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Nonvolatile and reconfigurable two-terminal electro-optic duplex memristor based on III-nitride semiconductors

Light(Science & Applications) 2024年第4期13卷 706-716页

作者： zhiwei xie Ke Jiang Shanli Zhang Jianwei Ben Mingrui Liu Shunpeng Lv Yang Chen Yuping Jia Xiaojuan Sun Dabing Li State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesDongnanhu Road No.3888Changchun 130033China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesYuquan Road No.19100049 BeijingChina These authors contributed equally:Zhiwei XieKe Jiang

With the fast development of artificial intelligence(AI),Internet of things(IOT),etc,there is an urgent need for the technology that can efficiently recognize,store and process a staggering amount of information.The AlScN material has unique advantages including immense remnant polarization,superior temperature stability and good latticematch to other III-nitrides,making it easy to integrate with the existing advanced III-nitrides material and device technologies.However,due to the large band-gap,strong coercive field,and low photo-generated carrier generation and separation efficiency,it is difficult for AlScN itself to accumulate enough photo-generated carriers at the surface/interface to induce polarization inversion,limiting its application in in-memory sensing and computing.In this work,an electro-optic duplex memristor on a GaN/AlScN hetero-structure based Schottky diode has been realized.This twoterminal memristor shows good electrical and opto-electrical nonvolatility and reconfigurability.For both electrical and opto-electrical modes,the current on/off ratio can reach the magnitude of 104,and the resistance states can be effectively reset,written and long-termly stored.Based on this device,the“IMP”truth table and the logic“False”can be successfully reproduced,indicating the huge potential of the device in the field of in-memory sensing and computing.

关键词： polarization duplex limiting

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Intake of tobacco nitrosamines of smokers in various provinces of China and their cancer risk:A meta-analysis

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Journal of Environmental Sciences 2024年第7期141卷 249-260页

作者： Xiao Li zhiwei Ye Jun Wang Pengfei Lin Xiaojin Zhang Shuguang xie Chao Chen Research Institute for Environmental Innovation(Suzhou) TsinghuaSuzhouJiangsu 215163China State Key Joint Laboratory of Environmental Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China Shenzhen Key Laboratory of Organic Pollution Prevention and Control State Key Laboratory of Urban Water Resource and EnvironmentHarbin Institute of TechnologyShenzhen 518055China State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Science and EngineeringPeking UniversityBeijing 100871China

Nitrosamines are a class of carcinogens which have been detected widely in food,water,some pharmaceuticals as well as tobacco.The objectives of this paper include reviewing the basic information on tobacco consumption and nitrosamine contents,and assessing the health risks of tobacco nitrosamines exposure to Chinese smokers.We searched the publications in English from“Web of Science”and those in Chinese from the“China National Knowledge Infrastructure”in 2022 and collected 151 literatures with valid information.The content of main nitrosamines in tobacco,including 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone(NNK),N-nitrosonornicotine(NNN),N-nitrosoanatabine(NAT),N-nitrosoanabasine(NAB),total tobacco-specific nitrosamines(TSNA),and N-nitrosodimethylamine(NDMA)were summarized.The information of daily tobacco consumption of smokers in 30 provinces of China was also collected.Then,the intakes of NNN,NNK,NAT,NAB,TSNAs,and NDMA via tobacco smoke were estimated as 1534ng/day,591 ng/day,685 ng/day,81 ng/day,2543 ng/day,and 484 ng/day by adult smokers in30 provinces,respectively.The cancer risk(CR)values for NNN and NNK inhalation intake were further calculated as 1.44×10^(-5)and 1.95×10^(-4).The CR value for NDMA intake via tobacco smoke(inhalation:1.66×10^(-4))indicates that NDMA is similarly dangerous in tobacco smoke when compared with the TSNAs.In China,the CR values caused by average nitrosamines intake via various exposures and their order can be estimated as the following:smoke(3.75×10^(-4))>food(1.74×10^(-4))>drinking water(1.38×10^(-5)).Smokers in China averagely suffer 200%of extra cancer risk caused by nitrosamines in tobacco when compared with non-smokers.

