TRIM34 attenuates colon inflammation and tumorigenesis by sustaining barrier integrity

作     者：Qiaoshi Lian Shanshan Yan Qi Yin Chenghua Yan Wanwei Zheng Wangpeng Gu Xinhao Zhao Weiguo Fan Xuezhen Li Liyan Ma Zhiyang Ling Yaguang Zhang Jie Liu Jinsong Li Bing Sun 

作者机构：State Key Laboratory of Cell BiologyCAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of Sciences320 Yueyang RoadShanghai200031China School of Life SciencesUniversity of Science and Technology of ChinaHefei230022China State Key Laboratory of Cell BiologyShanghai Key Laboratory of Molecular AndrologyCAS Center for Excellence in Molecular Cell ScienceShanghai institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of Sciences320 Yueyang RoadShanghai200031China Department of Digestive DiseasesHuashan HospitalFudan University12 Middle Wulumuqi RoadShanghai200040China Institutes of Biomedical Sciences and Department of ImmunologyShanghai Medical SchoolFudan University138 Yi Xue Yuan RoadShanghai200032China 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2021年第18卷第2期

页      面：350-362页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：We thank Dangsheng Li for critical suggestions.We are grateful to Guomei Lin for breeding the animals and Li Li for animal management.We also acknowledge the individuals involved in technical support at the Core Facility for Cell Biology and the Animal Core Facility.This work was supported by grants from the National Key Research and Development Program of China(2018YFA0507402) the National Natural Science Foundation of China(31230024) the Chinese Academy of Sciences(XDB19000000) the National Natural Science Foundation of China(81761128009 and 81630016) 

主　　题：Colon inflammation Goblet cell Toll-like receptor TRIM34 Muc2 

摘      要：Loss of the colonic inner mucus layer leads to spontaneously severe colitis and colorectal ***,key host factors that may control the generation of the inner mucus layer are rarely ***,we identify a novel function of TRIM34 in goblet cells(GCs)in controlling inner mucus layer *** DSS treatment,TRIM34 deficiency led to a reduction in Muc2 secretion by GCs and subsequent defects in the inner mucus *** outcome rendered TRIM34-deficient mice more susceptible to DSS-induced colitis and colitis-associated colorectal *** experiments demonstrated that TRIM34 controlled TLR signaling-induced Nox/Duox-dependent ROS synthesis,thereby promoting the compound exocytosis of Muc2 by colonic GCs that were exposed to bacterial TLR *** analysis revealed that TRIM34 levels in patient samples were correlated with the outcome of ulcerative colitis(UC)and the prognosis of rectal *** study indicates that TRIM34 expression in GCs plays an essential role in generating the inner mucus layer and preventing excessive colon inflammation and tumorigenesis.