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Comparative Study on Different Methods for Prediction of Thermal Insulation Performance of Thermal Barrier Coating Used on Turbine Blades

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Journal of Thermal Science 2024年第1期33卷 172-189页

作者： zhang zhixin ZENG Wu zhang Xiaodong ZENG Yuntao Advanced Gas Turbine Laboratory Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China Key Laboratory of Advanced Energy and Power Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China Innovation Academy for Light-duty Gas Turbine Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

As turbine inlet temperature gets higher and higher,thermal barrier coating(TBC) is more and more widely used in turbine *** turbine blades with TBC,it is of great significance to evaluate the temperature distribution of its substrate metal quickly and accurately,especially during the design *** different degrees of simplification such as whether to consider the change of the geometric size of the fluid domain by TBC and whether to consider the planar heat conduction in TBC,three different methods used in conjugate heat transfer(CHT) simulation to model the TBC of the turbine blades have been developed and widely used by ***,little research has been conducted to investigate the influence of the three methods on the temperature distribution of turbine *** fill this gap,three geometric models were *** are a solid conduction model with a substrate metal layer and a TBC layer,a transonic turbine vane with internal cooling and TBC,and a plate cylindrical film hole cooling model with *** methods were used in these geometric models and their differences were carefully analyzed and *** result shows that for the conduction model used in this paper,with the same TBC surface temperature distribution,the difference between the three methods is very small and can be *** a transonic turbine vane with internal cooling,regarding the local maximum temperature of the substrate-TBC interface,the largest difference between the method in which TBC is considered as a thermal resistance or a virtual layer of cells and the method in which three-dimensional heat conduction equation of TBC is solved occurs at the trailing *** difference near the leading edge is below *** employed to the film cooling model,the difference of the laterally averaged temperature of the substrate-TBC interface can be 8 K which is mainly due to the change of the length to diameter ratio of the film cooling hole by *** the substrate

关键词： turbine blade thermal barrier coating conjugate heat transfer film cooling hole

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Current observation and analysis based on mooring systems in the Andaman Sea

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Journal of Oceanology and Limnology 2024年第2期42卷 484-491页

作者： Yimeng WANG Jingsong GUO Dapeng QU zhixin zhang Chalermrat SANGMANEE Varintha VASINAMEKHIN Binghuo GUO First Institute of Oceanography and Key Laboratory of Marine Science and Numerical ModelingMinistry of Natural ResourcesQingdao 266061China Laboratory for Regional Oceanography and Numerical Modeling Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Shandong Key Laboratory of Marine Science and Numerical Modeling Qingdao 266061China Phuket Marine Biological Center Department of Marine and Coastal ResourcesPhuket 83000Thailand Marine and Coastal Resources Research&Development Institute Department of Marine and Coastal ResourcesBangkok 10210Thailand

The basic structure and intraseasonal evolution of currents in the southeastern Andaman Sea was analyzed based on data collected in 2017 from two subsurface moorings(C1 and C5).Periodic variation in the upper ocean currents of the Andaman Sea was investigated by combining observational and satellite *** observations show that rapid changes of current speed and direction occurred in May and June,with a significant increase in current velocity at the C1 *** the second half of the year,southward flow dominated at the C1 mooring,and alternating northward and southward flows were evident at the C5 mooring during the same period but the northward flow prevailed in boreal *** addition,analysis of the power spectra of the upper currents revealed that the tidal period at both moorings is primarily semidiurnal with weaker energy than that of the low-frequency *** upper ocean currents at the C1 and C5 moorings exhibited intraseasonal variation of 30-60 d and 120 d,while the zonal current at the C1 mooring exhibited a notable period of approximately 180 *** analysis indicated that the variability of currents in the Andaman Sea is influenced primarily by equatorial Kelvin waves and Rossby wave ***,our results suggest that equatorial Kelvin waves from the eastern Indian Ocean entered the Andaman Sea in the form of Wyrtki Jets and propagated primarily along two distinct pathways during the observation *** addition to coastal boundary Kelvin waves,it was found that a branch of the Wyrtki Jet that directly enters the Andaman Sea and flows northward along the slope of the continental shelf,and reflected Rossby wave packets by topography.

