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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao Liang Xingping Quan Xiaorui Geng Yujing Huang Yonghua Zhao lei Xi Zhen Yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

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Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng Zhao Bin Dai lei Ye Tao Song Shuai Huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

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A dynamic finite element model of human cervical spine with in vivo kinematic validation

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Chinese Science Bulletin 2014年第33期59卷 4578-4588页

作者： Jiajia Wang Zhihui Qian lei ren Luquan ren Key Laboratory of Bionic Engineering (Ministry of Education China) Jilin University School of Mechanical Aerospace and Civil EngineeringUniversity of Manchester

Most previous cervical spine finite element(FE) models were validated using in vitro cadaver measurement data from literatures. Although in vitro measurement can provide valuable data for model verification,the in vivo mechanical and physiological conditions of the cervical spine during its natural motions cannot be reproduced in vitro. In this study, a human FE model of skull(C0) and spinal vertebrae(C1–T1) was developed. The in vivo kinematic characteristics of head and neck were obtained from optoelectronic system, and used for the validation of the FE model. The simulation results showed good agreement with the measured data in left/right lateral bending and left/right axial rotation, while discrepancy existed during flexion. The predicted segmental cervical vertebral angles were compared against data from previous in vivo experiment, too. Furthermore, the skin shift data from previous study was used to compensate the experimental measurement during flexion and left/right lateral bending. The results showed the model was successfully validated with the in vivo experimental data.

关键词：有限元模型体内动态模型验证颈椎运动学特性测量数据实验数据文献利用

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Nonequilibrium reservoir engineering of a biased coherent conductor for hybrid energy transport in nanojunctions

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Chinese Physics B 2020年第12期29卷 44-49页

作者： Bing-zhong Hu lei-lei Nian Jing-Tao Lü School of Physics and Wuhan National High Magnetic Field Center Huazhong University of Science and TechnologyWuhan 430074China

We show that a current-carrying coherent electron conductor can be treated as an effective bosonic energy reservoir involving different types of electron–hole pair *** weak electron–boson coupling,hybrid energy transport between nonequilibrium electrons and bosons can be described by a Landauer-like *** allows for unified account of a variety of heat transport problems in hybrid electron–boson *** applications,we study the non-reciprocal heat transport between electrons and bosons,thermoelectric current from a cold-spot,and electronic cooling of the *** unified framework provides an intuitive way of understanding hybrid energy transport between electrons and bosons in their weak coupling *** opens the way of nonequilibrium reservoir engineering for efficient energy control between different quasi-particles at the nanoscale.

关键词： electron–hole pair hybrid energy transport nanojunction electron–phonon interaction

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Field resistance to spinosad in western flower thrips Frankliniella occidentalis(Thysanoptera:Thripidae)

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Journal of Integrative Agriculture 2016年第12期15卷 2803-2808页

作者： LI Dong-gang SHANG Xiao-yong Stuart Reitz Ralf Nauen lei zhong-ren Si Hyeock Lee GAO Yu-lin State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural Sciences Institute of Plant Protection Dezhou Academy of Agricultural Sciences Malheur County Extension Oregon State University Bayer Crop Science RD-SMRPest Control Biology Department of Agricultural Biotechnology Seoul National University

The western flower thrips, Frankliniella occidentalis, is one of the most destructive sucking pests of vegetables, fruits and ornamental crops in China. Spinosad is one of the most commonly used insecticides to manage thrips. To assess the incidence of spinosad resistance in F. occidentalis field populations in eastern China, survival rates for 24 different populations were compared with those of a susceptible laboratory strain. All populations showed significantly higher resistance to spinosad compared with the control as determined by comparing median lethal concentrations. Two populations from Shouguang and Liaocheng in Shandong Province were classified as having moderate and high levels of resistance to spinosad with a mean resistance ratio of 17.0 and 89.2, respectively. Our research indicates a widespread reduction in spinosad efficacy for controlling F. occidentalis field populations, and that resistance management strategies should be implemented as soon as practicable, to reduce the potential of progressive resistance development and loss of efficacy.

关键词： insecticide resistance spinosad bioassay Frankliniella occidentalis

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Multi-point airfoil optimization for axial-flow fan

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排灌机械工程学报 2019年第6期37卷 469-474页

作者： DUAN Haojie LIU lei DAI ren School of Energy and Power Engineering University of Shanghai for Science and Technology

Airfoil is the element of fan blade design. It is strongly anticipated to design a fan of ave- raged high performance over a wide operation range. Multi-point optimization design of airfoil for axial flow fan was proposed over specific operation range. Weighted objective function of airfoil lift-drag ratio was constructed for several operation points around the designing one. Airfoil was defined by parametric B-spline curve of limited shape controlling points. Results show that normal standard airfoils have remained spaces to be optimized under specific operation conditions. Airfoil performance is sensitive to flow′s Reynolds number and cascade solidity. Predicting flow transition along airfoil profile is essential to search for optimized one. Optimized airfoil of wide operation range is possible to obtain with prescribed fitness function. Obtainments of multi-point optimization may be relatively lower at design point, but positive obtainments are achieved at off-design ones. Resulted airfoil is specially suitable for axial flow fans operating frequently at off-design point such as air condition coolers.

