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Journal of Ocean University of China 2019年第2期18卷 358-364页

作者： YU Kaiben YU Shengqi liu Baohua liu zhongchen YANG Zhiguo KAN Guangming ZONG Le College of Marine Geo-Sciences Ocean University of China National Deep Sea Center State Oceanic Administration Laboratory for Marine Geology and Environment Pilot National Laboratory for Marine Science and Technology (Qingdao) Key Laboratory of Marine Sedimentology and Environmental Geology First Institute of Oceanography

A method of obtaining bottom backscattering strength by employing an omnidirectional projector and omnidirectional hydrophone is proposed. The backscattering strength is extracted from monostatic backscattering data. The method was adopted in an experiment conducted in the South Yellow Sea of China. The seafloor surface was relatively smooth and covered by a small quantity of shell fragments, as observed through a digital camera system. Sampling data showed that the main component of the sediment at this experimental site was fine sand. In this paper, we detail the calculation method. Preliminary results of backscattering strength as a function of grazing angle(20?–70?) in the frequency range of 6–24 kHz are presented. The measured backscattering strength increased with the grazing angle and changed more rapidly at large grazing angles(60?–70?). A comparison of the data at different frequencies reveals that the measured backscattering strength substantially rises with the increase of acoustic frequency. A fitting curve of Lambert's law against the measured data shows that the backscattering strength deviates from Lambert's law at large grazing angles.

关键词： acoustic scattering bottom backscattering strength fine sand Lambert’s law

TIPE-mediated up-regulation of MMP-9 promotes colorectal cancer invasion and metastasis through MKK-3/p38/NF-κB pro-oncogenic signaling pathway

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1049-1051页

作者： Huiyu Chen Yuhan Ye Yan Yang Mengya Zhong Lei Gu Zhaopu Han Jinhua Qiu zhongchen liu Xingfeng Qiu Guohong Zhuang Cancer Research Center School of MedicineXiamen UniversityXiamenFujianChina Department of Pathology Zhongshan Hospital Affiliated to Xiamen UniversityXiamenFujianChina Department of General Surgery Shanghai 10th People’s Hospital Affiliated to Tongji UniversityShanghaiChina Department of Gastrointestinal Surgery Zhongshan Hospital Affiliated to Xiamen UniversityXiamenFujianChina Organ Transplantation Institute of Xiamen University Fujian Provincial Key Laboratory of Organ and Tissue RegenerationSchool of MedicineXiamen UniversityXiamenFujianChina

Dear Editor,Colorectal cancer(CRC)is the third most common malignant tumor in human,ranking third in cancer-related mortality.1 Most colon cancer patients die of metastasis.2 Intriguingly,the deregulation of tumor necrosis factorα‑induced protein 8(TIPE)has been shown to play a vital regulatory role in tumor cell growth,proliferation,invasion,and metastasis.3 TIPE is a kind of cytoplasmic protein of 23 kDa.A large number of studies have shown that TIPE is closely related to the development of colon cancer.4 In addition,decreased expression of TIPE was linked to down-regulation of matrix metallopeptidase-1(MMP-1),MMP-9,and vascular endothelial growth factor receptor-2 in breast cancer.

关键词： metastasis TIP p38

RGD-FasL Induces Apoptosis in Hepatocellular Carcinoma

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Cellular & Molecular Immunology 2009年第4期6卷 285-293页

作者： zhongchen liu Juan Wang Ping Yin Jinhua Qiu Ruizhen liu Wenzhu Li Xin Fan Xiaofeng Cheng Caixia Chen Jiakai Zhang Guohong Zhuang Anti-Cancer Research Center Medical College Xiamen University 422Siming South Road Xiamen 361005 China School of Life Science Xiamen University 422 Siming South RoadXiamen 361005 China Zhongshan Hospital Xiamen University Lakeside South 201-209 Xiamen361004 China These authors contributed equally to this work Anti-Cancer Research Center Medical College Xiamen University 422 Siming South Road Xiamen 361005 China

