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Spectroscopic study on the interaction between[Hg(SCN)_4]^(2-) and hemoglobin

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Chinese Chemical Letters 2012年第11期23卷 1283-1286页

作者： Lun Fu Tian zhong fang liu Ling Kong Xiao Li Hu Shao Pu liu Education Ministry Key Laboratory on Luminescence and Real-Time Analysis School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China Institute of Mechanical Manufacturing Technology Chinese Academy of Engineering PhysicsMianyang 621900China

The interaction between [Hg（SCN）4]^2- and hemoglobin （Hb） under conditions that simulate a physiological environment was investigated by UV-vis spectroscopy, fluorescence spectroscopy, resonance Rayleigh scattering （RRS） spectroscopy and circular dichroism （CD） spectroscopy. The results obtained from the change of UV-vis and CD spectra, the quenching of Hb fluorescence and the enhancement of RRS intensity proved that a 10：1 type complex was formed between [Hg（SCN）4]^2- and Hb. The possible mechanism suggested for the interaction was that ten Hg（SCN）4]^2- anions entered the four subunits of a Hb molecule to react with some residues to form an adduct by coordination and electrostatic forces. The coordination of [Hg（SCN）4]^2- with Trp was the major cause of the fluorescence quenching of Hb.

关键词： [Hg(SCN)4]^2- Hemoglobin Toxicological evaluation Molecular spectroscopy

Determination of Potassium Ferrocyanide in Foods by Resonance Rayleigh Scattering Method with Basic Triaminotriphenylmethane Dyes

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Chinese Chemical Letters 2006年第12期17卷 1595-1598页

作者： Yong Li LI zhong fang liu Li Sha XIE Ling KONG Shao Pu liu School of Chemistry and Chemical Engineering Southwest University Chongqing 400715 Sichuan Entry-Exit Inspection and Quarantine Chengdu 610041

In this work, a sensitive, rapid and simple method for the determination of trace amounts of potassium ferrocyanide in salinized foods and table salt using EV as a RRS probe is established. The detection limit （3σ） of the EV system is 7.8 ng/mL. This new method is more suitable for the determination of the trace amounts of potassium ferrocyanide in colour salinized foods and it can not be disturbed by the color of salinized foods.

关键词： Resonance Rayleigh scattering basic triaminotdphenylmethane dyes potassiumferrocyanide.

Techniques of copper recovery from Mexican copper oxide ore

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Mining Science and Technology 2009年第1期19卷 45-48页

作者： CAO Zhan-fang zhong Hong liu Guang-yi ZHAO Shu-juan Institute of Chemistry and Chemical Engineering Central South University Changsha Hunan 410083 China

Mexican copper ore is a mixed ore containing mainly copper oxide and some copper sulfide that responds well to flotation. The joint techniques of flotation and leaching were studied. The results indicate that an ore containing 19.01% copper could be obtained at a recovery ratio of 35.02% by using sodium sulfide and butyl xanthate flotation. Over 83.33% of the copper oxide can be recovered from the railings by leaching in suitable conditions, such as 1 h stirring at a temperature around 25 ℃with a mixing speed of S00 r/min, an H2SO4 concentration of 1.0 mol/L and a mass ratio of the ore-slurry-liquid to solid （mL/ms） of 3. The overall yield of refined ore after flotation and leaching is over 89.18% of the copper, which is much better than sole flotation or leaching. A copper product containing more than 99.9% copper was obtained by using the process： flotation-agitation leaching- solvent extraction-electro-winning.

关键词： copper oxide ore flotation stirring leaching extraction

Poly(meta-phenylene) Derivative with Rigid Twisted Biphenyl Units in Backbone:Synthesis,Structural Characterization,Photophysical Properties and Electroluminescence

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Chemical Research in Chinese Universities 2007年第6期23卷 720-725页

作者： ZHENG Yan YANG Bing ZHANG Hai-quan LU Ping SHEN fang-zhong liu Lin-lin XU Hai YANG Guang-di MA Yu-guang Key Lab for Supramolecular Structure and Materials of Ministry of Education Jilin University Changchun 130012 P. R. China

A soluble poly（meta-phenylene） derivative with rigid twisted biphenyl unit was synthesized by the Yamamoto coupling reaction. The polymer is soluble in common organic solvents, and the number-average molecular weight is about 6500. The UV-Vis and quantum chemical calculation indicate that the different conformation segments named ＂conformers＂ exist in the polymer backbones; it was also further confirmed by the single crystal X-ray diffraction study of the dimeric model compound. The π-π^＊ transition of biphenyl segments of twisted and planar conformations made the polymer exhibit a strong absorption around 256 nm and a weak absorption at about 300 nm. Furthermore, the polymer exhibits a strong UV photoluminescence at 372 nm when the excitation wavelengths are longer than 300 run. The ultraviolet-emitting electroluminescence（EL） device with the single layer structure shows EL λmax of the derivative at 370 nm.

