for gastric ulcer healing in a rat

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Regenerative Biomaterials 2021年第2期8卷 129-139页

作者： zhongjun Cheng Rui Qing Shilei Hao Yi Ding Haimeng Yin GuoDong Zha Xiaoliang Chen Jingou Ji Bochu Wang Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400030China School of Chemistry and Chemical Engineering Chongqing UniversityChongqing 401331China Bijie Institute of Traditional Chinese Medicine Bijie CityGuizhou Province 551700China Media Lab Massachusetts Institute of TechnologyCambridgeMA 02142USA HEMOS(Chongqing)Bioscience Co. LtdChongqing 402760China Department of Nuclear Medicine Institution of Chongqing CancerChongqing 400030China

Hydrogel has been used for in suit gastric ulcer therapy by stopping bleeding,separating from ulcer from gastric fluids and providing extracellular matrix scaffold for tissue regeneration,however,this treatment guided with endoscopic catheter in most ***,we developed an oral keratin hydrogel to accelerate the ulcer healing without endoscopic guidance,which can specially adhere to the ulcer because of the high-viscosity gel formation on the wound surface in *** 50%of the ulcer-adhesive keratin hydrogel can resident in ethanol-treated rat stomach within 12 h,while approximately 18%of them maintained in health rat stomach in the same amount of ***,Keratin hydrogels accelerated the ethanol-induced gastric ulcer healing by stopping the bleeding,preventing the epithelium cells from gastric acid damage,suppressing inflammation and promoting *** oral administration of keratin hydrogel in gastric ulcer treatment can enhance the patient compliance and reduce the gastroscopy *** research findings reveal a promising biomaterial-based approach for treating gastrointestinal ulcers.

关键词： gastric ulcer keratin hydrogel adhesive oral administration

基于EDEM的带状深松全层施肥铲作业参数优化与试验

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农业机械学报 2021年第10期52卷 74-83页

作者：刘立晶马超刘忠军中国农业机械化科学研究院北京100083 土壤植物机器系统技术国家重点实验室北京100083

为了实现一次施肥满足作物不同生育期的养分需求并提高肥料利用率,设计了一种适用于带状免耕播种机的深松全层施肥铲,并对深松铲、施肥管和施肥板的夹角进行理论分析与设计,得到关键参数的理论值。采用二次回归通用旋转组合设计试验,以... 详细信息

为了实现一次施肥满足作物不同生育期的养分需求并提高肥料利用率,设计了一种适用于带状免耕播种机的深松全层施肥铲,并对深松铲、施肥管和施肥板的夹角进行理论分析与设计,得到关键参数的理论值。采用二次回归通用旋转组合设计试验,以肥量均匀变异系数为响应指标,以工作速度和作业深度为影响因子,利用EDEM建立深松全层施肥铲的离散元仿真模型,模拟深松全层施肥铲的工作过程,通过仿真分析得出试验数据;运用Design-Expert软件对试验数据进行方差分析和响应面分析,得到最优工作参数组合为:工作速度3.81 m/s,作业深度25.22 cm。取工作速度4 m/s、作业深度25 cm进行田间试验,结果表明,本文设计的施肥铲在最优工作参数下,0~5 cm、5~10 cm、10~15 cm、15~20 cm土层的肥量均匀性变异系数分别为41.05%、24.11%、20.31%、14.63%,试验值与理论优化值相对误差为10.89%、4.06%、2.37%、3.10%。

关键词：免耕播种机带状深松全层施肥 EDEM

面向碱性析氢反应的原子级优化Fe-Pt金属间化合物催化剂表面终结态探索

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Science Bulletin 2024年第8期69卷 1091-1099页

作者：梁庆孟繁玲李文文邹旭宋可心葛昕姜周刘玉华刘美琦李振宇董韬文陈中军张伟郑伟涛 Key Laboratory of Automobile materials(Ministry of Education) School of Materials Science and EngineeringElectron Microscopy CenterInternational Center of Future ScienceJilin Provincial International Cooperation Key Laboratory of High-Efficiency Clean Energy MaterialsJilin UniversityChangchun 130012China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Controlling the atomic arrangement of elemental atoms in intermetallic catalysts to govern their surface and subsurface properties is a crucial but challenging endeavor in electrocatalytic *** hydrogen evolution reaction(HER),adjusting the d-band center of the conventional noble-metallic Pt by introducing Fe enables the optimization of catalytic ***,a notable gap exists in research on the effective transition from disordered Fe/Pt alloys to highly ordered intermetallic compounds(IMCs)such as FePt_(3)in the alkaline HER,hampering their broader *** this study,a series of catalysts FePt_(3-x)H(x=5,6,7,8 and 9)supported on carbon nanotubes(CNTs)were synthesized via a simple impregnation method,along with a range of heat treatment processes,including annealing in a reductive atmosphere,to regulate the order degree of the arrangement of Fe/Pt atoms within the FePt_(3)*** using advanced microscopy and spectroscopy techniques,we systematically explored the impact of the order degree of FePt_(3)in the *** as-prepared FePt_(3)-8H exhibited notable HER catalytic activity with low overpotentials(η=37 mV in 1.0 mol L^(-1)KOH)at j=10 ma cm^(-2).The surface of the L1_(2)FePt_(3)-8H catalyst was demonstrated to be *** Pt on the surface was not easily oxidized due to the unique Fe/Pt coordination,resulting in significant enhancement of HER performance.

