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Study on the Role and Mechanisms of Interstitial Protein-Periostin in the Diagnosis and Treatment of Malignant Tumors

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Study on the Role and Mechanisms of Interstitial Protein-Per...

2016年浙江省医学会耳鼻咽喉头颈外科学学术年会

作者： Dong Ye zhisen Shen Shijie Qiu Qun Li Guoli Wang Department of Otorhinolaryngology-Head and Neck Surgery Lihuili Hospital of Ningbo University

Invasion and metastasis are the major characteristics of malignant tumors,which is a complex process involving multiple *** regulation is a precise,large and complicated biological control system,and its concrete mechanisms are not yet fully *** specific genes are expressed by mesenchymal cells mainly,and its expression products are molecules with various structures and functions,including secreted proteins and extracellular matrix *** gene is a newly identified mesenchymal specific gene and is an extracellular matrix secreted *** has special biological structures and features,which enable it to bind to various subtypes of integrin receptors on the surface of cell membrane,trigger relevant signal transduction pathway,change the survival microenvironment of cancer cells to facilitate their survival,invasion,metastasis,angiogenesis and enhance the tolerance to hypoxia and chemicals,therefore it’s closely related to the grade of malignancy,invasion and prognosis of malignant *** in-depth study of periostin,it is expected to be an ideal marker for the diagnosis and prognosis of tumors,as well as provide novel target for its treatment.

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塔河凝析气井井筒积液判断标准

断块油气田 2009年第3期16卷 68-69,92页

作者：刘志森长江大学油气钻采工程湖北省重点实验室湖北荆州434023

由于凝析气藏流体性质的特殊性,反凝析和气液分离常常造成井筒积液,严重影响气井产能。利用塔河凝析气井井筒积液前后的生产动态变化,求出了判断气井是否积液的临界动能因子,由此进一步计算出了各区块井的临界流量,并与李闽公式计算的... 详细信息

由于凝析气藏流体性质的特殊性,反凝析和气液分离常常造成井筒积液,严重影响气井产能。利用塔河凝析气井井筒积液前后的生产动态变化,求出了判断气井是否积液的临界动能因子,由此进一步计算出了各区块井的临界流量,并与李闽公式计算的结果和现场实际进行了对比,在此基础上结合实测流压梯度曲线,提出了塔河凝析气井井筒积液的判断标准。

关键词：动能因子临界流量井筒积液

Lamellar organic-inorganic architecture via screw growth

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Lamellar organic-inorganic architecture via screw growth

第十六届全国晶体生长与材料学术会议

作者： Yan Quan Halei Zhai zhisen Zhang Xurong Xu Ruikang Tang Centre for Biomaterials and Biopathways Department of Chemistry and State Key Laboratory of Silicon MaterialsZhejiang University Qiushi Academy for Advanced Studies Zhejiang University

The fabrication of organic-inorganic composites with well-defined lamellar internal structure is of great interest in current material *** by the biomineralization of nacre,we find that organic-inorganic lamellar hybrid can be achieved spontaneously and readily by using classical screw growth,which is well-described by Burton-Cabrera-Frank(BCF) theory for

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Long non-coding RNA Profiling in Laryngeal Squamous Cell Carcinoma and its Clinical Significance:Potential Biomarkers for LSCC

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Long non-coding RNA Profiling in Laryngeal Squamous Cell Car...

2014年浙江省医学会耳鼻咽喉头颈外科学学术年会

作者： zhisen Shen Qun Li Hongxia Deng Dakai Lu Haojun Song Junming Guo

Long non-coding RNAs(lncRNAs)are novel transcripts that may play important roles in *** study aimed to resolve the lncRNA profile of larynx squamous cell carcinoma(LSCC)and to determine its clinical *** global lncRNA expression profile in LSCC tissues was measured by lncRNA *** expressed lncRNAs were identified and levels of AC026166.2-001 and RP11-169D4.1-001lncRNAs in 87 LSCC samples and paired adjacent normal tissue were analyzed by real-time quantitative reverse transcriptase-polymerase chain reaction(qRT-PCR).The clinical significance of these lncRNAs in laryngeal cancer was analyzed and survival data were estimated by the Kaplan-Meier method and the logrank test.A receiver operating characteristic(ROC)curve was constructed to check the diagnostic *** lncRNA expression profile of tumor samples,684 lncRNAs were upregulated and 747 lncRNAs were downregulated(fold-change>2.0).Of these,AC026166.2-001 and RP11-169D4.1-001 were distinctly dysregulated.,with AC026166.2-001 exhibiting lower expression in cancer tissues and RP11-169D4.1-001higher *** verified that both AC026166.2-001 and RP11-169D4.1-001 were expressed at a lower level in cervical lymph nodes compared with paired laryngeal cancer tissues and paired normal ***11-169D4.1-001 levels were positively correlated with lymph node metastasis(P=0.007).From the survival analysis,decreased levels of AC026166.2-001 and RP11-169D4.1-001 were associated with poorer *** area under the ROC curve was up to 0.65 and 0.67,respectively,and the cut-off point of ACt was 11.23 and 10.53,***026166.2-001 and RP11-169D4.1-001 may act as novel biomarkers in LSCC and may be potential therapeutic targets for LSCC *** AC026166.2-001 and RP11-169D4.1-001 could be independent prognostic factors for survival in LSCC.