关键词： Poly(phenylene) Conformation UV light-emitting

钯(Ⅱ)与阿莫西林和氨苄西林相互作用的共振瑞利散射光谱及其分析应用

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化学学报 2008年第8期66卷 969-974页

作者：段慧刘忠芳刘绍璞西南大学化学化工学院重庆400715

在酸性介质中加热,使阿莫西林(AMO)和氨苄西林(AMP)等侧链含苄氨基的青霉素类抗生素发生降解,其降解产物青霉胺和苄氨基青霉醛在pH5左右的弱酸性介质中能进一步与钯(Ⅱ)反应形成物质的量比为1∶1∶1的混配型三元配合物,此时将引起共振... 详细信息

在酸性介质中加热,使阿莫西林(AMO)和氨苄西林(AMP)等侧链含苄氨基的青霉素类抗生素发生降解,其降解产物青霉胺和苄氨基青霉醛在pH5左右的弱酸性介质中能进一步与钯(Ⅱ)反应形成物质的量比为1∶1∶1的混配型三元配合物,此时将引起共振瑞利散射(RRS)的显著增强,并出现新的RRS光谱.钯(Ⅱ)与两种药物的反应产物具有相似的RRS光谱特征,最大散射波长均位于370nm.在一定范围内散射增强(△I)与药物的浓度成正比.该方法具有较高的灵敏度,对于AMO和AMP的检出限(3δ)分别为18.0和15.4ng·mL-1.此时侧链不含苄氨基的其他青霉素不产生类似反应,并且也允许一定量的其它物质存在,因此,方法有较好的选择性,可用于胶囊、片剂及血清、尿样中阿莫西林和氨苄西林的测定,能获得较满意的结果.

关键词：氨苄西林阿莫西林共振瑞利散射钯(Ⅱ)

A NEW BIFUNCTIONAL CHELATING AGENT α,ε-N,N'-BIS(L-CYSTEINYL)-L-LYSINE FOR RADIOLABELLING OF MONOCLONAL ANTIBODIES WITH TECHNETIUM-99M

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Chinese Chemical Letters 1991年第4期2卷 285-288页

作者： Bi zhong LI Yuan fang liu Yong Hui WU Department of Technical PhysicsYun Hua YE Department of Chemistry,Peking University,Beijing 100871

α,ε-N,N'-bis(L-cysteinyl)-L-lysine was synthesized and char- acterized for the first *** was then employed as a bifunctional chelating agent to chelate technetium-99m and subsequently conjugated to fragment F(ab')_2... 详细信息

关键词： A NEW BIFUNCTIONAL CHELATING AGENT L-CYSTEINYL L-LYSINE FOR RADIOLABELLING OF MONOCLONAL ANTIBODIES WITH TECHNETIUM-99M N,N BIS

为人民、与人民、由人民的设计:社会创新设计的路径、挑战与机遇

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装饰 2018年第5期 40-45页

作者：钟芳刘新清华大学美术学院协同创新生态设计中心

社会创新设计在当下的学术界有多种诠释方式。本文认为,从设计与人民大众的不同关系的角度包括为人民的设计,即对设计服务对象的放大;包括设计方法的创新,在与公众利益息息相关的产品及服务的设计过程中,采用参与式设计和协同设计的方法... 详细信息

社会创新设计在当下的学术界有多种诠释方式。本文认为,从设计与人民大众的不同关系的角度包括为人民的设计,即对设计服务对象的放大;包括设计方法的创新,在与公众利益息息相关的产品及服务的设计过程中,采用参与式设计和协同设计的方法,以最终达到最大的社会效益;社会创新设计还包括全新的设计理念,即由服务的使用者完全主导设计并实施,专业设计师以协作者的身份参与其中。无论从哪个角度理解社会创新设计,对当下的设计专业都带来了巨大的挑战与机遇。

关键词：社会创新设计参与式设计协同设计公共服务设计

长流程生产过程多重大时滞系统时间协调参数自调整控制策略

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中南大学学报（自然科学版） 2011年第9期42卷 2698-2703页

作者：喻寿益钟柳芳桂卫华谢永芳中南大学信息科学与工程学院湖南长沙410083

针对长流程生产过程多重大时滞系统难以闭环稳定控制的问题,说明多重大时滞系统形成的物理本质,分析系统的组成结构,引入脉冲响应等效系统的概念,提出多重时间协调参数自调整控制算法(M-TCPA)。该算法根据不同的时滞特性,通过时间协调... 详细信息

针对长流程生产过程多重大时滞系统难以闭环稳定控制的问题,说明多重大时滞系统形成的物理本质,分析系统的组成结构,引入脉冲响应等效系统的概念,提出多重时间协调参数自调整控制算法(M-TCPA)。该算法根据不同的时滞特性,通过时间协调原则修改n个控制器的输出。利用n个脉冲响应等效系统分别修改n个控制器的参数,使n个脉冲响应等效系统和多重大时滞系统匹配,跟踪被控制对象参数变化,保证系统控制精度和稳定性。研究结果表明:该控制算法是递推算法,计算量小,便于在线实现。将该控制策略应用于氧化铝生产连续碳酸化分解过程,氧化铝合格率提高了1.5%。

关键词：大时滞系统脉冲响应时间协调参数调整

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui liu Chao fang Qiuxia Peng Wen Qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway