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Journal of Genetics and Genomics 2024年第5期51卷 574-577页

作者： Jierong Wang Yuxi Peng Yiwen Xu zhiru li Gangming Zhan Zhensheng Kang Jing Zhao College of Plant Protection Northwest A&F UniversityYanglingShaanxi 712100China State Key Laboratory of Crop Stress Biology for Arid Areas Northwest A&F UniversityYanglingShaanxi 712100China College of life Science Northwest A&F UniversityYanglingShaanxi 712100China

The obligate biotrophic basidiomycete fungus Puccinia striformis ***(Pst)is the causative agent of wheat stripe(yellow)rust,a disease that results in severe damage to global wheat production(Chen and Kang,2017).This pathogen has a mixed reproductive mode encompassing both asexual and sexual *** asexual stage is accomplished by reinfecting wheat with urediniospores,while the sexual cycle involves five different spore types and two phylogenetically unrelated plant hosts wheat,which is the primary host,and barberry,which is the alternate host(Zhao et al.,2016).This extremely complex lifecycle facilitates large genetic variation among Pst populations,which is conducive to the emergence of new virulent races that can overcome wheat resistance genes,resulting in epidemics(Chen and Kang,2017).Secreted effector proteins,the key virulence factors in fungal pathogens,can not only suppress plant immune systems but also trigger host immune responses following recognition by plant receptors(Toruno et al.,2016).

关键词： Puccinia overcome wheat

肝移植术后患儿腹内高压的发生现状及危险因素分析

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中华护理杂志 2024年第12期59卷 1484-1489页

作者：卢芳燕戴燕红李志茹吉莉王燕王华芬浙江大学医学院附属第一医院护理部杭州市310003 浙江大学医学院附属第一医院肝移植中心杭州市310003

目的了解肝移植术后患儿腹内高压的发生现状,分析其危险因素,为临床医护人员早期识别高风险患儿,并制订肝移植术后患儿腹内高压预防和干预方案提供参考。方法该研究为前瞻性队列研究,连续选取2021年10月—2023年6月在浙江省某三级甲等... 详细信息

目的了解肝移植术后患儿腹内高压的发生现状,分析其危险因素,为临床医护人员早期识别高风险患儿,并制订肝移植术后患儿腹内高压预防和干预方案提供参考。方法该研究为前瞻性队列研究,连续选取2021年10月—2023年6月在浙江省某三级甲等医院肝移植中心接受肝移植手术的208例患儿作为调查对象,收集相关临床资料,采用经尿道膀胱测压法测量腹内压,描述其肝移植术后腹内高压的情况并进行分组,将腹内压≥10 mmHg(1 mmHg=0.133 kPa)作为腹内高压组,<10 mmHg作为非腹内高压组,采用单因素及Logistic回归分析筛选患儿发生腹内高压的危险因素。结果208例肝移植术后患儿中,51例(24.52%)发生腹内高压,其中12例(23.53%)为Ⅰ~Ⅱ级,39例(76.47%)为Ⅲ~Ⅳ级。Logistic回归分析结果显示,移植肝重量与受体体重比(OR=1.391)、术后机械通气时间(OR=1.006)、术后中心静脉压(OR=1.375)是肝移植术后患儿发生腹内高压的影响因素(P<0.05)。结论肝移植术后患儿腹内高压发生率高,移植肝重量与受体体重比大、术后机械通气时间长、术后中心静脉压高的患儿发生腹内高压的风险较高,临床医护人员应密切关注高风险患儿,加强腹内压的动态监测并及时干预,从而减少腹内高压的发生,改善患儿预后。

关键词：器官移植腹内高压危险因素儿科护理学

护士主导的肝移植患儿腹内压管理方案的构建及应用研究

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中华护理杂志 2024年第19期59卷 2319-2325页

作者：李志茹卢芳燕吉莉戴燕红张婉莹王华芬浙江大学医学院附属第一医院护理部杭州市310003 浙江大学医学院附属第一医院肝移植中心杭州市310003

目的构建护士主导的肝移植患儿腹内压管理方案,并探讨其应用效果。方法通过文献回顾、半结构式访谈和专家会议论证,构建护士主导的肝移植患儿腹内压管理方案。采用方便抽样法,选择2023年1月—12月浙江省某三级甲等医院肝移植ICU收治的16... 详细信息

目的构建护士主导的肝移植患儿腹内压管理方案,并探讨其应用效果。方法通过文献回顾、半结构式访谈和专家会议论证,构建护士主导的肝移植患儿腹内压管理方案。采用方便抽样法,选择2023年1月—12月浙江省某三级甲等医院肝移植ICU收治的162例患儿作为研究对象,按手术时间顺序分为试验组和对照组,将手术时间为2023年7月—12月的患儿作为试验组,将2023年1月—6月的患儿作为对照组。试验组在常规护理的基础上,采用护士主导的肝移植患儿腹内压管理方案进行干预;对照组采用肝移植术后常规护理。比较两组在ICU住院期间的平均腹内压、腹内高压发生率和分级、机械通气时长和ICU住院时长。结果护士主导的肝移植患儿腹内压管理方案包含4个一级条目、10个二级条目和20个三级条目。在方案应用过程中,共脱落4例,最终试验组纳入78例、对照组纳入80例。干预后,试验组在ICU住院期间的平均腹内压为(8.63±2.40)mmHg(1 mmHg=0.133 kPa),对照组为(9.23±3.19)mmHg,两组比较,差异无统计学意义(P=0.186);试验组腹内高压发生率为23.07%,对照组为41.25%,两组比较,差异具有统计学意义(P=0.015);试验组13例(16.67%)为I级腹内高压、5例(6.41%)为Ⅱ级,对照组22例(27.50%)为Ⅰ级腹内高压、9例(11.25%)为Ⅱ级、2例(2.50%)为Ⅲ级,两组比较,差异均无统计学差异(P>0.05);试验组机械通气时长为3.00(1.00,13.25)h,对照组为7.50(1.00,27.75)h,两组比较,差异具有统计学意义(P=0.034);试验组ICU住院时长为6.00(4.00,8.25)d,对照组为5.00(3.00,8.00)d,两组比较,差异无统计学意义(P=0.061)。结论该研究构建的护士主导的肝移植患儿腹内压管理方案具有科学性及实用性,实施该方案可有效降低患儿腹内高压的发生率、缩短机械通气时长。

关键词：肝移植腹内压护士儿科护理学

ICU感控护士在医院感染防控中的专业价值及启示

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中国护理管理 2024年第1期24卷 18-23页

作者：王华芬翁峰霞桑明卫建华李志茹浙江大学医学院附属第一医院护理部杭州市310003 浙江大学医学院附属第一医院外科监护室杭州市310003

通过对ICU感控护士的发展现状、5种专业价值角色(教育者、管理者、联络者、监测者、研究者)进行综述,提出发展我国ICU感控护士的思考与启示,包括重视其临床价值,明确其角色及职能,完善其培训和考核体系,从而为未来我国的感控护理人才队... 详细信息

通过对ICU感控护士的发展现状、5种专业价值角色(教育者、管理者、联络者、监测者、研究者)进行综述,提出发展我国ICU感控护士的思考与启示,包括重视其临床价值,明确其角色及职能,完善其培训和考核体系,从而为未来我国的感控护理人才队伍建设提供借鉴,更好地发挥ICU感控护士在医院感染防控中的作用,以期为有效降低ICU感染的发生率,改善ICU患者生存结局提供依据,进一步引领我国医院感染防控走向专业化的发展轨道。

关键词：重症监护室感控护士医院感染专业价值综述

Imitating trumpet shells: Mbius container molecules

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Science China Chemistry 2011年第3期54卷 454-460页

