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Multi-omics analysis of adamantinomatous craniopharyngiomas reveals distinct molecular subgroups with prognostic and treatment response significance

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中华医学杂志(英文版) 2024年第7期137卷 859-870页

作者： Wang Xianlong Zhao Chuan Lin Jincheng liu Hongxing Zeng Qiuhong Chen Huadong Wang Ye Xu Dapeng Chen Wen Xu Moping Zhang En Lin Da Lin zhixiong Sanbo Brain Hospital Capital Medical University Beijing 100093 Department of Bioinformatics School of Medical Technology and Engineering Key Laboratory of Medical Bioinformatics Key Laboratory of Ministry of Education for Gastrointestinal Cancer Fujian Medical University Fuzhou Fujian 350122 China Department of Neurosurgery

Background: Adamantinomatous craniopharyngioma (ACP) is the commonest pediatric sellar tumor. No effective drug is available and interpatient heterogeneity is prominent. This study aimed to identify distinct molecular subgroups of ACP based on the multi-omics profiles, imaging findings, and histological features, in order to predict the response to anti-inflammatory treatment and immunotherapies.Methods: Totally 142 Chinese cases diagnosed with craniopharyngiomas were profiled, including 119 ACPs and 23 papillary craniopharyngiomas. Whole-exome sequencing (151 tumors, including recurrent ones), RNA sequencing (84 tumors), and DNA methylome profiling (95 tumors) were performed. Consensus clustering and non-negative matrix factorization were used for subgrouping, and Cox regression were utilized for prognostic evaluation, respectively.Results: Three distinct molecular subgroups were identified: WNT, ImA, and ImB. The WNT subgroup showed higher Wnt/β-catenin pathway activity, with a greater number of epithelial cells and more predominantly solid tumors. The ImA and ImB subgroups had activated inflammatory and interferon response pathways, with enhanced immune cell infiltration and more predominantly cystic tumors. Mitogen-activated protein kinases (MEK/MAPK) signaling was activated only in ImA samples, while IL-6 and epithelial-mesenchymal transition biomarkers were highly expressed in the ImB group, mostly consisting of children. The degree of astrogliosis was significantly elevated in the ImA group, with severe finger-like protrusions at the invasive front of the tumor. The molecular subgrouping was an independent prognostic factor, with the WNT group having longer event-free survival than ImB (Cox,P = 0.04). ImA/ImB cases were more likely to respond to immune checkpoint blockade (ICB) therapy than the WNT group (P <0.01). In the preliminary screening of subtyping markers, CD38 was significantly downregulated in WNT compared with ImA and ImB (P = 0.01).Conclusions: ACP comprises three molecular subtypes with disti

关键词： Craniopharyngioma Central nervous system tumor Precision medicine beta Catenin Proto-Oncogene Proteins B-raf

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Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene

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Oncology Research 2024年第7期32卷 1185-1195页

作者： XIAOBI HUANG CHUNYUAN CHEN YONGYANG CHEN HONGLIAN ZHOU YONGHUA CHEN ZHONG HUANG YUliu XIE BAIYANG liu YUDONG GUO zhixiong YANG GUANGHUA CHEN WENMEI SU Department of Pulmonary Oncology Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Department of Thoracic Surgery Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Department of Orthopedics Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China

Background:Long non-coding RNAs are important regulators in cancer biology and function either as tumor suppressors or as oncogenes.Their dysregulation has been closely associated with tumorigenesis.LINC00265 is upregulated in lung adenocarcinoma and is a prognostic biomarker of this cancer.However,the mechanism underlying its function in cancer progression remains poorly understood.Methods:Here,the regulatory role of LINC00265 in lung adenocarcinoma was examined using lung cancer cell lines,clinical samples,and xenografts.Results:We found that high levels of LINC00265 expression were associated with shorter overall survival rate of patients,whereas knockdown of LINC00265 inhibited proliferation of cancer cell lines and tumor growth in xenografts.Western blot andﬂow cytometry analyses indicated that silencing of LINC00265 induced autophagy and apoptosis.Moreover,we showed that LINC00265 interacted with and stabilized the transcriptional co-repressor Switch-independent 3a(SIN3A),which is a scaffold protein functioning either as a tumor repressor or as an oncogene in a context-dependent manner.Silencing of SIN3A also reduced proliferation of lung cancer cells,which was correlated with the induction of autophagy.These observations raise the possibility that LINC00265 functions to promote the oncogenic activity of SIN3A in lung adenocarcinoma.Conclusions:Ourﬁndings thus identify SIN3A as a LINC00265-associated protein and should help to understand the mechanism underlying LINC00265-mediated oncogenesis.

