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在半金属衬底上四联苯分子的手性自组装

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中国科技论文在线精品论文 2023年第4期16卷 477-487页

作者：邹智星王浩王俊忠西南大学物理科学与技术学院重庆400715

本文利用低温扫描隧道显微镜(low temperature scanning tunneling microscopy,LT-STM)研究了四联苯分子在半金属Bi(111)表面上的超分子手性及其自组装结构。在极低的覆盖度下,四联苯分子形成纳米尺度的分子团簇,团簇中的分子有平躺和... 详细信息

本文利用低温扫描隧道显微镜(low temperature scanning tunneling microscopy,LT-STM)研究了四联苯分子在半金属Bi(111)表面上的超分子手性及其自组装结构。在极低的覆盖度下,四联苯分子形成纳米尺度的分子团簇,团簇中的分子有平躺和侧躺的取向。随着覆盖度的增加,四联苯分子形成多畴的自组装单层结构。自组装单层的基本结构单元是由两个平躺分子和一个侧躺分子构成的三聚体。高分辩的STM图表明,平躺的四联苯分子表现出结构对称性,而侧躺的四联苯分子表现为四个之字形的突起,表明四个苯环之间发生了扭曲,使得三聚体团簇具有超分子手性。有趣的是,在畴区内部相邻两个三聚体的手性相反;在畴界两侧两个三聚体的手性相同,表明同手性的三聚体之间存在空间位阻作用。当覆盖度增加到一个满层,畴界不复存在,整个分子单层形成长程有序的消旋结构。此外,由于分子与半金属衬底之间较弱的相互作用,无论是侧躺的分子还是平躺的分子,都会受到针尖电场的影响发生移动或转动。上述研究结果为理解四联苯分子和半金属之间的相互作用,超分子手性和分子自组装结构之间的关联,以及制备长程有序的界面结构提供了重要信息。

关键词：凝聚态物理超分子手性四联苯自组装扫描隧道显微镜(STM) 分子操纵

Hydrogel platform with tunable stiffness based on magnetic nanoparticles cross-linked GelMA for cartilage regeneration and its intrinsic biomechanism

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Bioactive Materials 2023年第7期25卷 615-628页

作者： Chenchen Zhou Chunli Wang Kang Xu zhixing Niu Shujuan zou Demao Zhang Zhiyong Qian Jinfeng Liao Jing Xie State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu610041China State Key Laboratory of Biotherapy State Key Laboratory and Collaborative Innovation Center of BiotherapyWest China HospitalSichuan UniversityChengdu610041SichuanChina "111"Project Laboratory of Biomechanics and Tissue Repair Bioengineering CollegeChongqing UniversityChongqing400044China College of Pharmacy Hubei University of Chinese MedicineWuhan430065China Department of Cardiology and Endodontics West China Hospital of StomatologySichuan UniversityChengduSichuan610064China

Cartilage injury affects numerous individuals,but the efficient repair of damaged cartilage is still a problem in *** is a potent scaffold candidate for tissue regeneration,but it remains a big challenge to improve its mechanical property and figure out the interaction of chondrocytes and ***,a novel hybrid hydrogel with tunable stiffness was fabricated based on methacrylated gelatin(GelMA)and iron oxide nanoparticles(Fe_(2)O_(3))through chemical *** stiffness of Fe_(2)O_(3)/GelMA hybrid hydrogel was controlled by adjusting the concentration of magnetic *** hydrogel platform with tunable stiffness modulated its cellular properties including cell morphology,microfilaments and Young’s modulus of ***,Fe_(2)O_(3)/GelMA hybrid hydrogel promoted oxidative phosphorylation of mitochondria and facilitated catabolism of lipids in *** a result,more ATP and metabolic materials generated for cellular physiological activities and organelle component replacements in hybrid hydrogel group compared to pure GelMA ***,implantation of Fe_(2)O_(3)/GelMA hybrid hydrogel in the cartilage defect rat model verified its remodeling *** study provides a deep understanding of the bio-mechanism of Fe_(2)O_(3)/GelMA hybrid hydrogel interaction with chondrocytes and indicates the hydrogel platform for further application in tissue engineering.

