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Measurements and characteristics of Al_(2)O_(3):Cr^(3+) coating for the proton beam imaging system

Radiation Detection Technology and Methods 2017年第1期1卷 54-60页

作者： zhirong zeng Quanzhi Yu Shaohong Wei Bin Zhou Quan Ji Tianjiao Liang Yuanbo Chen Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Dongguan Neutron Science Center Dongguan 523803China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of ScienceBeijing 100190China

Introduction To set up an online proton beam diagnostic system near the neutron production target of China Spallation Neutron Source(CSNS),a luminescence coating sprayed on the target windowand a corresponding optic system were *** the work,the fabrication of Al_(2)O_(3):Cr^(3+) coating was *** on the sprayed samples were performed to analyze the characteristics of the Al_(2)O_(3):Cr^(3+) *** and tests of coating samples Three kinds of powders with different Cr concentrations were used to fabricate the luminescence coating *** flame spraying,plasma spraying and D-gun spraying processes were ***(PL),X-ray diffraction(XRD),scanned electron mirror(SEM)and radioluminescence experiment by 300 MeV deuterium beam were carried out to analyze and characterize the *** The emission spectrum excited by 532-nm laser has two obvious peaks at 692.9 nm and 694.3 *** samples by flame spraying process with the powders obtained from melting method show higher luminescence intensity than the samples by plasma spraying *** is observed that the luminescence intensity has some relationships with the alpha phase in the samples,which is deduced from the XRD and photoluminescence tests results.A lower temperature during the flame spraying process will help to keep more alpha phase in the *** selected four samples show successful fluoresced results in the radioluminescence *** The luminescence intensity of the coating is improved greatly by the studies on the fabrication process and the characteristics of the *** luminescence coating used in beam diagnostics will be fabricated by the confirmed technical *** works will be continued to improve the characteristics of the luminescence light by controlling Cr concentration and annealing in 1200∼2000℃ environment in the future.

关键词： Al_(2)O_(3):Cr^(3+)luminescence coating Beam diagnostics Spallation target

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Serum exosomal microRNA-144-3p:a promising biomarker for monitoring Crohn’s disease

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Gastroenterology Report 2022年第1期10卷 313-321页

作者： Peng Chen Shanshan Huang Qiao Yu Kang Chao Ying Wang Gaoshi Zhou Xiaojun Zhuang zhirong zeng Minhu Chen Shenghong Zhang Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouP.R.China Department of Gastroenterology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouP.R.China Department of Gastroenterology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouP.R.China

Background:Crohn’s disease(CD)has a tendency for recurrence and requires adequate monitoring and personalized *** endoscopy is considerably invasive,serum biomarkers are required as alternatives for CD *** this,exosomal microRNAs(miRNAs)may serve as promising *** this study,we aimed to assess the role of serum exosomal microRNA-144-3p(miR-144-3p)as a biomarker for CD ***:We prospectively recruited 154 patients without a history of surgery(Cohort 1)and 75 patients who were to undergo intestinal resection(Cohort 2).Serum samples were collected from Cohort 1 before colonoscopy and from Cohort 2 before surgery and during post-operative colonoscopic *** serum levels of exosomal miR-144-3p were measured using quantitative reverse-transcription polymerase chain reaction(PCR).Correlations between relative exosomal miR-144-3p levels,disease activity,and disease behavior were *** area under the receiver-operating characteristic curve(AUC)was used to assess the predictive value of exosomal miR-144-3p regarding mucosal activity and postoperative ***:A 3.33-fold increase in serum exosomal miR-144-3p levels was recorded in patients with CD compared with those in healthy controls(P<0.001).The exosomalmiR-144-3p levels were positively correlated with the simple endoscopic score of CD(q=0.547,P<0.001)as well as the Rutgeerts score(q=0.478,P<0.001).Elevated exosomalmiR-144-3p levels were correlated with the penetrating disease with high specificity(100%[95%confidence interval,95.1%–100%]).The accuracy of exosomalmiR-144-3p for identifying post-operative recurrence was higher than that of C-reactive protein(CRP)(AUC,0.775 vs 0.639;P<0.001).Conclusions:Serum exosomal miR-144-3p is a reliable biomarker of mucosal inflammation and penetrating *** may identify endoscopic CD recurrence after intestinal resection with higher accuracy than CRP testing.

