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Review of a new bone tumor therapy strategy based on bifunctional biomaterials

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Bone Research 2021年第2期9卷 153-165页

作者： Jinfeng Liao Ruxia Han Yongzhi Wu zhiyong qian State Key Laboratory of Oral Diseases National Clinical Research Centre for Oral DiseasesState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalWest China Medical SchoolSichuan UniversityChengduSichuanP.R.China

Bone tumors,especially those in osteosarcoma,usually occur in *** standard clinical treatment includes chemotherapy,surgical therapy,and radiation ***,surgical resection often fails to completely remove the tumor,which is the main cause of postoperative recurrence and metastasis,resulting in a high mortality ***,bone tumors often invade large areas of bone,which cannot repair itself,and causes a serious effect on the quality of life of ***,bone tumor therapy and bone regeneration are challenging in the ***,this review presents the recent developments in bifunctional biomaterials to achieve a new strategy for bone tumor *** selected bifunctional materials include 3D-printed scaffolds,nano/microparticle-containing scaffolds,hydrogels,and bone-targeting *** related studies on bifunctional biomaterials combining tumor photothermal therapy with enhanced bone regeneration were ***,a perspective on the future development of biomaterials for tumor therapy and bone tissue engineering is *** review will provide a useful reference for bone tumor-related disease and the field of complex diseases to combine tumor therapy and tissue engineering.

关键词： biomaterials chemotherapy mortality

Extensible and swellable hydrogel-forming microneedles for deep point-of-care sampling and drug deployment

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Chinese Chemical Letters 2023年第6期34卷 90-100页

作者： Yuan Liu Ting Huang zhiyong qian Wei Chen Department of Pharmacology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Hubei Key Laboratory for Drug Target Research and Pharmacodynamic Evaluation Huazhong University of Science and TechnologyWuhan 430030China State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan UniversityCollaborative Innovation Center for BiotherapyChengdu 610041China

Microneedles are considered to be an effective,convenient,non-invasive,biosafety and compliant medical technology for vaccinations,biomarker testing,medical aesthetics and other related ***,further clinical and commercial translation of regular microneedles is hampered by challenges in manufacturability,cost variability,insufficient comfort,contamination and so *** innovations in functional biomaterials and chemical engineering technologies have been applied to develop extensible and swellable hydrogel-forming microneedles,achieving precise and controlled drug delivery and localized sampling from the target *** this review,we systematically summarize the latest development of the extensible and swellable hydrogel-forming microneedles,including deep point-of-care testing,drug deployment,wound healing and mucoadhesion *** addition,further analysis of the challenges and prospects for clinical application of current strategies is well *** is believed that the combined efforts of engineering,material,pharmaceutical and clinical research will contribute to the future success of this clinical and commercial translation.

关键词： Dynamic shape alteration Hydrogel-forming microneedles Controlled drug released Biomarker detection Interaction tunability

An injectable conductive hydrogel with dual responsive release of rosmarinic acid improves cardiac function and promotes repair after myocardial infarction

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Bioactive Materials 2023年第11期29卷 132-150页

作者： Linghong Zhang Zhongwu Bei Tao Li zhiyong qian Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu610041China Department of Pediatric Cardiac Surgery West China the Second HospitalSichuan UniversityChengdu610041China

Myocardial infarction (MI) causes irreversible damage to the heart muscle, seriously threatening the lives of patients. Injectable hydrogels have attracted extensive attention in the treatment of MI. By promoting the coupling of mechanical and electrical signals between cardiomyocytes, combined with synergistic therapeutic strategies targeting the pathological processes of inflammation, proliferation, and fibrotic remodeling after MI, it is expected to improve the therapeutic effect. In this study, a pH/ROS dual-responsive injectable hydrogel was developed by modifying xanthan gum and gelatin with reversible imine bond and boronic ester bond double crosslinking. By encapsulating polydopamine-rosmarinic acid nanoparticles to achieve on-demand drug release in response to the microenvironment of MI, thereby exerting anti-inflammatory, anti-apoptotic, and anti-fibrosis effects. By adding conductive composites to improve the conductivity and mechanical strength of the hydrogel, restore electrical signal transmission in the infarct area, promote synchronous contraction of cardiomyocytes, avoid induced arrhythmias, and induce angiogenesis. Furthermore, the multifunctional hydrogel promoted the expression of cardiac-specific markers to restore cardiac function after MI. The in vivo and in vitro results demonstrate the effectiveness of this synergistic comprehensive treatment strategy in MI treatment, showing great application potential to promote the repair of infarcted hearts.

