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城市公交智能电子站牌系统的设计与实现

地理空间信息 2022年第6期20卷 142-145页

作者：姜川陈晨李乐童赵智洋景强正元地理信息集团股份有限公司山东分公司山东济南250014

以长汀(原中央苏区)智能运营中心智能电子站牌专项建设为例,综合运用大数据、物联网、GIS等技术手段,在嵌入式仿古公交站牌硬件的基础上,设计并实现了集基础数据管理、电子站牌集中控制、视频监控、大数据可视化以及移动端等应用的一体... 详细信息

以长汀(原中央苏区)智能运营中心智能电子站牌专项建设为例,综合运用大数据、物联网、GIS等技术手段,在嵌入式仿古公交站牌硬件的基础上,设计并实现了集基础数据管理、电子站牌集中控制、视频监控、大数据可视化以及移动端等应用的一体化城市公交智能电子站牌系统,优化了公交出行的乘客体验。实践表明智能电子站牌播报公交实时位置准确、运行稳定可靠,构建了多元渠道的智慧公交出行服务体系,提升了乘客对公交出行的满意度。

关键词：城市公交智能电子站牌站点采集定位电子站牌集中控制智慧公交移动端

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Structural repurposing of SGLT2 inhibitor empagliflozin for strengthening anti-heart failure activity with lower glycosuria

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1671-1685页

作者： Yixiang Xu Chao Zhang Kai Jiang Xinchun Yang Feng Chen zhiyang Cheng Jinlong zhao Jiaxing Cheng Xiaokang Li Xin Chen Luoyifan Zhou Hao Duan Yunyuan Huang Yaozu Xiang Jian Li State Key Laboratory of Bioreactor Engineering Shanghai Frontiers Science Center of Optogenetic Techniques for Cell MetabolismFrontiers Science Center for Materiobiology and Dynamic ChemistryShanghai Key Laboratory of New Drug DesignSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China Shanghai East Hospital School of Life Sciences and TechnologyTongji UniversityShanghai 200092China East China University of Science and Technology-Tengbai Pharmaceutical Innovative Drugs Joint Research Institute Zhuhai Tengbai Pharmaceutical Co.Ltd.Zhuhai 519000China Hubei Key Laboratory of Genetic Regulation and Integrative Biology School of Life SciencesCentral China Normal UniversityWuhan 430079China Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from West Yunnan College of PharmacyDali UniversityDali 671000China Clinical Medicine Scientific and Technical Innovation Center Shanghai Tenth People's HospitalTongji University School of MedicineShanghai 200092China Key Laboratory of Tropical Biological Resources of Ministry of Education College of PharmacyHainan UniversityHaikou 570228China

Sodium-glucose cotransporter 2(SGLT2)inhibitors have been reapproved for heart failure(HF)therapy in patients with and without ***,the initial glucose-lowering indication of SGLT2i has impeded their uses in cardiovascular clinical practice.A challenge of SGLT2i then becomes how to separate their anti-HF activity from glucose-lowering *** address this issue,we conducted structural repurposing of EMPA,a representative SGLT2 inhibitor,to strengthen anti-HF activity and reduce the SGLT2-inhibitory activity according to structural basis of inhibition of *** to EMPA,the optimal derivative JX01,which was produced by methylation of C2—OH of the glucose ring,exhibited weaker SGLT2-inhibitory activity(IC_(50)>100 nmol/L),and lower glycosuria and glucose-lowering side-effect,better NHE1-inhibitory activity and cardioprotective effect in HF ***,JX01 showed good safety profiles in respect of single-dose/repeat-dose toxicity and hERG activity,and good pharmacokinetic properties in both mouse and rat ***,the present study provided a paradigm of drug repurposing to discover novel anti-HF drugs,and indirectly demonstrated that SGLT2-independent molecular mechanisms play an important role in cardioprotective effects of SGLT2 inhibitors.

