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M1-type microglia can induce astrocytes to deposit chondroitin sulfate proteoglycan after spinal cord injury

Neural Regeneration Research 2022年第5期17卷 1072-1079页

作者： Shui-Sheng Yu Zi-Yu Li xin-zhong xu Fei Yao Yang Luo Yan-Chang Liu Li Cheng Mei-Ge Zheng Jue-Hua Jing Department of Orthopedics The Second Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

After spinal cord injury(SCI),astrocytes gradually migrate to and surround the lesion,depositing chondroitin sulfate proteoglycan-rich extracellular matrix and forming astrocytic scar,which limits the spread of inflammation but hinders axon ***,microglia gradually accumulate at the lesion border to form microglial scar and can polarize to generate a pro-inflammatory M1 phenotype or an anti-inflammatory M2 ***,the effect of microglia polarization on astrocytes is ***,we found that both microglia(CX3 CR1^(+))and astrocytes(GFAP^(+))gathered at the lesion border at 14 days post-injury(dpi).The microglia accumulated along the inner border of and in direct contact with the astrocytes.M1-type microglia(i NOS^(+)CX3 CR1^(+))were primarily observed at 3 and 7 dpi,while M2-type microglia(Arg1^(+)CX3 CR1^(+))were present at larger numbers at 7 and 14 *** growth factor-β1(TGFβ1)was highly expressed in M1 microglia in vitro,consistent with strong expression of TGFβ1 by microglia in vivo at 3 and 7 dpi,when they primarily exhibited an M1 ***,conditioned media from M1-type microglia induced astrocytes to secrete chondroitin sulfate proteoglycan in *** effect was eliminated by knocking down sex-determining region Y-box 9(SOX9)in astrocytes and could not be reversed by treatment with TGFβ*** together,our results suggest that microglia undergo M1 polarization and express high levels of TGFβ1 at 3 and 7 dpi,and that M1-type microglia induce astrocytes to deposit chondroitin sulfate proteoglycan via the TGFβ1/SOX9 *** study was approved by the Institutional Animal Care and Use Committee of Anhui Medical University,China(approval ***20160052)on March 1,2016.

关键词： astrocytes astrocytic scar chondroitin sulfate proteoglycan M1/M2 polarization microglia sex-determining region Y-box 9 spinal cord injury transforming growth factor-β1

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Neuroprotective effects of monosialotetrahexosylganglioside

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Neural Regeneration Research 2015年第8期10卷 1343-1344页

作者： Ai-ping Xi zhong-xin xu Feng-li Liu Yan-li xu The Affiliated Hospital of Hebei University of Engineering School of Medicine Hebei University of Engineering

Monosialotetrahexosylganglioside（GM1）is a type of glycosphingolipid containing sialic acid that is closely related to cell-cell recognition,adhesion and signal ***1is mainly composed of ceramide and oligosaccharide ... 详细信息

关键词： conduction chains injured neuronal backbone exogenous intercellular lipids registered peroxidation

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Approach to monitoring, data processing and regularity on landslip in open-pits

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中国有色金属学会会刊：英文版 2005年第S1期15卷 132-135页

作者： MA Zhen-li, LI Zheng-zhong, xu xin-jun (Liaoning Technical University, Fuxin 123000, China)

A new method of landslip monitoring in open-pit is presented, in which the monitoring data processing and a variety of deformation curvilinear drawings are carried out by microcomputer system, based on the practice in... 详细信息

关键词： open-pit landslip observation line monitoring data processing landslip prediction

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TrkA regulates the regenerative capacity of bone marrow stromal stem cells in nerve grafts

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Neural Regeneration Research 2019年第10期14卷 1765-1771页

作者： Mei-Ge Zheng Wen-Yuan Sui Zhen-Dan He Yan Liu Yu-Lin Huang Shu-Hua Mu xin-zhong xu Ji-Sen Zhang Jun-Le Qu Jian Zhang Dong Wang Department of Orthopedics The Seventh Hospital of Sun Yat-sen UniversityShenzhenGuangdong ProvinceChina Department of Orthopedics The Second Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina School of Medicine Shenzhen UniversityShenzhenGuangdong ProvinceChina Department of Scientific Research The Seventh Hospital of Sun Yat-sen UniversityShenzhenGuangdong ProvinceChina Psychology & Social College of Shenzhen University ShenzhenGuangdong ProvinceChina Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen UniversityShenzhenGuangdong ProvinceChina

