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Intelligent identification of two-dimensional nanostructures by machine-learning optical microscopy

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Nano Research 2018年第12期11卷 6316-6324页

作者： Xiaoyang Lin zhizhong si Wenzhi Fu Jianlei Yang side Guo Yuan Cao Jin Zhang Xinhe Wang Peng Liu Kaili Jiang Weisheng Zhao Fert Beijing Research Institute School ofMicroelectronics & Beijing Advanced Innovation Center for Big Data and Brain Computing (BDBC)Beihang UniversityBeijing 100191China Beihang-GoertekJoint Microelectronics Institute Qingdao Research InstituteBeihang UniversityQingdao 266000China Fert Beijing Research Institute School of Computer Science and Engineering & Beijing Advanced Innovation Center for Big Data and Brain Computing (BDBC)Beihang UniversityBeijing 100191China State Key Laboratory of Low-Dimensional Quantum Physics Department of Physics & Tsinghua-Foxconn Nanotechnology Research CenterCollaborative Innovation Center of Quantum MatterTsinghua UniversityBeijing 100084China

Two-dimensional (2D) materials and their heterostructures, with wafer-scale synthesis methods and fascinating properties, have attracted significant interest and triggered revolutions in corresponding device applications. However, facile methods to realize accurate, intelligent, and large-area characterizations of these 2D nanostructures are still highly desired. Herein, we report the successful application of machine-learning strategy in the optical identification of 2D nanostructures. The machine-learning optical identification (MOI) method endows optical microscopy with intelligent insight into the characteristic color information of 2D nanostructures in the optical photograph. The experimental results indicate that the MOI method enables accurate, intelligent, and large-area characterizations of graphene, molybdenum disulfide, and their heterostructures, including identifications of the thickness, existence of impurities, and even stacking order. With the convergence of artificial intelligence and nanoscience, this intelligent identification method can certainly promote fundamental research and wafer-scale device applications of 2D nanostructures.

关键词： machine-learning optical identification two-dimensional (2D) material heterostructure artificial intelligence

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion injury.Autophagy occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains unclear.In this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion injury.We found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced autophagy.Furthermore,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating autophagy.Blocking autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion injury.Findings from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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几何结构对Fe薄膜反常能斯特效应的影响

西南科技大学学报 2024年第1期39卷 38-43页

作者：张志忠张小伟西南科技大学环境友好能源材料国家重点实验室四川绵阳621010

反常能斯特效应(Anomalous Nernst effect,ANE)是一种利用磁性材料进行热电转换的效应。利用磁控溅射方法在si基底上沉积生长Fe薄膜,探究了薄膜的厚度及几何尺寸对反常能斯特效应的影响。结果表明:Fe薄膜的厚度越小,ANE越明显,当薄膜厚... 详细信息

反常能斯特效应(Anomalous Nernst effect,ANE)是一种利用磁性材料进行热电转换的效应。利用磁控溅射方法在si基底上沉积生长Fe薄膜,探究了薄膜的厚度及几何尺寸对反常能斯特效应的影响。结果表明:Fe薄膜的厚度越小,ANE越明显,当薄膜厚度增加到50 nm以上时,ANE趋于不变,这与Fe薄膜电阻率随厚度的变化规律一致;在温差一定时,反常能斯特电压和Fe薄膜的宽长比成正比,即薄膜越宽电压信号越强,但在单位宽度下薄膜产生的反常能斯特电压维持不变,说明薄膜的几何尺寸对ANE有较大的影响。研究结果对反常能斯特效应相关器件设计具有指导意义。

关键词：反常能斯特效应热电效应磁控溅射 Fe薄膜

Genome-wide distribution and functions of the AAE complex in epigenetic regulation in Arabidopsis

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Journal of Integrative Plant Biology 2021年第4期63卷 707-722页

作者： Yi-Zhe Zhang Juncheng Lin zhizhong Ren Chun-Xiang Chen Daisuke Miki si-si Xie Jian Zhang Ya-Nan Chang Jing Jiang Jun Yan Qingshun Q.Li Jian-Kang Zhu Cheng-Guo Duan Shanghai Center for Plant Stress Biology and CAS Center of Excellence for Molecular Plant Sciences Chinese Academy of SciencesShanghai 201602China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems College of the Environment and EcologyXiamen UniversityXiamen 361102China State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifeng 475004China School of Life Sciences East China Normal UniversityShanghai 200241China Graduate College of Biomedical Sciences Western University of Health SciencesPomona 91766USA Department of Horticulture and Landscape Architecture Purdue UniversityWest Lafayette 47907USA

Heterochromatin is widespread in eukaryotic genomes and has diverse impacts depending on its genomic context.Previous studies have shown that a protein complex,the Asi1-AIPP1-EDM2(AAE)complex,participates in polyadenylation regulation of several intronic heterochromatin-containing genes.However,the genome-wide functions of AAE are still unknown.Here,we show that the Asi1 and EDM2 mostly target the common genomic regions on a genome-wide level and preferentially interacts with genetic heterochromatin.Polyadenylation(poly(A)sequencing reveals that AAE complex has a substantial influence on poly(A)site usage of heterochromatin-containing genes,includingnotonlyintronicheterochromatincontaining genes but also the genes showing overlap with heterochromatin.Intriguingly,AAE is also involved in the alternative splicing regulation of a number of heterochromatin-overlapping genes,such as the disease resistance gene RPP4.We provided evidence that genic heterochromatin is indispensable for the recruitment of AAE in polyadenylation and splicing regulation.In addition to conferring RNA processing regulation at genic heterochromatin-containing genes,AAE also targets some transposable elements(TEs)outside of genes(including TEs sandwiched by genes and island TEs)for epigenetic silencing.Our results reveal new functions of AAE in RNA processing and epigenetic silencing,and thus representimportantadvancesinepigenetic regulation.

关键词： alternative polyadenylation alternative splicing epigenetic regulation heterochromatin transcription

Corrected explicit-implicit domain decomposition algorithms for two-dimensional semilinear parabolic equations

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Science China Mathematics 2009年第11期52卷 2362-2388页

作者： LIAO HongLin SHI HanSheng SUN zhizhong Department of Mathematics Southeast UniversityNanjing 210096China Department of Applied Mathematics and Physics Institute of SciencesPLAUSTNanjing 211101China

Corrected explicit-implicit domain decomposition(CEIDD) algorithms are studied for parallel approximation of semilinear parabolic problems on distributed memory processors. It is natural to divide the spatial domain into some smaller parallel strips and cells using the simplest straightline interface(si) . By using the Leray-Schauder fixed-point theorem and the discrete energy method,it is shown that the resulting CEIDD-si algorithm is uniquely solvable,unconditionally stable and convergent. The CEIDD-si method always suffers from the globalization of data communication when interior boundaries cross into each other inside the domain. To overcome this disadvantage,a composite interface(CI) that consists of straight segments and zigzag fractions is suggested. The corresponding CEIDD-CI algorithm is proven to be solvable,stable and convergent. Numerical experiments are presented to support the theoretical results.

关键词： semilinear parabolic equation explicit-implicit domain decomposition method LeraySchauder fixed-point theorem discrete energy method convergence and stability

Mixed ion-electron conducting Li_(3)P for efficient cathode prelithiation of all-solid-state Li-ion batteries

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SmartMat 2023年第5期4卷 119-130页

作者： Jing Li Dan Liu Han Sun Deyu Qu zhizhong Xie Haolin Tang Jinping Liu Department of Chemistry School of ChemistryChemical Engineering and Life ScienceWuhan University of TechnologyWuhanChina Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory FoshanChina State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhanChina

All-solid-state batteries(ASSBs)using sulfide electrolytes hold promise for next-generation battery technology.Although using a pure Li metal anode is believed to maximize battery energy density,numerous recent studies have implicated that Li-ion anodes(e.g.,graphite and si)are more realistic candidates due to their interfacial compatibility with sulfide electrolytes.However,those Li-ion ASSBs suffer from an issue similar to liquid Li-ion batteries,which is a loss of active Li inventory owing to interfacial side reactions between electrode components,resulting in reduced available capacities and shortened cycle life.Herein,for the first time,we explore the potential of Li_(3)P for cathode prelithiation of Li-ion ASSBs.We identify that the crystallized Li_(3)P(c-Li_(3)P)has room-temperature ionic and electronic conductivities of both over 1o-4 s/cm.Such a mixed ion-electron conduct-ing feature ensures that the neat c-LisP affords a high Li+-releasing capacity of 983 mAh/g in ASSBs during the first charging.Moreover,the electro-chemical delithiation of c-LisP takes place below 2 V versus Li+/Li,while its lithiation dominates below 1 V versus Lit/Li.Once used as a cathode prelithiation regent for ASSBs,c-Li_(3)P only functions as a Li+donor without lithiation activity and can adequately compensate for the Li loss with minimal dosage added.Besides mitigating first-cycle Li loss,c-LisP prelithiation can also improve the battery cyclability by sustained release of low-dosage Li+ions in subsequent cycles,which have been embodied in several full ASSBs by coupling a LiCoO2 cathode with various types of anodes(including graphite,in foil,Sb,and si anode).Our work provides a universal cathode prelithiation strategy for high-efficiency Li-ion AsSBs.

关键词： all-solid-state batteries cathode prelithiation Li_(3)P lithium-ion batteries mixed ion-electron conductor

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基于信息融合的钢包精炼炉元素收得率预报

仪器仪表学报 2012年第4期33卷 795-800页

作者：徐喆毛志忠东北大学信息科学与工程学院沈阳110819 东北大学流程工业综合自动化国家重点实验室沈阳110819

为提高元素收得率的预报精度,针对元素收得率主要影响因素无法及时获得的问题,提出一种基于信息融合的预报方法。该方法对原始数据层与特征层分别进行融合操作。在原始数据层,首先将相关性较为明显的可测变量按照机理进行结合,然后使用... 详细信息

为提高元素收得率的预报精度,针对元素收得率主要影响因素无法及时获得的问题,提出一种基于信息融合的预报方法。该方法对原始数据层与特征层分别进行融合操作。在原始数据层,首先将相关性较为明显的可测变量按照机理进行结合,然后使用基于改进遗传算法的特征构建方法对由可测变量与结合变量组成的变量集合进行融合,使融合后的特征作为元素收得率主要影响因素的评价指标。在特征层,使用自适应神经-模糊推理系统对构建后的特征进行融合,从而得到元素收得率预报模型。将此方法应用于Q345B钢种si、Mn元素收得率的预报,实验结果表明所提出的方法不仅可以满足生产要求,而且比其他预报方法有更高的预报精度。

关键词：信息融合钢包精炼炉元素收得率遗传算法自适应神经-模糊推理系统

大健康人文视角下癌症丧亲者哀伤辅导的本土实践

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护理研究 2023年第9期37卷 1505-1511页

作者：姚尚满赵杜灵司嘉欣崔瑜王志中段志光山西医科大学人文社会科学学院山西030001 中共山西省委党校(山西行政学院) 山西医科大学健康人文研究中心

目的:基于中国香港李嘉诚基金会宁养(临终关怀)项目的实践,反思国内外哀伤辅导经验,引入更具本土化特征的大健康人文视角,希望通过专业社会工作者理念的注入,对哀伤辅导的本土化经验进行探索。方法:对现有的国内外哀伤辅导实践进行解读... 详细信息

目的:基于中国香港李嘉诚基金会宁养(临终关怀)项目的实践,反思国内外哀伤辅导经验,引入更具本土化特征的大健康人文视角,希望通过专业社会工作者理念的注入,对哀伤辅导的本土化经验进行探索。方法:对现有的国内外哀伤辅导实践进行解读,通过山西医科大学宁养(临终关怀)项目在山西省某肿瘤医院宁养院的具体实践,以哀伤事件时间轴为主线,提出切入哀伤辅导的4个阶段,深入剖析丧亲者各阶段的心理反应和可提供的辅导策略。结果:以利他主义为核心原则的社会工作与强调“全人观”的大健康人文理念具有内在相通之处,为当前探索癌症丧亲者哀伤辅导建构了有效的介入视角与实践模式。结论:融入大健康人文理念的哀伤辅导,能够更贴近中国文化体系,更能聚焦服务对象的心理与行为逻辑,是具有中国本土特色的丧亲者社会支持模式。

关键词：大健康人文社会工作哀伤辅导安宁疗护

Phase reaction of Au/Sn solder bonding for GaN-based vertical structure light emitting diodes

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Science China(Technological Sciences) 2010年第2期53卷 301-305页

作者： TIAN PengFei, SUN YongJian, CHEN zhizhong, QI ShengLi, DENG JunJing, YU TongJun, QIN ZhiXin & ZHANG GuoYi State Key Laboratory for Artificial Microstructure and Mesoscopic Physics, School of Physics, Peking University, Beijing 100871, China State Key Laboratory for Artificial Microstructure and Mesoscopic Physics School of Physics Peking University Beijing China

Au/Sn solder bonding on si substrates was used to fabricate the GaN-based vertical structure light emitting diodes (VSLEDs). The phase reaction of Au/Sn solder under different bonding conditions was investigated by the measurement of electron back scattering diffraction (EBSD), and the characteristics of VSLED were analyzed by scanning acoustic microscope (SAM), Raman scattering, current-voltage (I-V) and light output-current (L-I) curves. After the bonding process, horizontal stripes of Au/Sn phase (δ phase) and Au5Sn phase (ζ phase) were redirected to vertical stripes, and δ phase tended to move to the solder joint. Sn interstitial diffusion led to the distribution of δ phase and voids in Au/Sn solder, which could be seen in SAM and SEM images. Vertical distribution of the δ phase and ζ phase with proper voids in the Au/Sn bonding layer showed the best bonding quality. Good bonding quality led to little shift of the E2-high mode of Raman spectra peak in GaN after laser lift off (LLO). It also caused more light extraction and forward bias reduction to 2.9 V at 20 mA.

关键词： GaN LED bonding Au/Sn phase