关键词： Heart failure SGLT2 inhibitor Empagliflozin Structural repurposing NHE1(sodium-hydrogen exchanger 1)

TRIM34 attenuates colon inflammation and tumorigenesis by sustaining barrier integrity

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Cellular & Molecular Immunology 2021年第2期18卷 350-362页

作者： Qiaoshi Lian Shanshan Yan Qi Yin Chenghua Yan Wanwei Zheng Wangpeng Gu Xinhao zhao Weiguo Fan Xuezhen Li Liyan Ma zhiyang Ling Yaguang Zhang Jie Liu Jinsong Li Bing Sun State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of Sciences320 Yueyang RoadShanghai200031China School of Life Sciences University of Science and Technology of ChinaHefei230022China State Key Laboratory of Cell Biology Shanghai Key Laboratory of Molecular AndrologyCAS Center for Excellence in Molecular Cell ScienceShanghai institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of Sciences320 Yueyang RoadShanghai200031China Department of Digestive Diseases Huashan HospitalFudan University12 Middle Wulumuqi RoadShanghai200040China Institutes of Biomedical Sciences and Department of Immunology Shanghai Medical SchoolFudan University138 Yi Xue Yuan RoadShanghai200032China

Loss of the colonic inner mucus layer leads to spontaneously severe colitis and colorectal ***,key host factors that may control the generation of the inner mucus layer are rarely ***,we identify a novel function of TRIM34 in goblet cells(GCs)in controlling inner mucus layer *** DSS treatment,TRIM34 deficiency led to a reduction in Muc2 secretion by GCs and subsequent defects in the inner mucus *** outcome rendered TRIM34-deficient mice more susceptible to DSS-induced colitis and colitis-associated colorectal *** experiments demonstrated that TRIM34 controlled TLR signaling-induced Nox/Duox-dependent ROS synthesis,thereby promoting the compound exocytosis of Muc2 by colonic GCs that were exposed to bacterial TLR *** analysis revealed that TRIM34 levels in patient samples were correlated with the outcome of ulcerative colitis(UC)and the prognosis of rectal *** study indicates that TRIM34 expression in GCs plays an essential role in generating the inner mucus layer and preventing excessive colon inflammation and tumorigenesis.

关键词： Colon inflammation Goblet cell Toll-like receptor TRIM34 Muc2

APPLICATION OF BP NEURAL NETWORK IN COLOR TEMPERATURE CALCULATION

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APPLICATION OF BP NEURAL NETWORK IN COLOR TEMPERATURE CALCUL...

2009中国宁波国际计算机科学与技术学术大会

作者： Guanyun Xiao Hongxia zhao zhiyang Luo Mechanical Engineering Department Jinggangshan University

One of the important indexes of light source is its color rendering property,which is directly interfered the objects’ colors reflected to our *** object with good color rendering property is less of color distortion,so we need to test the parameters of light *** popular method for getting the relative color temperature has three steps,which is to firstly obtain color tri-stimulus values X,Y and Z from PR-655 spectraScan colorimeter,and then to calculate chromaticity coordinates of light source separately,at last to solve the relative color temperature with *** method is very complicated for the calculation,therefore,we try to set up the conversion relation between color temperature of light source and chromaticity coordinates（u,v） with neural network.

关键词： Color Temperature Neural Network Chromaticity Coordinates

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高速铁路桥梁振动噪声影响参数研究

石家庄铁道大学学报（自然科学版） 2021年第2期34卷 16-23页

作者：林玉森郭超明路嘉琦赵志杨刘涛石家庄铁道大学土木工程学院河北石家庄050043 石家庄铁道大学道路与铁道工程安全保障省部共建教育部重点实验室河北石家庄050043

为了探究桥梁结构的振动噪声,以24 m简支箱梁为研究对象进行车桥耦合动力分析,求解轨道不平顺作用下的竖向轮轨力。利用有限元与边界元结合方法,建立桥梁结构声场分析模型,此模型将竖向轮轨力作为激励,以桥梁结构的动力响应作为边界条件... 详细信息

