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Early-life famine exposure,adulthood obesity patterns,and risk of low-energy fracture

Frontiers of Medicine 2024年第1期18卷 192-203页

作者： Hongyan Qi Chunyan Hu Jie Zhang Lin Lin Shuangyuan Wang Hong Lin Xiaojing Jia Yuanyue Zhu Yi Zhang Xueyan Wu Mian Li Min Xu Yu Xu Tiange Wang zhiyun zhao Weiqing Wang Yufang Bi Meng Dai Yuhong Chen Jieli Lu Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the People’s Republic of ChinaShanghai National Center for Translational MedicineRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China

Malnutrition in early life increases the risk of osteoporosis,but the association of early-life undernutrition combined with adulthood obesity patterns with low-energy fracture remains *** study included 5323 community-dwelling subjects aged⩾40 years from ***-life famine exposure was identified based on the participants’birth *** obesity was assessed using the body mass index(BMI),and abdominal obesity was evaluated with the waist-to-hip ratio(WHR).Low-energy fracture was defined as fracture occurring after the age of⩾40 typically caused by falls from standing height or *** to the nonexposed group,the group with fetal,childhood,and adolescence famine exposure was associated with an increased risk of fracture in women with odds ratios(ORs)and 95%confidence intervals(CIs)of 3.55(1.57–8.05),3.90(1.57–9.71),and 3.53(1.05–11.88),respectively,but not in *** interactions were observed between fetal famine exposure and general obesity with fracture among women(P for interaction=0.0008).Furthermore,compared with the groups with normal BMI and WHR,the group of women who underwent fetal famine exposure and had both general and abdominal obesity had the highest risk of fracture(OR,95%CI:3.32,1.17–9.40).These results indicate that early-life famine exposure interacts with adulthood general obesity and significantly increases the risk of low-energy fracture later in life in women.

关键词： famine obesity body mass index waist-to-hip ratio low-energy fracture

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潜艇强机动变深规避鱼雷攻击仿真研究

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现代防御技术 2024年第1期52卷 124-129页

作者：丁文强丁浩赵志允海军潜艇学院山东青岛266199

潜艇利用强机动变深规避鱼雷末端攻击弹道是其规避鱼雷攻击的方法之一,也是潜艇防御鱼雷的最后措施。研究这种规避方法的可行性和有效性,可以为潜艇指挥员科学合理地操纵潜艇规避鱼雷攻击提供参考,对提高潜艇生命力和战斗力具有十分重... 详细信息

潜艇利用强机动变深规避鱼雷末端攻击弹道是其规避鱼雷攻击的方法之一,也是潜艇防御鱼雷的最后措施。研究这种规避方法的可行性和有效性,可以为潜艇指挥员科学合理地操纵潜艇规避鱼雷攻击提供参考,对提高潜艇生命力和战斗力具有十分重要的理论研究意义和军事应用价值。通过对强机动规避方案基本原理及不同机动方式的效果进行理论剖析,并对潜艇和鱼雷相对运动态势进行建模仿真计算,验证了潜艇强机动变深规避鱼雷攻击的效果。仿真计算表明,在一定距离范围内,高速机动的潜艇利用高压气吹除主压载水舱的水,同时采用上浮大舵角使潜艇大尾倾高速上浮至水面来规避鱼雷末端攻击弹道,随后迅速下潜到浅水层完成规避鱼雷攻击,这种战术机动规避措施在理论上是可行的,但是该方案采用时机亦应当充分考虑分析。

关键词：潜艇强机动变深规避鱼雷攻击仿真

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全球企业创新指数2023——指标体系、量表开发与态势分析

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科技进步与对策 2024年第1期41卷 161-172页

作者：马费成黄颖张琳赵志耘李纲武汉大学信息管理学院武汉大学大数据研究院武汉大学信息资源研究中心武汉大学科教管理与评价中心湖北武汉430072 中国科学技术信息研究所北京100038 武汉大学(武汉)数据智能研究院湖北武汉430072

2023年中央经济工作会议强调,“以科技创新引领现代化产业体系建设。要以科技创新推动产业创新,特别是以颠覆性技术和前沿技术催生新产业、新模式、新动能,发展新质生产力。”当前,新一轮科技革命和产业变革正在重构全球创新版图、重塑... 详细信息

