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Encapsulated Fe(IV)Molecular Complex for Photoacoustic Imaging

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CCS Chemistry 2024年第5期6卷 1184-1197页

作者： Ye Xu Chao Li zhong-yu yu Jiamin Wang Zhaoyang Liu Chao Jiang Zhen-Feng Chen Xiaoyu Wu Ming-Xing Li Hong Yang Zhao-Xi Wang Jonathan L.Sessler Department of Chemistry Center for Supramolecular Chemistry and CatalysisInnovative Drug Research CenterShanghai UniversityShanghai 200444 College of Chemistry and Materials Science Shanghai Key Laboratory of Rare Earth Functional MaterialsShanghai Frontiers Science Center of Biomimetic CatalysisShanghai Normal UniversityShanghai 200234 Sijing Community Health Service Center of Songjiang District Shanghai 201601 Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuilin 541004 Department of Chemistry The University of Texas at AustinAustinTexas 78712-1224

stable neutral Fe(IV)complex(Fe-HDCL),readily accessible on the g scale,was found to possess high water solubility and good stability(<5%degradation over 4 h upon photoirradiation).Fe-HDCL is green and absorbs light effectively in the visible region(500–800 nm)with aλmax at 650 nm(ɛ=7830 M^(−1)cm^(−1)).Fe-HDCL also exhibits photothermal(PT)behavior comparable to single-wall carbon nanotubes in the solid *** aqueous solution,high PT conversion(η=72.6%)is achieved,and a strong hyperthermia-based inhibition of cell growth is observed upon subjecting Fe-HDCL to near-infrared 730 nm laser *** biological studies in vitro and in vivo confirmed that Fe-HDCL is biocompatible,clears readily,and allows the visual detection of blood *** subjecting mice to intravenous injection at low doses(e.g.,50μmol·kg^(−1)),Fe-HDCL also permits the photoacoustic(PA)imaging of kidneys and the evaluation of renal fibrosis in mouse *** addition,Fe-HDCL allows PA-based imaging of brain tissues,presumably reflecting its ability to pass through the blood-brain *** thus propose that Fe-HDCL has a role to play as PT agent and as a photodiagnostic.

关键词： stable Fe(IV)complex blood-brain barrier molecular cage photoacoustic imaging renal fibrosis

Insights into rapid screening and molecular mechanism of novel Rosa roxburghii seeds pancreatic lipase/cholesterol esterase inhibitory peptides: A combined in silico and in vitro perspective

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Food Science and Human Wellness 2024年

作者： Hao Yin Jiangxiong Zhu yu zhong Danfeng Wang yun Deng Linnan Yang Lutao Gao Yongli Jiang Department of Food Science & Technology， Shanghai Jiao Tong University Shanghai Jiao Tong University yunnan (Dali) Research Institute School of Big Data， yunnan Agricultural University Faculty of Food Science and Engineering， Kunming University of Science and Technology

Rosa roxburghii seeds are by-products of Rosa roxburghii processing， and their protein hydrolysates (RTSPHs) were found to possess a variety of biological activities. This study aimed to rapidly identify pancreatic lipase (PL) and cholesterol esterase (CE) inhibitory peptides in Rosa roxburghii seeds protein (RTSPHs) and to elucidate their molecular mechanisms by combining peptidomics and virtual screening. The simulated intestinal environment worsened the peptide's inhibition of PL but catalyzed the inhibition of CE. The fraction less than 3 kDa in RTSPHs was found to have the highest PL/CE inhibitory activity， among which 17 promising inhibitory peptides were identified and screened by peptidomics and virtual screening. LFCMH， RIPAGSPF， and YFRPR showed good inhibitory abilities against both PL and CE. Molecular docking showed that peptides inhibited PL and CE mainly by hydrogen bonding and hydrophobic interactions with residues in the active site and surface loop. Inhibition kinetic revealed that the peptides were competitive and mixed-type inhibitors of PL/CE. Further， the three peptides， LFCMH， RIPAGSPF， and YFRPR， could effectively inhibit 3T3-L1 preadipocytes differentiation， increase high-density lipoprotein cholesterol content and decrease low-density lipoprotein cholesterol content. This study suggests that combining peptidomics with virtual screening is an effective strategy for rapid screening of PL/CE inhibitory peptides.

