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Visible Light-Mediated Construction of Sulfonated Dibenzazepines

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Chinese Journal of Chemistry 2021年第8期39卷 2220-2226页

作者： Chuan-Hua Qu Gui-Ting Song Jian-Hua Ou Dian-Yong Tang Zhi-Gang Xu zhong-zhu chen College of Pharmacy National&Local Joint Engineering Research Center of Targeted and Innovative TherapeuticsChongqing Key Laboratory of Kinase Modulators as Innovative MedicineChongqing University of Arts and SciencesChongqing 402160China

A new method to access sulfonated dibenz[b,e]azepines via visible-light photoredox catalysis is *** ying inexpe nsive and commercially available sulfonyl chlorides to form the sulfonyl radicals enables the alkyne addi... 详细信息

关键词： Photocatalysis Sulfonated dibenzazepines Radical reactions Ugi reaction Annulation

One-pot synthesis of natural-product inspired spiroindolines with anti-cancer activities

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Organic Chemistry Frontiers 2022年第3期9卷 682-686页

作者： Shi-Qiang Li Wei Yan Liu-Jun He Ming Zhang Dian-Yong Tang Hong-yu Li zhong-zhu chen Zhi-Gang Xu College of Pharmacy National&Local Joint Engineering Research Center of Targeted and Innovative TherapeuticsIATTIChongqing University of Arts and SciencesChongqing 402160China Department of Pharmaceutical Sciences College of PharmacyUniversity of Arkansas for Medical SciencesLittle RockAR 72205USA Department of Internal Medicine College of MedicineUniversity of Arkansas for Medical SciencesLittle RockAR 72205USA Cancer Center Academy of Medical Sciences and Sichuan Provincial People’s HospitalAffiliated Hospital of University of Electronic Science and technology of ChinaChengduSichuan 610000China

A post-Ugi/diastereoselective cascade reaction was developed to construct naturally existing spiroindolines via a facile and metal-free one-pot *** the construction,a new C-C bond was formed through a selective 5-exo-dig indole cyclization on the propiolamide;and a new C-N bond was diastereoselectively formed which controlled the configuration of three chiral centers simultaneously.

关键词： synthesis spiro centers

Cyano migration-mediated radical-polar crossover cyclopropanation

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Science China Chemistry 2025年第01期 241-248页

作者： Ziqiang Wang Yasu chen Jie Li chen zhu Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry Chemical Engineering and Materials ScienceSoochow University Frontiers Science Center for Transformative Molecules Zhangjiang Institute for Advanced Study and Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Shanghai Jiao Tong University

We report a novel cyano migration-mediated radical-polar crossover process, whereby both the sulfonylcyanation of aliphatic alkenes and the formation of cyclopropanes are concurrently achieved. This transformation yields a diverse array of multisubstituted cyclopropanes under mild photocatalytic conditions. Mechanistic studies elucidate that the reaction proceeds via intramolecular nucleophilic substitution, leading to the formation of the cyclopropane derivatives.

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The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying chen Yinyi Xiong Qin Zhou Ling-Qiang zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

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水杨酸对灌木幼苗抗旱性的影响

水土保持学报 2004年第2期18卷 166-169,185页

作者：姜中珠陈祥伟东北林业大学黑龙江哈尔滨150040

在水分胁迫条件下,以紫丁香、小叶锦鸡儿和乌苏里绣线菊2年生苗木为材料,叶面喷施不同浓度水杨酸。试验发现,水杨酸(SA)能有效降低水分胁迫条件下各树种叶片MDA含量,延缓可溶性蛋白质和叶绿素含量的下降。对各处理进行了抗旱性综合鉴定... 详细信息

