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Factors associated with gastrointestinal stromal tumor rupture and pathological risk:A single-center retrospective study

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World Journal of Radiology 2023年第12期15卷 350-358页

作者： jia-Zheng Liu zhong-wen jia Ling-Ling Sun Department of Radiology The Fourth Affiliated Hospital of China Medical UniversityShenyang 110033Liaoning ProvinceChina

BACKGROUND Gastrointestinal stromal tumor(GIST)is a rare gastrointestinal mesenchymal tumor with potential *** the tumor ruptures,regardless of tumor size and mitotic number,it can be identified into a high-risk *** is of great significance for the diagnosis,treatment,and prognosis of GIST if non-invasive examination can be performed before surgery to accurately assess the risk of *** To identify the factors associated with GIST rupture and pathological *** A cohort of 50 patients with GISTs,as confirmed by postoperative pathology,was selected from our *** and computed tomography data of the patients were *** regression analysis was used to evaluate factors associated with GIST rupture and pathological risk *** Pathological risk grade,tumor diameter,tumor morphology,internal necrosis,gas-liquid interface,and Ki-67 index exhibited significant associations with GIST rupture(P<0.05).Gender,tumor diameter,tumor rupture,and Ki-67 index were found to be correlated with pathological risk grade of GIST(P<0.05).Multifactorial logistic regression analysis revealed that male gender and tumor diameter≥10 cm were independent predictors of a high pathological risk grade of GIST[odds ratio(OR)=11.12,95%confidence interval(95%CI):1.81-68.52,P=0.01;OR=22.96,95%CI:2.19-240.93,P=0.01].Tumor diameter≥10 cm,irregular shape,internal necrosis,gas-liquid interface,and Ki-67 index≥10 were identified as independent predictors of a high risk of GIST rupture(OR=9.67,95%CI:2.15-43.56,P=0.01;OR=35.44,95%CI:4.01-313.38,P<0.01;OR=18.75,95%CI:3.40-103.34,P<0.01;OR=27.00,95%CI:3.10-235.02,P<0.01;OR=4.43,95%CI:1.10-17.92,P=0.04).CONCLUSION Tumor diameter,tumor morphology,internal necrosis,gas-liquid,and Ki-67 index are associated with GIST rupture,while gender and tumor diameter are linked to the pathological risk of *** findings contribute to our understanding of GIST and may inform non-invasive examination stra

关键词： Gastrointestinal stromal tumors Imaging findings Tumor rupture Pathological risk grades

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An analysis of anomalous weather and climate around the M_S=6.2 earthquake of Zhangbei region

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Acta Seismologica Sinica(English Edition) 1998年第6期11卷 73-80页

作者： QING SEN LI 1) YU MEI JIN 1) ZHI CHENG MIAO 1) wen zhong jia 1) GUI CAI jiaNG 2) 1) Zhangjiakou Meteorological Observatory of Hebei Province, Zhangjiakou 075000, China 2) Forth Middle School of Zhangjiakou

Through analysis we found that some mesoscale anomalous regions (10 1～10 2 km) of meteorological parameters such as the special drought areas, unusual warm areas, the largest snowfall center, low pressure area together with the epicenter area of M S=6.2 Zhangbei earthquake on January 10, 1998 are located at the same area, i.e. there appears the ″Five areas corresponding″ phenomenon. Meanwhile, three times of low pressure evolution are generated and develop in the earthquake area in five days after the occurrence of the earthquake. The abnormal variation of the lower limit of frozen soil layer shows indirectly that unusual warm in earthquake areas are related to the upward thermal conduction from the deeper layer of earth surface.