关键词： Magnetic nanoparticles Hydrogel Chondrocyte Cartilage defect Cellular metabolism

The chromosome-level Hemerocallis citrina Borani genome provides new insights into the rutin biosynthesis and the lack of colchicine

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Horticulture Research 2021年第1期8卷 1200-1209页

作者： zhixing Qing Jinghong Liu Xinxin Yi Xiubin Liu Guoan Hu Jia Lao Wei He Zihui Yang Xiaoyan zou Mengshan Sun Peng Huang Jianguo Zeng Hunan Key Laboratory of Traditional Chinese Veterinary Medicine Hunan Agricultural UniversityChangshaHunan 410128China College of Veterinary Medicine Hunan Agricultural UniversityChangshaHunan 410128China Wuhan Frasergen Bioinformatics Co. LtdWuhanHubei 430075China College of Animal Science and Technology Hunan Agricultural UniversityChangshaHunan 410125China Green Melody Bio-engineering Group Company Limited ChangshaHunan 410329China National and Local Union Engineering Research Center of Veterinary Herbal Medicine Resource and Initiative Hunan Agricultural UniversityChangsha 410128China

Hemerocallis citrina Borani(huang hua cai in Chinese)is an important horticultural crop whose flower buds are widely consumed as a delicious vegetable in *** we assembled a high-quality reference genome of *** using single-molecule sequencing and Hi-C *** genome assembly was 3.77 Gb and consisted of 3183 contigs with a contig N50 of 2.09 Mb,which were further clustered into 11 pseudochromosomes.A larger portion(3.25 Gb or 86.20%)was annotated as a repetitive content and 54,295 protein-coding genes were annotated in the *** evolution analysis showed that *** experienced a recent whole-genome duplication(WGD)event at~15.73 million years ago(Mya),which was the main factor leading to many multiple copies of orthologous *** used this reference genome to predict 20 genes involved in the rutin biosynthesis ***,our metabolomics data revealed neither colchicine nor its precursors in ***,challenging the long-standing belief that this alkaloid causes poisoning by the *** results of our disruptive research are further substantiated by our genomic finding that *** does not contain any genes involved in colchicine *** high-quality genome lays a solid foundation for genetic research and molecular breeding of ***.

关键词： insight alkaloid neither

The Contribution of LTB4/BLT1 Axis to the Progression of Systemic Sclerosis by Regulating Myofibroblast Formation

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The Contribution of LTB4/BLT1 Axis to the Progression of Sys...

Einstein Probe discovery of EP240408a: A peculiar X-ray transient with an intermediate timescale

第十一届全国免疫学学术大会

作者： Liang Minrui Jiaoyan lv zhixing Jiang Yinluo Xiong Rui He Hejian zou Division of Rheumatology Huashan Hospital Institute of Rheumatology Immunology and AllergyFudan University Department of Immunology School of Basic Medical SciencesFudan University Biotherapy Research Center Fudan University

Leukotriene B4(LTB4),a lipid mediator of inflammation,plays a key role in the autoimmune and inflammatory diseases via its high affinity receptor *** is recognized to be critical in the progression of systemic sclerosis(SSc),but the mechanism is still *** aimed to use BLT1-/-mice and BLT1 specific inhibitor to reveal the contribution of LTB4/BLT1 axis to the progression of SSc in a modified SSc-interstitial lung disease(ILD) mouse model by delivering bleomycin(BLM) via an osmotic *** the present study,LTB4 was observed to be up-regulated in the plasma of SSc ***,immunohistochemical analysis demonstrated overexpressions of BLT1 and leukotriene A4 hydrolase(LTA4H),the biosynthetic enzyme for LTB4,in both skin and lung tissues of SSc-ILD *** addition,the levels of BLT1 and LTB4 H were also increasedin the skin and lung tissues of SSc-ILD ***1-/-mice did not manifest the phenotype of SSc following the BLM treatment in the SSc-ILD mouse *** the reduction of α-SMA+ myofibroblasts was also found in the skin and lung tissues of BLT1-/-mice following the administration of BLM,compared with those in wide type ***,the addition of LTB4 was observed to promote fibroblast-myofibroblast transition and endothelial-myofibroblast transition in vitro using primary cell culture,which were reversed by BLT1 *** addition,LTB4 induced phosphorylation of Akt and m TOR in a time dependent manner in fibroblast,also fibroblast-myofibroblast transition induced by LTB4 was blocked by Akt or m TOR ***,LTB4 was not shown to stimulate the release of TGF-β1 in fibroblast,and TGF-β receptor antagonist was not shown to inhibit fibroblast-myofibroblast *** results uncover a possible role for LTB4/BLT1 driven myofibroblast formation in SSc-ILD pathogenesis and identify a pathway that may be amenable to therapeutic targeting.

关键词： Leukotriene B4(LTB4) BLT1 systemic sclerosis(SSc) interstitial lung disease(ILD)

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 222-240页

作者： Wenda Zhang Weimin Yuan zhixing Ling Yong Chen Nanda Rea Arne Rau Zhiming Cai Huaqing Cheng Francesco Coti Zelati Lixin Dai Jingwei Hu Shumei Jia Chichuan Jin Dongyue Li Paul O’Brien Rongfeng Shen Xinwen Shu Shengli Sun Xiaojin Sun Xiaofeng Wang Lei Yang Bing Zhang Chen Zhang Shuang-Nan Zhang Yonghe Zhang Jie An David Buckley Alexis Coleiro Bertrand Cordier Liming Dou Rob Eyles-Ferris Zhou Fan Hua Feng Shaoyu Fu Johan P.U.Fynbo Lluis Galbany Saurabh W.Jha Shuaiqing Jiang Albert Kong Erik Kuulkers Weihua Lei Wenxiong Li Bifang Liu Mingjun Liu Xing Liu Yuan Liu Zhu Liu Chandreyee Maitra Alessio Marino Itumeleng Monageng Kirpal Nandra Jeremy Sanders Roberto Soria Lian Tao Junfeng Wang Song Wang Tinggui Wang Zhongxiang Wang Qingwen Wu Xuefeng Wu Dong Xu Yanjun Xu Suijian Xue Yongquan Xue Zijian Zhang Zipei Zhu Hu zou Congying Bao Fansheng Chen Houlei Chen Tianxiang Chen Wei Chen Yehai Chen Yifan Chen Chenzhou Cui Weiwei Cui Yanfeng Dai Dongwei Fan Ju Guan Dawei Han Dongjie Hou Haibo Hu Maohai Huang Jia Huo Zhenqing Jia Bowen Jiang Ge Jin Chengkui Li Junfei Li Longhui Li Maoshun Li Wei Li Zhengda Li Tianying Lian Congzhan Liu Heyang Liu Huaqiu Liu Fangjun Lu Laidan Luo Jia Ma Xuan Mao Haiwu Pan Xin Pan Liming Song Hui Sun Yunyin Tan Qingjun Tang Yihan Tao Hao Wang Juan Wang Lei Wang Wenxin Wang Yilong Wang Yusa Wang Qinyu Wu Haitao Xu Jingjing Xu Xinpeng Xu Yunfei Xu Zhao Xu Changbin Xue Yulong Xue Ailiang Yan Haonan Yang Xiongtao Yang Yanji Yang Juan Zhang Mo Zhang Wenjie Zhang Zhen Zhang Zhen Zhang Ziliang Zhang Donghua Zhao Haisheng Zhao Xiaofan Zhao Zijian Zhao Hongyan Zhou Yilin Zhou Yuxuan Zhu Zhencai Zhu National Astronomical Observatories Chinese Academy of Sciences School of Astronomy and Space Sciences University of Chinese Academy of Sciences Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Institute of Space Sciences (ICE) CSIC Institut d’Estudis Espacials de Catalunya (IEEC) Max Planck Institute for Extraterrestrial Physics Innovation Academy for Microsatellites Chinese Academy of Sciences Department of Physics University of Hong Kong School of Physics and Astronomy University of Leicester School of Physics and Astronomy Sun Yat-sen University Department of Physics Anhui Normal University Shanghai Institute of Technical Physics Chinese Academy of Sciences Physics Department Tsinghua University Nevada Center for Astrophysics University of Nevada Las Vegas Department of Physics and Astronomy University of Nevada Las Vegas South African Astronomical Observatory Department of Astronomy University of Cape Town Department of Physics University of the Free State Université Paris Cité CNRS Astroparticule et Cosmologie Université Paris Cité CEA Paris-Saclay IRFU/DAp-AIM Department of Astronomy Guangzhou University Cosmic Dawn Center (DAWN) Niels Bohr Institute University of Copenhagen Department of Physics and Astronomy Rutgers the State University of New Jersey Institute for Cosmic Ray Research The University of Tokyo ESA/ESTEC Department of Astronomy School of Physics Huazhong University of Science and Technology INAF-Osservatorio Astrofisico di Torino Sydney Institute for Astronomy School of Physics The University of Sydney Department of Astronomy Xiamen University Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University Department of Astronomy University of Science and Technology School of Astronomy and Space Sciences University of Science and Technology of China Institute of Deep Space Sciences Deep Space Exploration Laboratory Department of Astronomy School of Physics and Astronomy Yunnan University Shanghai Astronomical Observatory Chi