在水分胁迫条件下,以紫丁香、小叶锦鸡儿和乌苏里绣线菊2年生苗木为材料,叶面喷施不同浓度水杨酸。试验发现,水杨酸(SA)能有效降低水分胁迫条件下各树种叶片MDA含量,延缓可溶性蛋白质和叶绿素含量的下降。对各处理进行了抗旱性综合鉴定,证明了水杨酸预处理在灌木树种抵御干旱方面作用明显。7.0×10-5mol/L的SA既能显著提高丁香、小叶锦鸡儿和乌苏里绣线菊的水分利用效率,又能显著提高它们的抗旱能力。

关键词：水杨酸灌木幼苗抗旱性水分胁迫条件

Recent progress on photoactive nonprecious transition-metal complexes

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Science China Chemistry 2025年第1期 46-95页

作者： zhong-Liang Gong Hong-Jie Zhang Yan cheng Jianxun Liu Yuhan Ai Yaqin Li Zhihui Feng Qiong Zhang Shaolong Gong Yong chen Chang-Jiang Yao Yuan-Yuan zhu Liang-Jin Xu Yu-Wu zhong CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences State Key Laboratory of Structural Cemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences School of Chemistry and Chemical Engineering Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of Technology State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical Engineering Beijing Institute of Technology College of Chemistry and Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Wuhan University School of Chemistry and Chemical Engineering Anhui University Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Photoactive complexes of nonprecious transition metals, mainly including those in the first-row and partially the second-row of the Periodic table of elements, have received increasing attention in view of their low cost and long-term sustainability. They are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices, artificial photosynthesis, photocatalysis, biodiagnostics, and therapeutics, etc. This review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes, including photoactive Zr, V, Cr, Mo, and W complexes, Mn complexes and hybrids, Fe, Co, Ni, and Cu complexes, and Zn and Cd complexes and hybrids. A particular focus is given on the molecular design, modulation of photophysical and photochemical properties, and applications of the representative and lately-developed nonprecious metal complexes. In addition, a perspective on the future development in this field is provided at the end of this review.

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Netrin-1 signaling pathway mechanisms in neurodegenerative diseases

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Neural Regeneration Research 2025年第4期20卷 960-972页

作者： Kedong zhu Hualong Wang Keqiang Ye Guiqin chen Zhaohui Zhang Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Neurology The First Hospital of Hebei Medical UniversityBrain Aging and Cognitive Neuroscience Laboratory of Heibei ProvinceShijiazhuangHebei ProvinceChina Faculty of Life and Health Sciences Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal *** profound impacts then extend into adulthood to encompass the maintenance of neuronal survival and synaptic *** amounts of evidence highlight several key points:(1)Diminished Netrin-1 levels exacerbate pathological progression in animal models of Alzheimer’s disease and Parkinson’s disease,and potentially,similar alterations occur in humans.(2)Genetic mutations of Netrin-1 receptors increase an individuals’susceptibility to neurodegenerative disorders.(3)Therapeutic approaches targeting Netrin-1 and its receptors offer the benefits of enhancing memory and motor function.(4)Netrin-1 and its receptors show genetic and epigenetic alterations in a variety of *** findings provide compelling evidence that Netrin-1 and its receptors are crucial targets in neurodegenerative *** a comprehensive review of Netrin-1 signaling pathways,our objective is to uncover potential therapeutic avenues for neurodegenerative disorders.

关键词： Alzheimer’s disease axon guidance colorectal cancer Netrin-1 receptors Netrin-1 signaling pathways Netrin-1 neurodegenerative diseases neuron survival Parkinson’s disease UNC5C

Exploring the potential of extrachromosomal DNA as a novel oncogenic driver

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Science China Life Sciences 2025年第1期 144-157页

作者： Huanbo zhu Longtao Huangfu Junbing chen Jiafu Ji Xiaofang Xing Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Division of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute Department of Gastrointestinal Cancer Center Peking University Cancer Hospital & Institute Department of Liver Surgery & Transplantation Liver Cancer InstituteZhongshan HospitalFudan University Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDivision of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute

Extrachromosomal DNA(ecDNA) is a form of circular DNA mostly found in tumor cells. Unlike the typical chromosomal DNA, ecDNA is circular, self-replicating, and carries complete or partial gene fragments. Although ecDNA occurrence remains a rare event in cancer, recent studies have shown that oncogene amplification on ecDNA is widespread throughout many types of cancer, implying that ecDNA plays a central role in accelerating tumor evolution. ecDNA has also been associated with increased tumor mutation burden, chromosomal instability, and even tumor microenvironment remodeling. ecDNA may be crucial in influencing tumor heterogeneity, drug sensitivity,oncogenic senescence, and tumor immunogenicity, leading to a worsening prognosis for tumor patients. In this way, several clinical trials have been conducted to investigate the importance of ecDNA in clinical treatment. In this review, we summarize the biogenesis, characteristics, and current research methods of ecDNA, discuss the vital role of ecDNA-caused tumor heterogeneity in cancers, and highlight the potential role of ecDNA in cancer therapy.

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床突旁动脉瘤患者不同治疗方式的效果分析

中国脑血管病杂志 2018年第11期15卷 561-566,577页

作者：孙青尤万春孙晓欧邵忠朱昀陈罡王中苏州大学附属第一医院神经外科 215006

目的探讨床突旁动脉瘤手术治疗以及血管内治疗的临床效果及相关并发症。方法回顾性连续纳入2012年1月至2017年6月苏州大学附属第一医院神经外科收治的床突旁动脉瘤患者72例,均经头颈部CT血管成像以及DSA检查证实,其中男27例,女45例。根... 详细信息

目的探讨床突旁动脉瘤手术治疗以及血管内治疗的临床效果及相关并发症。方法回顾性连续纳入2012年1月至2017年6月苏州大学附属第一医院神经外科收治的床突旁动脉瘤患者72例,均经头颈部CT血管成像以及DSA检查证实,其中男27例,女45例。根据接受治疗方式的不同,将72例患者分为血管内栓塞组(38例,支架辅助下弹簧圈栓塞)以及显微外科手术组(34例,包括动脉瘤夹闭术或颅内外血管旁路移植术+动脉瘤孤立术)。记录并分析两组患者基线资料及动脉瘤直径。基线资料包括年龄、性别、脑神经损伤情况、Hunt-Hess分级等。比较两组术后新发脑神经损伤、动脉瘤复发、格拉斯哥预后量表(GOS)评分等方面的差异,并对复发与未复发动脉瘤大小进行分析。对两组Hunt-Hess分级Ⅲ～Ⅳ级患者的年龄、动脉瘤直径及预后评分进行比较。结果 (1)血管内栓塞组患者年龄大于显微外科手术组[(60±10)岁比(54±10)岁,t=-2. 490],动脉瘤直径小于显微外科手术组[5(4,8) mm比9(5,16) mm,Z=3. 026],组间差异均有统计学意义(均P 0. 05)。(2)两组患者均完成术后6个月的随访,GOS评分、术后视力好转、术后即刻新发视力损伤的差异均无统计学意义(均P> 0. 05)。血管内栓塞组动脉瘤复发率高于显微外科手术组,组间差异有统计学意义[18. 4%(7/38)比2. 9%(1/34),χ~2=4. 350,P <0. 05]。(3)血管内栓塞组中,复发患者动脉瘤直径大于未复发者,组间差异有统计学意义[10(8,15) mm比5(3,7) mm,Z=-2. 356,P <0. 05]。(4)对于Hunt-Hess分级Ⅲ～Ⅳ级的动脉瘤患者,血管内栓塞组GOS评分小于显微外科手术组,组间差异有统计学意义[4(3,4)分比5(4,5)分,Z=-2. 282,P <0. 05]。结论对于床突旁动脉瘤,显微外科治疗的动脉瘤复发率低于血管内栓塞,且有利于Hunt-Hess分级Ⅲ～Ⅳ级患者的预后。

关键词：颅内动脉瘤床突旁动脉瘤显微外科手术血管内治疗