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Glucagon-like peptide-1 receptor agonists rescued diabetic vascular endothelial damage through suppression of aberrant STING signaling

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2613-2630页

作者： Xuemin He Siying Wen Xixiang Tang Zheyao Wen Rui Zhang Shasha Li Rong Gao Jin Wang Yanhua Zhu Dong Fang Ting Li Ruiping Peng Zhaotian Zhang Shiyi Wen Li zhou Heying Ai Yan Lu Shaochong Zhang Guojun Shi Yanming Chen Department of Endocrinology and Metabolic Diseases the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Guangdong Provincial Key Laboratory of Diabetology&Guangzhou Municipal Key Laboratory of Mechanistic and Translational Obesity Research the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China VIP Medical Service Center the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Clinical Immunology the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Ophthalmology the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China Department of Fundus Shenzhen Eye Hospital of Jinan UniversityShenzhen 518048China

Glucagon-like peptide-1 receptor agonists(GLP-1 RAs)protect against diabetic cardiovascular diseases and ***,their activity in diabetic retinopathy(DR)remains *** retrospective cohort study involving 1626 T2DM patients revealed superior efficacy of GLP-1 RAs in controlling DR compared to other glucose-lowering medications,suggesting their advantage in DR *** single-cell RNA-sequencing analysis and immunostaining,we observed a high expression of GLP-1R in retinal endothelial cells,which was down-regulated under diabetic *** of GLP-1 RAs significantly restored the receptor expression,resulting in an improvement in retinal degeneration,vascular tortuosity,avascular vessels,and vascular integrity in diabetic *** and GSEA analyses further implicated enhanced mitochondrial gene translation and mitochondrial functions by GLP-1 ***,the treatment attenuated STING signaling activation in retinal endothelial cells,which is typically activated by leaked mitochondrial *** of STING mRNA was positively correlated to the levels of angiogenic and inflammatory factors in the endothelial cells of human fibrovascular *** investigation revealed that the cAMP-responsive element binding protein played a role in the GLP-1R signaling pathway on suppression of STING *** study demonstrates a novel role of GLP-1 RAs in the protection of diabetic retinal vasculature by inhibiting STING-elicited inflammatory signals.

关键词： GLP-1 RAs STING signaling Retinal endothelial cells Mitochondrial leakage Retinal vascular dysfunction Diabetic retinopathy CREB Inflammation

Pregnancy Complicated With a Giant Pancreatic Tumor and Decompensation of Liver Cirrhosis:A Case Report and Literature Review

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Maternal-Fetal Medicine 2024年第1期6卷 50-53页

作者： Yi Yu Lirong Teng Juntao Liu Xinyan Liu Ping Peng Qian zhou Congcong Liu Department of Obstetrics and Gynecology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China National Clinical Research Center for Obstetric and Gynecologic Diseases Beijing 100730China

Pregnancy with solid pseudopapillary tumor of the pancreas(SPTP)is *** pregnancy hormones may cause tumor progression,the management and treatment of SPTP need to balance the safety of pregnant women and fetuses with surgical *** reported a case of a giant pancreatic tumor diagnosed during pregnancy that was considered to be *** also showed hepatitis B virus infection and severe decompensation of liver *** termination of pregnancy was *** patient has lived with the tumor until now without *** retrieved the published case reports,summarized the clinical characteristics of pregnancy with SPTP,and explored its management during the perinatal *** patients with SPTP have a good prognosis with good maternal and fetal outcomes,and it is important to choose an appropriate treatment method and ***,pregnancy combined with decompensated liver cirrhosis needs to be terminated in a timely manner because of its high-risk status.

关键词： Pregnancy complications Pancreatic tumor Solid pseudopapillary tumor of the pancreas Liver cirrhosis decompensation Abnormal coagulation function

新冠疫情下的儿童青少年健康危险行为:基于家庭风险的视角

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心理科学进展 2024年第8期32卷 1328-1341页

作者：周嘉雯王明怡北京林业大学人文社会科学学院心理学系北京100083

新冠疫情期间儿童青少年健康危险行为激增,但随着生活逐渐恢复,其影响仍在持续。新冠疫情期间儿童青少年健康危险行为的变化主要体现在屏幕使用时间过长、身体活动骤减、久坐时间增加、饮食单一、饮食不规律、晚睡更晚起等方面,本文构... 详细信息

新冠疫情期间儿童青少年健康危险行为激增,但随着生活逐渐恢复,其影响仍在持续。新冠疫情期间儿童青少年健康危险行为的变化主要体现在屏幕使用时间过长、身体活动骤减、久坐时间增加、饮食单一、饮食不规律、晚睡更晚起等方面,本文构建疫情背景下儿童青少年健康危险行为的家庭风险框架以解释健康危险行为变化的内在机制,这一框架结合生命史理论可为儿童青少年后疫情时代健康危险行为的持续提供解释。未来研究需长期追踪儿童青少年健康危险行为的发展轨迹,并加强家庭风险、生命史理论与儿童青少年健康风险行为关系的实证研究,为类似重大突发性事件、自然灾害等提供处理儿童青少年健康问题的普遍解决思路。