关键词： mooring observation Wyrtki Jet Rossby waves intraseasonal variation

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IL-13/IL-13RA2 signaling promotes colorectal cancer stem cell tumorigenesis by inducing ubiquitinated degradation of p53

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Genes & Diseases 2024年第1期11卷 495-508页

作者： Baoyu He Jing Liang Qianqian Qin Yuqin zhang Shuo Shi Jinghe Cao zhixin zhang Qingli Bie Rou Zhao Li Wei Baogui zhang Bin zhang Department of Laboratory Medicine Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJiningShandong 272000China Postdoctoral Mobile Station of Shandong University of Traditional Chinese Medicine JinanShandong 250355China Department of Reproductive Medicine Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJiningShandong 272000China Department of Gastrointestinal Surgery Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJiningShandong 272000China Institute of Forensic Medicine and Laboratory Medicine Jining Medical UniversityJiningShandong 272067China

Cancer stem cells(CSCs)are considered tumor-initiating cells and the main drivers of disease *** these rare cancer cells,however,remains challenging with respect to therapeutic ***,we report the up-regulation of IL-13RA2 expression in colorectal cancer(CRC)tissues and spheroid *** expression of IL-13RA2 was positively correlated with canonical stemness markers in *** further demonstrated that the level of IL-13 was up-regulated in the serum of CRC ***,recombinant IL-13(rIL13)stimulation promoted the sphere formation,proliferation,and migration of CRC cells in vitro and enhanced tumorigenesis in *** phenotype could be reversed by knocking down ***,IL-13 activated autophagy by inducing LC3I/LC3II transformation in CRC-CSCs,which was crucial for the biological functions of *** further demonstrated that IL-13RA2 acted as a modular link of the E3 ligase UBE3C and the substrate p53 protein,enhancing the interaction of UBE3C and p53,thereby inducing the K48-linked ubiquitination of *** conclusion,the IL-13/IL-13RA2 signaling cascade promotes CRC-CSC self-renewal and tumorigenesis by inducing p53 ubiquitination,adding an important layer to the connection between IL-13 and p53,which can be translated into novel targeted therapies.

关键词： Autophagy Colorectal cancer stem cells IL-13/IL-13RA2 signaling p53

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IL13RA2 promotes progression of infantile haemangioma by activating glycolysis and the Wnt/β-catenin signaling pathway

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Oncology Research 2024年第9期32卷 1453-1465页

作者： ZIYONG LIU TAO MA JINFANG LI WEI REN zhixin zhang Department of Cardiothoracic Surgery 970th Hospital of the People’s Liberation ArmyWeihai264209China Department of Cardiac Ultrasound Weihai Municipal HospitalWeihai264200China

Background:Interleukin 13 receptor subunit alpha 2(IL13RA2)plays an essential role in the progression of many ***,the role of IL13RA2 in infantile haemangioma(IH)is still *** and Methods:IL13RA2 expression in IH tissues was analyzed using western blot,qRT-PCR,and *** role of IL13RA2 in haemangioma-derived endothelial cells(HemECs)was determined following knockdown or overexpression of IL13RA2 using CCK-8,colony formation,apoptosis,wound healing,tubule formation,Transwell,and western ***:IL13RA2 expression was upregulated in IH ***13RA2 overexpression promoted proliferation,migration,and invasion of HemECs and induced glycolysis,which was confirmed with a glycolysis ***,IL13RA2 interacted withβ-catenin and activated the Wnt/β-catenin pathway in HemECs,which were involved in the above-mentioned effects of ***:These findings revealed that targeting IL13RA2 is a potential therapeutic approach for IH.

关键词： Infantile haemangioma IL13RA2 Glycolysis Wnt/β-catenin pathway

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The“depict”strategy for discovering new compounds in complex matrices:Lycibarbarspermidines as a case

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Journal of Pharmaceutical Analysis 2024年第3期14卷 416-426页

作者： Chen Han zhixin zhang Zhiyang Feng Chuanjia Zhai Xuejiao Li Yulian Shi Xiang Li Miao Li Ying Wang Gan Luo Xiaoyan Gao Department of Chinese Medicine Analysis School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing102488China

The comprehensive detection and identification of active ingredients in complex matrices is a crucial *** chromatography coupled with high-resolution mass spectrometry(LC-HRMS)is the most prominent analytical platform for the exploration of novel active compounds from complex ***,the LC-HRMS-based analysis workflow suffers from several bottleneck issues,such as trace content of target compounds,limited acquisition for fragment information,and uncertainty in interpreting relevant MS2 *** are vital antioxidant active ingredients in Lycii Fructus,while the reported structures are merely focused on dicaffeoylspermidines due to their low *** comprehensively detect the new structures of lycibarbarspermidine derivatives,a“depict”strategy was developed in this ***,potential new lycibarbarspermidine derivatives were designed according to the biosynthetic pathway,and a comprehensive database was established,which enlarged the coverage of lycibarbarspermidine ***,the polarity-oriented sample preparation of potential new compounds increased the concentration of the target ***,the construction of the molecular network based on the fragmentation pathway of lycibarbarspermidine derivatives broadened the comprehensiveness of ***,the weak response signals were captured by data-dependent scanning(DDA)followed by parallel reaction monitoring(PRM),and the efficiency of acquiring MS2 fragment ions of target compounds was significantly *** on the integrated strategy above,210 lycibarbarspermidine derivatives were detected and identified from Lycii Fructus,and in particular,170 potential new compounds were structurally *** integrated strategy improved the sensitivity of detection and the coverage of low-response components,and it is expected to be a promising pipeline for discovering new compounds.