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Characterization of rock thermophysical properties and factors affecting thermal conductivity−A case study of Datong Basin,China

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Journal of Groundwater Science and Engineering 2024年第1期12卷 4-15页

作者： Meng-lei Ji Shuai-chao Wei Wei Zhang Feng Liu yu-zhong Liao Ruo-xi yuan Xiao-xue Yan Long Li Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China Technology Innovation Center of Geothermal&Hot Dry Rock Exploration and Development Ministry of Natural ResourcesShijiazhuang 050061China China University of Geosciences(Beijing) Beijing 100083China

Rock thermal physical properties play a crucial role in understanding deep thermal conditions,modeling the thermal structure of the lithosphere,and discovering the evolutionary history of sedimentary *** advancements in geothermal exploration,particularly the identification of high-temperature geothermal resources in Datong Basin,Shanxi,China,have opened new *** study aims to characterize the thermal properties of rocks and explore factors influencing thermal conductivity in basins hosting high-temperature geothermal resources.A total of 70 groups of rock samples were collected from outcrops in and around Datong Basin,Shanxi *** property tests were carried out to analyze the rock properties,and the influencing factors of thermal conductivity were studied through experiments at different temperature and water-filled *** results indicate that the thermal conductivity of rocks in Datong,Shanxi Province,typically ranges from 0.690 W/(m·K)to 6.460 W/(m·K),the thermal diffusion coefficient ranges from 0.441 mm^(2)/s to 2.023 mm^(2)/s,and the specific heat capacity of the rocks ranges from 0.569 KJ/(kg·℃)to 1.117 KJ/(kg·°C).Experimental results reveal the impact of temperature and water saturation on the thermal conductivity of the *** thermal conductivity decreases with increasing temperature and rises with high water saturation.A temperature correction formula for the thermal conductivity of different lithologies in the area is proposed through linear *** findings from this study provide essential parameters for the assessment and prediction,development,and utilization of geothermal resources in the region and other basins with typical high-temperature geothermal resource.

关键词： Datong Basin Rock thermal conductivity Thermal diffusivity Specific heat capacity Influencing factors

Polygonatum sibiricum polysaccharides attenuated colitis via regulating gut microbiota mediated colonic NLRP3/ASC/Caspase-1/GSDMD signaling pathway

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Food Science and Human Wellness 2024年

作者： zhong-yu yuan Xin-yu Wang Jun Wang yuan Xu Jing Chen Shu-Qi yu Zhi-Ming Chen Pei-Lu Chen Ji-Xiao Zhu Wei-Feng Huang Guang-Hui Xu Li-Tao Yi Department of Chemical and Pharmaceutical Engineering， College of Chemical Engineering， Huaqiao University Xiamen Medicine Research Institute Research Center of Traditional Chinese Medicine Resources and Ethnic Medicine， Jiangxi University of Chinese Medicine Department of Gastroenterology and Hepatology， The First Affiliated Hospital of Xiamen University， Xiamen University Institute of Pharmaceutical Engineering， Huaqiao University Fujian Provincial Key Laboratory of Biochemical Technology， Huaqiao University

Polygonatum sibiricum has long been a popular functional food in Asia， known for its anti-inflammatory properties. However， its efficacy in alleviating colitis has yet to be investigated. This study aimed to explore the therapeutic potential of Polygonatum sibiricum polysaccharides (PSP) in dextran sulfate sodium (DSS)-induced colitis， focusing on the related pyroptosis mechanisms. Scanning electron microscopy (SEM) analysis showed that PSP possesses a smooth surface with no pore structure and a dense， lamellar structure adorned with numerous spherical entities. PSP treatment significantly reduced colitis symptoms and decreased pro-inflammatory cytokines， likely through suppression of the TLR4/NF-κB signaling pathway. Additionally， PSP attenuated NLRP3/ASC/Caspase-1/GSDMD-mediated pyroptosis and mitochondria damage in the colon， while enhanced the expression of tight junction and adherens junction proteins. Microbiota sequencing showed that PSP increased the abundance of phylum Bacteroidota and genus such as Muribaculaceae， Lactobacillus， Clostridia， and Lachnospiraceae， while decreased the phylum Proteobacteria and the genus Enterobacter， Escherichia-Shigella， and Blautia. In conclusion， this study demonstrates that PSP exerts the potential therapeutic role against colitis， which was mediated by the regulation of gut microbiota and the inhibition of colonic NLRP3/ASC/Caspase-1/GSDMD signaling pathway.

