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Propofol induces ferroptosis and inhibits malignant phenotypes of gastric cancer cells by regulating miR-125b-5p/STAT3 axis

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 2114-2128页

作者： Yi-Ping Liu zhong-zhi qiu Xu-Hui Li En-You Li Department ofAnesthesiology First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Department of Gastroenterology Heilongjiang Forest Industry Federation(Red Cross)HospitalHarbin 150008Heilongjiang ProvinceChina

BACKGROUND Gastric cancer is a common malignancy with poor prognosis,in which ferroptosis plays a crucial function in its *** is a widely used anesthetic and has antitumor potential in gastric ***,the effect of propofol on ferroptosis during gastric cancer progression remains *** To explore the function of propofol in the regulation of ferroptosis and malignant phenotypes of gastric cancer *** MTT assays,colony formation assays,Transwell assays,wound healing assay,analysis of apoptosis,ferroptosis measurement,luciferase reporter gene assay,and quantitative reverse transcription polymerase chain reaction were used in this *** Our data showed that propofol was able to inhibit proliferation and induce apoptosis of gastric cancer ***,propofol markedly repressed the invasion and migration of gastric cancer ***,propofol enhanced the erastin-induced inhibition of growth of gastric cancer ***,propofol increased the levels of reactive oxygen species,iron,and Fe2+in gastric cancer ***,propofol suppressed signal transducer and activator of transcription(STAT)3 expression by upregulating miR-125b-5p and propofol induced ferroptosis by targeting STAT3 in gastric cancer *** miR-125b-5p inhibitor or STAT3 overexpression reversed propofol-attenuated malignant phenotypes of gastric cancer *** Propofol induced ferroptosis and inhibited malignant phenotypes of gastric cancer cells by regulating the miR-125b-5p/STAT3 *** may serve as a potential therapeutic candidate for gastric cancer.

关键词： Gastric cancer Progression Ferroptosis Propofol miR-125b-5p STAT3

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Effect of cuproptosis on acute kidney injury after cardiopulmonary bypass in diabetic patients

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World Journal of Diabetes 2024年第10期15卷 2123-2134页

作者： Xi-Jin Deng Yi-Nan Wang Chuan-Bao Lv zhong-zhi qiu Ling-Xin Zhu Jing-Hui Shi Si-Ri-Gu-Leng Sana Department of Anesthesiology The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Department of The Health Management Service Evaluation Center The Health Management Service Evaluation Center of Heilongjiang ProvinceHarbin 150000Heilongjiang ProvinceChina Department of Anesthesiology The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 150001Guangdong ProvinceChina Department of Anesthesiology The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Department of Thoracic Surgery The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina

BACKGROUND Cardiopulmonary bypass(CPB)is a common procedure in cardiac *** is a high-risk factor for acute kidney injury(AKI),and diabetes is also such a *** can lead to copper *** is currently unclear whether AKI after CPB in diabetic patients is related to copper *** To explore whether the occurrence of CPB-AKI in diabetic patients is associated with *** Blood and urine were collected from clinical diabetic and non-diabetic patients before and after *** of copper ion,lactate,glucose,heat shock protein-70(HSP-70),and dihydrolipoamide dehydrogenase(DLAT)were determined.A diabetic rat model was established and CPB was *** rats were assessed for the development of CPB-AKI,and for the association of AKI with cuproptosis by detecting copper levels,iron-sulfur cluster proteins and observation of mitochondrial structure by electron *** CPB resulted in elevations of copper,lactate,HSP-70 and DLAT in blood and urine in both diabetic and nondiabetic *** was associated with pathologic and mitochondrial damage in the kidneys of diabetic ***-related proteins also appeared to be significantly *** CPB-AKI is associated with *** mellitus is an important factor aggravating CPB-AKI and cuproptosis.

关键词： Cardiopulmonary bypass Acute kidney injury Cuproptosis Diabetes Copper overload Iron-sulfur cluster proteins

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Coagulation indices and fibrinogen degradation products as predictive biomarkers for tumor-node-metastasis staging and metastasis in gastric cancer

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 110-120页

作者： Yi-Qing Shen qiu-Wan Wei Yi-Ren Tian Yun-zhi Ling Min Zhang Clinical Laboratory Civil Aviation Shanghai HospitalGubei Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200000China Clinical Laboratory Tongji Hospital of Tongji UniversityShanghai 200000China

BACKGROUND Gastric cancer(GC)is a prevalent malignancy with a substantial health burden and high mortality rate,despite advances in prevention,early detection,and *** with the global average,Asia,notably China,reports disproportionately high GC *** disease often progresses asymptoma-tically in the early stages,leading to delayed diagnosis and compromised ***,it is crucial to identify early diagnostic biomarkers and enhance treatment strategies to improve patient outcomes and reduce *** Retrospectively analyzed the clinical data of 148 patients with GC treated at the Civil Aviation Shanghai Hospital between December 2022 and December *** associations of coagulation indices-partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),fibrinogen,fibrinogen degradation products(FDP),fasting blood glucose,and D-dimer(D-D)with TNM stage and distant metastasis were *** Prolongation of APTT,PT,and TT was significantly correlated with the GC TNM ***,abnormal coagulation system activation was closely related to disease *** FDP and D-D were significantly associated with distant metastasis in GC(P<0.05),suggesting that increased fibrinolytic activity contributes to increased metastatic *** Our Results reveal coagulation indices,FDPs as GC biomarkers,reflecting abnormal coagulation/fibrinolysis,aiding disease progression,metastasis prediction,and helping clinicians assess thrombotic risk for early intervention and personalized treatment plans.