2023年中央经济工作会议强调,“以科技创新引领现代化产业体系建设。要以科技创新推动产业创新,特别是以颠覆性技术和前沿技术催生新产业、新模式、新动能,发展新质生产力。”当前,新一轮科技革命和产业变革正在重构全球创新版图、重塑全球经济结构,数字技术、低碳技术、生物技术等不断涌现。推动新质生产力的形成既要加强科技创新驱动力,又要加快新兴产业的培育壮大。企业作为科技创新主体,是推动战略性新兴产业快速健康发展的中坚力量。研究企业尤其是战略性新兴产业中企业创新发展现状对掌握全球前沿科技领域创新发展态势,建设现代化产业体系,不断推进中国式现代化深入发展具有重要意义。武汉大学(武汉)数据智能研究院等单位联合研制并首次发布“全球企业创新指数2023”(Global Enterprise Innovation Index,GEII 2023),报告基于客观数据和量化方法,系统刻画了当今全球战略性新兴产业企业创新发展格局。报告共分为指标篇、总体篇、行业篇3个篇章,受版面限制,本刊以特稿方式刊发该报告指标篇、总体篇,以为相关研究及决策咨询提供参考。

关键词：战略性新兴产业创新指数企业创新发展产业变革前沿科技产业创新版面限制决策咨询

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Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults

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Frontiers of Medicine 2024年第2期18卷 303-314页

作者： Yi Ding Xiaoli Xu Zhuojun Xin Qiuyu Cao Jiaojiao Huang Xianglin Wu Yanan Huo Qin Wan Yingfen Qin Ruying Hu Lixin Shi Qing Su Xuefeng Yu Li Yan Guijun Qin Xulei Tang Gang Chen Min Xu Tiange Wang zhiyun zhao Zhengnan Gao Guixia Wang Feixia Shen Zuojie Luo Li Chen Qiang Li Zhen Ye Yinfei Zhang Chao Liu Youmin Wang Tao Yang Huacong Deng Lulu Chen Tianshu Zeng Jiajun zhao Yiming Mu Shengli Wu Yuhong Chen Jieli Lu Weiqing Wang Guang Ning Yu Xu Yufang Bi Mian Li Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of ChinaShanghai Key Laboratory for Endocrine TumorState Key Laboratory of Medical GenomicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang330000China Department of Endocrinology The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China Department of Endocrinology The First Affiliated Hospital of Guangxi Medical UniversityNanning530000China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou310000China Department of Endocrinology Affiliated Hospital of Guiyang Medical UniversityGuiyang550000China Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200000China Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430000China Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou510000China Department of Endocrinology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450000China Department of Endocrinology The First Hospital of Lanzhou UniversityLanzhou730000China Fujian Provincial Hospital Fujian Medical UniversityFuzhou350000China Dalian Municipal Central Hospital Affiliated of Dalian Medical UniversityDalian116000China Department of Endocrinology The First Hospital of Jilin UniversityChangchun130000China Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China Qilu Hospital of Shandong University Jinan250000China Department of Endocrinology The Second Affiliated Hospital of Harbin Medical UniversityHarbin150000China Department of Endocrinology Cen

Studies have found a U-shaped relationship between sleep duration and chronic kidney disease(CKD)risk,but limited research evaluated the association of reallocating excessive sleep to other behavior with *** included 104538 participants from the nationwide cohort of the Risk Evaluation of Cancers in Chinese Diabetic Individuals:A Longitudinal Study,with self-reported time of daily-life *** isotemporal substitution models,we found that substituting 1 h of sleeping with sitting,walking,or moderate-to-vigorous physical activity was associated with a lower CKD ***-time physical activity displacement was associated with a greater prevalence reduction than occupational physical activity in working *** stratified analysis,a lower CKD prevalence related to substitution toward physical activity was found in long *** pronounced correlations were observed in long sleepers with diabetes than in those with prediabetes,and they benefited from other behavior substitutions toward a more active *** U-shaped association between sleep duration and CKD prevalence implied the potential effects of insufficient and excessive sleep on the kidneys,in which the pernicious link with oversleep could be reversed by time reallocation to physical *** divergence in the predicted effect on CKD following time reallocation to behavior of different domains and intensities and in subpopulations with diverse metabolic statuses underlined the importance of optimizing sleeping patterns and adjusting integral behavioral composition.

关键词： sleep physical activity chronic kidney disease isotemporal substitution behavioral pattern

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Robust Semi-Global Leaderless Consensus and Containment Control of Identical Linear Systems with Imperfect Actuators

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Journal of Systems Science & Complexity 2018年第1期31卷 69-86页

作者： SHI Liangren zhao zhiyun LIN Zongli Department of Automation Shanghai Jiao Tong University and Key Laboratory of System Control and Information Processing of Ministry of Education Shanghai 200240 China Key Laboratory of Advanced Control and Optimization for Chemical Processes (East China University of Science and Technology) Ministry of Education Shanghai 200237 China Charles L. Brown Department of Electrical and Computer Engineering University of Virginia P.O. Box 400743 Charlottesville VA 22904-4743 USA

This paper investigates both the robust semi-global leaderless consensus problem and the robust semi-global containment control problem for a group of identical linear systems with imperfect actuators. The imperfect actuators are characterized by nonlinearities such as saturation and dead zone and there input output relationships are not precisely known. The dynamics of follower agents are also affected by the input additive disturbances. Low-and-high gain feedback consensus protocols are constructed to solve these problems. More specifically, it is shown that robust semi-global leaderless consensus can be achieved over a connected undirected graph and robust semi-global containment control can be achieved when each follower agent has access to the information of at least one leader agent. Numerical simulation illustrates the theoretical results.

