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Geology and mineralization of the Dongping supergiant alkalic-hosted Au-Te deposit(>100 t Au)in Northern Hebei Province,China:A review

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China Geology 2024年第3期7卷 533-550页

作者： Shi-min Zhen Da-zhao Wang zhong-jian Zha Hai-jun Bai jiang Wang Development and Research Center of China Geological Survey Ministry of Natural ResourcesBeijing 100037China Technical Guidance Center for Mineral Resources Exploration Ministry of Natural ResourcesBeijing 100037China State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China Institute of Geological Surveying and Mapping Technology of Anhui Province Hefei 230022China Third Geological Brigade of Hebei Bureau of Geology and Mineral Resources Zhangjiakou 075000China Ulanqab Real Estate Registration Center Ulanqab 012099China

The Dongping deposit is the largest alkalic-hosted gold deposit in China containing>100 t of *** paper presents a new understanding for Dongping ore system,based on the previous *** mineralization originally occurred at 400-380 Ma,simultaneous with emplacement of the Shuiquangou alkaline complex,and was overprinted by the hydrothermal activity in the *** compositions of ores indicate metals of the deposit are mainly provided by the Shuiquangou ***-forming fluids are characterized by increasing oxygen fugacity and decreasing sulfur fugacity,while tellurium fugacity increased in the Stage II-2 and decreased in Stage *** systematic changes are closely related to the processes of mineral precipitation and fluid *** precipitation from Stage Ⅰ to Stage Ⅱ was triggered by fluid boiling,which leads to the precipitation of Pb-Bi-Te,due to decrement of sulfur *** of gas phase containing high concentration of H_2Te leads to precipitation of Te-Au-Ag minerals and native *** on these hypotheses,this paper present a polyphase metallogenic model as *** the Devonian,fluids were released from alkaline magmas,which carried ore-forming materials form the surrounding rocks and precipitate the early *** the Jurassic-Cretaceous,fluorine-rich fluids exsolved from highly factionated Shangshuiquan granite,which extracted and concentrated Au from the Shuiquangou complex and the Sanggan Group metamorphic rocks,and finally formed the Dongping gold deposit.

关键词： Mineralization and alteration Alkaline intrusion Au deposit Physicochemical conditions Metallogenic model Oxygen fugacity Sulfur fugacity Mechanisms of mineral precipitation Fluid boiling Fluorine-enriched fluid Dongping gold deposit North China Craton Mineral exploration engineering

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Frequency and risk factors of psychological distress among individuals with epilepsy before and during the outbreak of the SARS-CoV-2 Omicron variant in China:an online questionnaire survey

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Acta Epileptologica 2024年第1期7卷 36-43页

作者： Xiaoting Hao Qi Zhang Chenxi zhong Enzhi Li Yingqi jiang Jiajun Xu Yuanyuan Li Dong Zhou Bo Yan Department of Neurology West China HospitalSichuan University No37 Guoxue AlleyChengduSichuan Province610000China Department of Psychiatry and Mental Health West China HospitalSichuan University/West China School of Clinical MedicineSichuan UniversityChengdu610000China Department of Neurology Chengdu Shangjin Nanfu HospitalChengdu611730China West China School of Nursing Sichuan University Chengdu610000China Department of Clinical Research Management West China HospitalSichuan UniversityChengdu610000China

Background The COVID-19 pandemic substantially increases the risk of severe psychological distress among people with epilepsy(PWE),especially those with monthly household income12 should consult a psychiatrist,especially during major *** study was aimed to compare the frequency of psychological distress among Chinese PWE before and during the outbreak of the SARS-CoV-2 Omicron variant,and to identify risk factors for such *** In this prospective study,we collected sociodemographic data of PWE aged>14 years,who were treated at our center during December 1 to 15,*** participants completed the 6-item Kessler Psychological Distress Scale before the outbreak and again during the *** visitors who were unrelated to those patients during the outbreak were included as a *** logistic regression analysis was performed to identify risk factors of severe psychological distress and its *** Of the 223 PWE,127 were tested positive for SARS-CoV-2,while 174 of 218 controls were positive for *** neurological symptoms were similar between PWE and controls with *** average Kessler score of PWE was significantly higher during the outbreak than before it(9.93±3.98 vs.8.52±0.23,P<0.001).The average score of controls during the outbreak(5.146±0.35,P<0.001)was significantly lower than that of the *** identified three independent predictors for severe psychological distress in PWE during the outbreak,i.e.,monthly household income<5000 RMB(OR=0.252,95%CI 0.064–0.998,P=0.048),severe psychological distress before the outbreak(OR=0.067,95%CI 0.026–0.174,P<0.001),and seizure onset within 30 days before the assessment during the outbreak(OR=0.356,95%CI 0.157–0.805,P=0.013).Of the three predictors,the last one was also an independent predictor for exacerbation of psychological distress during the outbreak(OR=0.302,95%CI 0.123–0.741,P