关键词： laryngeal cancer lncRNA expression profile AC026166.2-001 RP11-169D4.1-001

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传统聚落仪式空间及其当代社区适应性研究

建筑学报 2016年第12期 118-119页

作者：林志森

本研究拟通过整体性研究、量化研究弥补以往研究的不足。整体性体现从“社会一空间过程”角度完整认识中国传统聚落形态仪式空间；量化研究体现在TGIS数据库的数据存储、管理、提取、分析的研究过程和研究成果上，以期对聚落形态与社区... 详细信息

本研究拟通过整体性研究、量化研究弥补以往研究的不足。整体性体现从“社会一空间过程”角度完整认识中国传统聚落形态仪式空间；量化研究体现在TGIS数据库的数据存储、管理、提取、分析的研究过程和研究成果上，以期对聚落形态与社区结构相关性及其仪式空间类型进行数字化表达。建立时空数据模型及数据库等．实现研究手段和研究方法的延展与创新。

关键词：空间过程传统聚落社区适应性 GIS数据库时空数据模型聚落形态结构相关性

STUDIES ON THE ORGANOSILICON REACTIVE INTERMEDIATES——Ⅳ.GENERATION AND REACTION OF CYCLOPROPYLPHENYLSILYLENE BY PHOTOCHEMICAL METHOD

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有机化学 1986年第6期 430-431页

作者： Wu Shihui Xiao Fei Tao Fenggang Lin zhisen Department of Chemistry,Fudan University,Shanghai

In the chemistry of silylene and carbene,owing to the special abilities of cyclo-propyl containing silylenes and carbenes,they have attracted many organic *** carbene chemistry,the ring-expansion and fragmentation of cycloprop-ylphenylcarbene gave out the cyclobutene derivative and alkyne and *** to find out the reaction products of its counterpart silylene,the cyclopropylp-henylsilylene was investigated.

关键词： organosilicon compound reactive intermediate photocbemistry

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机械自动变速(AMT)系统选挂挡过程控制

机械传动 2014年第9期38卷 52-54页

作者：张志森四川文理学院物理与机电工程学院四川达州635000

对机械自动变速系统的选挂挡过程控制进行研究,应用二次线性最优控制器,对选挂挡机构驱动电机位置进行控制设计,完成控制算法与程序开发。在此基础上,应用相应的试验台架进行换挡过程验证。结果表明,在二次线性最优控制器控制条件下,AM... 详细信息

对机械自动变速系统的选挂挡过程控制进行研究,应用二次线性最优控制器,对选挂挡机构驱动电机位置进行控制设计,完成控制算法与程序开发。在此基础上,应用相应的试验台架进行换挡过程验证。结果表明,在二次线性最优控制器控制条件下,AMT系统的换挡过程可靠、挡位跟随迅速。

关键词：机械自动变速电机建模最优控制台架试验

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不同分散剂对SiC晶须分散作用的探讨

材料导报 2005年第12期19卷 121-123页

作者：李绍纯戴长虹牛志森杨辉浙江大学材料与化学工程学院杭州310027 青岛理工大学土木工程学院青岛266033 山东淄博益泰电瓷股份有限公司淄博255129

利用离心沉降分光光度法对 SiC 晶须在4种不同分散剂中的分散行为进行了研究,探讨了不同分散剂的分散效果,并对其分散机理进行了分析。结果表明,分散剂的分散能力顺序为焦磷酸钠>六偏磷酸钠>吐温80>聚乙二醇;不同类型分散剂混合使用的... 详细信息

利用离心沉降分光光度法对 SiC 晶须在4种不同分散剂中的分散行为进行了研究,探讨了不同分散剂的分散效果,并对其分散机理进行了分析。结果表明,分散剂的分散能力顺序为焦磷酸钠>六偏磷酸钠>吐温80>聚乙二醇;不同类型分散剂混合使用的分散效果要比使用1种分散剂的好。

关键词： SiC晶须分散剂分光光度法

Application of EGF for regeneration of tympanic membrane perforation:a meta-analysis of randomized controlled trials

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Application of EGF for regeneration of tympanic membrane per...

2019年浙江省医学会耳鼻咽喉头颈外科学学术大会

作者： Yi Shen Xu Yao Yi Hu Juntao Huang Yuyuan Zhang zhisen Shen Department of Otolaryngology Head and Neck Surgery Ningbo Medical Center of Lihuili HospitalThe Affiliated Hospital of Ningbo University School of Medicine Ningbo University

Objectives:To investigate the effectiveness of epidermal growth factor(EGF) versus placebo or no intervention in the treatment of tympanic membrane(TM) perforations from randomized controlled trials(RCTs).Methods:PubMed,EMBASE,Cochrane,Wanfang and CNKI databases were screened from their inceptions to June ***-analysis was performed to calculate the data via RevMan version 5.3 and STATA ***:Our meta-analysis has revealed that the application of EGF can significantly enhance the closure rate(RR=1.23,95 CI% [1.13,1.33],P<0.01,I=38%) as well as shorten the healing time for TM regeneration(SMD=-1.63,95 CI% [-1.90,-1.36],P<0.01,I=0%).In terms of hearing improvement,the evidence is limited(SMD=0.22,95 CI% [-0.1,0.53],P=0.18,I=0%).Conclusions:EGF is effective for patients with tympanic membrane perforations due to its ease,availability and safety.

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