A network pharmacology approach to determine the active ingredients and potential targets of Chinese herb Juglans mandshurica Maxim. for treatment of lung cancer
作者机构：Department of Natural Products Chemistry Key Laboratory of Structure-Based Drug Design and Discovery Ministry of Education School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 PR China
出 版 物：《Asian Journal of Traditional Medicines》 (亚洲传统医药（英文）)
年 卷 期：2019年第14卷第1期
页 面：13-21页
学科分类：10[医学]
主 题：Juglans mandshurica network pharmacology lung cancer
摘 要：Using molecular docking and computer network pharmacology, the active ingredients from the anticancer herb medicine, Juglans mandshurica Maxim, and the potential targets related to lung cancer were screened out rapidly. Compounds-targets network of J. mandshurica in lung cancer treatment was constructed based on the network analysis. Additionally, the intermolecular forces between the top ten active compounds and the key target protein were explored. At the systemic level, the active components, potential targets, and interactive relations of J. mandshurica in the treatment of lung cancer were studied.
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