为了探究桥梁结构的振动噪声,以24 m简支箱梁为研究对象进行车桥耦合动力分析,求解轨道不平顺作用下的竖向轮轨力。利用有限元与边界元结合方法,建立桥梁结构声场分析模型,此模型将竖向轮轨力作为激励,以桥梁结构的动力响应作为边界条件,分析噪声声压级的频率分布特性和传播规律。研究表明,桥梁结构噪声最大值位于列车加载位置附近,声波能量由桥梁结构向外部空间辐射,其频段主要在100 Hz以下,分布于桥梁结构正上方与正下方。桥梁结构噪声在传播过程中,其衰减性随着传播距离增大而逐渐增加;噪声声压随车辆速度增加而增大,随桥梁刚度和腹板厚度的增大而减小。

关键词：铁路桥梁振动噪声边界元噪声声压级刚度

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三种砜吡草唑主要代谢物的合成

合成化学 2024年第9期32卷 833-839页

作者：李志洋尹迪张宇飞柳红霞钟玉君彭雨晴周昊谢练武赵东江中南林业科技大学理学院湖南长沙410004 长沙嘉桥生物科技有限公司湖南长沙410000

为了满足除草剂代谢物毒理试验的需求,本研究设计并优化了砜吡草唑的3个主要代谢物M1、M3和M4的合成路径。通过全新的合成路径,以1-甲基-3-三氟甲基-4-氯甲基-5-二氟甲氧基-1-H-吡唑为起始原料,经过一系列反应步骤,成功合成了M1和M3。... 详细信息

为了满足除草剂代谢物毒理试验的需求,本研究设计并优化了砜吡草唑的3个主要代谢物M1、M3和M4的合成路径。通过全新的合成路径,以1-甲基-3-三氟甲基-4-氯甲基-5-二氟甲氧基-1-H-吡唑为起始原料,经过一系列反应步骤,成功合成了M1和M3。以2-甲基-2-丙烯酸和溴肟为原料,经过一系列反应后成功合成M4。通过核磁共振氢谱、液相质谱和高效液相色谱等方法对代谢物的结构和纯度进行了确定。经过优化合成工艺,M1、M3和M4的产率分别达到了76.9%、82.5%和70.1%。合成的代谢物纯度可达97%以上。本研究首次从合成路线的角度出发,成功设计并制备了这3种砜吡草唑代谢物,为农药登记和农残质检等领域提供了重要的研究基础。

关键词：砜吡草唑代谢物合成路径工艺优化毒理试验农药登记

Sunny Sisters Spreading Sunshine Report on Practice of Coporate Social Responsibility from Sunny Sisters

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China Standardization 2011年第1期56卷 20-23页

作者： Liu zhiyang

In August in order to collect matenal for our magazine China Standardization, Ms. zhao Hongchun （the ctdef editor of our press） and I went to SAC to meet Mr. Ji Enning who is responsible for the service standatdization in the service deparanent of SAC. As we wanted to understand the service standardization and the implementation in corporate social responsibility in China, we asked him to recommend a few enterprises that did an excellent job in implementation of social responsibility. The first enterprise he recommended to us was Jinan Yangguang Dajie Co.,

关键词： Sunny Sisters Spreading Sunshine Report on Practice of Coporate Social Responsibility from Sunny Sisters

A human antibody potently neutralizes RSV by targeting the conserved hydrophobic region of prefusion F

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Science China(Life Sciences) 2023年第4期66卷 729-742页

作者： Chunyan Yi Caixia Su Xiaoyu Sun Xiao Lu Chuanya Si Caixuan Liu Zhuo Yang Hong Yuan Yuying Huang Jing Wen Yonghui He Yaguang Zhang Liyan Ma Yao Cong Gan zhao zhiyang Ling Bin Wang Bing Sun State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Key Laboratory of Medical Molecular Virology(MOE/MOH) Department of Medical Microbiology and ParasitologySchool of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghai 200032China MedimScience.Co Hangzhou 311217China Shanghai Institute of Infectious Disease and Biosecurity Shanghai Medical CollegeFudan UniversityShanghai 200032China