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中国式现代化道路下的粮食安全:实践历程与提升路径

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科技导报 2024年第6期42卷 35-41页

作者：巴雪真钟钰中国农业科学院农业经济与发展研究所北京100081

确保粮食安全是中国式现代化建设的基础保障和必然要求。辨析了中国式现代化与粮食安全的内在联系,即中国粮食安全是14亿多人吃饱吃好的重要基础、实现全体人民共同富裕的组成部分、满足物质文明进而追求精神文明的重要前提、人与自然... 详细信息

确保粮食安全是中国式现代化建设的基础保障和必然要求。辨析了中国式现代化与粮食安全的内在联系,即中国粮食安全是14亿多人吃饱吃好的重要基础、实现全体人民共同富裕的组成部分、满足物质文明进而追求精神文明的重要前提、人与自然和谐共生的产物以及世界和平发展的重要保障。回顾了中国式现代化道路下粮食安全的实践历程,中国实现了从“吃不饱”到“吃得好”、从“压产区”到“一盘棋”、从“粮食足”到“精神富”、从“重产出”到“强绿色”、从“被动参与”到“主动建设”的转变,走出了一条符合中国特色的粮食安全道路。提出了未来应从推进粮食安全由数量安全向质量和能力安全转变、健全种粮农民收益保障机制和主产区利益补偿机制、推动乡村实现物质文明与精神文明建设协调发展、基于大食物观加快构建多元化食物供给体系、积极参与粮食安全国际合作及全球粮食安全治理等方面努力,切实提高粮食安全保障水平。

关键词：中国式现代化粮食安全粮食生产

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中国粮食安全治理的特征及路径

科技导报 2024年第16期42卷 6-13页

作者：周琳钟钰中国农业科学院农业经济与发展研究所北京100081

中国粮食安全治理一直循着粮食安全目标不断演进,当前逐渐形成了新型农业经营主体为核心、绿色生产为手段的粮食生产格局。中国粮食安全治理体系通过自我革新以适应不断变化的治理目标,参与主体日益增加,治理手段逐渐多样,能够较好保障... 详细信息

中国粮食安全治理一直循着粮食安全目标不断演进,当前逐渐形成了新型农业经营主体为核心、绿色生产为手段的粮食生产格局。中国粮食安全治理体系通过自我革新以适应不断变化的治理目标,参与主体日益增加,治理手段逐渐多样,能够较好保障粮食安全水平。但针对粮食安全治理体系与治理能力现代化要求,仍需要克服一系列挑战,如资源约束导致粮食生产进入瓶颈期,气候变化和国际环境对粮食安全产生持续冲击,粮食生产比较效益低、耕地撂荒、耕地“非粮化”“非农化”问题持续存在,农业技术应用推广仍然滞后。建议发展智慧农业提高资源利用效率,加强基础设施建设缓解气候变化的影响,加快推进国际合作缓解粮食系统压力,推进高标准农田建设提高土地产出力,优化农技推广体系提高技术效率。

关键词：粮食安全粮食安全治理农业技术

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地块规模与化肥投入:减施逻辑及其证据

华中农业大学学报 2024年第3期43卷 27-38页

作者：吴刚钟钰中国农业科学院农业经济与发展研究所北京100081

本文基于诱致性技术变迁理论分析地块规模约束下的化肥减施逻辑,利用2020年中国乡村振兴综合调查(CRRS)7个省(自治区)的玉米种植户数据,运用两阶段最小二乘法(two-stage least squares regression,2SLS)分析地块规模对化肥投入的影响。... 详细信息

