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Histopathological diagnosis of microvascular invasion in hepatocellular carcinoma:Is it reliable?

World Journal of Gastroenterology 2025年第5期31卷 105-116页

作者： Liu-Jun Li Chao-Qun Wu Fei-Le Ye Zhou Xuan Xiao-Li Zhang Jian-Ping Li Jia Zhou zhong-Zhen Su Department of Ultrasound The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina Department of Ultrasound The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Department of Pathology The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Department of Pathology The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina

BACKGROUND Microvascular invasion(MVI)is a critical prognostic factor for postoperative hepatocellular carcinoma recurrence,but the reliability of its current pathological diagnosis remains *** To evaluate the accuracy of current 7-point sampling methods and propose an optimal pathological protocol using whole-mount slide imaging(WSI)for better MVI *** We utilized 40 New Zealand white rabbits to establish VX2 liver tumor *** entire tumor-containing liver lobe was subsequently obtained,following which five different sampling protocols(A-E)were employed to evaluate the detection rate,accuracy,quantity,and distribution of MVI,with the aim of identifying the optimal sampling *** VX2 liver tumor models were successfully established in 37 rabbits,with an incidence of MVI of 81.1%(30/37).The detection rates[27%(10/37),43%(16/37),62%(23/37),68%(25/37),and 93%(14/15)]and quantity(15,36,107,125,and 395)of MVI increased significantly from protocols A to *** distribution of MVI showed fewer MVIs farther away from the tumor,but the percentage of MVI detected quantity gradually increased from 6.7%to 48.3%in the distant nonneoplastic liver tissue from protocols A to *** C was identified as the optimal sampling method by comparing them in *** sampling protocol of three consecutive interval WSIs at the tumor center(WSI3)was further screened to determine the optimal number of *** A(7-point sampling method)exhibited only 46%accuracy and a high false-negative rate of 67%.Notably,the WSI3 protocol improved the accuracy to 78%and decreased the false-negative rate to 27%.CONCLUSION The current 7-point sampling method has a high false-negative rate in MVI *** contrast,the WSI3 protocol provides a practical and effective approach to improve MVI diagnostic accuracy,which is crucial for hepatocellular carcinoma diagnosis and treatment planning.

关键词： Hepatocellular carcinoma Microvascular invasion Histopathological diagnosis Whole-mount slide imaging Sampling protocol

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Metastasizing to the colon from triple-negative breast cancer:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 443-455页

作者： Ben-Quan Wang Xing-Gui Fang Ben-Hong Xiang Xiao-Jiao Wang Ming Cao Cheng-Le Zhuang zhong-Chen Liu Zheng Wang Department of Gastrointestinal Surgery The First People’s Hospital of WuhuWuhu 241000Anhui ProvinceChina Department of Breast Surgery The First People’s Hospital of WuhuWuhu 241000Anhui ProvinceChina Department of Pathology The First People’s Hospital of WuhuWuhu 241000Anhui ProvinceChina Department of Gastrointestinal Surgery Colorectal Cancer CenterShanghai Tenth People’s Hospital Affiliated to Tongji UniversityShanghai 200000China

BACKGROUND Breast cancer(BC)metastasis to the gastrointestinal tract is uncommon,colonic metastasis from BC(CMBC)is even *** SUMMARY This report describes a 44-year-old female patient with metastatic triple-negative BC in the ascending colon who underwent laparoscopic radical right *** patient had undergone left modified radical mastectomy only 15 months ago and stopped chemotherapy just 3 months *** diagnosis of CMBC was made based on the previous history of BC and positive results of several specific immunohistochemical markers(gross cystic disease fluid protein 15,mammaglobin,GATA-binding protein 3,and cytokeratin 7)for breast *** CMBC should be highly cautious in patients with a previous history of BC,especially triple-negative BC,and further examination to aid in diagnosis.

关键词： Breast cancer Colon metastasis Colonoscopy Pathology Surgery Review Case report

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Over 200 times current enhancement via buckling triboelectric nanogenerator at ultra-low speed for monitoring the swelling of lithium ion batteries

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Science Bulletin 2025年第2期70卷 148-152页

作者： Maoyi Zhang Chaosheng Hu Tongtong Zhang Chris R.Bowen Rui Li YongAn Huang Yewang Su zhong Lin Wang Ya Yang Beijing Key Laboratory of Micro-Nano Energy and Sensor Center for High-Entropy Energy and SystemsBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 101400China State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China Department of Mechanical Engineering University of BathBath BA27AKUK State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of TechnologyDalian 116024China State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China School of Material Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332-0245USA

Sensors deployed within the Internet of Things(Io T)require a stable and continuous electrical energy supply[1].The traditional approach to provide an energy supply relies primarily on battery power,which has specific shortcomings;these include integration difficulties,the need for frequent charging or replacement,and environmental pollution associated with battery production and *** solve the challenge of delivering an energy supply to sensors,researchers have designed self-powered sensors or have produced power for sensors by scavenging mechanical energy from the surrounding *** generators[2],piezoelectric generators[3]and triboelectric nanogenerators(TENGs)[4,5]are common approaches to scavenge mechanical *** have been widely used in the development of self-powered sensors and the supply of electrical energy to sensors due to their high performance,low cost,and wide range of potential materials[6].

关键词： battery buckling swelling

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Palmitoylation-mediated NLRP3 inflammasome activation in teleosts highlights evolutionary divergence in immune regulation

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Zoological Research 2025年第01期 3-14页

作者： Li Nie Xiang-Yu Wu Zi-Yue Zhao Chen-Jie Fei Ting-Fang Zhu Jian-zhong Shao Jiong Chen State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products School of Marine SciencesNingbo University Laboratory of Biochemistry and Molecular Biology School of Marine Sciences Ningbo University Key Laboratory of Aquaculture Biotechnology of Ministry of Education Ningbo University College of Life Sciences Key Laboratory for Cell and Gene Engineering of Zhejiang Province Zhejiang University

NLRP3 inflammasome activation is pivotal for cytokine secretion and pyroptosis in response to diverse stimuli,playing a crucial role in innate immunity. While extensively studied in mammals, the regulatory mechanisms governing NLRP3 activation in non-mammalian vertebrates remain largely unexplored. Teleosts, as basal vertebrates,represent an ideal model for exploring the evolutionary trajectory of inflammasome regulation. In this study, ABE assays, confocal microscopy, and biochemical analyses were applied to systematically characterize the mechanisms underlying NLRP3 inflammasome in teleosts,using large yellow croakers(Larimichthys crocea, Lc) and zebrafish(Danio rerio, Dr) as representative models. Our findingsrevealedapreviouslyunrecognized palmitoylation-dependent regulatory mechanism essential for teleost NLRP3 activation. Specifically, zDHHC18-mediated palmitoylation at a teleost-specific cysteine residue(C946 in Lc NLRP3, C1037 in Dr NLRP3) was required for the translocation of NLRP3 to the dispersed trans-Golgi network, facilitating its subsequent recruitment to the microtubule-organizing center. This membrane trafficking was crucial for inflammasome assembly and downstream inflammatory responses. These findings provide new insights into the distinct regulatory mechanisms of NLRP3 activation in teleosts, highlighting an evolutionary divergence that contributes to innate immunity adaptation in early vertebrates.

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Effect of SPTLC1 on type 2 diabetes mellitus

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World Journal of Diabetes 2025年第2期16卷 151-162页

作者： Bo Yi Yan Bao zhong-Yuan Wen Department of Endocrinology Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