关键词： N-nitrosamine Tobacco Cancer risk Tobacco specific nitrosamines(TSNAs) N-nitrosodimethylamine(NDMA)

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Rational design of biodegradable semiconducting polymer nanoparticles for NIR-II fluorescence imaging-guided photodynamic therapy

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Nano Research 2024年第6期17卷 5399-5408页

作者： Xuxuan Gu Jinlong Shen zhiwei Xu Wenqi Wang Ying Wu Wen Zhou Chen xie Quli Fan State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Nanjing University of Posts&Telecommunications9 Wenyuan RoadNanjing 210023China

Semiconducting polymer nanoparticles(SPNs)have shown great promise in second near-infrared window(NIR-II)phototheranostics.However,the issue of long metabolic time significantly restricts the clinical application of SPNs.In this study,we rationally designed a biodegradable SPN(BSPN50)for NIR-II fluorescence imaging-guided photodynamic therapy(PDT).BSPN50 is prepared by encapsulating a biodegradable SP(BSP50)with an amphiphilic copolymer F-127.BSP50 is composed of NIR-II fluorescent diketopyrrolopyrrole(DPP)segment and degradable poly(phenylenevinylene)(PPV)segment with the ratio of 50/50.BSPN50 has both satisfactory degradability under myeloperoxidase(MPO)/hydrogen peroxide(H_(2)O_(2))and NIR-II fluorescence emission upon 808 nm laser excitation.Furthermore,BSPN50 shows good photodynamic efficacy under 808 nm laser irradiation.BSPN50 shows a faster degradation rate than BSPN100 which has no PPV segment both in vitro and in vivo.In addition,BSPN50 can effectively diagnose tumor via NIR-II fluorescence imaging and inhibit the tumor growth by PDT.Thus,our study provides a rational approach to construct biodegradable nanoplatforms for efficient tumor NIR-II phototheranostics.

关键词： near-infrared(NIR)-II fluorescence imaging semiconducting polymer nanoparticles photodynamic therapy tumor imaging

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A proteomic landscape of pharmacologic perturbations for functional relevance

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Journal of Pharmaceutical Analysis 2024年第1期14卷 128-139页

作者： zhiwei Liu Shangwen Jiang Bingbing Hao Shuyu xie Yingluo Liu Yuqi Huang Heng Xu Cheng Luo Min Huang Minjia Tan Jun-Yu Xu State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing210023China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesZhongshanGuangdong528400China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing210023China

Pharmacological perturbation studies based on protein-level signatures are fundamental for drug discovery. In the present study, we used a mass spectrometry (MS)-based proteomic platform to profile the whole proteome of the breast cancer MCF7 cell line under stress induced by 78 bioactive compounds. The integrated analysis of perturbed signal abundance revealed the connectivity between phenotypic behaviors and molecular features in cancer cells. Our data showed functional relevance in exploring the novel pharmacological activity of phenolic xanthohumol, as well as the noncanonical targets of clinically approved tamoxifen, lovastatin, and their derivatives. Furthermore, the rational design of synergistic inhibition using a combination of histone methyltransferase and topoisomerase was identified based on their complementary drug fingerprints. This study provides rich resources for the proteomic landscape of drug responses for precision therapeutic medicine.

关键词： Proteomics Drug Perturbation Drug target Drug combination

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Tackling application limitations of high-safetyγ-butyrolactone electrolytes:Exploring mechanisms and proposing solutions

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Journal of Energy Chemistry 2024年第6期93卷 193-201,I0005页

作者： Haojun Wu Zhangyating xie Guanjie Li Lei Zheng zhiwei Zhao Jiarong He Yanbin Shen Jiahao Hu Zhangquan Peng Guiming Zhong Lidan Xing Weishan Li School of Chemistry South China Normal UniversityGuangzhou 510006GuangdongChina National and Local Joint Engineering Research Center of MPTES in High Energy and Safety LIBs Engineering Research Center of MTEES(Ministry of Education)Research Center of BMET(Guangdong Province)and Key Lab.of ETESPG(GHEI)South China Normal UniversityGuangzhou 510006GuangdongChina Laboratory of Advanced Spectroelectrochemistry and Li-ion Batteries Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina i-Lab CAS Center for Excellence in NanoscienceSuzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of SciencesSuzhou 215123JiangsuChina School of Chemical Engineering Faculty of SciencesEngineering and TechnologyThe University of AdelaideSA 5005Australia

Developing wide-temperature and high-safety lithium-ion batteries(LIBs)presents significant challenges attributed to the absence of suitable solvents possessing broad liquid range and non-flammability properties.γ-Butyrolactone(GBL)has emerged as a promising solvent;however,its incompatibility with graphite anode has hindered its application.This limitation necessitates a comprehensive investigation into the underlying mechanisms and potential solutions.In this study,we achieve a molecular-level understanding of the perplexing interphase formation process by employing in-situ spectroelectrochemical techniques and density function calculations.Our findings reveal that,even at high salt concentrations,GBL consistently occupies the primary Li^(+)solvation sheath,leading to extensive GBL decomposition and the formation of a high-impedance and inorganic-poor solid-electrolyte interphase(SEI)layer.Contrary to manipulating solvation structures,our research demonstrates that the utilization of filmforming additives with higher reduction potential facilitates the pre-establishment of a robust SEI film on the graphite anode.This approach effectively inhibits GBL decomposition and significantly enhances the battery's lifespan.This study provides the first reported intrinsic understanding of the unique GBLgraphite incompatibility and offers valuable insights for the development of wide-temperature and high-safety LIBs.