关键词： Myocardial infarction Responsive hydrogel Rosmarinic acid Conductivity Combined treatment

Nanovaccines for cancer immunotherapy:Current knowledge and future perspectives

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Chinese Chemical Letters 2023年第8期34卷 57-68页

作者： Yiming Wu Zhe Zhang Yuquan Wei zhiyong qian Xiawei Wei Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy and Cancer CenterNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China

Cancer immunotherapy harnesses the immune system to attack tumors and has received extensive attention in recent *** vaccines as an important branch of immunotherapy are designed for delivering tumor antigens to antigen-presenting cells(APCs)to stimulate a strong immune response to against tumors,representing a potentially therapeutic and prophylactic effect with the long-term anticancer ***,the disappointing outcomes of their clinical use might be attributed to dilemma in antigen selection,immunogenicity,lymph nodes(LNs)targeting ability,lysosomal escape ability,immune evasion,***,aiming to overcome these barriers,has been utilized in cancer vaccine development for *** preclinical and clinical studies demonstrate positive results in nanomaterials-based cancer vaccines with considerable improvement in the vaccine *** this review,we systematically introduced the characteristics of nanovaccines and highlighted the different types of nanomaterials used for cancer vaccine *** addition,the opportunities and challenges of the emerging nanotechnology-based cancer vaccines were discussed.

关键词： Cancer immunotherapy Cancer vaccines Nanoparticles Antitumor immune response Clinical transformation

Nanoparticles targeting tumor-associated macrophages:A novel anti-tumor therapy

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Nano Research 2022年第3期15卷 2177-2195页

作者： Siyuan Chen Furong Qin Manni Wang Yuquan Wei zhiyong qian Xiawei Wei Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of BiotherapyNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China

The immunosuppressive tumor microenvironment(TME)is crucial in the occurrence of tumorigenesis,metastasis,and drug *** all stromal cells,tumor-associated macrophages(TAMs)are recognized as vital components causing the TME to be favorable for cancer cells and are also main targets in cancer *** date,nanoparticle(NP)-based drug delivery systems,as new technology platforms,have exhibited considerable advantages,such as targeted drug delivery at tumor sites,enhanced drug transport efficiency,and controllable drug release profiles,which provide new approaches for cancer *** TAM-targeting nanoparticles,various therapeutic strategies have been developed by varying their design,namely,by blocking TAM recruitment,promoting TAM transformation,and directly diminishing existing *** the current review,we provide a brief overview of the role of TAMs in the tumor microenvironment and their functions and highlight strategies for TAM ***,the applications of nanoparticles in targeting TAMs to improve cancer therapeutic efficiency are summarized.

关键词： tumors immunotherapy tumor-associated macrophages nanoparticles

An injectable conductive hydrogel restores electrical transmission at myocardial infarct site to preserve cardiac function and enhance repair

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Bioactive Materials 2023年第2期20卷 339-354页

作者： Linghong Zhang Tao Li Yan Yu Kun Shi Zhongwu Bei Yongjun qian zhiyong qian State Key Laboratory of Biotherapy State Key Laboratory and Collaborative Innovation Center of BiotherapyWest China HospitalSichuan UniversityChengdu610041SichuanPR China Department of Cardiovascular Surgery West China HospitalSichuan UniversityChengdu610041SichuanPR China

Myocardial infarction(MI)leads to massive cardiomyocyte death and deposition of collagen *** fibrous tissue disrupts electrical signaling in the myocardium,leading to cardiac systolic and diastolic dysfunction,as well as *** hydrogels are a promising therapeutic strategy for ***,we prepared a highly water-soluble conductive material(GP)by grafting polypyrrole(PPy)onto non-conductive *** component was added to the gel system formed by the Schiff base reaction between oxidized xanthan gum(OXG)and gelatin to construct an injectable conductive *** prepared self-healing OGGP3(3 wt%GP)hydrogel had good biocompatibility,elastic modulus,and electrical conductivity that matched the natural *** prepared biomaterials were injected into the rat myocardial scar tissue 2 days after *** found that the cardiac function of the rats treated with OGGP3 was improved,making it more difficult to induce *** electrical resistivity of myocardial fibrous tissue was reduced,and the conduction velocity of myocardial tissue was *** analysis showed reduced infarct size,increased left ventricular wall thickness,increased vessel density,and decreased inflammatory response in the infarcted *** findings clearly demonstrate that the OGGP3 hydrogel attenuates ventricular remodeling and inhibits infarct dilation,thus showing its potential for the treatment of MI.