关键词： Epilepsy Neurological symptoms Psychological distress COVID-19 pandemic

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Emerging role of vitamin D_(3)in alleviating intestinal structure injury caused by Aeromonas hydrophila in grass carp(Ctenopharyngodon idella)

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Animal Nutrition 2024年第1期16卷 202-217页

作者： Yao Zhang Xiao-Qiu Zhou Wei-Dan jiang Pei Wu Yang Liu Hong-Mei Ren Lu Zhang Hai-Feng Mi Ling Tang Cheng-Bo zhong Lin Feng Animal Nutrition Institute Sichuan Agricultural UniversityChengduChina Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengduChina Key Laboratory for Animal Disease-Resistant Nutrition of China Ministry of Education Sichuan Agricultural UniversityChengduChina Healthy Aquaculture Key Laboratory of Sichuan Province Tongwei Co.Ltd.ChengduChina Sichuan Animal Science Academy Sichuan Animtech Feed Co.Ltd.ChengduChina

Bacterial pathogens destroy the structural integrity of functional organs in fish,leading to severe challenges in the aquaculture *** D_(3)(VD_(3))prevents bacterial infections and strengthens immune system function via vitamin D receptor(VDR).However,the correlation between VD_(3)/VDR and the structural integrity of functional organs remains *** study aimed to investigate the influence of VD_(3)supplementation on histological characteristics,apoptosis,and tight junction characteristics in fish intestine during pathogen infection.A total of 540 healthy grass carp(257.24±0.63 g)were fed different levels of VD_(3)(15.2,364.3,782.5,1,167.9,1,573.8,and 1,980.1 IU/kg)for 70 ***,fish were challenged with Aeromonas hydrophila,a pathogen that causes intestinal *** present study demonstrated that optimal supplementation with VD_(3)(1)alleviated intestinal structural damage,and inhibited oxidative damage by reducing levels of oxidative stress biomarkers;(2)attenuated excessive apoptosisrelated death receptor and mitochondrial pathway processes in relation to p38 mitogen-activated protein kinase signaling(P<0.05);(3)enhanced tight junction protein expression by inhibiting myosin light chain kinase signaling(P<0.05);and(4)elevated VDR isoform expression in fish intestine(P<0.05).Overall,the results demonstrated that VD_(3)alleviates oxidative injury,apoptosis,and the destruction of tight junction protein under pathogenic infection,thereby strengthening pathogen defenses in the *** finding supports the rationale for VD_(3)intervention as an essential practice in sustainable aquaculture.

关键词： Aeromonas hydrophila Antibacterial property Grass carp(Ctenopharyngodon idella) Intestinal health Vitamin D_(3)

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The lysine methyltransferase SMYD2 facilitates neointimal hyperplasia by regulating the HDAC3-SRF axis

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Acta Pharmaceutica Sinica B 2024年第2期14卷 712-728页

作者： Xiaoxuan zhong Xiang Wei Yan Xu Xuehai Zhu Bo Huo Xian Guo Gaoke Feng Zihao Zhang Xin Feng Zemin Fang Yuxuan Luo Xin Yi Ding-Sheng jiang Division of Cardiovascular Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Key Laboratory of Organ Transplantation Ministry of EducationNHC Key Laboratory of Organ TransplantationChinese Academy of Medical SciencesWuhan 430030China School of Life Science and Technology Key Laboratory of Developmental Genes and Human DiseaseSoutheast UniversityNanjing 210096China Department of Cardiology Renmin Hospital of Wuhan UniversityWuhan 430060China