关键词：新冠疫情健康危险行为儿童青少年家庭风险生命史理论

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Research progress of permanent ferrite magnet materials

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Journal of Central South University 2024年第6期31卷 1723-1762页

作者： XU Bin CHEN Yu-feng zhou Yu-juan LUO Bi-yun ZHONG Shou-guo LIU Xing-ao School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China

Permanent ferrite magnet materials are extensively employed due to their exceptional magnetic properties and *** fast development in electromobile and household appliance industries contributes to a new progress in permanent ferrite *** paper reviews the deveolpement and progress of permanent ferrite magnet industry in recent *** emergence of new raw material,the advancement of perparation methods and manufacturing techniques,and the potential applications of permanent ferrite materials are introduced and ***,nanocrystallization plays a crucial role in achieving high performance at a low cost and reducing reliance on rare earth resources,and therefore it could be a promising development trendency.

关键词： permanent ferrite magnetic materials high-performance nanosizing

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抗磷脂综合征相关心血管疾病的表现及新进展

中国循环杂志 2024年第3期39卷 306-312页

作者：陈梓欣达布西力特周洲张洋中国医学科学院、北京协和医学院、国家心血管病中心、阜外医院实验诊断中心北京100037

抗磷脂综合征(APS)是以反复发生血栓事件和妊娠并发症以及抗磷脂抗体持续阳性为特点的一种系统性自身免疫性疾病。APS可以影响包括心血管系统在内的多个器官和系统,APS相关心血管疾病会给患者生命造成严重威胁。在2023年更新的美国风湿... 详细信息

抗磷脂综合征(APS)是以反复发生血栓事件和妊娠并发症以及抗磷脂抗体持续阳性为特点的一种系统性自身免疫性疾病。APS可以影响包括心血管系统在内的多个器官和系统,APS相关心血管疾病会给患者生命造成严重威胁。在2023年更新的美国风湿病学会(ACR)联合欧洲抗风湿病联盟(EULAR)APS分类标准中,将瓣膜病变纳入了APS的临床标准,这也提示应该重视APS合并的心血管疾病。本文将对APS合并的常见心血管疾病的表现及机制进行综述。

关键词：抗磷脂综合征抗磷脂抗体心血管疾病血栓形成

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高速精确的光纤光栅信号解调方案设计

激光杂志 2024年第7期45卷 205-209页

作者：张伟周丽淮阴工学院江苏淮阴223200

为提升光纤光栅的应用效果,为此,设计高速精确的光纤光栅信号解调方案。依据LPFG的光纤光栅信号解调原理,设计两个LPFG双边缘滤波器处理两路反射光,并且利用光电探测器探测光功率结果,以此解调光栅的中心波长;采用光纤干涉仪检测解调频... 详细信息

为提升光纤光栅的应用效果,为此,设计高速精确的光纤光栅信号解调方案。依据LPFG的光纤光栅信号解调原理,设计两个LPFG双边缘滤波器处理两路反射光,并且利用光电探测器探测光功率结果,以此解调光栅的中心波长;采用光纤干涉仪检测解调频率,对其进行正反扫描,依据光传播时延引起的解调误差和解调频率扫描方向之间的关联,完成解调结果补偿。测试结果显示:该方案具有较好可行性,光谱发生不同程度重叠时,光纤光栅信号的解调结果标准差均小于1.85 pm;光栅波长的解调误差均在-5~5 pm之间;有效降低解调误差,提升光纤光栅解调精度,可靠获取信号中的信息。

关键词：高速精确光纤光栅信号解调光功率中心波长解调频率误差补偿光谱重叠

Bone-targeting engineered small extracellular vesicles carrying anti-miR-6359-CGGGAGC prevent valproic acid-induced bone loss

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Signal Transduction and Targeted Therapy 2024年第2期9卷 751-765页