We previously demonstrated that overexpression of tropomyosin receptor kinase A(TrkA)promotes the survival and Schwann celllike differentiation of bone marrow stromal stem cells in nerve grafts,thereby enhancing the regeneration and functional recovery of the peripheral *** the present study,we investigated the molecular mechanisms underlying the neuroprotective effects of TrkA in bone marrow stromal stem cells seeded into nerve *** marrow stromal stem cells from Sprague-Dawley rats were infected with recombinant lentivirus vector expressing rat TrkA,TrkA-shRNA or the respective *** cells were then seeded into allogeneic rat acellular nerve allografts for bridging a 1-cm right sciatic nerve ***,8 weeks after surgery,hematoxylin and eosin staining showed that compared with the control groups,the cells and fibers in the TrkA overexpressing group were more densely and uniformly arranged,whereas they were relatively sparse and arranged in a disordered manner in the TrkA-shRNA *** blot assay showed that compared with the control groups,the TrkA overexpressing group had higher expression of the myelin marker,myelin basic protein and the axonal marker neurofilament *** TrkA overexpressing group also had higher levels of various signaling molecules,including TrkA,pTrkA(Tyr490),extracellular signal-regulated kinases 1/2(Erkl/2),pErk1/2(Thr202/Tyr204),and the anti-apoptotic proteins Bcl-2 and *** contrast,these proteins were downregulated,while the pro-apoptotic factors Bax and Bad were upregulated,in the TrkA-shRNA *** levels of the TrkA effectors Akt and pAkt(Ser473)were not different among the *** results suggest that TrkA enhances the survival and regenerative capacity of bone marrow stromal stem cells through upregulation of the Erk/Bcl-2 *** procedures were approved by the Animal Ethical and Welfare Committee of Shenzhen University,China in December 2014(approval ***-2014-001219).

关键词： nerve regeneration bone marrow stromal stem cells tropomyosin receptor kinase A receptor lentiviral vector shRNA extracellular signal-regulated protein kinases 1/2 Bcl-2 nerve grafts peripheral nerve regeneration survival neural regeneration

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The role of Rho/Rho-kinase pathway and the neuroprotective effects of fasudil in chronic cerebral ischemia

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Neural Regeneration Research 2015年第9期10卷 1441-1449页

作者： Ya-yun Yan Xiao-ming Wang Yan Jiang Han Chen Jin-ting He Jing Mang Yan-kun Shao zhong-xin xu Department of Neurology China-Japan Union Hospital Jilin University

The Rho/Rho-kinase signaling pathway plays an important role in cerebral ischemia/reperfusion injury. However, very few studies have examined in detail the changes in the Rho/Rho-kinase signaling pathway in chronic cerebral ischemia. In this study, rat models of chronic cerebral ischemia were established by permanent bilateral common carotid artery occlusion and intra- gastrically administered 9 mg/kg fasudil, a powerful ROCK inhibitor, for 9 weeks. Morris water maze results showed that cognitive impairment progressively worsened as the cerebral ischemia proceeded. Immunohistochemistry, semi-quantitative RT-PCR and western blot analysis showed that the expression levels of Rho-kinase, its substrate myosin-binding subunit, and its relat- ed protein alpha smooth muscle actin, significantly increased after chronic cerebral ischemia. TUNEL staining showed that chronic cerebral ischemia could lead to an increase in neuronal apoptosis, as well as the expression level of caspase-3 in the frontal cortex of rats subjected to chronic cerebral ischemia. Fasudil treatment alleviated the cognitive impairment in rats with chronic cerebral ischemia, and decreased the expression level of Rho-kinase, myosin-binding subunit and alpha smooth muscle actin. Furthermore, fasudil could regulate cerebral injury by reducing cell apoptosis and decreasing caspase-3 expression in the frontal cortex. These findings demonstrate that fasudil can protect against cognitive impairment induced by chronic cerebral ischemia via the Rho/Rho-kinase signaling pathway and anti-apoptosis mechanism.