关键词： Intermetallic Hydrogen evolution reaction Surface Catalyst

自体血回输对剖宫产后大出血患者凝血功能转归的影响及体会

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国际麻醉学与复苏杂志 2024年第6期45卷 597-601页

作者：曾华北夏春华程智永单以东张瑜张中军江南大学无锡医学院江南大学附属医院麻醉科无锡214122 宿迁市妇幼医院麻醉科宿迁223800

目的探讨自体血回输对剖宫产后大出血患者凝血功能恢复的影响。方法纳入2020年1月至2022年7月收治于宿迁市妇幼医院产科发生剖宫产后大出血患者,使用分层区组随机化法将患者分为两组(每组30例):对照组(A组)、观察组(B组)。A组进行同种... 详细信息

目的探讨自体血回输对剖宫产后大出血患者凝血功能恢复的影响。方法纳入2020年1月至2022年7月收治于宿迁市妇幼医院产科发生剖宫产后大出血患者,使用分层区组随机化法将患者分为两组(每组30例):对照组(A组)、观察组(B组)。A组进行同种异体输血,B组进行自体血回输。记录两组患者术前12 h、术后12 h的红细胞(RBC)、血红蛋白(Hb)、血细胞比容(Hct)等血常规指标,凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、凝血酶时间(TT)、纤维蛋白原(Fib)等凝血功能指标,血栓弹力图(TEG)R值、K值、α角、最大振幅(ma)值等指标。比较两组出血量>2000 ml的患者术前12 h、术后12 h血常规及凝血功能指标。记录两组患者术后不良反应(发热、感染、过敏、溶血)的发生情况。结果B组术后12 h Hb、Hct、RBC、Fib高于A组(均P2000 ml的患者术后12 h Hb、Hct、RBC、Fib高于A组出血量>2000 ml的患者(均P2000 ml的患者(均Pma值高于A组(均P0.05)。结论对于剖宫产后大出血患者,相较于异体输血,自体血回输的患者术后血液指标恢复情况可能更好,凝血功能的恢复也更快,不良反应的发生率更低。

关键词：自体血回输剖宫产后大出血凝血功能检测

Origin and characteristics of grain dolomite of Ordovician ma5^5 Member in the northwest of Ordos Basin, NW China

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Petroleum Exploration and Development 2019年第6期46卷 1182-1194页

作者： ZHANG Xi ZHANG Tingshan LEI Bianjun ZHANG Jingxuan ZHANG Ji ZHAO zhongjun YONG Jinjie School of Geoscience and Technology Southwest Petroleum UniversityChengdu 610500China Royal Melbourne Institute of Technology University MelbourneVIC 3001Australia PetroChina Changqing Oilfield Company Xi’an 710018China

The origin of grain dolomite in M55 Member of Ordovician majiagou Formation in northwestern Ordos Basin was studied by geochemical and petrological tests on core *** of cores,thin sections and casting thin sections,analysis of cathodoluminescence,X-ray diffraction,microscopic sampling of trace elements,laser samplingδ18O andδ13C,and fluid inclusion homogenization temperature were *** results show that the dolomite is the product of recrystallization of micritic to crystal powder dolomite rather than the product of dolomitization of grain *** the spherical grains are residual gypsum and halite pseudo crystals identical with those in the host micritic *** spherical particles of dolomite has similar trace elements andδ18O andδ13C characteristics to micritic ***,Mn/Sr ratio of the fine-medium dolomite between the dolomite grains is about 5-8,while Mn/Sr ratios of calcite in limestone,micritic dolostone in micritic dolomite,and micritic and powdery dolomite are about 0-2,indicating that the dolomite experienced strong *** temperature of inclusions of fine-medium dolomite is about 148.19°C,higher than that of inclusions in micritic to crystal powder dolomite(about 122.60°C),which also supports the conclusion that the grain dolomite experienced burial diagenesis and negative shift ofδ18O andδ***δ18O,δ13C values of micritic to crystal powder dolomite match with the negative migration,but those of calcite in limestone don’*** is of great significance to elucidate the genesis of"dolomite recrystallization"for the prediction of such dolomite reservoirs.

关键词： Ordos Basin Ordovician majiagou Formation trace element δ13C δ18O fluid inclusions diagenesis grain dolomite dolomite origin