We report the discovery of a peculiar X-ray transient,EP240408a,by Einstein Probe （EP） and follow-up studies made with EP,Swift,NICER,GROND,ATCA and other ground-based multiwavelength *** new transient was first detected with Wide-field X-ray Telescope （WXT） on board EP on April 8th,2024,manifested in an intense yet brief X-ray flare lasting for *** flare reached a peak flux of 3.9×10-9erg cm-2s-1in 0.5-4 ke V,～300 times brighter than the underlying X-ray emission detected throughout the *** and more precise follow-up observations by EP/FXT,Swift and NICER confirmed the finding of this new *** X-ray spectrum is non-thermal in 0.5-10 ke V,with a power-law photon index varying *** X-ray light curve shows a plateau lasting for ～4 d,followed by a steep decay till becoming undetectable ～10 d after the initial *** on its temporal property and constraints from previous EP observations,an unusual timescale in the range of 7-23 d is found for EP240408a,which is intermediate between the commonly found fast and long-term *** counterparts have been found in optical and near-infrared,with the earliest observation at 17 h after the initial X-ray detection,suggestive of intrinsically weak emission in these *** demonstrate that the remarkable properties of EP240408a are inconsistent with any of the transient types known so far,by comparison with,in particular,jetted tidal disruption events,gamma-ray bursts,X-ray binaries and fast blue optical *** nature of EP240408a thus remains an *** suggest that EP240408a may represent a new type of transients with intermediate timescales of the order of～10 *** detection and follow-ups of more of such objects are essential for revealing their origin.

关键词： X-ray transients ${\bm~{Einstein~~Probe}}$

基于频率比与AHP模型的西藏东部地区滑坡易发性评价

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自然灾害学报 2023年第2期32卷 235-242页

作者：邹富宝付卓樊风雷吴华郭治兴西藏大学工学院西藏拉萨850000 西藏大学高原地表环境遥感监测联合实验室西藏拉萨850000 华南师范大学地理科学学院广东广州510631 波密地质灾害教育部野外科学观测研究站西藏林芝860000 广东省科学院生态环境与土壤研究所广东广州510650

滑坡是破坏性极强的自然灾害,因此,对我国高风险滑坡进行快速监测尤为必要。当前,遥感技术为滑坡监测提供了重要的支撑。文中通过选取数字高程数据(digital elevation model, DEM)及衍生数据(坡度、坡向)、断层、地层岩性、地震点等因... 详细信息

滑坡是破坏性极强的自然灾害,因此,对我国高风险滑坡进行快速监测尤为必要。当前,遥感技术为滑坡监测提供了重要的支撑。文中通过选取数字高程数据(digital elevation model, DEM)及衍生数据(坡度、坡向)、断层、地层岩性、地震点等因子开展了西藏东部地区滑坡的评价与等级划分。文中通过对各因子进行归一化处理,运用频率比法和层次分析法(analytic hierarchy process, AHP)对各评价因子进行分析,并获得各因子风险等级的权重系数,进而构建了一个滑坡易发性评价模型(landslide susceptibility assessment, LSA)。结论如下:1)LSA可以很好地表达滑坡空间分布情况;2)据实际滑坡点统计分析,可知西藏东部地区的滑坡主要分布在左贡县、墨脱县、察雅县、洛隆县和丁青县;3)西藏东部地区滑坡高易发区主要分布在道路沿线,中易发区主要分布在西藏东部地区的东北部和西南部,低易发区主要分布在唐古拉山山脉一带。

关键词：滑坡易发性评价频率比法层次分析法西藏东部地区

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TMD控制优化设计及振动台试验研究

土木工程学报 2006年第7期39卷 19-25页

作者：李创第黄天立李暾邹万杰方重林志兴广西工学院广西柳州545006 同济大学上海200092

以Kanai-Tajimi谱作为理论分析和振动台试验的地震激励模型,在运用复模态法获得多自由度带TMD结构随机地震响应解析解的基础上,对TMD结构参数的优化取值问题进行系统的理论与试验研究,运用常规的和基于动力可靠性约束的两种优化设计方法... 详细信息

以Kanai-Tajimi谱作为理论分析和振动台试验的地震激励模型,在运用复模态法获得多自由度带TMD结构随机地震响应解析解的基础上,对TMD结构参数的优化取值问题进行系统的理论与试验研究,运用常规的和基于动力可靠性约束的两种优化设计方法,得出TMD结构的优化参数取值,并通过一个三层2m×2m×6m的大尺度TMD减震结构模型的振动台试验,检验优化设计方法的有效性,该方法可用于基础隔震结构、带TLD减震结构以及带TMD、TLD抗风结构的优化设计。