本文基于诱致性技术变迁理论分析地块规模约束下的化肥减施逻辑,利用2020年中国乡村振兴综合调查(CRRS)7个省(自治区)的玉米种植户数据,运用两阶段最小二乘法(two-stage least squares regression,2SLS)分析地块规模对化肥投入的影响。实证结果表明:扩大地块规模可以降低化肥投入强度,提高化肥投入效率。异质性分析发现,与小农户相比,规模农户扩大地块规模对化肥减施的影响更大;对于化肥投入强度越高、投入效率越低的农户,扩大地块规模对化肥投入的影响越大。进一步的分析发现,机械作业替代农业劳动,是扩大地块规模促进化肥减施的作用机制。

关键词：地块规模化肥投入化肥投入强度化肥投入效率机械作业

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耕地保护考核和粮食安全考核“合二为一”的基础与推进路径

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中州学刊 2024年第9期 47-54页

作者：刘慧钟钰中国农业科学院农业经济与发展研究所北京100081

为让耕地保护目标更好地服务于保障国家粮食安全总目标,我国开始推动耕地保护考核和粮食安全考核“合二为一”。从制度基础看,修订后的《省级政府耕地保护责任目标考核办法》和《粮食安全省长责任制考核办法》都经过多年应用实践,在奖... 详细信息

为让耕地保护目标更好地服务于保障国家粮食安全总目标,我国开始推动耕地保护考核和粮食安全考核“合二为一”。从制度基础看,修订后的《省级政府耕地保护责任目标考核办法》和《粮食安全省长责任制考核办法》都经过多年应用实践,在奖惩措施、结果运用等方面都具有较高的借鉴价值;从实践基础看,地方探索取得初步成效,典型省份的耕地面积、粮食播种面积都稳中有增。然而考核只是手段,耕地保护党政同责和粮食安全党政同责都实行不久。更好发挥这两项考核“合二为一”对确保各项政策措施落实见效的作用,还需要从根本上理顺关系、构建机制,为此,应着力从以下两方面推进:其一,推动形成党政齐抓共管的工作格局,重点是从讲政治的高度看待耕地保护和粮食安全问题,厘清党政权责界限,统筹协调各部门形成合力,充分发挥考核“指挥棒”作用和督察“利剑”作用;其二,构建以主产区为主、主销区和产销平衡区共同支撑的国家粮食安全保障格局,重点是主产区优先享有政策扶持和利益补偿,主销区对主产区承担横向利益补偿义务,加快产销平衡区经济发展。

关键词：党政同责考核耕地保护粮食安全

再论“藏粮于技”战略:内涵辨识、理论支撑与未来取向

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中国农业大学学报 2024年第3期29卷 311-322页

作者：高芸钟钰中国农业科学院农业经济与发展研究所北京100081

“两藏”战略是中国粮食安全的根本之策。为梳理“藏粮于技”概念缘起和内涵,以马克思主义科技观、技术创新与技术变迁理论、制度与技术的关系为理论基础,分析了“藏粮于技”战略的理论逻辑和内涵演变。结果表明:1)“藏粮于技”是中国... 详细信息

“两藏”战略是中国粮食安全的根本之策。为梳理“藏粮于技”概念缘起和内涵,以马克思主义科技观、技术创新与技术变迁理论、制度与技术的关系为理论基础,分析了“藏粮于技”战略的理论逻辑和内涵演变。结果表明:1)“藏粮于技”是中国共产党马克思主义科技观的重要实践,其制度创新与技术创新双向互促特色鲜明。2)“藏”的内涵包括市场和产量调控、完善粮食市场体系和价格形成机制,建立精准、科学合理的粮食调控体系,并解决粮食安全、生态安全、食品安全、农民增收等可持续问题。3)“技”的内容扩展为全要素、全产业链、多学科技术集成和应用,技术扩散呈现多主体交互、反馈,农业技术与数字技术融合发展。本研究从科技自强自立、摆脱路径依赖、内涵式发展道路和创新体系效能4个方面提出对策建议,为进一步明确“藏粮于技”战略未来取向和实现路径提供了决策参考。

关键词：粮食安全战略藏粮于技技术进步制度创新马克思主义科技观