关键词： Crohn’s disease microRNA-144-3p serum biomarker exosome

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Development and validation of a nomogram to predict indolent course in patients with ulcerative colitis:a single-center retrospective study

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Gastroenterology Report 2022年第1期10卷 405-412页

作者： Na Li Shukai Zhan Caiguang Liu Tong Li Tong Tu Baili Chen Yao He Minhu Chen zhirong zeng Xiaojun Zhuang Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:The natural disease course for patients with ulcerative colitis(UC)is heterogeneous and few data are available on the indolent course of UC and its related *** aimed to develop and validate a nomogramto predict indolent course in patients with ***:Data of patients diagnosed with UC in the First Affiliated Hospital of Sun Yat-sen University(Guangzhou,China)between April 2007 and February 2021 were retrospectively *** course was defined as a disease course without need for strict interventions(steroids,immunomodulators,biological agents,hospitalization,or surgery therapy)during the follow-up *** whole cohort was randomly divided into training set and validation *** nomogram was constructed in the training set based on the results of univariate and multivariate Cox regression *** performance of the nomogram was assessed by the concordance index(C-index),area under the receiver-operating characteristic curve(AUC),and calibration *** addition,we internally validated the nomogramvia the bootstrap method and the validation ***:Of 969 treatment-naive patients with UC,771(79.6%)had an indolent course after *** these,313 patients were included in the development and validation of the *** nomogram incorporating age,disease activity,C-reactive protein,and platelet count showed good calibration and *** C-index was 0.759(0.741 in bootstrap validation)and the AUC at 2,4,and 6 years was 0.767,0.782,and 0.775,*** nomogramperformed well when applied to the validation ***:A majority of patients with UC had an indolent course after *** nomogram developed in this study might be useful in therapeutic decision-making and follow-up management for patients with UC.

关键词： ulcerative colitis indolent course predict nomogram

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Design of imaging system for CSNS near-target beam diagnostics

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Radiation Detection Technology and Methods 2018年第2期2卷 38-46页

作者： zhirong zeng Shanhua Zhang Weilin Cheng Quanzhi Yu Shaohong Wei Bin Zhou Donghui Zhu Quan Ji Aijun zeng Tianjiao Liang Yuanbo Chen Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Dongguan Neutron Science Center Dongguan 523803China Shanghai Institute of Optics and Fine Mechanics Chinese Academy of ScienceShanghai 201800China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of ScienceBeijing 100190China

Introduction China Spallation Neutron Source(CSNS)is an accelerator-based pulsed neutron source which produces neutron with spallation reaction induced by proton bombarding tungsten *** increasing beam powers and influences on target,near-target monitoring becomes extreme *** this situation,an optical imaging system for proton beam diagnostics and monitoring near the target is being developed at CSNS,which can provide real-time images of the beam on target and beam distribution *** imaging system design and development In the design of CSNS target imaging system,coating of Cr^(3+):Al_(2)O_(3) is used to convert particle radiation into emission *** to the geometry limits of CSNS target station,a special optical system was designed and fabricated to collect the emission *** the proton beams strike on the target,the coating on the target will be excited,emitting luminescence at the same *** mirrors and lenses of the optical system image the distribution of emission light into a radiation-hard imaging fiber,which transmits the images to the GigE camera located at low-dose area outside of the target *** was written on the LabView platform to control the camera and analyze the images on ***-up of the imaging system was manufactured to test and evaluate the performances of the *** important characteristics of the system were obtained and *** Tests on the mock-up of the system present reliably expectation for beam *** imaging system has been installed at CSNS *** work will be continued to improve the properties of the system.

关键词： Beam diagnostics Beam profile Imaging system Luminescent coating

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A New Immunofluorescence Assay for Fecal Calprotectin Distinguishes Inflammatory Bowel Disease from Functional Bowel Disease

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Open Journal of Gastroenterology 2018年第11期8卷 405-414页

作者： Lixia Xu Peisi Rao Xin Liu zhirong zeng Department of Gastroenterology and Hepatology The First Affiliated Hospital of Sun Yat-sen Guangzhou China Department of Gastroenterology and Hepatology The First Affiliated Hospital of Sun Yat-sen University Guangzhou China Zhongshan School of Medicine Sun Yat-sen University Guangzhou China