关键词： LINC00265 Autophagy Lung adenocarcinoma(LUAD) Cancer progression Switch-independent 3a(SIN3A)

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生成式人工智能赋能普惠金融:现实基础、关键风险挑战与应对策略

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学术前沿 2024年第6期 86-93页

作者：刘志雄中国政法大学商学院

普惠金融是写好金融“五篇大文章”的重要组成部分。当前,我国普惠金融发展面临可持续性、普及性不足以及信用体系不完善等挑战。近年来,生成式人工智能迅猛发展,正在成为信息化、数字化、智能化的新型技术基座,其拥有强大的知识编码和... 详细信息

普惠金融是写好金融“五篇大文章”的重要组成部分。当前,我国普惠金融发展面临可持续性、普及性不足以及信用体系不完善等挑战。近年来,生成式人工智能迅猛发展,正在成为信息化、数字化、智能化的新型技术基座,其拥有强大的知识编码和储存能力、文本和代码理解及生成能力以及复杂任务的推理能力,能够对普惠金融产生数据资源化、数据资产化、数字信任、风险控制、降本增效五大效应,从而有效赋能普惠金融高质量发展。

关键词：生成式人工智能普惠金融融合机理伦理风险

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Evolutionary divergence of subgenomes in common carp provides insights into speciation and allopolyploid success

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Fundamental Research 2024年第3期4卷 589-602页

作者： Lin Chen Chengyu Li Bijun Li Xiaofan Zhou Yulin Bai Xiaoqing Zou zhixiong Zhou Qian He Baohua Chen Mei Wang Yaguo Xue Zhou Jiang Jianxin Feng Tao Zhou Zhanjiang liu Peng Xu State Key Laboratory of Mariculture Breeding College of Ocean and Earth SciencesXiamen UniversityXiamen 361102China Fujian Key Laboratory of Genetics and Breeding of Marine Organisms College of Ocean and Earth SciencesXiamen UniversityXiamen 361102China State Key Laboratory of Marine Environmental Science College of Ocean and Earth SciencesXiamen UniversityXiamen 361102China Integrative Microbiology Research Centre South China Agricultural UniversityGuangzhou 510642China College of Fisheries Henan Normal UniversityXinxiang 453007China Henan Academy of Fishery Science Zhengzhou 450044China Department of Biology College of Arts and SciencesSyracuse UniversitySyracuse 13244USA

Hybridization and polyploidization have made great contributions to speciation,heterosis,and agricultural production within plants,but there is still limited understanding and utilization in animals.Subgenome structure and expression reorganization and cooperation post hybridization and polyploidization are essential for speciation and allopolyploid success.However,the mechanisms have not yet been comprehensively assessed in animals.Here,we produced a high-fidelity reference genome sequence for common carp,a typical allotetraploid fish species cultured worldwide.This genome enabled in-depth analysis of the evolution of subgenome architecture and expression responses.Most genes were expressed with subgenome biases,with a trend of transition from the expression of subgenome A during the early stages to that of subgenome B during the late stages of embryonic development.While subgenome A evolved more rapidly,subgenome B contributed to a greater level of expression during development and under stressful conditions.Stable dominant patterns for homoeologous gene pairs both during development and under thermal stress suggest a potential fixed heterosis in the allotetraploid genome.Preferentially expressing either copy of a homoeologous gene at higher levels to confer development and response to stress indicates the dominant effect of heterosis.The plasticity of subgenomes and their shifting of dominant expression during early development,and in response to stressful conditions,provide novel insights into the molecular basis of the successful speciation,evolution,and heterosis of the allotetraploid common carp.

关键词： Allotetraploid Subgenome structural evolution Homoeologous expression Expression dominance shift Environmental adaptation

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The adaptive transition of glioblastoma stem cells and its implications on treatments

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1199-1211页

作者： Zeyu Wang Hao Zhang Shengchao Xu zhixiong liu Quan Cheng Department of Neurosurgery Xiangya HospitalCentral South UniversityChangshaP.R.China National Clinical Research Center for Geriatric Disorders ChangshaP.R.China Department of Clinical Pharmacology Xiangya HospitalCentral South UniversityChangshaP.R.China