BACKGROUND Although numerous single nucleotide polymorphism in multiple genes involve in the risk of type 2 diabetes mellitus(T2D),the single gene defects of T2D with strong family history is not clear ***1 are causative for hereditary sensory and autonomic neuropathy,which is clinical overlapping with diabetic peripheral *** with adipocyte-specific deletion of SPTLC1 had impaired glucose tolerances and insulin ***,it is necessary to investigate the SPTLC1 mutations in adult-onset T2D with strong family *** To analyze the role of SPTLC1 mutation on adult-onset T2D with strong family *** By whole-exome sequence analysis of a patient with T2D and his family members,an uncertain variant in SPTLC1 was *** analysis was used to evaluate the influence of mutation,rare variant gene-level associations for SPTLC1 in T2D,and the relationship between SPTLC1 mRNA and T2D in human islets from *** effect of G371R of SPTLC1 on the characteristics of inflammatory cytokines and apoptosis was also tested on human embryonic kidney(HEK)293 *** A single nucleotide variation in SPTLC1(c.1111G>A:p.G371R)was identified in a family with *** deleterious variant was predicted by functional analysis through hidden Markov models and mendelian clinically applicable pathogenicity *** pathogenicity might be derived from the different amino acid *** HEK 293T cells,p.G371R of SPTLC1 induced the expression of tumor necrosis factor-αand the percent of ***,rare variant gene-level associations for SPTLC1 also refer to the high risk of T2D(the overall odds ratio=2.4968,P=0.0164).Data from GSE25724 showed that SPTLC1 mRNA was lower in pancreatic islets from T2D human islets(P=0.046),and was as sociated with the decreased level of insulin mRNA expression(Spearman r=0.615,P=0.025).CONCLUSION The study classified SPTLC1 p.G371R mutation as the likely pathogenic mutation from an a

关键词： Apoptosis Diabetic peripheral neuropathy Gene mutation Inflammation SPTLC1 Type 2 diabetes mellitus

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《桃花源记》文本生成问题再探

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文学遗产 2025年第1期 55-67页

作者：钟书林上海师范大学人文学院

陈寅恪先生曾指出“陶渊明《拟古》诗之第二首可与《桃花源记》互相引证发明”,以陈先生之说为先导,再论《桃花源记》文本之生成,可以引发新的思考。陶渊明《拟古》诗咏田畴,寄寓深意。田畴、陶渊明身处汉魏、晋宋易代之际,有诸多相契合... 详细信息

陈寅恪先生曾指出“陶渊明《拟古》诗之第二首可与《桃花源记》互相引证发明”,以陈先生之说为先导,再论《桃花源记》文本之生成,可以引发新的思考。陶渊明《拟古》诗咏田畴,寄寓深意。田畴、陶渊明身处汉魏、晋宋易代之际,有诸多相契合处,故能深感共鸣。这是其创作《桃花源记》的初衷和素材来源。作为文学作品,它来源于生活而又高于生活,透过其文本的层级演进,其中既有箕子、田畴等生活原型,又有对《近游赋》等文本的借鉴,更有作者归园田居的躬耕实践和文学驰骋、理想寄托等合力。同时,《桃花源记》是体现陈寅恪新自然说的重要篇章,而其中远离尘嚣,崇尚淳真的观念,亦是陶渊明新自然观的重要特征,真正的桃源之境,即淳真之境。

关键词：陶渊明田畴箕子《桃花源记》文本生成

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数字化技术在重度牙周炎治疗中的应用

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国际口腔医学杂志 2025年第1期52卷 1-10页

作者：钟良军杭州师范大学附属医院口腔医学中心、杭州市牙周病诊疗中心杭州310000

重度牙周炎损害牙齿支持组织的健康并影响咀嚼功能,甚至导致牙列缺损或缺失。在重度牙周炎的诊疗中,数字化技术的应用可以提高诊疗的精准性和高效性,为患者提供了更优的治疗效果和诊疗体验。目前口腔临床常用的数字化技术手段和器械包... 详细信息

重度牙周炎损害牙齿支持组织的健康并影响咀嚼功能,甚至导致牙列缺损或缺失。在重度牙周炎的诊疗中,数字化技术的应用可以提高诊疗的精准性和高效性,为患者提供了更优的治疗效果和诊疗体验。目前口腔临床常用的数字化技术手段和器械包括数字化牙周电子探针、牙周内镜、数字化口腔扫描和3D打印、数字化电子咬合记录仪、电子面弓等。本文就上述几种数字化技术在重度牙周炎诊疗中,从临床检查、诊断、治疗规划到治疗实施等各个环节的应用进行阐述。

关键词：数字化技术重度牙周炎牙周治疗

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中国特色应急管理理论研究的基本图谱

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中国社会科学 2025年第1期 47-67+205页

作者：钟开斌薛澜中共中央党校(国家行政学院)应急管理研究院清华大学公共管理学院

伴随实践发展和理论研究推进，应急管理已经成为中国公共管理研究的重点领域。中国现有的应急管理研究还比较零散，尚未形成清晰完整的总体图景，不利于理论研究的持续深入和学科的稳定发展。以“事件特征—管理体系—时空环境”的综合... 详细信息

