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Chinese Chemical Letters 2022年第4期33卷 1997-2000页

作者： zhiyang yan Bin Sun Panyi Huang Haiyun Zhao Hao Ding Weike Su Can Jin Collaborative Innovation Center of yangtze River Delta Region Green Pharmaceuticals Zhejiang University of TechnologyHangzhou 310014China College of Pharmaceutical Sciences Zhejiang University of TechnologyHangzhou 310014China

An efficient photocatalytic alkylation/cyclization of allylic amide with N-hydroxyphthalimide ester has been developed. The transformation is taken advantage of alkyl radicals to attack allylic amide with the assist of inexpensive rose bengal as photocatalyst to prepare a series of alkyl substituted oxazolines in moderate to excellent yields. High regioselectivity, operational safety, mild conditions and excellent substrate generality give this protocol broad application prospects.

关键词： Photocatalysis Oxazolines Allylic amide N-Hydroxyphthalimide ester Alkylation/cyclization Decarboxylation

Simple and versatile in situ thermo-sensitive hydrogel for rectal administration of SZ-A to alleviate inflammation and repair mucosal barrier in ulcerative colitis

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Chinese Chemical Letters 2024年第6期35卷 462-468页

作者： Yu yan Jiawei Song Dongdong Liu Zihan Liu Jialing Cheng zhiyang Chen yanfang yang Weizhe Jiang Hongliang Wang Jun Ye Yuling Liu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China College of Pharmacy Guangxi Medical UniversityNanning 530021China Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Ulcerative colitis(UC)is a chronic inflammatory bowel disease characterized by persistent inflammation of the colon and disrupted intestinal *** mori(Sangzhi)alkaloids(SZ-A),derived from twigs of mulberry,were approved by the National Medical Products Administration in 2020 for treating type 2 diabetes *** evidence has confirmed that SZ-A also alleviates non-alcoholic fatty liver disease and ameliorates inflammation,indicating its potential to address inflammation in ***,the treatment of UC faces challenges due to low drug delivery efficiency and short retention *** overcome these challenges,an injectable and adherent in-situ thermo-sensitive hydrogel containing SZ-A was developed for rectal drug delivery,utilizing the thermo-sensitive polymers Poloxamer 407and *** thermo-sensitive hydrogel system was designed with a moderate gelation temperature of 32±0.5℃,a short gelation time of 64 s,a p H range of 7-10,high moisturizing capability exceeding 90%,and moderate mechanical strength of 4-5 *** a rat model with UC,the in situ thermo-sensitive hydrogel significantly extended the retention time at the colonic site and enabled sustained release after rectal *** of UC were markedly reduced following rectal administration of SZ-A thermosensitive ***,the release of inflammatory factors,such as interleukin-1β(IL-1β),IL-6,IL-18,tumor necrosis factor-α(TNF-α),and transforming growth factor-β1(TGF-β1),significantly decreased in the SZ-A thermo-sensitive hydrogel *** integrity of the colonic mucosal barrier was significantly enhanced following the application of SZ-A thermo-sensitive *** conclusion,rectal administration of SZ-A in situ thermo-sensitive hydrogel effectively alleviated UC symptoms,inhibited the secretion of inflammatory factors,and promoted the repair of the colonic mucosal *** approach holds promise as a potential treatment for UC.

关键词： Ulcerative colitis SZ-A Thermo-sensitive hydrogel Rectal administration Alleviation of inflammation Mucosal barrier repair

论新历史主义视域下大女主商战剧的叙事话语转变与身份认同

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南京艺术学院学报（音乐与表演版） 2024年第1期 131-134页

作者：陈琰高智阳南京艺术学院传媒学院江苏南京210013

大女主商战剧是一种以女性为主角,展现现代商业体系中利益冲突的电视剧杂糅类型。这一类型在20世纪90年代开始就已经出现,当前呈现出新的发展态势。以新历史主义的视角对特定时期价值观重新审视,大女主商战剧存在叙事话语的转变、对传... 详细信息

大女主商战剧是一种以女性为主角,展现现代商业体系中利益冲突的电视剧杂糅类型。这一类型在20世纪90年代开始就已经出现,当前呈现出新的发展态势。以新历史主义的视角对特定时期价值观重新审视,大女主商战剧存在叙事话语的转变、对传统剧情模式进行突破,强调现代性与历史感的文本联结,其背后体现出的是新时代女性力量的崛起和性别主体意识的增强。

关键词：大女主商战剧新历史主义叙事话语身份认同

中小企业融资难背景下的商业银行信用风险缓释行为研究:信用风险转移or贷款出售?