关键词： γ-Butyrolactone/Graphite incompatibility Unique solvation structure SEI film Lithium-ion batteries

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The highly selective catalytic hydrogenation of CO_(2)to CO over transition metal nitrides

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Chinese Journal of Chemical Engineering 2022年第3期35卷 248-254页

作者： Yichao Wu zhiwei xie Xiaofeng Gao Xian Zhou Yangzhi Xu Shurui Fan Siyu Yao Xiaonian Li Lili Lin Institute of Industrial Catalysis State Key Laboratory of Green Chemistry Synthesis TechnologyCollege of Chemical EngineeringZhejiang University of TechnologyHangzhou 310014China Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China

Three transition metal-like facet centered cubic structured transition metal nitrides,γ-Mo_(2)N,β-W_(2)N andδ-NbN,are synthesized and applied in the reaction of CO_(2)hydrogenation to CO.Among the three nitride catalysts,theγ-Mo_(2)N exhibits superior activity to target product CO,which is 4.6 and 76 times higher than the other two counterparts ofβ-W_(2)N andδ-NbN at 600℃,respectively.Additionally,γ-Mo_(2)N exhibits excellent stability on both cyclic heating-cooling and high space velocity steady state operation.The deactivation degree of cyclic heating-cooling evaluation after 5 cycles and long-term stability performance at 773 and 873 K in 50 h are all less than 10%.In-situ XRD and kinetic studies suggest that theγ-Mo_(2)N itself is able to activate both of the reactants CO_(2)and H_(2).Below 400℃,the reaction mainly occurs at the surface ofγ-Mo_(2)N catalyst.CO_(2)and H_(2)competitively adsorbe on the surface of catalyst and CO_(2)is the relatively stronger surface adsorbate.At a higher temperature,the interstitial vacancies of theγ-Mo_(2)N can be reversibly filled with the oxygen from CO_(2)dissociation.Both of the surface and bulk phase sites ofγ-Mo_(2)N participate in the high temperature CO_(2)hydrogenation pathway.

关键词： Carbon dioxide Chemical reaction Catalysis Reverse water gas shift(RWGS)reaction Transition metal nitride In-situ X-ray diffraction characterization

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Harpoon-shaped topological photonic crystal for on-chip beam splitter

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Science China(Physics,Mechanics & Astronomy) 2024年

作者： zhiwei Guan Ruixue Dou Chuangxin xie Tianyimei Zuo Liyu Huang Keyin Wen Chaofeng Wang Huapeng Ye Junmin Liu Ze Dong Dianyuan Fan Shuqing Chen Institute of Microscale Optoelectronics Shenzhen University College of Physics and Engineering Technology Minzu Normal University of Xingyi Guangdong Provincial Key Laboratory of Optical Information Materials and Technology and Institute of Electronic Paper Displays South China Academy of Advanced Optoelectronics South China Normal University College of New Materials and New Energies Shenzhen Technology University School of Information and Electronics Beijing Institute of Technology

The advancement of integrated optical communication networks necessitates the deployment of on-chip beam splitters for efficient signal interconnections at network nodes. However, the pursuit of micron-scale beam splitting with large corners and reducing the device footprint to boost connection flexibility often results in phase mismatches. These mismatches, which stem from radiation modes and backward scattering, pose significant obstacles in creating highly integrated and interference-resistant connections. To address this, we introduce a solution based on the topological valley-contrasting state generated by photonic crystals with opposing valley Chern numbers, manifested in a harpoon-shaped structure designed to steer the splitting channels.This approach enables adiabatic mode field evolution over large corners, capitalizing on the robust phase modulation capabilities and topological protection provided by the subwavelength-scale valley-contrasting state. Our demonstration reveals that beam splitters with large corners of 60°, 90°, and 120°exhibit insertion loss fluctuations below 2.7 dB while maintaining a minimal footprint of 8.8μm×8.8μm. As a practical demonstration, these devices facilitate three-channel signal connections, successfully transmitting quadrature phase shift keying signals at 3.66 Tbit/s with bit error rates below the forward error correction threshold, demonstrating performance comparable to that in defects scenarios. By harnessing the unidirectional excitation feature, we anticipate significant enhancements in the capabilities of signal distribution and connection networks through a daisy chain configuration.

