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Gene signatures to therapeutics:Assessing the potential of ivermectin against t(4;14)multiple myeloma

World Journal of Clinical Oncology 2024年第1期15卷 115-129页

作者： Yang Song Hao-Jun zhang Xia Song Jie Geng Hong-Yi li li-zhong zhang Bo Yang Xue-Chun Lu School of Basic Medicine Medical School of Chinese PLABeijing 100853China School of Basic Medicine Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Hematology The Second Medical CentreChinese PLA General HospitalBeijing 100853China

BACKGROUND Multiple myeloma(MM)is a terminal differentiated B-cell tumor disease characterized by clonal proliferation of malignant plasma cells and excessive levels of monoclonal immunoglobulins in the bone *** translocation,(t)(4;14),results in high-risk MM with limited treatment ***,there is an urgent need for identification and validation of potential treatments for this MM *** data and sequencing information from public databases could offer opportunities for the discovery of new diagnostic or therapeutic *** To elucidate the molecular basis and search for potential effective drugs of t(4;14)MM subtype by employing a comprehensive *** The transcriptional signature of t(4;14)MM was sourced from the Gene Expression *** datasets,GSE16558 and GSE116294,which included 17 and 15 t(4;14)MM bone marrow samples,and five and four normal bone marrow samples,*** the differentially expressed genes were identified,the Cytohubba tool was used to screen for hub ***,the hub genes were analyzed using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes *** the STRING database and Cytoscape,protein–protein interaction networks and core targets were *** small-molecule drugs were identified and validated using the Connectivity Map database and molecular docking analysis,*** In this study,a total of 258 differentially expressed genes with enriched functions in cancer pathways,namely cytokine receptor interactions,nuclear factor(NF)-κB signaling pathway,lipid metabolism,atherosclerosis,and Hippo signaling pathway,were *** hub genes(cd45,vcam1,ccl3,cd56,app,cd48,btk,ccr2,cybb,and cxcl12)were *** drugs,including ivermectin,deforolimus,and isoliquiritigenin,were predicted by the Connectivity Map database to have potential therapeutic effects on t(4;14)*** molecular docking,ivermectin showed strong binding affinity to all 10 ide

关键词： Multiple myeloma Functional enrichment analysis Molecular docking simulation Gene expression profiling Therapeutic target Ivermectin

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A bifunctional POM-based Cu-viologen complex with mixed octamolybdate clusters for rapid oxidation desulfurization and effective photogeneration of hydrogen

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Rare Metals 2024年第1期43卷 236-246页

作者： lin Yang zhong zhang Chao-Nan zhang Xiu-li Wang College of Chemistry and Materials Engineering Bohai UniversityJinzhou 121013China Professional Technology Innovation Center of liaoning Province for Conversion Materials of Solar Cell Bohai UniversityJinzhou 121013China

The design and synthesis of catalysts for the oxidation desulfurization and production of hydrogen are extremely important for solving environmental pollution and energy ***,a novel bifunctional [α-Mo_(8)O_(26)]^(4-)/[β-Mo_(8)O_(26)]^(4-)-based Cu-viologen complex H_(4)[Cu_(2)~ⅠCl_(2)(Hbcbpy)_(4)] [α-Mo_(8)O_(26)] [β-Mo8O_(26)]·H_(2)O(BHU-2,Hbcbpy=1-(4-carboxybenzyl)-4,4'-bipyridinium) was synthesized and characterized by single-crystal X-ray diffraction(XRD),infrared radiation spectra,powder X-ray diffraction(PXRD) and X-ray photoelectron spectroscopy(XPS) *** structural characteristic of BHU-2 is the presence of two types of octamolybdate clusters [α-Mo_(8)O_(26)]^(4-)/[β-Mo_(8)O_(26)]^(4-)and a new binuclear Cu~Ⅰ-Hbcbpy complex linked by Cl-bridges[Cu_(2)ⅠCl_(2)(Hbcbpy)_(4)]^(4+).BHU-2 as a heterogeneous catalyst exhibits excellent activities to the oxidation desulfurization and photocatalytic hydrogen *** room temperature,BHU-2 can catalyze 96% conversion of methyl phenyl sulfide with 98% selectivity,and the process obeys the pseudo-first-order reaction kinetic with the half-life of9.6 *** notorious 2-chloroethyl ethyl sulfide can achieve 99% conversion with 98% selectivity within only1 min at the presence of BHU-2,and the turnover frequency(TOF) is up to 7400 h^(-1).BHU-2 also exhibits high catalytic activity for the oxidation of other aromatic and aliphatic thioethers within short time at room ***,BHU-2 shows a high catalytic activity for visible-light-driven hydrogen evolution with an H_(2) evolution rate of 1677.85 μmol·g^(-1)·h^(-1) within 10 ***,the catalytic activities do not decrease evidently after three cycles,revealing the prominent structural stability and recyclability.