作者： Xudong Xie Peng Cheng Liangcong Hu Wu zhou Detai Zhang Samuel Knoedler Guodong Liu Yuan Xiong Hang Xue Yiqiang Hu Barbara Kern Doha Obed Adriana CPanayi Lang Chen Chenchen Yan Ze Lin Guandong Dai Bobin Mi Yingze Zhang Guohui Liu Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration Wuhan 430022China Department of Clinical Laboratory Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022P.R.China Division of Plastic Surgery Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02152USA Department of Plastic Surgery and Hand Surgery Klinikum Rechts der IsarTechnical University of MunichMunichGermany Medical Center of Trauma and War Injuries Daping HospitalArmy Medical UniversityChonqing 400042China Department of Plastic Surgery Campus CharitéMitte|Campus Virchow-KlinikumCharité-Universitätsmedizin Berlincorporate member of Freie Universität BerlinHumboldt-Universität zu Berlin and Berlin Institute of HealthBerlinGermany Berlin Institute of Health Charité-Universitätsmedizin BerlinBerlinGermany Department of Plastic AestheticHand and Reconstructive SurgeryHannover Medical SchoolHannoverGermany Department of Hand Plastic and Reconstructive SurgeryMicrosurgeryBurn CenterBG Trauma Center LudwigshafenUniversity of HeidelbergLudwig-Guttmann-Strasse 1367071 Ludwigshafen/RhineGermany Pingshan District People’s Hospital of Shenzhen Pingshan General Hospital of Southern Medical UniversityShenzhenGuangdong 518118China Department of Orthopaedic Surgery The Third Hospital of Hebei Medical UniversityNO.139 Ziqiang RoadShijiazhuang 050051China

The clinical role and underlying mechanisms of valproic acid(VPA)on bone homeostasis remain ***,we confirmed that VPA treatment was associated with decreased bone mass and bone mineral density(BMD)in both patients and *** effect was attributed to VPA-induced elevation in osteoclast formation and *** RNA-sequencing,we observed a significant rise in precursor miR-6359 expression in VPA-treated osteoclast precursors in vitro,and further,a marked upregulation of mature miR-6359(miR-6359)in vivo was demonstrated using quantitative real-time PCR(qRT-PCR)and miR-6359 fluorescent in situ hybridization(miR-6359-FISH).Specifically,the miR-6359 was predominantly increased in osteoclast precursors and macrophages but not in neutrophils,T lymphocytes,monocytes and bone marrow-derived mesenchymal stem cells(BMSCs)following VPA stimulation,which influenced osteoclast differentiation and bone-resorptive ***,VPA-induced miR-6359 enrichment in osteoclast precursors enhanced reactive oxygen species(ROS)production by silencing the SIRT3 protein expression,followed by activation of the MAPK signaling pathway,which enhanced osteoclast formation and activity,thereby accelerating bone ***,there are no medications that can effectively treat VPA-induced bone ***,we constructed engineered small extracellular vesicles(E-sEVs)targeting osteoclast precursors in bone and naturally carrying anti-miR-6359 by introducing of EXOmotif(CGGGAGC)in the 3’-end of the anti-miR-6359 *** confirmed that the E-sEVs exhibited decent bone/osteoclast precursor targeting and exerted protective therapeutic effects on VPA-induced bone loss,but not on ovariectomy(OVX)and glucocorticoid-induced osteoporotic models,deepening our understanding of the underlying mechanism and treatment strategies for VPA-induced bone loss.

关键词： miR protective stimulation

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饲料企业战略性人力资源培训管理计划研究

中国饲料 2024年第8期 108-111页

作者：周莉娜河南应用技术职业学院河南郑州450000

人力资源是饲料企业最有活力的资源之一。如何激发人才潜力,实现人才价值,服务企业发展,是饲料企业制订战略性人力资源培训管理计划时需要重点考虑的内容。本文以饲料企业为研究对象,在阐述战略性人力资源培训管理计划重要性的基础上分... 详细信息

人力资源是饲料企业最有活力的资源之一。如何激发人才潜力,实现人才价值,服务企业发展,是饲料企业制订战略性人力资源培训管理计划时需要重点考虑的内容。本文以饲料企业为研究对象,在阐述战略性人力资源培训管理计划重要性的基础上分析现阶段战略性人力资源培训管理计划在饲料企业中的应用,研究发现,当前饲料企业存在人才管理计划不详细、创新水平不足、内部员工培训匮乏等问题,文章针对这些问题提出解决方案,以期对饲料企业的健康良性发展有所助益。

关键词：饲料企业人力资源战略性培训管理计划

Effect of trace oxygen on plasma nitriding of titanium foil

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Chinese Physics B 2024年第6期33卷 548-551页

作者：周海涛熊希雅马可欣罗炳威罗飞申承民 Beijing Institute of Aeronautical Materials Aero Engine Corporation of ChinaBeijing 100095China Beijing National Laboratory of Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

Titanium nitride films are prepared by plasma enhanced chemical vapor deposition method on titanium foil using N_(2) as precursor. In order to evaluate the effect of oxygen on the growth of titanium nitride films, a small amount of O_(2) is introduced into the preparation process. The study indicates that trace O_(2) addition into the reaction chamber gives rise to significant changes on the color and micro-morphology of the foil, featuring dense and long nano-wires. The as-synthesized nanostructures are characterized by various methods and identified as TiN, Ti_(2) N, and TiO_(2) respectively. Moreover, the experiment results show that oxide nanowire has a high degree of crystallinity and the nitrides present specific orientation relationships with the titanium matrix.

关键词： nitride oxide nanostructure crystalline plasma-enhanced chemical vapor deposition system(PECVD)