TIPE-mediated up-regulation of MMP-9 promotes colorectal cancer invasion and metastasis through MKK-3/p38/NF-κB pro-oncogenic signaling pathway
作者机构：Cancer Research CenterSchool of MedicineXiamen UniversityXiamenFujianChina Department of PathologyZhongshan Hospital Affiliated to Xiamen UniversityXiamenFujianChina Department of General SurgeryShanghai 10th People’s Hospital Affiliated to Tongji UniversityShanghaiChina Department of Gastrointestinal SurgeryZhongshan Hospital Affiliated to Xiamen UniversityXiamenFujianChina Organ Transplantation Institute of Xiamen UniversityFujian Provincial Key Laboratory of Organ and Tissue RegenerationSchool of MedicineXiamen UniversityXiamenFujianChina
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2020年第5卷第1期
页 面：1049-1051页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by National Natural Scientific Foundation of China(No.81272720) Natural Science Foundation of Fujian Province(Grant No.2018J01138) the joint research project of Health and Education of Fujian Province(WKJ2016-2-17)
主 题：metastasis TIP p38
摘 要：Dear Editor,Colorectal cancer(CRC)is the third most common malignant tumor in human,ranking third in cancer-related mortality.1 Most colon cancer patients die of metastasis.2 Intriguingly,the deregulation of tumor necrosis factorα‑induced protein 8(TIPE)has been shown to play a vital regulatory role in tumor cell growth,proliferation,invasion,and metastasis.3 TIPE is a kind of cytoplasmic protein of 23 kDa.A large number of studies have shown that TIPE is closely related to the development of colon cancer.4 In addition,decreased expression of TIPE was linked to down-regulation of matrix metallopeptidase-1(MMP-1),MMP-9,and vascular endothelial growth factor receptor-2 in breast cancer.
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