关键词： Coagulation indexes Fibrinogen degradation products Gastric cancer Tumor-node-metastasis staging Distant metastasis

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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting qiu Na Li Zhengxiang Zhou Ru Ye Liyan zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

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经食管超声心动图监测冠状动脉旁路移植术前后冠状静脉窦血流动力学变化

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临床麻醉学杂志 2014年第3期30卷 248-250页

作者：钟治球史宏伟葛亚力魏海燕高玉洁南京医科大学附属南京儿童医院麻醉科 210008 南京医科大学附属南京医院南京市第一医院麻醉科

目的应用经食管超声心动图(TEE)监测冠心病患者冠状动脉旁路移植术(CABG)前后冠状静脉窦(CS)的血流动力学变化。方法 29例择期需行CABG的患者,全麻诱导后行TEE检测,分别测量CABG前后患者CS血流指标及相关血流动力学指标。结果 27例患者C... 详细信息

目的应用经食管超声心动图(TEE)监测冠心病患者冠状动脉旁路移植术(CABG)前后冠状静脉窦(CS)的血流动力学变化。方法 29例择期需行CABG的患者,全麻诱导后行TEE检测,分别测量CABG前后患者CS血流指标及相关血流动力学指标。结果 27例患者CABG后心脏指数(CI)、左室射血分数(LVEF)明显高于CABG前(P<0.05);与CABG前比较,CABG后CS前向血流峰值流速(SPV、DPV)与前向血流速度时间积分(SVTI+DVTI)均明显增高,CS血流量(CSBF)明显增高(P<0.05);CS最大直径(CSD)CABG前后差异无统计学意义。结论 CABG术中使用TEE可方便、快速、定量地测定CS血流量变化,CABG术后早期CS血流量明显增加,与LVEF及CI改变一致。

关键词：冠状动脉旁路移植术冠状静脉窦经食管超声心动图

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不同种类有机物对污染农田土壤重金属活性的影响

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农业资源与环境学报 2017年第6期34卷 517-524页

作者：倪中应邱志腾石一珺章明奎桐庐县农业和林业技术推广中心浙江桐庐311500 浙江大学环境与资源学院浙江杭州310058

为了解施用不同种类有机物对污染农田土壤重金属行为的影响,布设了田间小区试验,观察研究施用6种不同类型有机物对土壤水溶性重金属和农作物对重金属吸收等的影响。试验设7个处理,分别为对照(不施有机肥)、施新鲜水稻秸秆、新鲜鸡粪、... 详细信息

为了解施用不同种类有机物对污染农田土壤重金属行为的影响,布设了田间小区试验,观察研究施用6种不同类型有机物对土壤水溶性重金属和农作物对重金属吸收等的影响。试验设7个处理,分别为对照(不施有机肥)、施新鲜水稻秸秆、新鲜鸡粪、鸡粪堆肥、新鲜猪粪、猪粪堆肥和商品有机肥,动态检测土壤中水溶性重金属含量、田面水中重金属浓度及收获水稻籽粒中重金属含量的变化。结果表明,与不施有机物的对照处理比较,施用各类有机物在试验前期均可明显提高土壤中水溶性重金属和田面水中重金属的含量,总体上以施用新鲜猪粪的最高,其次为新鲜鸡粪,施用商品有机肥的最低。土壤中水溶性重金属含量随试验时间增长逐渐下降。施用各类有机物对水稻籽粒中重金属的积累影响不明显。土壤中水溶性重金属及田面水中重金属含量均与相应的水溶性碳(DOC)浓度呈显著相关性,表明因有机物施用增加土壤中DOC浓度可能是土壤中水溶性重金属含量增加的主要原因;而不同有机物对土壤重金属活性影响的差异可能与有机物本身的分解程度及可释放DOC大小有关。但施用有机物引起的农田土壤水溶性重金属含量的增加是暂时的,对水稻生长后期籽粒中重金属积累的影响不明显。

关键词：有机肥重金属活化农产品安全

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Quartz luminescence dating of a centennial coastal foredune from Changle in Fujian Province,East China Sea

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Journal of Mountain Science 2022年第9期19卷 2601-2610页

作者： JIN Jian-hui LI zhi-zhong LING zhi-yong qiu Jun-jie Key Laboratory for Subtropical Resources and Environment of Fujian Province Fujian Normal UniversityFuzhou 350007China School of Geographical Sciences Fujian Normal UniversityFuzhou 350007China Qinghai Institute of Salt Lakes Chinese Academy of SciencesXi'ning 810008China