伴随实践发展和理论研究推进，应急管理已经成为中国公共管理研究的重点领域。中国现有的应急管理研究还比较零散，尚未形成清晰完整的总体图景，不利于理论研究的持续深入和学科的稳定发展。以“事件特征—管理体系—时空环境”的综合分析框架，从突发事件的发生规律和演化特征、应对突发事件的管理体系以及突发事件应对活动所处的时空环境三个层次，可以勾勒中国特色应急管理理论研究的基本图谱，探寻未来中国特色应急管理理论研究的重点领域和优先发展主题。中国特色应急管理理论研究主要包括基于中国情境的突发事件演化机理、基于党政统领的应急管理体制、基于全生命周期的应急管理过程、基于刚柔相济的应急管理制度、基于优势互补的应急管理工具、基于宏观影响的应急管理环境共6个重点领域、21个优先发展主题。

关键词：应急管理研究图谱知识体系学科建设中国情境

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AIGC背景下信息网络过失犯罪情报发现及自动化提示问题研究

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情报杂志 2025年第3期44卷 81-89页

作者：钟晨赵爽上海交通大学上海200030 中国人民公安大学北京100091

[研究目的]AIGC背景下的信息网络过失犯罪活动层出不穷,有必要对这一专门现象进行情报发现及自动化提示问题研究,从而为AIGC平稳发展、信息网络正确利用和犯罪预防问题解决提供参照。[研究方法]在梳理前人研究成果基础上确定研究方法设... 详细信息

[研究目的]AIGC背景下的信息网络过失犯罪活动层出不穷,有必要对这一专门现象进行情报发现及自动化提示问题研究,从而为AIGC平稳发展、信息网络正确利用和犯罪预防问题解决提供参照。[研究方法]在梳理前人研究成果基础上确定研究方法设计目标和基本思路,开展面向过失犯罪活动的情报发现和面向涉罪用户的自动化提示流程设计,同时将其整合为一个完整的方法运行机制。[研究结果/结论]以抖音“游戏账号找回制裁”现象作为案例进行方法应用实证,结果表明能够对AIGC背景特征、过失犯罪活动特点、类型、异常行为、重点用户及自动化提示进行结果概括,方法性能良好、符合既定预期目标。

关键词： AIGC 信息网络过失犯罪情报发现自动提示刑事诉讼

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“大、小、重、慢”疾病定义与全科医生“4善”定位的探讨

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中国全科医学 2025年第1期28卷 125-128页

作者：李敏王仲清华大学附属北京清华长庚医院临床医学院全科医学系北京市102218 北京清华长庚医院全科与健康医学部北京市102218

随着我国医药卫生体制的深度改革,特别是分级诊疗制度的推进,全科医生在基层医疗保健体系中的角色日益重要。全科医生不仅是居民健康的第一道防线,更是常见疾病预防、诊断、治疗及健康教育的关键执行者。国家对全科医生提出了“小病善... 详细信息

随着我国医药卫生体制的深度改革,特别是分级诊疗制度的推进,全科医生在基层医疗保健体系中的角色日益重要。全科医生不仅是居民健康的第一道防线,更是常见疾病预防、诊断、治疗及健康教育的关键执行者。国家对全科医生提出了“小病善治、大病善识、重病善转、慢病善管”的临床定位。本文通过问答形式,分析“小、大、重、慢”疾病的分类与全科医生的“4善”定位,探讨全科医生在新医改时代下的重要职能及挑战。访谈者认为虽然分级诊疗制度旨在优化医疗资源配置,但在实践中仍面临“大、小、重、慢”疾病分类的模糊性和基层医疗资源的不均衡分配等问题。全科医生在这个体系中扮演着至关重要的角色,其需要具备综合的临床诊疗能力,并与专科医生共同制定临床判断标准和诊疗标准。为了应对这些挑战并充分发挥全科医生在现代医疗体系中的作用,迫切需要对全科医学教育和实践进行进一步改革与优化,同时强化全科医生的角色定位,以确保在提升医疗服务质量和效率的同时,实现公平和可持续的健康保障体系。

关键词：全科医学全科医生分级诊疗医疗体系改革疾病分类医疗资源优化

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