Glioblastoma is the most malignant tumor occurring in the human central nervous system with overall median survival time<14.6 months.Current treatments such as chemotherapy and radiotherapy cannot reach an optimal remission since tumor resistance to therapy remains a challenge.Glioblastoma stem cells are considered to be responsible for tumor resistance in treating glioblastoma.Previous studies reported two subtypes,proneural and mesenchymal,of glioblastoma stem cells manifesting different sensitivity to radiotherapy or chemotherapy.Mesenchymal glioblastoma stem cells,as well as tumor cells generate from which,showed resistance to radiochemotherapies.Besides,two metabolic patterns,glutamine or glucose dependent,of mesenchymal glioblastoma stem cells also manifested different sensitivity to radiochemotherapies.Glutamine dependent mesenchymal glioblastoma stem cells are more sensitive to radiotherapy than glucose-dependent ones.Therefore,the transition between proneural and mesenchymal subtypes,or between glutamine-dependent and glucose-dependent,might lead to tumor resistance to radiochemotherapies.Moreover,neural stem cells were also hypothesized to participate in glioblastoma stem cells mediated tumor resistance to radiochemotherapies.In this review,we summarized the basic characteristics,adaptive transition and implications of glioblastoma stem cells in glioblastoma therapy.

关键词： glioblastoma chemotherapy treatment

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领域知识演化分析方法综述

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数据分析与知识发现 2024年第1期8卷 1-15页

作者：李雪思张智雄王宇飞刘熠中国科学院文献情报中心北京100190 中国科学院大学经济与管理学院信息资源管理系北京100190

【目的】领域知识演化分析是图书情报学界长期关注的一个重要研究问题。本文对国内外有关领域知识演化分析方法的研究进行总结梳理,为后续的相关研究提供参考。【文献范围】利用领域知识演化的关键词在CNKI和Web of Science中检索,并对... 详细信息

【目的】领域知识演化分析是图书情报学界长期关注的一个重要研究问题。本文对国内外有关领域知识演化分析方法的研究进行总结梳理,为后续的相关研究提供参考。【文献范围】利用领域知识演化的关键词在CNKI和Web of Science中检索,并对检索结果进行人工判读和分析,选取与领域知识演化分析方法密切相关的84篇重点文献进行综述。【方法】通过回顾研究文献,对领域知识演化的相关概念进行辨析,在此基础上将现有的领域知识演化分析方法分为基于引用、基于结构和基于内容的三类。在对每类分析方法梳理过程中,首先辨析该类方法的理论依据,然后阐述该类方法的基本分析思路并介绍相关进展,最后对现有的领域知识演化分析方法进行总结和展望。【结果】现有的三类领域知识演化分析方法依托于各自的科学理论,借助技术的进步和数据资源的完善,不断深化改进演化分析的思路框架;虽然取得了丰富的研究成果,但并没有在知识演化分析的研究角度上产生突破,无法根本性地解决当前研究视角下的局限性。【局限】基于筛选后的文献进行综述分析,可能未全面覆盖相关的研究工作。【结论】领域知识演化分析的未来研究中有以下两个方向值得重点关注:一是尝试拓展新的领域知识演化分析切入点,二是尝试交叉融合已有的研究方法以改善现有分析方法下的局限。

关键词：领域知识知识演化演化分析

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基于语步识别的科技文献结构化自动综合工具构建

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数据分析与知识发现 2024年第2期8卷 65-73页

作者：刘熠张智雄王宇飞李雪思中国科学院文献情报中心北京100190 中国科学院大学经济与管理学院信息资源管理系北京100190

【目的】借鉴文献综合(Synthesis)的思想,利用人工智能技术构建科技文献结构化自动综合工具,以结构化的形式自动梳理文献集的研究脉络与研究骨架,揭示文献集的要点与看点。【方法】提出了一种基于语步识别的科技文献结构化自动综合工具... 详细信息

【目的】借鉴文献综合(Synthesis)的思想,利用人工智能技术构建科技文献结构化自动综合工具,以结构化的形式自动梳理文献集的研究脉络与研究骨架,揭示文献集的要点与看点。【方法】提出了一种基于语步识别的科技文献结构化自动综合工具的建设思路,即通过语步识别与研究问题、研究方法、研究进展短语抽取,自动揭示单篇文献中的关键知识内容;通过层次聚类与类簇标签生成,实现多篇文献的知识整理归纳;通过设计树形综合结构,指导结构化综合结果输出。【结果】研发了结构化自动综合工具,能够自动综合文献集内容,并按照“研究问题-研究方法-研究进展”的树形结构揭示文献集的研究脉络与骨架。【局限】由于聚类技术的限制,目前还存在聚类准确率不足、聚类簇个数难以确定等问题,影响了自动综合效果。【结论】基于语步识别技术,构建面向实际应用的结构化自动综合工具,支持文献检索、自动综合、结果循证等功能,验证了基于语步识别实现结构化自动综合思路的可行性和有效性。

关键词：科技文献语步识别结构化自动综合短语抽取层次聚类类簇标签生成

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农地流转对农业数字经济发展的影响

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湖南农业大学学报（社会科学版） 2024年第2期25卷 22-29页