The Aeolian foredunes in the southern coast of China are records of paleoenvironmental changes for marine monsoon region. Intensive studies have been conducted to decipher their formation and paleoenvironmental implications in which chronology played a key role. However, robust dating results are still limited due to the scarcity of organic materials for radiocarbon and the limited application of quartz optically stimulated luminescence(OSL). Here, we collected 11 OSL samples and 140 grainsize samples from the Changle section with a thickness of 7 m from a coastal foredune in Fujian Province. The dating results indicated that the section spanned a time period from 0.32±0.04 ka(depth of 700 cm) to 0.18±0.02 ka(depth of 80 cm), after removal of age outliers. According to the OSL ages and sedimentary structural characteristics, the section could be divided into two stages, i.e. the stable accumulation period with an age range of 0.32-0.18 ka from the depth of 700 cm to 80 cm, and the activation period above the depth of 60 cm, at which the dune erosion was retained. The foredune development due to increased transport of dune sediment at the top part of the section was the result of recent human *** the foredunes, normal cross-bedding was generated by seasonal changes in wind *** changes in the wind direction were the primary cause for various sedimentary bedding within the dunes.

关键词： Optically stimulated luminescence Grain size Oblique foredune Coastal South China

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Micromechanics-based analysis for predicting asphalt concrete modulus

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第6期11卷 415-424页

作者： Xing-yi ZHU zhi-yi HUANG zhong-xuan YANG Wei-qiu CHEN Department of Civil Engineering Zhejiang University Hangzhou 310058 China Department of Engineering Mechanics Zhejiang University Hangzhou 310027 China

The elastic modulus of asphalt concrete(AC) is an important material parameter for pavement *** prediction and determination of elastic modulus,however,largely depends on laboratory tests which cannot reflect explicitly the influence of the microstructure of *** this end,a micromechanical model based on stepping scheme is *** is given to the influence of interfacial debonding and interlocking effect between the aggregates and asphalt mastic using the concept of effective *** on asphalt mixture with various microstructures are conducted to verify the proposed *** is shown that the prediction is generally in agreement with experimental *** affecting the elastic modulus of AC are also discussed in light of the proposed method.

关键词： Asphalt concrete(AC) Micromechanics Microstructure Effective bonding Optimum design Elastic modulus

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Corrosion behavior of three Ag–50Cu alloys prepared by different processes in NaCl solutions

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Rare Metals 2017年第1期36卷 61-68页

作者： zhong-qiu Jia qiu-Ying Liang qiu-Yue Tian zhong-qiu Cao Yan Wang College of Chemistry-and Chemical Engineering Shenyang Normal University Shenyang 110034 China

Corrosion behavior of two nanocrystalline bulk Ag–50Cu alloys and one coarse-grained counterpart prepared by liquid-phase reduction(LPR), mechanical alloying(MA) and powder metallurgy(PM) methods,respectively, were investigated in Na Cl solutions. They were finished by means of PARM273 A and M5210 electrochemical apparatus through potentiodynamic polarization method and electrochemical impedance spectroscopy(EIS) technique. The results show that corrosion rates of three Ag–50Cu alloys increase with the increment of Na Cl solution concentrations. Corrosion rates of LPRAg–50Cu alloy are a little higher than those of PMAg–50Cu alloy,but evidently lower than those of MAAg–50Cu alloy. The difference in corrosion rates is attributed to the large reduction in the grain size and homogeneous microstructure of nanocrystalline alloys. Passive current densities decrease and afterward increase for PMAg–50Cu alloy,decrease for MAAg–50Cu alloy, and increase for LPRAg–50Cu alloy with the increment of Na Cl solution concentrations. After the grain sizes are refined, passive current densities become lower.

关键词： Copper alloys Corrosion Corrosion rate Corrosive effects Electrochemical corrosion Electrochemical impedance spectroscopy Electrochemistry Grain size and shape Mechanical alloying Nanocrystals Powder metallurgy Reduction Silver Silver alloys

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Theory of an m×n apple surface network with special boundary

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Communications in Theoretical Physics 2023年第6期75卷 138-149页

作者： zhi-zhong Tan Department of physics Nantong UniversityNantong226019China

As is well known,any condition change in a network model will affect the research method and *** paper studies an arbitrary m×n apple surface network with a pair of non-uniform boundary resistors,which is a complex network that has not been solved *** research process of this paper consists of four strict basic steps according to RT-V *** the breakthrough of matrix transformation and eigenvector solution,two exact potential function formulae and two equivalent resistance formulae are derived.A series of applications and special cases are given to help readers understand the *** particular,we have drawn eight visualized potential function images,which can intuitively understand the changing characteristics of potential *** establishment of theoretical results provides a new theoretical basis for related interdisciplinary research.

关键词： surface structure resistor network RT-V method matrix equation potential function exact solution

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