关键词： nerve regeneration chronic cerebral ischemia fasudil Rho-kinase alpha smooth muscleactin myosin-binding subunit cognitive impairment caspase-3 apoptosis neural regeneration

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Neuroprotective effects of Activin A on endoplasmic reticulum stress-mediated apoptotic and autophagic PC12 cell death

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Neural Regeneration Research 2017年第5期12卷 779-786页

作者： Long-xing xue Hong-yu Liu Yang Cui Yue Dong Jiao-qi Wang Qiu-ye Ji Jin-ting He Min Yao Ying-ying Wang Yan-kun Shao Jing Mang zhong-xin xu Department of Neurology China-Japan Union Hospital lilin University Changchun Jilin province China Research Center China-Japan Union Hospital Jilin University Changchun Jilin Province China

Activin A, a member of the transforming growth factor-beta superfamily, plays a neuroprotective role in multiple neurological diseases. Endoplasmic reticulum（ER） stress-mediated apoptotic and autophagic cell death is implicated in a wide range of diseases, including cerebral ischemia and neurodegenerative diseases. Thapsigargin was used to induce PC12 cell death, and Activin A was used for intervention. Our results showed that Activin A significantly inhibited morphological changes in thapsigargin-induced apoptotic cells, and the expression of apoptosis-associated proteins [cleaved-caspase-12, C/EBP homologous protein（CHOP） and cleaved-caspase-3] and biomarkers of autophagy（Beclin-1 and light chain 3）, and downregulated the expression of thapsigargin-induced ER stress-associated proteins [inositol requiring enzyme-1（IRE1）, tumor necrosis factor receptor-associated factor 2（TRAF2）, apoptosis signal-regulating kinase 1（ASK1）, c-Jun N-terminal kinase（JNK） and p38]. The inhibition of thapsigargin-induced cell death was concentration-dependent. These findings suggest that administration of Activin A protects PC12 cells against ER stress-mediated apoptotic and autophagic cell death by inhibiting the activation of the IRE1-TRAF2-ASK1-JNK/p38 cascade.

关键词： nerve regeneration Activin A endoplasmic reticulum stress apoptosis autophagy c-Jun N-terminal kinase p38 neural regeneration

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植物病原物无毒基因及其功能

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生物工程学报 2002年第1期18卷 5-9页

作者：蔡新忠徐幼平郑重浙江大学植物保护系浙江大学分析测试中心杭州310029

植物抗病基因与病原物无毒基因产物间直接或间接相互作用导致产生的基因对基因抗性是植物抗病性的重要形式。无毒基因已在多种植物病原物 ,包括真菌、细菌、病毒和卵菌等中得到克隆。绝大多数已克隆无毒基因之间 ,及其与已知蛋白之间 ,... 详细信息

植物抗病基因与病原物无毒基因产物间直接或间接相互作用导致产生的基因对基因抗性是植物抗病性的重要形式。无毒基因已在多种植物病原物 ,包括真菌、细菌、病毒和卵菌等中得到克隆。绝大多数已克隆无毒基因之间 ,及其与已知蛋白之间 ,均无显著序列同源性。然而 ,多数已克隆植物抗病基因有较高序列一致性 ,产物往往具有相似的结构域。由序列一致性很高的抗病基因产物与没有明显序列同源性的无毒基因产物相互作用 ,介导产生的过敏性细胞坏死和抗病性 ,在产生速度、强度和组织特异性等方面均可能有显著差异。无毒基因具有双重功能 :在含互补抗病基因植物中表现无毒效应 ,而在不含互补抗病基因植物中显示小种、菌株、致病型。

关键词：植物病原物无毒基因功能毒性致病性

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串并混联机床几何误差建模与实验

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吉林大学学报（工学版） 2017年第1期47卷 137-144页