作者： MA Fang WANG FangFang li zhiru WU Di li ZeSheng GU FengLong State Key Laboratory of Theoretical and Computational Chemistry Institute of Theoretical Chemistry Jilin University Changchun 130023 China Department of Chemistry Huaibei Normal University Anhui 235000 China Center for Computational Quantum Chemistry South China Normal University Guangzhou 510631 China

Mbius container molecules C64H8,C60N4H4,and C58N6H2 with topological one-sided characteristics were constructed at the first time by imitating natural trumpet *** structure is an open cage with an inner hexagonal *** bridge joints the outer and inner surfaces of the cage to form a new one-sided Mbius *** optimized structures of the three molecules in the singlet(the ground state),triplet and quintet states are obtained using the density functional theory(B3LYP).For the ground state structures of the three Mbius molecules,their oxidizabilities are weaker than that of the C60 and reducibilities are close to that of the stable C80 cage and slightly stronger than that of the *** may show that the unusual Mbius structures have some *** potential properties were predicted,for example,the special aromaticity of the bridge ring due to the unique interaction between the bridge and the cage *** findings enlarge the knowledge of Mbius molecules. The idea of bionic and topological imitating in chemistry may promote the design of new complex-shaped nano-molecules and molecular devices.

关键词： aromaticity density functional calculation IR spectroscopy Mbius strip molecular container

A covalent attraction between two molecular cation TTF·^+

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Science China Chemistry 2009年第11期52卷 1980-1986页

作者： WANG FangFang WANG Yi WANG BingQiang WANG YinFeng MA Fang li zhiru State Key Laboratory of Theoretical and Computational Chemistry Institute of Theoretical ChemistryJilin UniversityChangchun 130023China Basic Course of Public Security Department China Criminal Police UniversityShenyang 110035China

The optimized structure of the tetrathiafulvalence radical-cation dimer(TTF·+-TTF·+) with all-real frequencies is obtained at MP2/6-311G level,which exhibits the attraction between two molecular cation TTF·+.The new attraction interaction is a 20-center-2-electron intermolecular covalent π /π bonding with a telescope *** covalent π /π bonding has the bonding energy of about -21 kcal·mol-1 and is concealed by the Coulombic repulsion between two TTF·+ *** intermolecular covalent attraction also influences the structure of the TTF·+ subunit,i.e.,its molecular plane is bent by an angle θ=5.6°.This work provides new knowledge on intermolecular interaction.

关键词： radical-cation dimmer attraction between cations intermolecular interaction π /π bonding TTF

儿科重症监护护士腹内压监测知信行的现状调查

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International Journal of Nursing Sciences 2024年第3期11卷 381-386,I0005页

作者：李志茹卢芳燕戴燕红盛美君苏丽丹姚萍王华芬 Department of Nursing The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Surgical Intensive Care Unit Children’s HospitalZhejiang University School of MedicineHangzhouChina Pediatric Intensive Care Unit The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Pediatric Intensive Care Unit Huzhou Central HospitalHuzhouChina

目的旨在评估儿科重症监护护士对腹内压监测的知识、态度和实践现状及培训需求,为临床制订相关培训方案和操作流程提供参考依据。方法采用横断面调查法。2023年4月-6月选取浙江省8所三级甲等医院212名儿科重症监护护士为研究对象。采用... 详细信息