关键词： Myocardial infarction Injectable hydrogel Conductivity Cardiac function

Safety evaluation of microbial pesticide (HaNPV) based on PCR method

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Frontiers of Chemical Science and Engineering 2019年第2期13卷 377-384页

作者： Miao Zhao Shufei Li Qinghong Zhou Dianming Zhou Ning He zhiyong qian Departmnet of Toxicology Tianjin Centers for Disease Control and PreventionTianjin 300011China State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan UniversityChangsha 410082China

Microbial pesticides can prevent and control diseases and pests of crops, and has become one of the important measures to ensure food and environmental safety. However, the potential harm of microbial pesticides to humans and animals is a serious concern at home and abroad. In this paper, we have investigated the infectivity and pathogenicity of a representative of viral microbial pesticides, helicoverpa armigera nuclear polyhedrosis virus (HaNPV), by specific and highly sensitive polymerase chain reaction technology. The results show that HaNPV can be gradually cleared in a short time after getting into blood of experimental rats, and does not infect other tissues or organs of animals;also indicate that the test subjects are not infectious to experimental rats after intravenous injection of HaNPV. Our method has good specificity and repeatability, and could provide an important reference for establishment of infectivity and pathogenicity detection methods for viral microbial pesticides in future.

关键词： microbial pesticides HaNPV acute intravenous injection infectivity pathogenicity

地下滴灌土壤水分分布对作物根系构型影响的研究现状与展望

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中国农机化学报 2025年第1期46卷 227-235页

作者：钱智勇王东博王东黄国亮杨振杰张毅杰云南农业大学机电工程学院昆明市650201

地下滴灌土壤水分分布对作物根系生长与构型的影响,是国内外学者研究的热点课题之一。依次从地下滴灌技术的基本原理与类型,影响地下滴灌性能的主要因素,地下滴灌土壤水分分布对不同作物根系构型的影响与重塑等方面进行系统文献研究。... 详细信息

地下滴灌土壤水分分布对作物根系生长与构型的影响,是国内外学者研究的热点课题之一。依次从地下滴灌技术的基本原理与类型,影响地下滴灌性能的主要因素,地下滴灌土壤水分分布对不同作物根系构型的影响与重塑等方面进行系统文献研究。随着新型地下滴灌技术的不断涌现,节水潜力的挖掘不断提升。因此,地下滴灌技术创新以及探究环境、作业、材质等多因素耦合影响机制,是提升地下滴灌技术应用与推广程度的重要课题。地下滴灌的灌水器可通过灵活布设,使得土壤水分更精准分布在作物根区周围。因此,以地下滴灌土壤水分为关键因子,开展作物根系构型的重塑研究是国内外学者应进一步关注的方向。提出以作物根系构型为出发点,探究新型空间多点源地下滴灌技术重塑根系构型的研究思路;并针对云南土壤与气候特点,提出新型根区微灌技术——空间多点源地下滴灌,利用根区不同方位滴头靶点重塑根系构型提升作物环境抗性,为解决云南高原山地季节性干旱问题提供参考。

关键词：地下滴灌技术土壤水分分布根系构型根系重塑

Bone-targeting melphalan prodrug with tumor-microenvironment sensitivity： Synthesis, in vitro and in vivo evaluation

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Chinese Chemical Letters 2018年第11期29卷 1609-1612页

作者： Can Chen Yiyan Li Xiaoping Yu Qinglin Jiang Xiaohong Xu qian Yang zhiyong qian The First Affiliated Hospital Chengdu Medical College Chengdu 610500 China The School of Pharmacy College Key Laboratory of Sichuon Province for Specific Structure of Small Molecule Drugs Chengdu Medical College Chengdu 610500 China The Public Health Deportment Chengdu Medical College Chengdu 610500 China State Key Laboratory and Collaborative Innovation Center of Biotherapy West China Hospital Sichuan University Chengdu 610041 China

Bone tumor is a refractory neoplastic growth of tissue in bone. According to the unique environment and phys-chemical characteristics of bone tissues, the chemotherapeutic agents are unlikely to prolong the survival of patients and often associated with systemic side effects. The bone targeting drug delivery via systemic administration may provide both better treatment efficacy and less frequent administration. In this study, we describe the synthesis, in vitro and in vivo evaluation of novel melphalan-bisphosphonate hybrids, with a tumor microenvironment sensitive linkage, which could be enzymatic activation under tumor microenvironment conditions. We have also evaluated the in vitro targeting efficiency of these prodrugs via the affinity of hydroxyapatite （HA） and cellular proliferation. The in vivo distribution suggested the bisphosphonate conjugated prodrugs with high bone selectivity.

关键词： Bone targeted Bisphosphonates Melphalan Tumor-microenvironment sensitive Prodrug