作者：曲兴田赵永兵刘海忠王昕杨旭陈行德吉林大学机械科学与工程学院长春130022

以多体系统理论为基础,研究了串并混联机床的几何误差。考虑各运动轴的定位误差、直线度误差、角度误差以及垂直度误差的综合作用,提出一种机床综合误差建模方法。通过对该机床各部件拓扑结构进行抽象化描述,推导出混联机床两相邻体间... 详细信息

以多体系统理论为基础,研究了串并混联机床的几何误差。考虑各运动轴的定位误差、直线度误差、角度误差以及垂直度误差的综合作用,提出一种机床综合误差建模方法。通过对该机床各部件拓扑结构进行抽象化描述,推导出混联机床两相邻体间相对运动的特征矩阵,建立了混联机床的整机综合误差模型。利用激光干涉仪对X、Y轴多项几何误差进行测量,并将测得的几何误差带入综合误差模型。通过分析所测的各项几何误差以及综合误差分布和演变规律发现:X、Y轴定位误差对整机综合误差的影响最大,直线度误差次之,角度误差影响最小;在精度要求不高的情况下,角度误差对综合误差的影响可忽略。

关键词：机械制造自动化综合误差模型几何误差串并混联机床

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Recent Advances in Artificial Sensory Neurons: Biological Fundamentals, Devices, Applications, and Challenges

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NANO-MICRO LETTERS 2025年第1期17卷 1-49页

作者： zhong, Shuai Su, Lirou xu, Mingkun Loke, Desmond Yu, Bin Zhang, Yishu Zhao, Rong Guangdong Inst Intelligence Sci & Technol Zhuhai 519031 Hengqin Peoples R China Zhejiang Univ Coll Integrated Circuits Hangzhou 3112000 Peoples R China ZJU Hangzhou Global Sci & Technol Innovat Ctr Hangzhou 310027 Peoples R China Singapore Univ Technol & Design Dept Sci Math & Technol Singapore 487372 Singapore Tsinghua Univ Dept Precis Instruments Beijing 100084 Peoples R China Tsinghua Univ Ctr Brain Inspired Comp Res Beijing 100084 Peoples R China Tsinghua Univ IDG McGovern Inst Brain Res Beijing 100084 Peoples R China

Biological fundamentals and recent progress of artificial sensory neurons are systematically *** device, performance metrics, and potential applications of artificial sensory neurons are *** for the future development of artificial sensory neurons are discussed. Spike-based neural networks, which use spikes or action potentials to represent information, have gained a lot of attention because of their high energy efficiency and low power consumption. To fully leverage its advantages, converting the external analog signals to spikes is an essential prerequisite. Conventional approaches including analog-to-digital converters or ring oscillators, and sensors suffer from high power and area costs. Recent efforts are devoted to constructing artificial sensory neurons based on emerging devices inspired by the biological sensory system. They can simultaneously perform sensing and spike conversion, overcoming the deficiencies of traditional sensory systems. This review summarizes and benchmarks the recent progress of artificial sensory neurons. It starts with the presentation of various mechanisms of biological signal transduction, followed by the systematic introduction of the emerging devices employed for artificial sensory neurons. Furthermore, the implementations with different perceptual capabilities are briefly outlined and the key metrics and potential applications are also provided. Finally, we highlight the challenges and perspectives for the future development of artificial sensory neurons.

关键词： Artificial intelligence Emerging devices Artificial sensory neurons Spiking neural networks Neuromorphic sensing

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A low redox potential and long life organic anode material for sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 557-564页

作者： Zhi Li Yang Wei Kang Zhou xin Huang xing Zhou Jie xu Taoyi Kong Junwei Lucas Bao Xiaoli Dong Yonggang Wang Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Fudan University Department of Chemistry Boston College School of Materials Science and Engineering Anhui University of Technology

Sodium-ion batteries （SIBs） with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials（>1 V）.Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material （tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na4TDC） has been developed with low redox potential （<0.7 V） and excellent cyclic *** three-sodium storage mechanism was demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na4TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg *** pairing with a thick Na3V2（PO4）3cathode (20.6 mg cm-2),the as-fabricated full cell exhibited high operating voltage （2.8 V）,excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na4TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

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