关键词： Mass spectrometric detection Weak response signals Complex matrices Novel lycibarbarspermidines

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Incorporating physiological knowledge into correlative species distribution models minimizes bias introduced by the choice of calibration area

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Marine Life Science & Technology 2024年第2期6卷 349-362页

作者： zhixin zhang Jinxin Zhou Jorge García Molinos Stefano Mammola Ákos Bede‑Fazekas Xiao Feng Daisuke Kitazawa Jorge Assis Tianlong Qiu Qiang Lin CAS Key Laboratory of Tropical Marine Bio-resources and Ecology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Guangdong Provincial Key Laboratory of Applied Marine Biology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Marine Biodiversity and Ecological Evolution Research Center South China Sea Institute of OceanologyGuangzhou 510301China Global Ocean and Climate Research Center South China Sea Institute of OceanologyGuangzhou 510301China Institute of Industrial Science The University of Tokyo5-1-5 KashiwanohaKashiwaChiba 277-8574Japan Arctic Research Center Hokkaido UniversitySapporoHokkaido 001-0021Japan Finnish Museum of Natural History University of HelsinkiHelsinkiFinland Molecular Ecology Group(MEG) Water Research Institute(IRSA)National Research Council of Italy(CNR)28922 Verbania PallanzaItaly National Biodiversity Future Center(NBFC) PalermoItaly Institute of Ecology and Botany HUN-REN Centre for Ecological ResearchVácrátótHungary Department of Environmental and Landscape Geography ELTE Eötvös Loránd UniversityBudapestHungary Department of Biology University of North CarolinaChapel HillNC 27599USA Centre of Marine Sciences University of AlgarveCampus de GambelasFaroPortugal CAS Key Laboratory of Experimental Marine Biology Institute of OceanologyChinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China

Correlative species distribution models(SDMs)are important tools to estimate species’geographic distribution across space and time,but their reliability heavily relies on the availability and quality of occurrence *** can be biased when occurrences do not fully represent the environmental requirement of a *** tested to what extent species’physiological knowledge might influence SDM *** on the Japanese sea cucumber Apostichopus japonicus within the coastal ocean of East Asia,we compiled a comprehensive dataset of occurrence *** then explored the importance of incorporating physiological knowledge into SDMs by calibrating two types of correlative SDMs:a naïve model that solely depends on environmental correlates,and a physiologically informed model that further incorporates physiological information as *** further tested the models’sensitivity to calibration area choices by fitting them with different buffered areas around known *** with naïve models,the physiologically informed models successfully captured the negative influence of high temperature on *** and were less sensitive to the choice of calibration *** naïve models resulted in more optimistic prediction of the changes of potential distributions under climate change(i.e.,larger range expansion and less contraction)than the physiologically informed *** findings highlight benefits from incorporating physiological information into correlative SDMs,namely mitigating the uncertainties associated with the choice of calibration *** these promising features,we encourage future SDM studies to consider species physi-ological information where available.

关键词： Bayesian approach Climate change Habitat suitability Physiological knowledge Species distribution model

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共同富裕背景下社区教育高质量发展的作用机制、现实壁垒和破解之道

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教育与职业 2024年第2期1050卷 78-84页

作者：张志欣常州工学院师范学院江苏常州213022

在驱动经济高质量发展、实现共同富裕的过程中,社区教育发挥着重要作用。当前,社区教育公平机制尚未健全,社区教育服务供需矛盾突出,社区教育品质有待提升,多元主体协同共治格局尚未形成,成为阻滞社区教育高质量发展的壁垒。社区教育应... 详细信息

在驱动经济高质量发展、实现共同富裕的过程中,社区教育发挥着重要作用。当前,社区教育公平机制尚未健全,社区教育服务供需矛盾突出,社区教育品质有待提升,多元主体协同共治格局尚未形成,成为阻滞社区教育高质量发展的壁垒。社区教育应基于共同富裕战略目标:匡正教育失衡,打通高质量社区教育助力共同富裕的“最后一公里”;加大教育供给,践行高质量社区教育助力共同富裕的新使命;提升教育品质,筑牢高质量社区教育助力共同富裕的根基;优化协同共治,构建高质量社区教育助力共同富裕的“共同体”。