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运筹与管理 2024年第6期33卷 214-219页

作者：刘志洋马延安东北师范大学经济与管理学院吉林长春130117

在面临高风险的中小企业贷款时,商业银行如何签订信用衍生产品合约来缓解自身信用风险,进而在支持中小企业和民营企业融资时实现自身的最大效用,成为商业银行支持中小企业融资需要重点考虑的问题。本文将信用风险转移工具与贷款出售相结... 详细信息

在面临高风险的中小企业贷款时,商业银行如何签订信用衍生产品合约来缓解自身信用风险,进而在支持中小企业和民营企业融资时实现自身的最大效用,成为商业银行支持中小企业融资需要重点考虑的问题。本文将信用风险转移工具与贷款出售相结合,比较了存在道德风险与不存在道德风险情况下商业银行的效用差异。理论模型分析表明,当不存在道德风险时,贷款出售市场会保证商业银行实现贷款的期望收益;但监管成本的存在使得信用风险转移工具的使用效用低于贷款的预期收益,且合约支付没有呈现出状态分离特征,商业银行会倾向于使用贷款出售来转移信用风险。在存在道德风险时,贷款出售市场并没有完全对冲商业银行的信用风险;而对于信用风险转移工具而言,当信用风险缓释工具卖方资产管理能力非常强,且大于监管惩罚的期望值时,商业银行能够获得高于贷款预期收益的效用,信用风险转移工具是更优的选择。

关键词：信用风险缓释信用风险转移贷款出售中小企业融资

维普期刊数据库博看期刊

Research progress of severe acute respiratory syndrome coronavirus 2 on aerosol collection and detection

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Chinese Chemical Letters 2024年第1期35卷 108-115页

作者： Xinyu Zhang Yuting Chen Yueying Pan Xinye Ma Gui Hu Song Li yan Deng Zhu Chen Hui Chen yanqi Wu Zhihong Jiang zhiyang Li Hunan Key Laboratory of Biomedical Nanomaterials and Devices Hunan University of TechnologyZhuzhou 412007China State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacao 999078China Shenzhen Lemniscare Med Technol Co.Ltd. Shenzhen 518000China Department of Clinical Laboratory the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China

The outbreak of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in late 2019 has negatively affected people's lives and *** the mode of transmission of SARS-CoV-2 is of great concern,this review discusses the sources of virus aerosols and possible transmission ***,we discuss virus aerosol collection methods,including natural sedimentation,solid impact,liquid impact,centrifugal,cyclone and electrostatic adsorption ***,we review common virus aerosol detection methods,including virus culture,metabolic detection,nucleic acid-based detection and immunology-based detection ***,possible solutions for the detection of SARS-CoV-2 aerosols are ***-of-care testing has long been a focus of *** the near future,the development of an instrument that integrates sampling and output results will enable the real-time,automatic monitoring of patients.

关键词： Virus aerosol Aerosol transmission Aerosol collection Aerosol detection Protective measure

Studies on chemical constituents of Ailanthus altissima(Mill.)Swingle and their antioxidant activity

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Asian Journal of Traditional Medicines 2020年第6期15卷 320-327页

作者： Wanyi Shi Yuxi Wang zhiyang yan Xiaoxiao Huang Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development Liaoning ProvinceSchool of Traditional Chinese Materia MedicaShenyang Pharmaceutical UniversityShenyang 110016China

Ailanthus altissima(Mill.)Swingle is a deciduous tree belonging to the Simaroubaceae *** root and stem bark are traditional medicines for treating many diseases,such as diarrhea,dreaminess and intestinal tract *** investigation of Ailanthus altissima(Mill.)Swingle led to the isolation of eight *** structures of these compounds were identified by analyzing their NMR spectroscopic *** them,compounds 1,4,5,6 and 8 were isolated from Ailanthus *** the first *** antioxidant activities of these compounds were determined by DPPH radical scavenging method.