关键词： Polyoxometalate Metal-organic complex Viologen Oxidation desulfurization Photocatalytic hydrogen production

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SEI/dead li-turning capacity loss for high-performance anode-free solid-state lithium batteries

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Journal of Energy Chemistry 2024年第9期96卷 145-152页

作者： Qianwen Yin Tianyu li Hongzhang zhang Guiming zhong Xiaofei Yang Xianfeng li Division of Energy Storage Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Long-Duration and Large-Scale Energy Storage Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina Laboratory of Advanced Spectro-Electrochemistry and lithium-Ion Batteries Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina

Anode-free solid-state lithium metal batteries(AF-SSLBs)have the potential to deliver higher energy density and improved safety beyond lithium-metal ***,the unclear mechanism for the fast capacity decay in AF-SSLBs,either determined by dead li or solid electrolyte interface(SEI),limits the proposal of effective strategies to prolong cycling *** clarify the underlying mechanism,herein,the evolution of SEI and dead li is quantitatively analyzed by a solid-state nuclear magnetic resonance(ss-NMR)technology in a typical liPF6-based polymer *** results show that the initial capacity loss is attributed to the formation of SEI,while the dead li dominates the following capacity loss and the growth rate is 0.141 mA h cm^(−2)cycle−*** reduce the active li loss,the combination of inorganic-rich SEI and self-healing electrostatic shield effect is proposed to improve the reversibility of li deposition/dissolution behavior,which reduces the capacity loss rate for the initial SEI and following dead li generation by 2.3 and 20.1 folds,*** a result,the initial Coulombic efficiency(ICE)and stable CE increase by 15.1%and 15.3%in li-Cu cells,which guides the rational design of high-performance AF-SSLBs.

关键词： Solid-state lithium batteries Solid-state NMR Anode-free SEI Dead li

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Effect of wall-disruption on nutrient composition and in vitro digestion of camellia and lotus bee pollens

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Food Science and Human Wellness 2024年第3期13卷 1567-1577页

作者： Yuan Yuan Shun zhong Zeyuan Deng Guangyan li Jinwu zhang Hongyan li State Key Laboratory of Food Science and Resources Nanchang UniversityNanchang 330047China Nanchang Tongxin Zichao Biological Engineering Co. Ltd.Nanchang 330052China

The nutrient digestion,absorption and biological activity of bee pollen may be limited due to the complex pollen ***,the effect of superfine grinding technology on the release of nutrients from bee pollen were investigated,and their antioxidant activities and in vitro digestion were explored in this *** showed that the content of nutrients in bee pollen increased after wall *** them,fat content increased by 22.55%-8.31%,protein content increased by 0.54%-4.91%,starch content increased by 36.31%-48.64%,soluble sugar content increased by 20.57%-29.67%,total phenolic acid content increased by 11.73%-86.98%and total flavonoids content increased by 14.29%-24.79%.At the same time,the antioxidant activity increased by 14.84%-46.00%.Furthermore,the active components such as phenolic compounds in the wall-disruption bee pollen were more readily to be released during the in vitro digestion,and easier to be absorbed because of their higher *** activities during in vitro digestion were also improved in walldisruption bee *** findings provide evidence that bee pollen wall disruption was suggested,thus,it is more conducive to exerting the value of bee pollen in functional foods.

关键词： Bee pollen Nutrients Wall disruption Phenolic compounds In vitro digestion

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Application of the Conditional Nonlinear Local Lyapunov Exponent to Second-Kind Predictability

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Advances in Atmospheric Sciences 2024年第9期41卷 1769-1786页

作者： Ming zhang Ruiqiang DING Quanjia zhong Jianping li Deyu LU State Key Laboratory of Earth Surface Processes and Resource Ecology(ESPRE)/Key Laboratory of Environmental Change and Natural Disasters of Chinese Ministry of EducationBeijing Normal UniversityBeijing 100875China Department of Ocean Science Hong Kong University of Science and TechnologyHong KongChina College of Oceanic and Atmospheric Sciences/Frontiers Science Center for Deep Ocean Multispheres and Earth System(DOMES)/Key Laboratory of Physical Oceanography Ministry of Education/Academy of the Future Ocean/Center for Ocean Carbon NeutralityOcean University of ChinaQingdao 266100China Laoshan Laboratory Qingdao 266237China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China College of Earth Science University of Chinese Academy of SciencesBeijing 100049China