关键词： TMD 复模态随机地震响应动力可靠性约束的优化设计大型振动台模型试验

扬子板块北缘光雾山地区钾长花岗岩年代学、地球化学特征及构造意义

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矿物岩石 2019年第2期39卷 14-24页

作者：魏国安邹光富潘伟奇罗茂金马志鑫毛琼余学磊河南建筑职业技术学院河南郑州450000 中国地质调查局成都地质调查中心四川成都610081 成都理工大学四川成都610059 华北油田研究院河北任丘062252

为了限定扬子板块北缘地区新元古代岩浆活动事件的准确时间及和探讨岩石成因,本文对出露于四川省南江县光雾山钾长花岗岩进行了LA-ICP-MS锆石U-Pb定年和岩石地球化学研究。结果表明光雾山地区钾长花岗岩锆石U-Pb年龄为836.3Ma±8.3Ma,... 详细信息

为了限定扬子板块北缘地区新元古代岩浆活动事件的准确时间及和探讨岩石成因,本文对出露于四川省南江县光雾山钾长花岗岩进行了LA-ICP-MS锆石U-Pb定年和岩石地球化学研究。结果表明光雾山地区钾长花岗岩锆石U-Pb年龄为836.3Ma±8.3Ma,属于新元古代花岗岩。岩石具有高w(SiO2)(72.68%~78.10%),w(K2O)(4.26%~5.32%),w(Na2O)(1.68%~3.38%),相对富钾(K2O/Na2O=1.12~2.54),高碱(w(Na2O+K2O)=7.64%~8.99%),低P2O5含量等特征,铝饱和指数A/CNK=0.99~1.49,光雾山花岗岩属于过铝质高钾钙碱性花岗岩。岩石具有轻稀土元素相对富集,重稀土元素亏损的特征,具有明显Eu负异常,δEu为0.48~0.73。光雾山花岗岩微量元素表现出Rb,Th,K,Nd,Sm元素富集,Ba,Nb,Ta,Sr,P,Ti元素亏损的特点。地球化学研究表明,光雾山钾长花岗岩主要以粘土岩部分熔融为主及少部分含粘土的变质杂砂岩部分熔融形成的。岩浆可能来源于本区结晶基底新太古界-古元古界后河岩群和褶皱基底中-新元古界火地亚群中深变质岩为代表的地壳物质的部分熔融产物,为壳源成因类型,具有岛弧型花岗岩特征,形成于岛弧构造环境。光雾山钾长花岗岩的形成是新元古界时期扬子板块与华北板块之间的俯冲碰撞、岛弧形成构造演化过程中使区域地壳不断加厚和地壳深融作用的响应。扬子陆块北缘南江地区约836Ma同碰撞岛弧型钾长花岗岩的发现,表明该地区在约836Ma时为Rodinia超大陆汇聚形成阶段,此时期该区Rodinia超大陆尚未进入大陆裂解阶段。

关键词：钾长花岗岩锆石U-Pb定年地球化学光雾山扬子板块北缘

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硬皮病鉴别诊断

上海医药 2017年第Z1期38卷 -页

作者：梁敏锐姜智星邹和建黄琼复旦大学附属华山医院风湿免疫科复旦大学风湿、免疫、过敏性疾病研究中心复旦大学附属华山医院皮肤科上海 200040

硬皮病(系统性硬化症)是一种少见的多脏器受累的系统性自身免疫性疾病,以皮肤纤维化为特征表现.许多疾病临床上也可表现为皮肤变硬和组织纤维化,易与硬皮病混淆.本文强调皮肤病理对硬皮病鉴别诊断的重要性,综述了成人硬肿病、硬化性黏... 详细信息

硬皮病(系统性硬化症)是一种少见的多脏器受累的系统性自身免疫性疾病,以皮肤纤维化为特征表现.许多疾病临床上也可表现为皮肤变硬和组织纤维化,易与硬皮病混淆.本文强调皮肤病理对硬皮病鉴别诊断的重要性,综述了成人硬肿病、硬化性黏液水肿、嗜酸性筋膜炎、慢性移植物抗宿主病、肾源性系统性纤维化、硬化萎缩性苔藓和僵硬皮肤综合征等硬皮病类似疾病的临床表现、病因、病理形态和治疗方法.

关键词：硬皮病系统性硬化症鉴别诊断