关键词： Ailanthus altissima(Mill.)Swingle lignans phenylpropanoids antioxidant activity

Network pharmacology-based virtual screening of natural products from Peperomia dindygulensis for the application to treat liver cancer

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Asian Journal of Traditional Medicines 2019年第6期14卷 253-259页

作者： Zhikang Duan Han Zhang Peng Zhao zhiyang yan Xiaoxiao Huang Department of Products Chemistry Shenyang Pharmaceutical UniversityShenyang 110016China

Traditional Chinese medicine plays an increasingly important role in cancer treatment for the property of the complex components and *** dindygulensis,belonging to Piperaceae family,was proved to be effective to the treatment of cancer,but the action mechanism is *** this study,we employed molecular docking and network pharmacology methods to predict the effective compositions,potential target proteins and potential biological *** compounds were predicted to have potential activity for liver-cancer target ***,we analyzed the biological pathways based on compounds-target network,which may be play an important role in liver *** article is presented to explore the active ingredients of *** and provide crucial material for the further research and development of the plant.

关键词： Peperomia dindygulensis network pharmacology potential target biological pathway

A network pharmacology approach to determine the active ingredients and potential targets of Chinese herb Juglans mandshurica Maxim. for treatment of lung cancer

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Asian Journal of Traditional Medicines 2019年第1期14卷 13-21页

作者： Yeqing Du Qiang Ren zhiyang yan Xiaoxiao Huang Shaojiang Song Department of Natural Products Chemistry Key Laboratory of Structure-Based Drug Design and Discovery Ministry of Education School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 PR China

Using molecular docking and computer network pharmacology, the active ingredients from the anticancer herb medicine, Juglans mandshurica Maxim, and the potential targets related to lung cancer were screened out rapidly. Compounds-targets network of J. mandshurica in lung cancer treatment was constructed based on the network analysis. Additionally, the intermolecular forces between the top ten active compounds and the key target protein were explored. At the systemic level, the active components, potential targets, and interactive relations of J. mandshurica in the treatment of lung cancer were studied.

关键词： Juglans mandshurica network pharmacology lung cancer

Research review in the main chemical components and biological activities of Daphne aurantiaca Diels

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Asian Journal of Traditional Medicines 2019年第6期14卷 295-302页

作者： yangyang Zhang zhiyang yan Hao Zhang Guodong Yao Xiaoxiao Huang Department of Natural Products Chemistry Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&DevelopmentLiaoning ProvinceSchool of Traditional Chinese Materia MedicaShenyang Pharmaceutical UniversityShenyang 110016PR China

Daphne aurantiaca Diels belongs to the Daphne *** of Thymelaeaceaen family and flavonoids,terpenoids,lignans,phenylpropanoids are the main chemical components isolated from this *** the extracts of Daphne aurantiaca Diels have been reported with multiple pharmacological activities and good development prospects,which have drawn enormous ***,this review summarized the research progress on the chemical components and the pharmacological effects of Daphne aurantiaca Diels.

关键词： Daphne aurantiaca Diels chemical components pharmacological activities

多孔介质微观结构对柴油机颗粒捕集器性能影响的模拟探究

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哈尔滨工程大学学报 2024年第5期45卷 886-893页

作者：李志军李智洋李振国王妍杨绵松天津大学内燃机燃烧学国家重点实验室天津300072 中国汽车技术研究中心有限公司天津300300

为了优化柴油机颗粒捕集器的捕集、压降性能,本文基于孔径概率密度函数和孔隙率分布函数建立了二维柴油机颗粒捕集器孔道微观结构模型,考虑了拦截机理和扩散机理用以计算颗粒在过滤器中的沉积分布情况和捕集效率。计算结果表明:多孔介... 详细信息

为了优化柴油机颗粒捕集器的捕集、压降性能,本文基于孔径概率密度函数和孔隙率分布函数建立了二维柴油机颗粒捕集器孔道微观结构模型,考虑了拦截机理和扩散机理用以计算颗粒在过滤器中的沉积分布情况和捕集效率。计算结果表明:多孔介质微观结构和入口速度对颗粒捕集效率的影响与粒径有关,100 nm粒径颗粒随流速增大初始捕集效率降低最为明显,1000 nm粒径颗粒在不同均匀性的过滤壁下的捕集效率差超过了30%;孔径分布函数方差越大,颗粒就会更多地分布在过滤壁前端,捕集效率也越高,但较大的孔径方差会导致捕集器的初始压降增大和捕集过程结束时的性能出现恶化。

关键词：颗粒捕集器数值模拟微观结构概率密度函数压降捕集效率