关键词：共同富裕社区教育高质量发展

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中国特色管理学理论研究的现实反思和破局而立

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当代经济管理 2024年第2期46卷 41-54页

作者：张志鑫钱晨清华大学经济管理学院北京100084

当前中国管理理论发展滞后于现实管理实践,发展中国特色管理学理论是我国管理学者的时代使命和重要任务。研究系统回顾西方管理理论的发展进程,将其总结为“科学严谨性与实践相关性”“实证主义与后实证主义”“普适性与情境化”之争鸣... 详细信息

当前中国管理理论发展滞后于现实管理实践,发展中国特色管理学理论是我国管理学者的时代使命和重要任务。研究系统回顾西方管理理论的发展进程,将其总结为“科学严谨性与实践相关性”“实证主义与后实证主义”“普适性与情境化”之争鸣。基于此,阐述中国管理理论研究面临的两个突出问题,即科学精神的缺失和主体间性的解耦。从历史视角深入探讨“和”文化、“人性”文化和“义利”文化是构建中国管理理论的文化基因,通过引入“鞍钢宪法”探讨其对国外管理思想的超越以及对中国管理理论的启示。最后,指出中国特色管理理论研究的总体对策思路,包括蓄势学术自信、架梁话语体系、反躬中国实践和弘扬科学精神。

关键词：中国管理理论情境文化基因实证主义科学精神

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创新要素集聚对农业绿色技术进步空间溢出效应分析

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生态经济 2024年第1期40卷 103-110页

作者：张志新妙丽英山东理工大学经济学院山东淄博095138

基于2010—2020年中国31个省份的面板数据,采用空间杜宾模型实证分析创新要素集聚对农业绿色技术进步的空间溢出效应。研究结果表明:从全国来看,创新要素集聚对农业绿色技术进步的影响具有明显正向空间溢出效应,不仅驱动本地农业绿色技... 详细信息

基于2010—2020年中国31个省份的面板数据,采用空间杜宾模型实证分析创新要素集聚对农业绿色技术进步的空间溢出效应。研究结果表明:从全国来看,创新要素集聚对农业绿色技术进步的影响具有明显正向空间溢出效应,不仅驱动本地农业绿色技术进步,还推动邻近地区农业绿色技术进步。创新要素集聚对农业绿色技术进步的空间溢出效应以短期效应为主。从区域来看,沿海、内陆地区创新要素集聚对农业绿色技术进步具有明显空间溢出效应,而沿边地区空间溢出效应不明显。对此,可改善创新要素引入制度、优化地区间创新要素互动机制、构建区域间农业绿色技术进步成果互通平台,持续促进农业绿色技术进步,以实现农业农村可持续发展。

关键词：创新要素集聚农业绿色技术进步空间溢出效应短期效应

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基于LDA与共现网络动态分析的技术机会识别

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科研管理 2024年第2期45卷 176-188页

作者：王金凤张芷芯冯立杰张珂郑州大学管理学院河南郑州450001 上海海事大学中国(上海)自贸区供应链研究院上海201306 上海海事大学物流工程学院上海201306 郑州大学信息管理学院河南郑州450001

直面未来科技发展的高度不确定性以及技术复杂性不断叠加的外部环境,亟须采用科学高效的分析方法识别技术创新机会。为此,本文从专利文本挖掘与关键词共现网络融合的动态分析视角构建了技术机会识别路径。首先,进行专利数据的获取及预处... 详细信息

直面未来科技发展的高度不确定性以及技术复杂性不断叠加的外部环境,亟须采用科学高效的分析方法识别技术创新机会。为此,本文从专利文本挖掘与关键词共现网络融合的动态分析视角构建了技术机会识别路径。首先,进行专利数据的获取及预处理,进而运用LDA模型提取具象领域的技术主题及关键词,并引入TF-IDF指标进行重要度分析;其次,分别构建技术关键词整体共现网络和基于技术主题的包含时间窗口的关键词共现子网络;再次,基于共现强度分析及共现网络动态分析探究技术主题及关键词的演化过程,以此将关键词划分为持续型、衰退型、新兴型和舍弃型等4种类型,进而识别出具有发展潜力的技术机会;最后,以无人船为例,识别了动力技术主题、姿态测量技术主题和定位导航技术主题中路径规划、传感器等持续型的技术机会和激光雷达、惯性导航等新兴型的技术机会。本文不仅弥补了静态共现网络难以揭示技术领域动态演化过程的局限性,而且避免了在创新过程中掩盖或误判一些技术机会的问题,为企业高效识别技术创新机会提供了可资借鉴的决策参考依据。

关键词：技术机会识别 LDA模型共现网络动态分析无人船

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