Despite impressive results obtained in animal models, the clinical use of Fas ligand （FasL） as an anticancer drug is limited by severe toxicity. Systemic toxicity of death ligands may be prevented by using genes encoding membrane-bound death ligands and by targeted transgene expression through either targeted transduction or targeted transcription. Selective induction of tumor cell death is a promising anticancer strategy. A fusion protein is created by fusing the extracellular domain of Fas ligand （FasL） to the peptide arginine-glycine-aspartic acid （RGD） that selectively targets avβ-integrins on tumor endothelial cells. The purpose of this study is to evaluate the effects of RGD-FasL on tumor growth and survival in a murine hepatocellular carcinoma （HCC） tumor model. Treatment with RGD-FasL displaying an obvious suppressive effect on the HCC tumor model as compared to that with FasL （p 〈 0.05） and resulted in a more additive effect on tumor growth delay in this model. RGD-FasL treatment significantly enhanced mouse survival and caused no toxic effect, such as weight loss, organ failure, or other treatment-related toxicities. Apoptosis was detected by flow cytometric analysis and TUNEL assays; those results also showed that RGD-FasL is a more potent inducer of cell apoptosis for H22 and H9101 cell lines than FasL （p 〈 0.05）. In conclusion, RGD-FasL appears to be a low-toxicity selective inducer of tumor cell death, which merits further investigation in preclinical and clinical studies. Furthermore, this approach offers a versatile technology for complexing target ligands with therapeutic recombinant proteins. To distinguish the anti-tumor effects of FasL in vivo, tumor and liver tissues were harvested to examine for evidence of necrotic cells, tumor cells, or apoptotic cells by Hematoxylin and eosin （H＆E） staining.

关键词： FasL RGD-FasL apoptosis tumor targeting

Combination of Human Fas （CD95/Apo-1） Ligand with Adriamycin Significantly Enhances the Efficacy of Antitumor Response

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Cellular & Molecular Immunology 2009年第3期6卷 167-174页

作者： zhongchen liu Ruizhen liu Jinhua Qiu Ping Yin Fanghong Luo Jinhua Su Wenzhu Li Caixia Chen Xin Fan Jiakai Zhang Guohong Zhuang Anti-Cancer Research Center Medical College Xiamen University 422 Siming South Road Xiamen Fujian 361005 China Zhongshan Hospital Xiamen University 201-209 Lakeside South Xiamen Fujian 361004 China College of Life Science Xiamen University 422 Siming South Road Xiamen Fujian 361005 China These authors contributed equally to this work

The prognosis of hepatocellular carcinoma （HCC） is poor, even with the combined treatment of curative resection and adjuvant chemoradiotherapy. To solve this problem, many biologic therapies have been investigated. Fas ligand （FasL, CD95L） is mainly expressed in activated T lymphocytes and natural killer （NK） cells, and plays a central role in both cell-mediated immunity and immune downregulation. Several studies have shown that FasL is expressed in HCC. In the present report, we prepared recombinant human pET-22b（＋）/FasL protein and investigated the effect of FasL on HCC cells in vitro and on tumor growth in a murine HCC tumor model. The well-known cytotoxic chemotherapeutic reagent adriamycin （ADM） served as a control. We found that FasL effectively suppressed the viability of H22 tumor cells and significantly induced the apoptosis of H22 cells. The apoptotic levels of cells treated with FasL-ADM were significantly higher than those treated with FasL or ADM alone, and the FasL-ADM combination resulted in a more than additive effect on tumor growth delay in this model. The results suggested that combined treatment of FasL and other chemotherapeutic agents may be a new approach to improve the efficacy of chemotherapy for HCC.

关键词： hepatocellular carcinoma combination therapy FasL ADM apoptosis

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超声速条件下旋成体声爆典型影响因素分析

空气动力学学报 2019年第4期37卷 655-662,689页

作者：冷岩钱战森刘中臣航空工业空气动力研究院沈阳110034 高速高雷诺数气动航空科技重点实验室沈阳110034

声爆问题是制约未来超声速客机进入真正商业运营的关键技术之一。航空工业气动院发展了基于近场CFD模拟和远场传播模型相结合的混合声爆数值预测平台ARI_Boom,基于典型旋成体模型。在Ma=1.41~6.0范围内,研究了飞行参数和外形参数对地面... 详细信息

声爆问题是制约未来超声速客机进入真正商业运营的关键技术之一。航空工业气动院发展了基于近场CFD模拟和远场传播模型相结合的混合声爆数值预测平台ARI_Boom,基于典型旋成体模型。在Ma=1.41~6.0范围内,研究了飞行参数和外形参数对地面声爆特征(包括最大过压和特征正冲量)的影响。首先给出了ARI_Boom预测平台计算方法介绍,并通过典型算例对其进行验证;其次,基于所建立平台研究了飞行参数和外形参数对地面声爆特征影响。结果表明:针对所研究构型,减小半锥角、减小长细比、降低飞行马赫数和提高飞行高度均能减弱地面声爆特征;随着钝度系数的增加,最大过压先减小后增加,并存在最佳钝度。