关键词： strong earthquake in Zhangbei area especial drought areas unusual warm areas largest snowfall inverted trough of low pressure

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Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： jia Zhao Taixi Feng Guimin Lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

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玉屏风颗粒治疗过敏性鼻炎患儿的疗效研究

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中国现代药物应用 2021年第3期15卷 110-112页

作者：杨眉钟嘉雯珠海市妇幼保健院药学部 519000

目的分析玉屏风颗粒治疗过敏性鼻炎患儿的临床疗效。方法80例过敏性鼻炎患儿,以单盲随机抽样法分为参照组和实验组,各40例。参照组患儿予以孟鲁司特钠治疗,实验组患儿在参照组基础上予以玉屏风颗粒治疗。比较两组患儿临床疗效、症状体... 详细信息

目的分析玉屏风颗粒治疗过敏性鼻炎患儿的临床疗效。方法80例过敏性鼻炎患儿,以单盲随机抽样法分为参照组和实验组,各40例。参照组患儿予以孟鲁司特钠治疗,实验组患儿在参照组基础上予以玉屏风颗粒治疗。比较两组患儿临床疗效、症状体征消失时间、不良反应发生率。结果实验组总有效率95.00%高于参照组的75.00%,差异有统计学意义(P0.05)。结论玉屏风颗粒可有效减轻过敏性鼻炎患儿流涕、鼻塞等症状,临床疗效显著,且不良反应较少,值得借鉴。

关键词：玉屏风颗粒过敏性鼻炎孟鲁司特钠

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关于中国穆斯林经学文献印行的考察——以小经《开达尼》版本为例

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北方民族大学学报（哲学社会科学版） 2012年第4期 118-124页

作者：韩中义朱亮钟文佳陕西师范大学西北民族研究中心陕西西安710062

我国穆斯林传承伊斯兰教基本知识是有一定渠道的,但学者对这一问题的研究重视不够。笔者以小经《开达尼》版本为例,探索经学文献民间印行文本的刊行、翻译、版本流变、校勘等内容,借此说明穆斯林民间知识传播的传承方式。中国穆斯林通... 详细信息

我国穆斯林传承伊斯兰教基本知识是有一定渠道的,但学者对这一问题的研究重视不够。笔者以小经《开达尼》版本为例,探索经学文献民间印行文本的刊行、翻译、版本流变、校勘等内容,借此说明穆斯林民间知识传播的传承方式。中国穆斯林通过书面印(抄)本方式的宗教知识传播,承担起了自身文化相沿的内在使命,进而延续着自身的文化血脉。

关键词：中国穆斯林经学文献小经《开达尼》

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基于蛋白组学技术探究六味地黄丸治疗卵巢储备减退小鼠的作用机制

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中国中药杂志 2023年第12期48卷 3224-3234页

作者：高婷仲佳雯秦岭王雪怡李晓荣罗玉雪宁夏医科大学中医学院宁夏银川750000 宁夏医科大学中医学院宁夏银川750004 宁夏医科大学生育力保持重点实验室宁夏银川750004 宁夏医科大学少数民族医药现代化教育部重点实验室宁夏银川750004 银川市中医医院宁夏银川750000

利用蛋白组学技术探究六味地黄丸对卵巢储备功能减退(diminished ovarian reserve, DOR)的治疗效用和可能作用机制。首先采用环磷酰胺60 mg·kg^(-1)联合白消安6 mg·kg^(-1)一次性腹腔注射制备DOR模型小鼠,药物注射后连续观察小鼠动情... 详细信息

利用蛋白组学技术探究六味地黄丸对卵巢储备功能减退(diminished ovarian reserve, DOR)的治疗效用和可能作用机制。首先采用环磷酰胺60 mg·kg^(-1)联合白消安6 mg·kg^(-1)一次性腹腔注射制备DOR模型小鼠,药物注射后连续观察小鼠动情周期,以动情周期紊乱判定造模是否成功。造模成功后,给予小鼠六味地黄丸混悬液连续灌胃28 d;结束后选取4只雌鼠按照2∶1与雄鼠进行合笼观察孕产率;剩余小鼠在灌胃结束后的次日采血、取卵巢。苏木素-伊红(HE)染色、透射电镜下观察卵巢形态及超微结构变化;ELISA检测血清激素和氧化水平变化;定量蛋白组学技术分析小鼠造模前后和六味地黄丸干预前后卵巢蛋白的差异表达情况。结果显示,六味地黄丸能够调节DOR小鼠动情周期,改善小鼠血清激素水平,提高血清抗氧化水平,促进卵泡发育,保护卵巢颗粒细胞线粒体形态,提高DOR小鼠产仔数和存活数;显著负调节DOR模型相关的12个差异表达蛋白,这些差异蛋白主要参与了脂质分解代谢、炎症反应、免疫调节、辅酶生物合成等生物过程,并在鞘脂代谢、花生四烯酸代谢、核糖体、细胞铁死亡、cGMP-PKG信号通路等显著富集。总之,DOR的发生和六味地黄丸对其的防治作用与多种生物途径有关,主要包括氧化应激、炎症反应和免疫调节;“线粒体-氧化应激-细胞凋亡”是六味地黄丸治疗DOR的关键;YY1、CYP4F3是引发线粒体功能障碍、ROS积累的关键上游靶点,花生四烯酸代谢通路是药物作用的主要信号通路。