目的旨在评估儿科重症监护护士对腹内压监测的知识、态度和实践现状及培训需求,为临床制订相关培训方案和操作流程提供参考依据。方法采用横断面调查法。2023年4月-6月选取浙江省8所三级甲等医院212名儿科重症监护护士为研究对象。采用自行编制的腹内压监测知信行评估问卷进行调查,包括知识(14个条目)、态度(6个条目)和实践(8个条目)3个维度,共28个条目。结果护士问卷总分为(60.73±8.35)分;知识维度得分为(7.84±2.35)分,得分率为56.0%;态度维度得分为(25.16±3.23)分,得分率为83.9%;实践维度得分为(28.44±6.46)分,得分率为69.3%。接受过腹内压监测培训的护士问卷总分、知识和行为维度得分均高于未接受培训的护士;年龄≤30岁的护士知识维度得分高于年龄>30岁的护士(P<0.05)。55.7%的护士认为目前的知识不足以有效地进行腹内压监测。难以识别腹内高压高危人群(64.6%)、不熟悉腹内压测量的操作流程(55.6%)和护患比分配不合理(52.8%)是护士实施腹内压监测的主要障碍因素。结论儿科重症监护护士对腹内压监测持积极的态度,但其知识水平和实践行为仍有待加强,特别是对已发表的共识定义、腹内压测量方法和监测频率方面的知识是不充分的。护理管理人员要根据护士的培训需求和实施腹内压监测的潜在障碍因素,实施针对性的腹内压监测培训方案,以促进腹内压监测的标准化和科学性。

关键词：态度重症监护室腹内压知识监测护理人员儿科行为

重症监护过渡期患儿父母照护体验质性研究的Meta整合

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中华急危重症护理杂志 2024年第4期5卷 327-334页

作者：吴静韵卢芳燕王华芬鲍瑞洁李志茹饶雨欣浙江大学医学院附属第一医院护理部杭州市310003 浙江大学医学院附属第一医院肝胆胰外科杭州市310052

目的系统评价儿童重症监护过渡期父母照护体验,为制订改善父母照护体验的护理干预策略提供参考。方法计算机检索国内外相关数据库中关于儿童重症监护过渡期父母照护体验的质性研究,检索时限为建库至2023年5月12日。根据澳大利亚乔安娜... 详细信息

目的系统评价儿童重症监护过渡期父母照护体验,为制订改善父母照护体验的护理干预策略提供参考。方法计算机检索国内外相关数据库中关于儿童重症监护过渡期父母照护体验的质性研究,检索时限为建库至2023年5月12日。根据澳大利亚乔安娜布里格斯研究所循证卫生保健中心质性研究质量评价工具进行文献评价,采用汇集性整合法对提取结果进行归纳和整合。结果共纳入10篇文献,提炼出53个研究结果,归纳为10个新类别,形成4个整合结果:过渡期间的双重情感体验交织、应对儿童重症监护过渡期的多重变化、患儿父母寻求多维度的社会支持系统、儿童重症监护过渡期的照护信息不足。结论在患儿从重症监护室转至普通病房的过渡期中,护理人员应加强与患儿父母的沟通,疏导其负性情绪,多渠道满足父母的照护需求,以提升父母的照护能力,保障患儿及其父母顺利过渡。

关键词：重症监护室儿童照护体验 Meta整合质性研究循证护理学

Combinational use of Trabectedin and Pegylated liposomal Doxorubicin for Recurrent Ovarian Cancer:A Meta-analysis of Phase Ⅲ Randomized Controlled Trials

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Combinational use of Trabectedin and Pegylated Liposomal Dox...

Exploring causality with biliary atresia at different levels:two-sample Mendelian randomization study

2022CCTB中国肿瘤标志物学术大会暨中国整合肿瘤学大会暨第十六届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者： Chao li zhiru li Sichuan Qionglai Medical Center Hospital