Coronary restenosis is an important cause of poor long-term prognosis in patients with coronary heart ***,we show that lysine methyltransferase SMYD2 expression in the nucleus is significantly elevated in serum-and PDGF-BB-induced vascular smooth muscle cells(VSMCs),and in tissues of carotid artery injury-induced neointimal ***2 overexpression in VSMCs(Smyd2-vTg)facilitates,but treatment with its specific inhibitor LLY-507 or SMYD2 knockdown significantly inhibits VSMC phenotypic switching and carotid artery injury-induced neointima formation in *** sequencing revealed that SMYD2 knockdown represses the expression of serum response factor(SRF)target genes and that SRF overexpression largely reverses the inhibitory effect of SMYD2 knockdown on VSMC ***3 directly interacts with and deacetylates SRF,which enhances SRF transcriptional activity in ***,SMYD2 promotes HDAC3 expression via tri-methylation of H3K36 at its ***966,a specific inhibitor of HDAC3,not only counteracts the pro-proliferation effect of SMYD2 overexpression on VSMCs,but also inhibits carotid artery injury-induced neointima formation in ***3 partially abolishes the inhibitory effect of SMYD2 knockdown on VSMC proliferation in a deacetylase activity-dependent *** results reveal that the SMYD2-HDAC3-SRF axis constitutes a novel and critical epigenetic mechanism that regulates VSMC phenotypic switching and neointimal hyperplasia.

关键词： Neointimaformation Histonemethylation Histoneacetylation SRFacetylation SMYD2 HDAC3 LLY-507 RGFP966

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Association between MTHFR c.677C>T variant and erectile dysfunction among males attending fertility clinic

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Asian Journal of Andrology 2024年第1期26卷 41-45页

作者： Shun Bai Ming-Zhen Li Yang-Yang Wan Xue-Chun Hu Yi-Xun Liu Xian-Hong Tong Tong-hang Guo Lu Zong Ran Liu Yuan-Qi Zhao Ping Xiang Bo Xu Xiao-Hua jiang Department of Gynecology and Obstetrics Reproductive and Genetic HospitalThe First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China NHC Key Laboratory of Male Reproduction and Genetics Guangdong Provincial Reproductive Science Institute(Guangdong Provincial Fertility Hospital)Guangzhou 510600China Department of Urology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Wannan Medical College Wuhu 241002China

Genetic risk factors have been shown to contribute to the development of sexual ***,the role of methylenetetrahydrofolate reductase(MTHFR)gene variants in the risk of erectile dysfunction(ED)remains *** this study,we recruited 1254 participants who underwent ED assessed by the International Index of Erectile *** MTHFR c.677C>T variant was also measured by fluorescence polymerase chain reaction(PCR).No significant difference in the genotypic frequency of the MTHFR C677T polymorphism(CC,CT,and TT)was observed between men from the ED and non-ED *** addition,on binary logistic regression analysis,both crude and adjusted models showed that the risk of ED was not significantly associated with the C677T ***,a significantly higher frequency of the 677TT polymorphism was found in severe and moderate ED(P=O.02).The positive correlation between the MTHFR 677TT polymorphism and severe ED was confirmed by logistic regression analysis,even after adjusting for potential confounders(odds ratio[OR]=2.46,95%confidence interval[CI]:1.15-5.50,P=0.02).These findings suggest a positive correlation between the MTHFR 677TT polymorphism and the risk of severe *** of MTHFR gene polymorphisms may provide complementary information for ED patients during routineclinicaldiagnosis.

关键词： erectile dysfunction gene variant genetic risk factors methylenetetrahydrofolate reductase sexual function

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Millisecond dynamics of colloidal suspension studied by X-ray photon correlation spectroscopy at the Shanghai Synchrotron Radiation Facility

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Nuclear Science and Techniques 2024年第1期35卷 1-9页

作者： Chen-Hui Cui Zi-Mu Zhou Lin-Feng Wei Song-Lin Li Feng Tian Xiu-Hong Li Zhi Guo Yi-Hui Xu Huai-Dong jiang Ren-zhong Tai Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Center for Transformative Science ShanghaiTech UniversityShanghai 201210China

X-ray photon correlation spectroscopy(XPCS)has emerged as a powerful tool for probing the nanoscale dynamics of soft condensed matter and strongly correlated materials owing to its high spatial resolution and penetration *** technique requires high brilliance and beam coherence,which are not directly available at modern synchrotron beamlines in *** facilitate future XPCS experiments,we modified the optical setup of the newly commissioned BL10U1 USAXS beamline at the Shanghai Synchrotron Radiation Facility(SSRF).Subsequently,we performed XPCS measurements on silica suspensions in glycerol,which were opaque owing to their high *** were collected using a high frame rate area detector.A comprehensive analysis was performed,yielding correlation functions and several key dynamic *** the results were consistent with the theory of Brownian motion and demonstrated the feasibility of XPCS at ***,by carefully optimizing the setup and analyzing the algorithms,we achieved a time resolution of 2 ms,which enabled the characterization of millisecond dynamics in opaque systems.