Respiratory syncytial virus(RSV) continues to pose serious threats to pediatric populations due to the lack of a vaccine and effective antiviral drugs. RSV fusion(F) glycoprotein mediates viral-host membrane fusion and is a key target for neutralizing antibodies. We generated 23 full-human monoclonal antibodies(hm Abs) against prefusion F protein(pre-F) from a healthy adult with natural RSV infection by single B cell cloning technique. A highly potent RSV-neutralizing hm Ab, named as 25-20, is selected, which targets a new site Φ-specific epitope. Site-directed mutagenesis and structural modelling analysis demonstrated that 25-20 mainly targets a highly conserved hydrophobic region located at the a4 helix and a1 helix of pre-F, indicating a site of vulnerability for drug and vaccine design. It is worth noting that 25-20 uses an unreported inferred germline(i GL) that binds very poorly to pre-F, thus high levels of somatic mutations are needed to gain high binding affinity with pre-F. Our observation helps to understand the evolution of RSV antibody during natural infection. Furthermore, by in silico prediction and experimental verification, we optimized 25-20 with KD values as low as picomolar range. Therefore, the optimized 25-20 represents an excellent candidate for passive protection against RSV infection.

关键词： RSV human antibody potent neutralization conserved epitope somatic mutations affinity maturation

Unconventional Petroleum Sedimentology:A Key to Understanding Unconventional Hydrocarbon Accumulation

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Engineering 2022年第11期18卷 62-78页

作者： Caineng Zou Zhen Qiu Jiaqiang Zhang zhiyang Li Hengye Wei Bei Liu Jianhua zhao Tian Yang Shifa Zhu Huifei Tao Fengyuan Zhang Yuman Wang Qin Zhang Wen Liu Hanlin Liu Ziqing Feng Dan Liu Jinliang Gao Rong Liu Yifan Li Research Institute of Petroleum Exploration and Development China National Petroleum CorporationBeijing 100083China National Energy Shale Gas Research and Development(Experiment)Center Beijing 100083China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Department of Geology Colorado College Colorado SpringsColoradoCO 80903USA School of Geoscience and Technology Southwest Petroleum UniversityChengdu 610500China Key Laboratory of Tectonics and Petroleum Resources of Ministry of Education China University of GeosciencesWuhan 430074China College of Geosciences China University of PetroleumQingdao 266580China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Institute of Sedimentary Geology Chengdu University of TechnologyChengdu 610059China China University of Petroleum Beijing 102249China Oil and Gas Research Center Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China College of Earth Sciences Jilin UniversityChangchun 130061China School of Energy Resources China University of Geosciences(Beijing)Beijing 100083China

The commercial exploitation of unconventional petroleum resources(e.g.,shale oil/gas and tight oil/gas)has drastically changed the global energy structure within the past two ***-spot intervals(areas),the most prolific unconventional hydrocarbon resources,generally consist of extraordinarily high organic matter(EHOM)deposits or closely associated sandstones/carbonate *** formation of sweet-spot intervals(areas)is fundamentally controlled by their depositional and subsequent diagenetic settings,which result from the coupled sedimentation of global or regional geological events,such as tectonic activity,sea level(lake level)fluctuations,climate change,bottom water anoxia,volcanic activity,biotic mass extinction or radiation,and gravity flows during a certain geological *** shales with EHOM content and their associated high-quality reservoir rocks deposited by the coupling of major geological events provide not only a prerequisite for massive hydrocarbon generation but also abundant hydrocarbon storage *** Ordovician-Silurian Wufeng-Longmaxi shale of the Sichuan Basin,Devonian Marcellus shale of the Appalachian Basin,Devonian-Carboniferous Bakken Formation of the Williston Basin,and Triassic Yanchang Formation of the Ordos Basin are four typical unconventional hydrocarbon systems selected as case studies *** each case,the formation of sweet-spot intervals for unconventional hydrocarbon resources was controlled by the coupled sedimentation of different global or regional geological events,collectively resulting in a favorable environment for the production,preservation,and accumulation of organic matter,as well as for the generation,migration,accumulation,and exploitation of *** petroleum sedimentology,which focuses on coupled sedimentation during dramatic environmental changes driven by major geological events,is key to improve the understanding of the formation and distribution of sweet-spot intervals(areas)

关键词： Sedimentology Black shales Fine-grained sediments Organic matter accumulation Extraordinarily high organic matter Unconventional petroleum