关键词： multi-point optimization geometry description lift-drag ratio operation range axial-flow fan

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MICROSTRUCTURE CHARACTERISTICS AT THE BOND INTERFACE

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Chinese Journal of Mechanical Engineering 2005年第4期18卷 555-558页

作者： Li Junhui Han lei zhong Jue College of MechanicaI-Electronical Engineering Central South University Changsha 410083 China

Lift-off and section characteristics at the interface of thermosonic bond are observed by using scanning electron microscope （KYKY2800） with EDS-test. Results show that the peeling underdeveloped bonds simulate atorns （or doughnut） with an unbonded central region and ridged peripheral region is bonded hardly, Inside roundness at flip chip bonding center are discovered. Bond strength is located between the severely ridged periphery and the non-adhering central area of the bond. For constant force and time, the ridged area of the bond pattern increases when more power is applied. For constant force and power, the ridged location of the bonded region moves closer to the bond center with time. Results of EDS-tests at Au-Al and Au-Ag interfaces show that Kirkendall diffusibility at Au-Ag interface occur and the diffusing speed of Au-atomic is faster than that of Ag, and that intermetallic compounds at Au-Al interface is generated possibly. And these would be helpful for further research about thermosonic bonding.

关键词： Bonded interface Thermosonic bonding Microstructure

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EFFECT OF ULTRASONIC POWER ON THE HEAVY ALUMINUM WEDGE BONDING STrenGTH

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Chinese Journal of Mechanical Engineering 2005年第4期18卷 515-518页

作者： Wang Fuliang Han lei zhong Jue College of Mechanical and Electrical Engineering Central South UniversityChangsha 410083 China

Eleven groups of wire bonding experiments are carried out on an experiment platform （restructured with a U3000 heavy aluminum wedge wire bonder）. Pure silicon aluminum wire （300 μm in diameter, 2.94-3.92 N in average pull force） and nickel coated aluminum substrates are used in the experiments. During the experiment process, only ultrasonic power rate parameter is changed and the other bonding parameters are kept as constant, The bonding force and time are 4.90 N and 100 ms respectively. After the bonding experiments, shear strength tests are carried out on the bonds as the bonding strength criterion. From those experiments and test results, some conclusions are obtained： In the small ultrasonic power rate conditions （about 20%-30%）, with the power increasing, the bonding strength enhances accordingly; However, in the large ultrasonic power rate conditions （about 45%-70%）, the bonding strength decreases accordingly and over bonding happens. Only when the ultrasonic power rate is in a moderate condition （about 35%-40%） can good and stabilized bonding strength be acquired.

关键词： Ultrasonic wire bonding Ultrasonic power Over bonding Heavy aluminum wire

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Is the W-boson mass enhanced by the axion-like particle,dark photon,or chameleon dark energy?

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Science China(Physics,Mechanics & Astronomy) 2022年第12期65卷 145-152页

作者： Guan-Wen Yuan lei Zu lei Feng Yi-Fu Cai Yi-zhong Fan Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei230026China Department of Astronomy School of Physical SciencesUniversity of Science and Technology of ChinaHefei230026China CAS Key Laboratory for Researches in Galaxies and Cosmology University of Science and Technology of ChinaHefei230026China

The W-boson mass(m W=(80.4335±0.0094)Ge V)measured by the Collider Detector at Fermilab Collaboration is greater than the standard model(SM)prediction at a confidence level of 7σ,strongly suggesting the presence of new particles or *** the literature,various new particles and/or fields have been introduced to explain the astrophysical and experimental data,and their presence,in principle,may also enhance the W-boson *** this study,we investigate axion-like particle(ALP),dark photon(DP),and chameleon dark energy(DE)models for a solution to the W-boson mass *** find that the ALP and DP interpretations have been significantly narrowed down by global electroweak *** possibility of attributing the W-boson mass anomaly to the chameleon DE is ruled out by other experiments.

关键词： W-boson mass axion-like particle dark photon chameleon dark energy

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A fast algorithm for multivariate Hermite interpolation

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Applied Mathematics(A Journal of Chinese Universities) 2014年第4期29卷 438-454页

作者： lei Na TENG Yuan ren Yu-xue School of Mathematics Jilin University

Multivariate Hermite interpolation is widely applied in many fields, such as finite element construction, inverse engineering, CAD etc.. For arbitrarily given Hermite interpolation conditions, the typical method is to compute the vanishing ideal I （the set of polynomials satisfying all the homogeneous interpolation conditions are zero） and then use a complete residue system modulo I as the interpolation basis. Thus the interpolation problem can be converted into solving a linear equation system. A generic algorithm was presented in [18], which is a generalization of BM algorithm [22] and the complexity is O（τ^3） where r represents the number of the interpolation conditions. In this paper we derive a method to obtain the residue system directly from the relative position of the points and the corresponding derivative conditions （presented by lower sets） and then use fast GEPP to solve the linear system with O（（τ ＋ 3）τ^2） operations, where τ is the displacement-rank of the coefficient matrix. In the best case τ = 1 and in the worst case τ = [τ/n], where n is the number of variables.

关键词： vanishing ideal multivariate Hermite interpolation displacement structure fast GEPP algorithm.

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