关键词： XPCS SSRF Silica suspension Glycerol Brownian motion Millisecond dynamics

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Insights into rapid screening and molecular mechanism of novel Rosa roxburghii seeds pancreatic lipase/cholesterol esterase inhibitory peptides: A combined in silico and in vitro perspective

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Food Science and Human Wellness 2024年

作者： Hao Yin jiangxiong Zhu Yu zhong Danfeng Wang Yun Deng Linnan Yang Lutao Gao Yongli jiang Department of Food Science & Technology Shanghai Jiao Tong University Shanghai Jiao Tong University Yunnan (Dali) Research Institute School of Big Data Yunnan Agricultural University Faculty of Food Science and Engineering Kunming University of Science and Technology

Rosa roxburghii seeds are by-products of Rosa roxburghii processing， and their protein hydrolysates (RTSPHs) were found to possess a variety of biological activities. This study aimed to rapidly identify pancreatic lipase (PL) and cholesterol esterase (CE) inhibitory peptides in Rosa roxburghii seeds protein (RTSPHs) and to elucidate their molecular mechanisms by combining peptidomics and virtual screening. The simulated intestinal environment worsened the peptide's inhibition of PL but catalyzed the inhibition of CE. The fraction less than 3 kDa in RTSPHs was found to have the highest PL/CE inhibitory activity， among which 17 promising inhibitory peptides were identified and screened by peptidomics and virtual screening. LFCMH， RIPAGSPF， and YFRPR showed good inhibitory abilities against both PL and CE. Molecular docking showed that peptides inhibited PL and CE mainly by hydrogen bonding and hydrophobic interactions with residues in the active site and surface loop. Inhibition kinetic revealed that the peptides were competitive and mixed-type inhibitors of PL/CE. Further， the three peptides， LFCMH， RIPAGSPF， and YFRPR， could effectively inhibit 3T3-L1 preadipocytes differentiation， increase high-density lipoprotein cholesterol content and decrease low-density lipoprotein cholesterol content. This study suggests that combining peptidomics with virtual screening is an effective strategy for rapid screening of PL/CE inhibitory peptides.

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Advanced Potassium-Ion Batteries with High Areal Capacity

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CCS Chemistry 2024年第4期6卷 1011-1023页

作者： Song Chen jiang zhong Hongli Deng Qiliang Wei Xiaohua Shen Xinxin Jia Shengyang Li Qiusheng Zhang Jian Zhu Bingan Lu Weiyou Yang State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringCollege of Materials Science and EngineeringCollege of Physics and ElectronicsHunan Key Laboratory of Two-Dimensional MaterialsEngineering Research Center of Advanced Catalysis of the Ministry of EducationHunan UniversityChangsha 410082 Institute of Micro/Nano Materials and Devices Ningbo University of TechnologyNingbo 315211

High areal capacity is one of the critically important points for potassium-ion batteries(PIBs)for practical applications,which relies on high areal-massloading electrodes operating at high reversible ***,it is remarkably restricted by the mechanical instability and sluggish charge transfer induced by the increased mass *** overcome such challenge,we report the rationally designed bimetallic selenides CoSe2/SnSe2 heterostructures confined in hierarchical carbon nanofibers(CSSe@CNFs),which enables the electrodes robust mechanical stability,enhanced electron transport,and reduced ion-diffusion energy barrier for facilitating reaction ***,an impressive areal mass loading up to 25.3 mg cm^(−2)was achieved,which endowed a high areal capacity of 7.58 mAh cm^(−2)for such a free-standing *** is stateof-the-art among the PIBs,exceeding that of today’s industry standard(∼3 mAh cm^(−2)for LIBs).Furthermore,it delivered long-term stability over 3700 cycles at high current density(∼2 mA cm^(−2),vs 1 mA cm^(−2)in LIBs).Moreover,the as-constructed full battery achieved a high energy density of 172.8 Wh kg-1 at 0.05 A g^(−1)with a satisfied cycle stability over 2000 cycles at 2 A g^(−1)and high reversibility with Coulombic efficiency of 100%;thus,signifying its bright future toward commercial application for advanced PIBs.