关键词：卵巢储备功能减退六味地黄丸蛋白组学卵巢颗粒细胞线粒体氧化应激

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Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng Bo Shao Chao-Min Xu Ke Wang jia-Zhu wen Li-Kang Luo jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

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Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin zhongliang Li wen‑Xia Su jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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升清降浊胶囊干法制粒工艺优化及颗粒性状、填充效果分析

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中医药导报 2022年第2期28卷 57-60,86页

作者：黄益穗钟文嘉叶秀群广州中医药大学第一附属医院广东广州510405

目的:以升清降浊胶囊为模型,优化其干法制粒工艺参数,验证最优工艺参数和干法制粒工艺的可行性。方法:采用Box-Behnken响应面法,以压辊间隙、压辊油压、送料转速、压辊转速作为考察因素,以制得颗粒的一次成型率(Y1)作为考察指标,优化干... 详细信息

目的:以升清降浊胶囊为模型,优化其干法制粒工艺参数,验证最优工艺参数和干法制粒工艺的可行性。方法:采用Box-Behnken响应面法,以压辊间隙、压辊油压、送料转速、压辊转速作为考察因素,以制得颗粒的一次成型率(Y1)作为考察指标,优化干法制粒工艺参数。结果:最优工艺参数为压辊间隙1.1 mm,压辊油压161 bar,送料转速84 r/min,压辊转速20 r/min,颗粒的一次成型率均值为52.8%,RSD为1.50%。结论:升清降浊胶囊使用干法制粒技术可行,该技术可有效提高生产效率,促进规模化生产进程。

关键词：升清降浊胶囊 Box-Behnken响应面法干法制粒技术一次成型率工艺优化

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16.48% Efficient solution-processed CIGS solar cells with crystal growth and defects engineering enabled by Ag doping strategy

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Journal of Energy Chemistry 2025年第1期100卷 59-65页

作者： Mengyu Xu Shaocong Yan Ting Liang jia jia Shengjie Yuan Dongxing Kou Zhengji Zhou wenhui Zhou Yafang Qi Yuena Meng Litao Han Sixin Wu Key Laboratory for Special Functional Materials of MOE National & Local Joint Engineering Research Centre for High-efficiency Display and Lighting Technology School of Nanoscience and Materials Engineering Henan University

Solution-processed Cu（In,Ga）Se2（CIGS） solar cells suffer from serious carrier recombination and power conversion efficiency（PCE） loss because of the poor film properties and easy formation of ***, we propose Ag&Se co-selenization strategy to enhance the crystallization and passivate harmful defects of the CIGS films. The formation of Ag-Se phase during the selenization process enables the formation of large grains and suppresses the deep level defects. It is found that Ag doping can enlarge the depletion region width, lower the Urbach energy and prolong the carrier lifetime. As a result, a champion solution-processed CIGS solar cell presents a high efficiency of 16.48% with the highly improved opencircuit voltage（VOC） of 662 m V and fill factor（FF） of 75.8%. This work provides an efficient strategy to prepare high quality solution-processed CIGS films for high-performance CIGS solar cells.

关键词： CIGS solar cells Solution-processed method Ag doping Crystal growth Defects engineering

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