关键词： Consensus containment control dead zone leaderless consensus multi-agent systems saturation

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Robust semi-global leader-following practical consensus of a group of linear systems with imperfect actuators

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Science China(Information Sciences) 2017年第7期60卷 195-206页

作者： Liangren SHI zhiyun zhao Zongli LIN Department of Automation Shanghai Jiao Tong University Key Laboratory of Advanced Control and Optimization for Chemical Processes(East China University of Science and Technology) Ministry of Education Charles L. Brown Department of Electrical and Computer Engineering University of Virginia

This paper considers the problem of semi-global leader-following consensus of a multi-agent system whose agent dynamics are represented by linear systems. The input output characteristics of the follower agent actuators, such as those of saturation and dead-zone, are imperfect, not precisely known, and subject to the effect of disturbances. Two consensus control algorithms, of the low-and-high gain feedback type and the low gain based variable structure control type, are proposed for solving the consensus problem. It is shown that both of these control algorithms achieve semi-global leader-following practical consensus in the presence of the imperfectness of the actuators when the communication topology among the follower agents is represented by a strongly connected and detailed balanced directed graph and the leader agent is a neighbor of at least one follower agent. The theoretical results are illustrated by numerical simulation.

关键词： consensus leader-following actuator saturation dead-zone low-and-high gain feedback low gain based variable structure control

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Experimental Verification of a Multi-robot Distributed Control Algorithm with Containment and Group Dispersion Behaviors: the Case of Dynamic Leaders

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IEEE/CAA Journal of Automatica Sinica 2014年第1期1卷 54-60页

作者： Hejin Zhang zhiyun zhao Ziyang Meng Zongli Lin Department of Automation and Key Laboratory for System Control and Information Processing of Ministry of Education Shanghai Jiao Tong University the Access Linnaeus Centre School of Electrical Engineering Royal Institute of Technology Charles L. Brown Department of Electrical and Computer Engineering University of Virginia

This paper studies the containment and group dispersion control for a multi-robot system in the presence of dynamic leaders. Each robot is represented by a doubleintegrator dynamic model and a distributed control algorithm is developed to drive the multi-robot system to follow a group of dynamic leaders with containment and group dispersion behaviors. The effectiveness of the algorithm is then verified on a multi-robot control platform.

关键词： Heuristic algorithms Mobile robots Robot kinematics Trajectory Dispersion Decentralized control

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新疆红树莓不同产地与品种果实多酚物质含量特征与抗氧化活性研究

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石河子大学学报（自然科学版） 2024年第5期42卷 552-559页

作者：马佳正孙芳芳张瑞瑞赵致韵童雨竹马松梅石河子大学理学院新疆石河子832003 石河子花园乳业有限公司新疆石河子832003 石河子大学药学院新疆石河子832003 石河子大学食品学院新疆石河子832003

探究新疆红树莓不同产地和品种的果实中多酚物质含量特征与抗氧化能力的差异,分析多酚物质含量与抗氧化活性之间的相关性,并解析其土壤驱动因素,为果实的科学利用和红树莓种植布局提供科学参考。以新疆5个种植产区和2个红树莓品种:玛纳... 详细信息

探究新疆红树莓不同产地和品种的果实中多酚物质含量特征与抗氧化能力的差异,分析多酚物质含量与抗氧化活性之间的相关性,并解析其土壤驱动因素,为果实的科学利用和红树莓种植布局提供科学参考。以新疆5个种植产区和2个红树莓品种:玛纳斯‘哈瑞太兹’、石河子142团‘哈瑞太兹’、那拉提乡‘秋英’、巴依托海‘秋英’、巴依托海‘哈瑞太兹’的成熟期果实为研究材料,对其总黄酮、总多酚、鞣花酸、绿原酸等多酚物质的含量特征和抗氧化活性进行测定与对比分析,并揭示与其不同产地土壤理化性质的相关性。结果表明:(1)新疆不同产地的红树莓品种中,果实的多酚物质含量与抗氧化活性在产区及品种之间表现出显著的差异,总体上总黄酮含量、鞣花酸含量、SOD活性和DPPH清除率在不同产区之间的地理差异大于品种间的差异,但总多酚含量和FRAP清除能力在不同品种之间表现出显著差异;(2)‘秋英’和‘哈瑞太兹’不同产地果实的总黄酮、绿原酸和原花青素含量对其抗氧化能力均具有显著的积极作用;(3)土壤有机质、碱解氮、全氮、速效磷和全磷对红树莓果实多酚物质合成与积累及其抗氧化能力均具有显著的积极作用,而土壤容重对果实绿原酸含量产生负向影响。