In order to quantify the influence of external forcings on the predictability limit using observational data,the author introduced an algorithm of the conditional nonlinear local Lyapunov exponent(CNLLE)*** effectiveness of this algorithm is validated and compared with the nonlinear local Lyapunov exponent(NLLE)and signal-to-noise ratio methods using a coupled Lorenz *** results show that the CNLLE method is able to capture the slow error growth constrained by external forcings,therefore,it can quantify the predictability limit induced by the external *** this basis,a preliminary attempt was made to apply this method to measure the influence of ENSO on the predictability limit for both atmospheric and oceanic variable *** spatial distribution of the predictability limit induced by ENSO is similar to that arising from the initial conditions calculated by the NLLE *** similarity supports ENSO as the major predictable signal for weather and climate *** addition,a ratio of predictability limit(RPL)calculated by the CNLLE method to that calculated by the NLLE method was *** RPL larger than 1 indicates that the external forcings can significantly benefit the long-term predictability *** instance,ENSO can effectively extend the predictability limit arising from the initial conditions of sea surface temperature over the tropical Indian Ocean by approximately four months,as well as the predictability limit of sea level pressure over the eastern and western Pacific ***,the impact of ENSO on the geopotential height predictability limit is primarily confined to the troposphere.

关键词： conditional nonlinear local Lyapunov exponent second-kind predictability coupled Lorenz model ENSO

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Multiscale Simulation of Microstructure Evolution during Preparation and Service Processes of Physical Vapor Deposited c-TiAlN Coatings

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Computers, Materials & Continua 2024年第6期79卷 3435-3453页

作者： Yehao Long Jing zhong Tongdi zhang li Chen lijun zhang State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083China

Physical Vapor Deposited(PVD)TiAlN coatings are extensively utilized as protective layers for cutting tools,renowned for their excellent comprehensive *** optimize quality control of TiAlN coatings for cutting tools,a multi-scale simulation approach is proposed that encompasses the microstructure evolution of coatings considering the entire preparation and service lifecycle of PVD TiAlN *** scheme employs phase-field simulation to capture the essential microstructure of the PVD-prepared TiAlN ***,cutting simulation is used to determine the service temperature experienced during cutting processes at varying ***-Hilliard modeling is finally utilized to consume the microstructure and service condition data to acquaint the microstructure evolution of TiAlN coatings throughout the cutting *** methodology effectively establishes a correlation between service temperature and its impact on the microstructure evolution of TiAlN *** is expected that the present multi-scale numerical simulation approach will provide innovative strategies for assisting property design and lifespan prediction of TiAlN coatings.

关键词： Multiscale phase-field TiAlN coatings PVD cutting

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Predictability of the 7·20 extreme rainstorm in Zhengzhou in stochastic kinetic-energy backscatter ensembles

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Science China Earth Sciences 2024年第7期67卷 2226-2241页

作者： Min YANG Peilong YU lifeng zhang Xiaobing PAN Quanjia zhong Yunying li College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China Key Laboratory of High Impact Weather(Special) China Meteorological AdministrationChangsha 410073China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment ChangeNanjing University of Information Science and TechnologyNanjing 210044China Department of Ocean Science Hong Kong University of Science and TechnologyHong Kong 999077China

The scale-dependent predictability of the devastating 7·20 extreme rainstorm in Zhengzhou,China in 2021 was investigated via ensemble experiments,which were perturbed on different scales using the stochastic kinetic-energy backscatter(SKEB)scheme in the WRF model,with the innermost domain having a 3-km grid *** daily rainfall(RAIN24h)and the cloudburst during 1600-1700 LST(RAIN1h)were *** demonstrated that with larger perturbation scales,the ensemble spread for the rainfall maximum widens and rainfall forecasts become closer to the *** ensembles with mesoscale or convective-scale perturbations,RAIN1h loses predictability at scales smaller than 20 km and RAIN24h is predictable for all *** in ensembles with synoptic-scale perturbations,the largest scale of predictability loss extends to 60 km for both RAIN1h and ***,the average positional error in forecasting the heaviest rainfall for RAIN24h(RAIN1h)was 400 km(50-60)*** southerly low-level jet near Zhengzhou was assumed to be directly responsible for the forecast uncertainty of *** rapid intensification in low-level cyclonic vorticity,mid-level divergence,and upward motion concomitant with the jet dynamically facilitated the *** analysis of the divergent,rotational and vertical kinetic spectra and the corresponding error spectra showed that the error kinetic energy at smaller scales grows faster than that at larger scales and saturates more quickly in all ***-scale perturbations not only boost larger-scale error growth but are also conducive to error growth at all scales through a downscale cascade,which indicates that improving the accuracy of larger-scale flow forecast may discernibly contributes to the forecast of cloudburst intensity and position.