关键词：超声速飞行器声爆外形参数飞行参数影响分析

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声爆近场压力测量风洞试验技术研究进展

空气动力学学报 2019年第4期37卷 636-645页

作者：刘中臣钱战森冷岩中国航空工业空气动力研究院沈阳110034 高速高雷诺数气动力航空科技重点实验室沈阳110034

声爆是超声速民用飞机研制的关键问题之一,风洞试验作为开展声爆研究必不可少的技术手段具有重要研究意义。简要介绍了声爆风洞试验的特点与难点,分析了声爆风洞试验技术的发展趋势。按照空间压力测量装置的不同,将试验技术归纳为测压... 详细信息

声爆是超声速民用飞机研制的关键问题之一,风洞试验作为开展声爆研究必不可少的技术手段具有重要研究意义。简要介绍了声爆风洞试验的特点与难点,分析了声爆风洞试验技术的发展趋势。按照空间压力测量装置的不同,将试验技术归纳为测压板、静压探针、测压轨、无反射测压轨等四类空间压力测量技术。重点针对基于无反射测压轨的空间压力精确测量技术和数据修正技术进行了总结与分析。无反射测压轨具有试验效率高、测量精度高、可有效降低流场非均匀扰动误差等优点,是声爆近场压力测量技术的重要发展方向。

关键词：声爆风洞试验空间压力测量无反射测压轨空间平均

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声爆近场空间压力风洞测量技术

航空学报 2020年第4期41卷 109-121页

作者：刘中臣钱战森冷岩高亮杰航空工业空气动力研究院沈阳110034 高速高雷诺数气动力航空科技重点实验室沈阳110034

针对暂冲式超声速风洞中的声爆试验,发展了近场空间压力精确测量技术,以航空工业空气动力研究院的FL-60风洞为例,开展了技术验证。FL-60风洞是一座典型的亚跨超三声速下吹式风洞,其试验马赫数范围为0.3~4.2,试验段尺寸为1.2m×1.2m,单... 详细信息

针对暂冲式超声速风洞中的声爆试验,发展了近场空间压力精确测量技术,以航空工业空气动力研究院的FL-60风洞为例,开展了技术验证。FL-60风洞是一座典型的亚跨超三声速下吹式风洞,其试验马赫数范围为0.3~4.2,试验段尺寸为1.2m×1.2m,单车次试验时间通常为数十秒。根据暂冲式风洞试验时间短、耗气量大等特点,设计了无反射测压轨以代替传统的静压探针,大幅提高了声爆近场空间压力的测量效率。通过CFD技术对无反射测压轨的流动特性、模型安装位置以及风洞试验段中的波系进行了分析,验证了测压轨设计方案的可行性。采用Seeb-ALR低声爆标模和自行设计的带喷流的旋成体模型进行了验证性试验,采用参考车次方法和空间平均技术获得了高质量的数据,试验测量结果与CFD计算结果一致性较好,验证了声爆近场空间压力测量系统设计的合理性。

关键词：声爆近场空间压力测量无反射测压轨空间平均

发动机喷管羽流对近场声爆特性影响的风洞试验技术

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航空学报 2023年第2期44卷 136-149页

作者：刘中臣钱战森李雪飞冷岩郭大鹏中国航空工业空气动力研究院沈阳110034 中国航空工业空气动力研究院高超声速气动力/热技术重点实验室沈阳110034 中国航空工业空气动力研究院高速高雷诺数气动力航空科技重点实验室沈阳110034

超声速飞行所引发的声爆问题是困扰新一代环保型超声速客机发展的关键技术难题,发动机喷管羽流对全机声爆特性尤其是后激波特性具有重要影响。设计了单喷管喷流试验模型及声爆试验装置,评估了风洞试验段洞壁反射激波对模型近场压力测量... 详细信息

