Factors associated with gastrointestinal stromal tumor rupture and pathological risk:A single-center retrospective study

作     者：Jia-Zheng Liu Zhong-Wen Jia Ling-Ling Sun 

作者机构：Department of RadiologyThe Fourth Affiliated Hospital of China Medical UniversityShenyang 110033Liaoning ProvinceChina 

出 版 物：《World Journal of Radiology》 (世界放射学杂志（英文版）（电子版）)

年 卷 期：2023年第15卷第12期

页      面：350-358页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Gastrointestinal stromal tumors Imaging findings Tumor rupture Pathological risk grades 

摘      要：BACKGROUND Gastrointestinal stromal tumor(GIST)is a rare gastrointestinal mesenchymal tumor with potential *** the tumor ruptures,regardless of tumor size and mitotic number,it can be identified into a high-risk *** is of great significance for the diagnosis,treatment,and prognosis of GIST if non-invasive examination can be performed before surgery to accurately assess the risk of *** To identify the factors associated with GIST rupture and pathological *** A cohort of 50 patients with GISTs,as confirmed by postoperative pathology,was selected from our *** and computed tomography data of the patients were *** regression analysis was used to evaluate factors associated with GIST rupture and pathological risk *** Pathological risk grade,tumor diameter,tumor morphology,internal necrosis,gas-liquid interface,and Ki-67 index exhibited significant associations with GIST rupture(P0.05).Gender,tumor diameter,tumor rupture,and Ki-67 index were found to be correlated with pathological risk grade of GIST(P0.05).Multifactorial logistic regression analysis revealed that male gender and tumor diameter≥10 cm were independent predictors of a high pathological risk grade of GIST[odds ratio(OR)=11.12,95%confidence interval(95%CI):1.81-68.52,P=0.01;OR=22.96,95%CI:2.19-240.93,P=0.01].Tumor diameter≥10 cm,irregular shape,internal necrosis,gas-liquid interface,and Ki-67 index≥10 were identified as independent predictors of a high risk of GIST rupture(OR=9.67,95%CI:2.15-43.56,P=0.01;OR=35.44,95%CI:4.01-313.38,P0.01;OR=18.75,95%CI:3.40-103.34,P0.01;OR=27.00,95%CI:3.10-235.02,P0.01;OR=4.43,95%CI:1.10-17.92,P=0.04).CONCLUSION Tumor diameter,tumor morphology,internal necrosis,gas-liquid,and Ki-67 index are associated with GIST rupture,while gender and tumor diameter are linked to the pathological risk of *** findings contribute to our understanding of GIST and may inform non-invasive examination stra