Aims: To investigate the diagnostic value of fecal calprotectin (FC) determined by a new immunofluorescence assay-fluorescence enzyme immunoassay (FEIA) in patient with inflammatory bowel disease (IBD) or functional bowel disease, compared with the typical ELISA kit. Methods: FC was determined simultaneously by FEIA and an ELISA kit in 26 patients with functional bowel disease and 77 patients with IBD. We compared the difference of FC levels between patients with IBD and patients with functional bowel disease. Receiver operating characteristics curve (ROC) was constructed to obtain the optimal cut-off value of FC for distinguishing IBD from functional bowel disease and the corresponding sensitivity and specificity. Results: The median FC levels of patients with IBD in clinical active stage or clinical remission stage was significantly higher than that of patients with functional bowel disease. The median FC levels of patients with IBD in clinical active stage, IBD in clinical remission stage and functional bowel disease were as follow: 699.91 (346.14 ~ 1647.54) μg/g;407.36 (121.81 ~ 878.48) μg/g;39.04 (12.09 ~ 81.04) μg/g when FC was measured by FEIA. The median FC levels were 716.99 (240.42 ~ 1232.53) μg/g;338.46 (53.08 ~ 692.82) μg/g;41.44 (11.77 ~ 73.19) μg/g among such above three groups of patients respectively, when FC was measured by ELISA kit. The diagnostic value of IBD with FC determined by FEIA (optimal cut-off = 131.79 μg/g) and ELISA kit (optimal cut-off = 121.85 μg/g) presented an area under the curve of 0.881 and 0.873, respectively. Conclusions: FC determined by FEIA was an accurate surrogate marker to distinguish IBD from functional bowel disease.

关键词： Inflammatory Bowel Disease Functional Bowel Disease Fecal Calprotectin

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基于世界大学第三方指数评价的粤港澳大湾区高等教育竞争力态势分析

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高教探索 2020年第12期 84-92页

作者：曾志嵘王慧师璐南方医科大学卫生管理学院广东医科大学人文与管理学院南方医科大学教学发展中心广州510515

利用世界大学第三方指数工具,分析粤港澳大湾区高等教育竞争力水平,对粤港澳大湾区高等教育发展进行SWOT分析,探究湾区高等教育竞争力提升过程中的机遇与挑战,提出提升战略。结果发现,粤港澳大湾区高等教育竞争力列四大湾区第二位,但一... 详细信息

利用世界大学第三方指数工具,分析粤港澳大湾区高等教育竞争力水平,对粤港澳大湾区高等教育发展进行SWOT分析,探究湾区高等教育竞争力提升过程中的机遇与挑战,提出提升战略。结果发现,粤港澳大湾区高等教育竞争力列四大湾区第二位,但一流高校竞争力不足;相较纽约湾、旧金山湾和东京湾明确的湾区标识,粤港澳大湾区定位不明确;内部高等教育发展存在多方面差异,香港高校师资力量、学术研究和国际化表现优于粤澳高校,但与珠三角地区教育成果和学生培养结果相比,表现不突出。建议依托国家发展战略,明确粤港澳大湾区国际化发展定位,借鉴世界一流湾区竞争力提升路径,整合三地优质资源,建立湾区互补式融合发展平台,打造区域高等教育中心。

关键词：高等教育竞争力态势发展策略粤港澳大湾区世界大学第三方指数

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我国城市社区卫生服务政策演进逻辑及走向研究

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中国全科医学 2023年第34期26卷 4239-4245页

作者：黄锦玲曾志嵘南方医科大学第三附属医院医务科广东省广州市510630 广东医科大学公共卫生与健康研究院广东省东莞市523808

背景城市社区卫生服务是推进社区卫生高质量发展的关键,但既往研究较少探讨社区卫生服务政策的演变逻辑和发展趋势,较难全面回答我国社区卫生服务政策如何产生、演变和走向等问题。目的了解社区卫生服务政策发布现况、演进逻辑及未来... 详细信息

背景城市社区卫生服务是推进社区卫生高质量发展的关键,但既往研究较少探讨社区卫生服务政策的演变逻辑和发展趋势,较难全面回答我国社区卫生服务政策如何产生、演变和走向等问题。目的了解社区卫生服务政策发布现况、演进逻辑及未来走向,以期为推进社区卫生服务高质量发展及落实分级诊疗制度提供参考。方法于2019年12月—2022年3月,检索中央人民政府网、国家卫生健康委及省级相关官方网站,以及中国知网、中国社区卫生协会等平台,以获取1997年1月—2022年3月国家层面发布的社区卫生服务改革相关政策(n=98)。借助政策取向分析模式,对纳入政策进行分析。结果我国城市社区卫生服务政策变迁历经了4个核心阶段:以“转型建框”为中心的初步探索阶段(1997—2002年)、以公共卫生网底为抓手的规范建设阶段(2003—2008年)、以机制改革为重点的繁荣发展阶段(2009—2016年)、以提质赋能为核心的深化变革阶段(2017—2022年)。我国社区卫生服务政策的变迁遵循着以下演变逻辑:动力机制由市场化向专业化与社会社群联动治理演变,目标取向由规模扩张向内涵质量提升转变,执行策略选择由以权威工具为主向多种工具协同转变,政策话语由以经济学话语为主向多元化话语规则转变。结论我国社区卫生服务政策应促进双协同治理框架和机制创新,加强专业系统间协同及其与社会社群治理体系的有效协同联动;促进以健康为核心的社区价值医疗和信任医疗,建立和完善基层特色服务能力和质量评价标准;促进政策工具的多元化运用和匹配性,适应社区卫生健康利益主体多元化的需求。