超声速飞行所引发的声爆问题是困扰新一代环保型超声速客机发展的关键技术难题,发动机喷管羽流对全机声爆特性尤其是后激波特性具有重要影响。设计了单喷管喷流试验模型及声爆试验装置,评估了风洞试验段洞壁反射激波对模型近场压力测量的影响,重点针对通气支臂对喷管羽流的支撑干扰问题进行了分析与优化。基于中国航空工业空气动力研究院FL-60风洞,开展了发动机喷管羽流对旋成体单喷管模型近场声爆特性影响试验技术研究,试验来流马赫数2.0、落压比(NPR)范围1~20.39。研究结果表明,通过对来流马赫数、通气支臂外形、喷流模型长度、通气支臂与模型的相对位置等参数的综合优化,消除了通气支臂带来的支撑干扰对喷管羽流的影响,确保在风洞试验段受限空间内模型近场压力测量不受洞壁反射和通气支臂波系的影响;喷管羽流主要对模型尾部的近场压力特征产生影响,在来流马赫数一定的条件下,提高喷管NPR使喷流状态从过膨胀到欠膨胀,喷管唇口激波逐渐增强、位置逐渐向上游移动,抑制了喷管船尾膨胀波的发展。

关键词：声爆喷管羽流落压比支撑干扰风洞试验

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基于概率模型的声爆试验数据分析

航空学报 2023年第2期44卷 92-100页

作者：徐善劼吕宏强刘中臣冷岩刘学军南京航空航天大学模式分析与机器智能工业和信息化部重点实验室南京211106 中国空气动力研究与发展中心空气动力学国家重点实验室绵阳621000 中国空气动力研究与发展中心气动噪声控制重点实验室绵阳621000 南京大学软件新技术与产业化协同创新中心南京210023 南京航空航天大学航空学院南京210016 中国航空工业空气动力研究院高速高雷诺数气动力航空科技重点实验室沈阳110034

声爆是研制超声速民用飞机所需解决的关键问题之一,风洞试验是开展声爆研究的重要方式。简要介绍了进行声爆试验的方法与困难及相应的应对措施,以及超声速风洞声爆试验模型近场空间压力精确测量技术。重点针对国际上通常采用的精确测量... 详细信息

声爆是研制超声速民用飞机所需解决的关键问题之一,风洞试验是开展声爆研究的重要方式。简要介绍了进行声爆试验的方法与困难及相应的应对措施,以及超声速风洞声爆试验模型近场空间压力精确测量技术。重点针对国际上通常采用的精确测量数据修正技术:参考车次方法及空间平均方法,分析其原理及不足。提出概率模型方法对声爆试验进行数据分析,将复杂的风洞环境中各种不确定因素所造成的干扰参数化,用概率模型表达其不确定性。概率模型方法无需进行参考车次试验,用更少的数据得到更为准确的结果,并在与传统方法结果对比中表现出了该方法的合理性及可行性。

关键词：声爆风洞试验近场概率模型空间压力测量空间平均方法

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高超声速火星进入环境中颗粒运动特性研究

力学学报 2023年第7期55卷 1451-1462页

作者：邢好运刘卓汪球赵伟高亮杰刘中臣钱战森中国科学院力学研究所高温气体动力学国家重点实验室北京100190 中国科学院大学工程科学学院北京100049 中国航空工业空气动力研究院沈阳110034

火星大气中会发生不同规模的沙尘暴,大气中蕴含的尘埃颗粒会对高速进入的火星探测器表面造成侵蚀并导致壁面热流增加,给探测器的热防护系统设计带来巨大挑战.文章针对高超声速火星进入环境两相流动问题,基于Euler-Lagrange框架建立非平... 详细信息

火星大气中会发生不同规模的沙尘暴,大气中蕴含的尘埃颗粒会对高速进入的火星探测器表面造成侵蚀并导致壁面热流增加,给探测器的热防护系统设计带来巨大挑战.文章针对高超声速火星进入环境两相流动问题,基于Euler-Lagrange框架建立非平衡流场与颗粒的单向耦合计算方法,采用模态半径为0.35μm的火星大气颗粒分布模型,研究不同尺寸颗粒在流场中的运动轨迹,获得高温相变模型对颗粒运动的影响以及不同粒径颗粒的撞击能量分布.结果表明,颗粒在高温流场中运动会吸热融化甚至蒸发,高温相变模型导致的颗粒直径减小对小尺寸颗粒运动轨迹有较大影响;当前计算状态下,直径3μm以上的颗粒具有较大的Stokes数且颗粒半径在运动过程中基本保持不变,其运动轨迹受流场影响较小,该尺寸颗粒的撞击分数均达95%以上,是造成壁面撞击的主要颗粒尺寸;撞击能量分数结果表明,直径3~10μm之间的颗粒是撞击能量的主要来源,约占总撞击能量的80%.

关键词：火星进入颗粒流单向耦合高超声速热防护系统