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MpbR,an essential transcriptional factor for Mycobacterium tuberculosis survival in the host,modulates PIM biosynthesis and reduces innate immune responses

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Journal of Genetics and Genomics 2019年第12期46卷 575-589页

作者： Yugang Li Weihui Li zhiwei xie Hui Xu Zheng-Guo He National Key Laboratory of Agricultural Microbiology College of Life Science and TechnologyHuazhong Agricultural UniversityWuhan430070China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi UniversityNanning530004China

Mycobacterium tuberculosis possesses unique cellular envelope components that contribute to bacterial escape from host immune surveillance.Phosphatidylinositol mannosides(PIMs)and their higher derivatives are important molecules implicated in host-pathogen interactions in the course of tuberculosis.However,the biosynthetic regulation of these specific lipids and its effect on the bacterial fate in the infected host remain unclear.Here,we show that a hypothetical M.tuberculosis transcriptional factor designated as MpbR negatively regulates two transporter genes and affects mycobacterial PIM biosynthesis and biofilm formation.MpbR inhibits the accumulation of acylated PIM lipids and triggers the mycobacterium to reduce the production of reactive oxygen species and NO during infection,which enhances the survival of M.tuberculosis in macrophages.MpbR deletion reduces M.tuberculosis lung burdens and inflammation of infected mice.These findings provide new insights into the regulation of mycobacterial lipid metabolism and its correlation with pathogenesis of M.tuberculosis.

关键词： Mycobacterium tuberculosis Transcriptional factor Lipid metabolism

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风机荷载作用下频率比对砂土动力响应的影响

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同济大学学报（自然科学版） 2024年第5期52卷 738-748页

作者：张艳贾敏才蒋明镜谢志伟同济大学土木工程学院上海200092 同济大学岩土及地下工程教育部重点实验室上海200092 同济大学土木工程防灾减灾全国重点实验室上海200092 苏州科技大学土木工程学院江苏苏州215009

海上风机在运行过程中风荷载与波浪荷载频率耦合作用对土体动力特性的影响不容忽略,为了探究这种影响,采用多向循环动单剪系统(VDDCSS)对砂土进行了一系列试验研究,分析了双向剪切频率比f_(r)对砂土动应变、动孔压比以及动强度的影响。... 详细信息

海上风机在运行过程中风荷载与波浪荷载频率耦合作用对土体动力特性的影响不容忽略,为了探究这种影响,采用多向循环动单剪系统(VDDCSS)对砂土进行了一系列试验研究,分析了双向剪切频率比f_(r)对砂土动应变、动孔压比以及动强度的影响。试验结果表明:剪应变发展受双向频率耦合及应力组合效应的影响。循环应力比(C_(SR))为0.15时,双向频率耦合效应大于应力组合作用;随着应力水平的增加(C_(SR)=0.20或0.25),频率耦合效应和应力组合作用均得到了加强。在低应力水平时,破坏试样的孔压曲线呈“上凹型”且频率比对试样孔压发展影响不大。而随着应力水平增加(C_(SR)=0.20或0.25),孔压最终值u_(max)随之增大。除f_(r)=1.00与10.00对应试样外,土体动强度随f_(r)与C_(SR)值增大而减少。f_(r)=5.00对应试样应变大、孔压值高、强度低的原因与此比值下土体受双向频率耦合与应力组合的叠加效果增强有关。

关键词：循环单剪频率比动应变动孔压动强度

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面向简化规则的集成学习模型及规则约简策略

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计算机应用研究 2024年第6期41卷 1743-1748页

作者：张纬之韩珣谢志伟石胜飞哈尔滨工业大学计算学部哈尔滨150001 智能警务四川省重点实验室四川泸州646000 四川警察学院道路交通管理系四川泸州646000 黑龙江农垦职业学院哈尔滨150025

随着机器学习模型的广泛应用,研究者们逐渐认识到这类方法的局限之处。这些模型大多数为黑盒模型,导致其可解释性较差。为了解决这一问题,以集成学习模型为基础,提出了一种基于规则的可解释模型以及规则约简方法,包括生成优化的随机森... 详细信息

随着机器学习模型的广泛应用,研究者们逐渐认识到这类方法的局限之处。这些模型大多数为黑盒模型,导致其可解释性较差。为了解决这一问题,以集成学习模型为基础,提出了一种基于规则的可解释模型以及规则约简方法,包括生成优化的随机森林模型、冗余规则的发现和约简等步骤。首先,提出了一种随机森林模型的评价方法,并基于强化学习的思想对随机森林模型的关键参数进行了优化,得到了更具可解释性的随机森林模型。其次,对随机森林模型中提取的规则集进行了冗余消除,得到了更加精简的规则集。在公开数据集上的实验结果表明,生成的规则集在预测准确率和可解释性方面均表现优秀。

关键词：可解释模型规则学习集成学习规则约简

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