关键词： bimetal selenides heterostructure mass loading areal capacity potassium-ion battery

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Emergent ultra-high temperature ferromagnetism in La_(2)CoO_(4±x) thin films

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Nano Research 2024年第8期17卷 7250-7255页

作者： Ziang Meng Han Yan Peixin Qin Zhuo Yin Peiheng jiang Xiaorong Zhou Xiaoning Wang Hongyu Chen Li Liu Zhiyuan Duan Guojian Zhao Weisheng Zhao Fengxia Hu Qinghua Zhang Zhicheng zhong Zhiqi Liu School of Materials Science and Engineering Beihang UniversityBeijing 100191China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China CAS Key Laboratory of Magnetic Materials and Devices and Zhejiang Province Key Laboratory of Magnetic Materials and Application Technology Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Fert Beijing Institute School of Integrated Circuit Science and EngineeringBeihang UniversityBeijing 100191China

Searching for novel ferromagnetic oxides with high Curie temperature(TC)has been one of the main goals for oxide *** well-known perovskite cobaltate LaCoO_(3)is a classical ferromagnet in its thin-film form;however,it suffers from a low TC(~85 K).Here we report a new type of ferromagnetic La-Co-O films with an ultrahigh TC of~820 *** are fabricated by pulsed laser deposition from a LaCoO_(3)target at low oxygen partial *** structural analysis indicates that they crystallize in terms of the Ruddlesden–Popper phase of La_(2)CoO_(4±x).In sharp contrast to the antiferromagnetism of bulk La_(2)CoO_(4),the strong ferromagnetism in the La_(2)CoO_(4±x) thin films is firmly demonstrated by magnetometry measurements,X-ray magnetic circular dichroism characterization,and magnetotransport *** importantly,density functional theory calculations indicate that the nonstoichiometric oxygen induces an antiferromagnetic-to-ferromagnetic phase transition,accompanied by the orbital reconstruction of Co 3d ***,our study provides an attractive strategy for designing or synthesizing exotic magnetic oxides with high ordering temperatures.

关键词： ferromagnetic oxides ultra-high Curie temperature La_(2)CoO_(4) spin current transport oxygen engineering

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Review of 2D Bi_(2)X_(3)(X=S,Se,Te):from preparation to photodetector

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Rare Metals 2024年第6期43卷 2349-2370页

作者： Zhi Zeng Dong-Bo Wang Xuan Fang Jia-Mu Cao Bing-Ke Zhang Jing-Wen Pan Dong-Hao Liu Si-hang Liu Shu-Jie Jiao Tian-Yuan Chen Gang Liu Lian-Cheng Zhao Jin-zhong Wang Department of Optoelectronic Information Science School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001China Changchun University Science and Technology School of PhysicsThe State Key Laboratory of High Power Semiconductor LasersChangchun 130022China School of Astronautics Harbin Institute of TechnologyHarbin 150001China Center for High Pressure Science and Technology Advanced Research Shanghai 201203China

Detector has become an indispensable part of human *** increasing demand for photodetectors with high performance has promoted the research of novel *** the same time,with the development of rising material system,two-dimensional(2D)materials attract a lot of attention,while the suitable option for fabricating photodetector is still *** prospering of bismuth chalcogenides injected new vitality for material field,thereinto,the unique topological insulator characteristics make the research on bismuth selenide(Bi_(2)X_(3))and bismuth telluride(Bi_(2)X_(3)) intriguing.2D Bi_(2)X_(3) also exhibits unique features among various 2D materials,of which,the adjustable narrow energy band gap and polarization-sensitive photocurrent contribute to the promising application of high performance and broadband *** this review,from a bottom-up perspective,we summarize fundamental properties,synthesis method,photodetector performance of 2D Bi_(2)X_(3) based on the previous study,which provide an overall perspective of 2D Bi_(2)X_(3).Wherein,the section of the photodetector is specifically discu ssed with regard to pure Bi_(2)X_(3) photodetector and heterojunction photodetector.A brief summary and outlook were also explored in the end.

关键词： Bi_(2)X_(3) Preparation 2D Photodetector

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