关键词：新疆不同产地红树莓果实多酚物质含量抗氧化活性土壤驱动因素

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基于网络文本的烟台葡萄酒旅游形象感知研究

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中阿科技论坛（中英文） 2024年第10期 23-27页

作者：杜莲张颜辉聂寒玉赵志云烟台科技学院山东蓬莱265600 北京工商大学商学院北京100048 烟台市蓬莱区葡萄与葡萄酒产业发展服务中心山东蓬莱265600

文章基于携程、去哪儿、马蜂窝等旅游网站搜集的有效评论作为研究数据,运用网络文本分析法,通过定性和定量研究手段,探讨了游客对烟台葡萄酒旅游的认知和情感反应。研究结果显示,烟台葡萄酒旅游在游客心中形成了以葡萄酒为核心,融合历... 详细信息

文章基于携程、去哪儿、马蜂窝等旅游网站搜集的有效评论作为研究数据,运用网络文本分析法,通过定性和定量研究手段,探讨了游客对烟台葡萄酒旅游的认知和情感反应。研究结果显示,烟台葡萄酒旅游在游客心中形成了以葡萄酒为核心,融合历史文化、自然风光和高质量服务的综合性旅游形象。情感分析结果显示,游客普遍对烟台葡萄酒旅游持积极态度,但仍存在一些消极情感反馈,主要涉及服务与价格、设施与环境、信息互动和商业推广等方面。为进一步促进烟台市葡萄酒旅游产业的健康发展,文章提出了加强服务人员培训,提高服务质量的同时优化价格体系;加大投入改善旅游设施,打造舒适且具有特色的旅游环境;建立多渠道的游客信息反馈机制,利用新媒体平台加强与游客的互动交流;制定多元化的推广策略,挖掘烟台葡萄酒旅游的独特卖点等具体对策建议。

关键词：葡萄酒旅游旅游形象感知网络文本分析烟台市

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In vitro study of micro-dystrophin gene-modified mesenchymal stem cells

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Neural Regeneration Research 2010年第7期5卷 496-501页

作者： Daidi zhao zhiyun Lian Libin Liu Li Luo Huiying Li Ju Liu Hongyu Zhou Department of Neurology West China Hospital of Sichuan University Chengdu 610041 Sichuan Province China

BACKGROUND： Studies have shown that the transplantation of mesenchymal stem cells （MSCs） improves dystrophin expression in muscle cell membrane of mdx mice and plays a role in ameliorating sport injuries to the myocyte. In addition, dystrophin gene plasmid injection exhibits therapeutic effect in mdx mice. However, these two methods exhibit shortcomings, such as low rate of post-transplantation expression. Therefore, the present study determined the combinatorial effects of these two methods. OBJECTIVE： To transfect and observe effects of pSL139 plasmid carrying the micro-dystrophin gene into MSCs, as well as in vitro micro-dystrophin gene expression in transfected MSCs. DESIGN, TIME AND SETTING： A comparative, molecular biology study was performed at the Laboratory of Tissue Engineering, West China Medical Center, Sichuan University from March 2007 to February 2008. MATERIALS： The pSL139 plasmid was cloned and provided by the Department of Neurology, Washington University, USA. Lipofectamine 2000 was purchased from Invitrogen, USA. Mouse anti-human dystrophin N-based terminal monoclonal antibody was purchased from Chemicon, USA. METHODS： Differential velocity adherent technique and density gradient centrifugation were combined to separate and culture MSCs from C57/BL10 mice. The cells were induced to trans-differentiate into osteoblasts. Subsequently, the Lipofectamine 2000 method was used to mediate transfection of plasmid pSL139 into third generation MSCs. MAIN OUTCOME MEASURES： Semi-quantitative reverse transcription polymerase-chain reaction and immunofluorescence were respectively employed to detect micro-dystrophin mRNA and protein expressions in MSCs. RESULTS： At 48 hours after MSC transfection with plasmid pSL139, a 379-kb target band was observed by agarose gel electrophoresis. Immunofluorescence revealed micro-dystrophin expression up to 45%-55%. CONCLUSION： Micro-dystrophin mRNA and protein were highly expressed in pSL139-transfected MSCs, which provided

关键词： Duchenne muscular dystrophy mesenchymal stem cells micro-dystrophin gene modification

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