关键词：社区卫生服务卫生政策卫生保健改革政策制订发展历程演变逻辑

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家庭医生签约服务标化工作量测算及应用研究

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中国全科医学 2021年第16期24卷 2022-2027,2033页

作者：李婕朱先曾志嵘南方医科大学卫生管理学院广东省广州市510515 南方医科大学公共卫生学院广东省广州市510515 广东医科大学公共卫生与健康研究院广东省湛江市524023

背景家庭医生签约服务不断推进,亟需一套科学、公平、实用、可操作的绩效管理模式,而工作量的测算是绩效管理的核心。目的针对家庭医生签约服务新的基层卫生健康服务供给的规律和特点,核定广州市家庭医生签约服务项目,选用科学合适的方... 详细信息

背景家庭医生签约服务不断推进,亟需一套科学、公平、实用、可操作的绩效管理模式,而工作量的测算是绩效管理的核心。目的针对家庭医生签约服务新的基层卫生健康服务供给的规律和特点,核定广州市家庭医生签约服务项目,选用科学合适的方法对家庭医生签约服务标化工作量进行测算,对家庭医生团队进行科学、动态的绩效管理。方法于2018年选取广州市60家社区卫生服务中心作为样本单位采用问卷调查、半结构化访谈、客观观察和主观评估等研究方法,测算并校正家庭医生签约服务工作量,并对标化工作量在绩效和补偿方面的应用进行探讨。结果将广州市家庭医生签约服务项目分成6大类152项。以为居民当面建立一份健康档案(含发放居民健康卡)为1个标准点数值,综合考虑时间因素、体力因素、技术因素和压力含量因素,确定了包括152项家庭医生签约服务项目点数值,并通过最小二乘法估计结合岭回归估计建立RBRVS工作量函数关系式,拟合优度在89%以上,并以标化工作量为基础进行绩效分配的模拟。结论以标准化工作量点数表为基础的绩效分配,在家庭医生签约服务领域标化工作量的应用使得绩效收入分配和财政补偿方案更加简单、易行,可以对机构实现更为精确有效的补偿,充分体现医生的劳动价值,鼓励医生多劳多得、优劳优得。

关键词：家庭医生签约服务标化工作量财政补偿社区卫生服务中心

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科研要素在大学第三方评估中的运用及比较

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科技管理研究 2018年第23期38卷 81-85页

作者：师璐曾志嵘南方医科大学卫生管理学院广东广州510515

当前科研相关要素在国内外主要大学第三方评价指标体系中占据着关键地位,科研质量与水平、学术的声誉与影响力、科研的国际协作力在大学第三方评估中越来越受重视。比较研究大学第三方评估中科研要素的运用,提出要理性认识和看待科研质... 详细信息

当前科研相关要素在国内外主要大学第三方评价指标体系中占据着关键地位,科研质量与水平、学术的声誉与影响力、科研的国际协作力在大学第三方评估中越来越受重视。比较研究大学第三方评估中科研要素的运用,提出要理性认识和看待科研质量排名内涵及其对大学综合排名的影响,要将科研创新中追求真理、追求卓越的精神内涵融入大学精神,要推动科研学术资源的教学转化与服务转化,要警惕和摒弃提升科研水平的短期效应和短视行为。以期为高校科技管理部门、教育行政管理部门等提供决策参考和建议。

关键词：大学第三方评估科研要素比较研究

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白细胞介素33在IBD炎症进展和黏膜愈合中的作用

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胃肠病学 2013年第2期18卷 118-121页

作者：杨庆帆曾志荣中山大学附属第一医院消化内科 510080

炎症性肠病(IBD)主要包括溃疡性结肠炎(UC)和克罗恩病(CD),近年其发病呈上升趋势。IBD的发病机制尚不明确,研究表明免疫炎症反应起重要作用。白细胞介素33(IL-33)是新近发现的炎症因子,越来越多证据表明其参与IBD发病。本文就IL-33在IB... 详细信息

炎症性肠病(IBD)主要包括溃疡性结肠炎(UC)和克罗恩病(CD),近年其发病呈上升趋势。IBD的发病机制尚不明确,研究表明免疫炎症反应起重要作用。白细胞介素33(IL-33)是新近发现的炎症因子,越来越多证据表明其参与IBD发病。本文就IL-33在IBD炎症进展和黏膜愈合中的作用作一综述。

关键词：结肠炎溃疡性 Crohn病白细胞介素33 炎症黏膜愈合

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