关键词： Stochastic kinetic-energy backscatter(SKEB) Extreme rainfall Ensemble forecast Predictability

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Variation characteristics of acid rain in Zhuzhou,Central China over the period 2011-2020

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Journal of Environmental Sciences 2024年第4期138卷 496-505页

作者： Jiahao Ren liquan Zhu Xi zhang Yuqian Luo Xuecai zhong Bowen li Yuwen Wang Kai zhang State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Zhuzhou Environment Monitoring Center Zhuzhou 412000China Faculty of Environmental Engineering The University of Kitakyushu1–1 HibikinoWakamatsuKitakyushuFukuoka 808-0135Japan College of Natural Resources and Environment South China Agricultural UniversityGuangzhou 510642China

Zhuzhou was one of the most polluted cities in China with the serious acid *** to the implementation of air pollution control measures from 2016 to 2018,the acid rain pollution in this city has *** order to understand the recent situation,a comprehensive study on the acid rain was carried out from January 2011 to December *** pH values during the study period varied from 3.3 to 7.5,with a volume-weighted mean value of *** predominant acidic components of the precipitation were SO_(4)^(2-)and NO_(3)^(-),accounting for 89.3% of the total *** ratio of non-sea-salt SO_(4)^(2-)to NO_(3)^(-)showed a decreasing trend,revealing that the pollution type of acid rain changed from sulfuric acid type to sulfuric acid and nitric acid compound *** correlation analysis(p<0.05)showed that SO_(4)^(2-)was positively correlated with NH_(4)^(+),Ca^(2+),and Mg^(2+);hence,it predominated in precipitation as(NH_(4))_(2)SO_(4),NH_(4)HSO_(4),CaSO_(4),and MgSO_(4).Significant positive correlation of Ca^(2+)with Mg^(2+)shows that they may originated mainly from *** positive correlation between SO_(4)^(2-)and F^(-)and Cl^(-)indicate that their source may be related to the non-ferrous metal smelting industry in *** correlation analysis shows that emissions from the non-ferrous metal smelting industry in the area have a large significant on SO_(4)^(2-)and F^(-)in precipitation,while Cl^(-)may still be emitted from other anthropogenic sources.

关键词： Acid rain pH Chemical composition Neutralization factor Correlation analysis

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Advances in methane emissions from agricultural sources:Part *** and mitigation

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Journal of Environmental Sciences 2024年第6期140卷 279-291页

作者： Xiaokun Wu Ying zhang Yinghui Han Yagang zhang Yuhang zhang Xiaodan Cheng Pei zhong Xue Yuan Yuanxun zhang Zhengqiang li State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206China Hebei Key Laboratory of Physics and Energy Technology North China Electric Power UniversityBaoding 071003China College of Resources and Environment University of Chinese Academy of SciencesBeijing 101408China Interdisciplinary Mathematics Institute University of South CarolinaColumbiaSC 29208United States Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China

Methane is one of the major greenhouse gases(GHGs)and agriculture is recognized as its primary *** accounting is a prerequisite for developing effective agriculture mitigation *** this review,methane accounting methods and research status for various agricultural emission source including rice fields,animal enteric fermentation and livestock and poultry manure management were overview,and the influencing factors of each emission source were analyzed and *** the same time,it analyzes the different research efforts involving agricultural methane accounting and makes recommendations based on the actual ***,mitigation strategies based on accounting results and actual situation are *** review aims to provide basic data and reference for agriculture-oriented countries and regions to actively participate in climate action and carry out effective methane emission mitigation.

关键词： Methane emission Agricultural sources Accounting methodology Mitigation Emission influencing factors

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Collaborative robust dispatch of electricity and carbon under carbon allowance trading market

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Global Energy Interconnection 2024年第4期7卷 391-401页

作者： Songyu Wu Xiaoyan Qi Xiang li Xuanyu liu Bolin Tong Feiyu zhang zhong zhang Electric Power Research Institute of State Grid liaoning Electric Power Co. Shenyang 110006P.R.China School of Electrical Engineering Dalian University of TechnologyDalian 116024P.R.China

The launch of the carbon-allowance trading market has changed the cost structure of the power *** is an asynchronous coupling mechanism between the carbon-allowance-trading market and the day-ahead power-system *** this study,a data-driven model of the uncertainty in the annual carbon price was ***,a collaborative,robust dispatch model was constructed considering the annual uncertainty of the carbon price and the daily uncertainty of renewable-energy *** model is solved using the column-and-constraint generation *** operation and cost model of a carbon-capture power plant(CCPP)that couples the carbon market and the economic operation of the power system is also *** critical,profitable conditions for the economic operation of the CCPP were *** studies demonstrated that the proposed low-carbon,robust dispatch model reduced carbon emissions by 2.67%compared with the traditional,economic,dispatch *** total fuel cost of generation decreases with decreasing,conservative,carbon-price-uncertainty levels,while total carbon emissions continue to *** the carbon-quota coefficient decreases,the system dispatch tends to increase low-carbon unit *** study can provide important guidance for carbon-market design and the low-carbon-dispatch selection strategies.

关键词： Asynchronous coupling mechanism Collaborative robust optimization Carbon price uncertainty Carbon capture power plant Low carbon dispatch

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