Background:In recent years,pegylated liposomal doxorubicin(PLD) has been used to improve the survival of patients with ovarian cancer;however,it is unclear whether the combinational use of PLD with other drugs is more ***,this study aimed to evaluate the efficacy and safety of trabectedin combined with PLD in treating recurrent ovarian cancer by ***:PubMed,Medical literature Analysis and Retrieval System Online(MEDliNE),Excerpta Medica Database(EMBASE),Cochrane library clinical controlled trials(CENTRAL) and *** databases were searched to retrieve all potentially eligible clinical trials as of May 15,*** hazard ratios(HRs),risk ratios,and 95%confidence intervals(CIs) were calculated using Review Manager software 5.4(RevMan5.4).Results:A total of 1248 patients with recurrent ovarian cancer from two phase Ⅲ randomized control trials were included in the *** results revealed that trabectedin combined with PLD chemotherapy significantly improved overall survival(OS) in patients with BRCA-mutated recurrence(HR,0.49;95% CI,[0.33-0.73];p= 0.0004) and in patients with platinum-sensitive recurrence whose platinum-free interval(PFI) was 6-12 months(HR,0.66;95% CI,[0.52-0.84];p= 0.0005).In addition,progression-free survival(PFS) was significantly improved in patients with recurrent ovarian cancer compared with PLD alone(HR,0.86;95% CI,[0.74-0.99];p= 0.03);PFS was significantly improved in patients with BRCA gene-mutated recurrence(HR,0.58;95% CI,[0.40-0.58];p = 0.004),and in patients with platinum-sensitive recurrence(HR,0.73;95% CI,[0.56-0.95];p = 0.02).Trabectedin combined with PLD was more prone to grade 3-4 toxic side effects than PLD alone(p<0.05);however,fatal adverse events related to non-toxic side effects ***:Trabectedin combined with PLD significantly improves OS and PFS in patients with BRCA-mutated and/or platinum-sensitive recurrent ovarian *** potential use of trabecte

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World Journal of Pediatric Surgery 2024年第2期7卷 150-157页

作者： Shaowen liu Jiayinaxi Musha zhiru Wang Xueting Wang Tengfei li Jianghua Zhan Clinical School of Paediatrics Tianjin Medical UniversityTianjinChina Department of General Surgery Tianjin Children's HospitalTianjinChina Urumqi City First People's Hospital(Urumqi Children's Hospital) UrumqiChina

Background In recent years,Mendelian randomization(MR)has been widely used to infer causality of related disease risk ***,this strategy has not been applied to biliary atresia(BA).Methods Genome-wide association studies(GWAS)data of 41 inflammatory cytokines,731 immune cell traits,and 1400 metabolites were obtained from public databases as exposure *** outcome information was obtained from a GWAS meta-analysis of 499 children with BA and 1928 normal *** variance weighting was the primary causality *** Q-test,MR-Egger intercept,MR pleiotropy residual sum and outlier,and'leave-one-out'analyses were used for sensitivity *** MR,MR-Steiger,and linkage Disequilibrium Score were used to exclude the effects of reverse causality,genetic association,and linkage *** MR results showed that a total of seven traits had potential causal relationships with BA,including three inflammatory cytokines:eotaxin(odds ratio(OR)=1.45,95%confidence interval(CI):1.08 to 1.95,pFDR=0.18),G-CSF(OR=4.21,95%CI:1.75 to 10.13,pFDR=0.05)and MCP-1/MCAF(OR=1.53,95%CI:1.12 to 2.10,pFDR=0.14);three immune cell traits:CD8dim NKT/T cells ratio(OR=0.59,95%CI:0.45 to 0.77,pFDR=0.06),CD8dim NKT counts(OR=0.58,95%CI:0.43 to 0.78,pFDR=0.06),CD8dim NKT/lymphocyte ratio(OR=0.63,95%CI:0.49 to 0.81,pFDR=0.06);one metabolite:X-12261 levels(OR=2.86,95%CI:1.73 to 4.74,pFDR=0.06).Conclusions In this study,eotaxin,G-CSF,MCP-1/MCAF,and X-12261 levels were shown to be risk factors for ***,CD8dim NKT/T cells ratio,CD8dim NKT counts,and CD8dim NKT/lymphocyte ratio were protective factors for *** findings provided a promising genetic basis for the etiology,diagnosis,and treatment of BA.

关键词： protective analysis. diagnosis