作者：谢祎泠刘志雄湖南农业大学经济学院湖南长沙410128 中国政法大学商学院北京100088

基于2014—2021年全国省级面板数据,利用熵值法和固定效应模型,以农业机械化水平为调节变量,分析农地流转对农业数字经济发展的影响。结果表明:从整体上看,中国农业数字经济发展水平呈现良好的增长态势,但呈现出明显的“东高西低”的分... 详细信息

基于2014—2021年全国省级面板数据,利用熵值法和固定效应模型,以农业机械化水平为调节变量,分析农地流转对农业数字经济发展的影响。结果表明:从整体上看,中国农业数字经济发展水平呈现良好的增长态势,但呈现出明显的“东高西低”的分布特征;农地流转能够显著促进农业数字经济发展,且存在显著的空间异质性,具体表现为东部地区农地流转促进了农业数字经济发展,中西部地区为负且不显著;农业机械化水平在农地流转对农业数字经济发展的影响中发挥着正向调节效应。

关键词：农地流转规模经营农业数字经济农业机械化

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Design and experiment of variable rate orchard sprayer based on laser scanning sensor

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International Journal of Agricultural and Biological Engineering 2018年第1期11卷 101-108页

作者： Longlong Li Xiongkui He Jianli Song Yajia liu Aijun Zeng liu Yang Chaohui liu zhixiong liu Center for Chemicals Application Technology(CCAT) College of ScienceChina Agricultural UniversityBeijing 100193China Wuxi Zhongbo Machinery Manufacturing Co. LtdWuxi 214028China Beijing Hualing Feichi Information Technology CO. LTDBeijing 100094China

During different growth periods,canopy size and density in orchards are variable,which need application conditions(flow rate and air flow)to be adjusted to match the canopy’s characteristics.In order to improve orchard sprayer’s automatic operating performance,an automatic variable-rate orchard sprayer(VARS)fixed with 40 electromagnetic valves and 8 brushless fans was developed based on the canopy’s spatial dimensions.Each solenoid valve and brushless motor can be individually adjusted in real-time through pulse width modulation(PWM)signals emitted by a control system to adjust each nozzle’s spout and fan rotation speed.A high-precision laser scanning sensor(light detecting and ranging,LIDAR)was adopted as the detector to measure the canopy volume using the variable rate algorithm principle.Field experiments were conducted in an apple orchard,and conventional air blast sprayer(CABS)and directed air-jet sprayer(DAJS)were tested as a comparison.Results showed that on average,46%less spraying solution was applied compared to conventional applications,while penetration rate was similar to DAJS.Normalized deposition in the canopy with variable application was higher than that of conventional applications,indicating that electronic sprayers are more efficient than conventional sprayers.It was also observed that VARS could significantly reduce off-target loss.The field experiment showed that the newly developed variable-rate sprayer can greatly reduce pesticide use and protect the environment for the orchard fruit production,and also provide a reference for design and performance optimization for plant protection machinery.

关键词： variable rate orchard sprayer spatial dimension air volume flow rate laser scanning sensor precision agriculture

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RCEP成员国数字贸易竞争力测算及影响因素研究

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对外经贸实务 2024年第5期42卷 56-66页

作者：刘志雄刘情广西民族大学广西南宁530007

数字贸易的发展迸发着强大的力量,RCEP的签订与生效为其成员国数字贸易的发展带来了新机遇。文章基于2005—2021年RCEP15个成员国的数字贸易数据,在测算数字贸易综合竞争力的基础上,以迈克尔·波特的“钻石模型”为理论依据,选择9个影... 详细信息

数字贸易的发展迸发着强大的力量,RCEP的签订与生效为其成员国数字贸易的发展带来了新机遇。文章基于2005—2021年RCEP15个成员国的数字贸易数据,在测算数字贸易综合竞争力的基础上,以迈克尔·波特的“钻石模型”为理论依据,选择9个影响数字贸易竞争力的因素,对RCEP数字贸易国际竞争力的影响因素进行实证。结果显示:RCEP成员国数字贸易的规模呈现不断扩大的态势,但整体上竞争力优势不明显,区域成员国内部数字贸易发展不平衡,存在较大差距;信息化设施、城市化水平、数字贸易产业开放度和相关政策对RCEP成员国数字贸易国际竞争力产生显著的积极作用,并且对中日韩澳新五国和东盟十国具有异质性的影响。据此,文章提出积极推进城市化建设、挖掘数字需求消费、扩大数字贸易开放程度、完善数字基础设施和注重RCEP政策优势的建议对策。

关键词： RCEP 数字贸易竞争力影响因素钻石模型

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