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Polyphenol based hybrid nano-aggregates modified collagen fibers of biological valve leaflets to achieve enhanced mechanical,anticoagulation and anti-calcification properties

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Journal of Leather Science and Engineering 2022年第4期4卷 394-408页

作者： Shufen Li Shiying Lang zhiqian chen Jingruo chen Weihua Zhuang Yangrui Du Yawen Yao Gongyan Liu Mao chen Laboratory of Heart Valve Disease West China HospitalSichuan University37 Guoxue AlleyChengdu 610041China The Key Laboratory of Leather Chemistry and Engineering of Ministry of Education College of Biomass Science and EngineeringSichuan UniversityChengdu 610065China University of California Davis 1 Shields AveDavisCA 95616USA Faculty of Science and Engineering Aachen-Maastricht Institute for Biobased Materials(AMIBM)Maastricht UniversityBrightlands Chemelot Campus6167 RD GeleenThe Netherlands Department of Cardiology West China HospitalSichuan University37 Guoxue AlleyChengdu 610041China Regenerative Medicine Research Center West China HospitalSichuan University37 Guoxue AlleyChengdu 610041China

Glutaraldehyde(Glut)-crosslinked porcine pericardium and bovine pericardium are mainly consisted of collagen and widely used for the preparation of heterogenous bioprosthetic heart valves(BHV),which play an important role in the replacement therapy of severe valvular heart disease,while their durability is limited by degeneration due to calcification,thrombus,endothelialization difficulty and prosthetic valve endocarditis.Herein,we develop a novel BHV,namely,TPly-BP,based on natural tannic acid and polylysine to improve the durability of Glut crosslinked bovine pericardium(Glut-BP).Impressively,tannic acid and polylysine could form nanoaggregates via multiple hydrogen bonds and covalent bonds,and the introduction of nanoaggregates not only improved the mechanical properties and collagen stability but also endowed TPly-BP with good biocompatibility and hemocompatibility.Compared to Glut-BP,TPly-BP showed significantly reduced cytotoxicity,improved endothelial cell adhesion,a low hemolysis ratio and obviously reduced platelet adhesion.Importantly,TPly-BP exhibited great antibacterial and in vivo anti-calcification ability,which was expected to improve the in vivo durability of BHVs.These results suggested that TPly-BP would be a potential candidate for BHV.

关键词： Tannic acid Bioprosthetic heart valve Antibacterial and anti-calcification

Autologous fibroblasts induce fibrosis of the nucleus pulposus to maintain the stability of degenerative intervertebral discs

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Bone Research 2020年第1期8卷 63-75页

作者： chen chen Tangjun Zhou Xiaojiang Sun chen Han Kai Zhang Changqing Zhao Xunlin Li Haijun Tian Xiao Yang Yifan Zhou zhiqian chen An Qin Jie Zhao Shanghai Key Laboratory of Orthopaedic Implants Department of Orthopaedic Surgery Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of Medicine

Lumbar degenerative disc diseases cause low back pain(LBP). The maintenance of the height and stability of the intervertebral disc(IVD) space is an effective treatment for LBP. The following study evaluated the effects of fibroblast injection on intervertebral disc degeneration(IDD) in a preclinical setting. Compared with the IDD group, the fibroblast treatment group demonstrated effective maintenance of IVD height, reduced endplate degeneration, and improved nuclear magnetic resonance signals and overall histological structure. In doing so, fibrotic IVDs maintained the stability and biomechanics of the vertebra. This finding is in agreement with clinical findings that human nucleus pulposus(NP) fibrosis is essential for the maintenance of IVD height and mechanical properties in patients following percutaneous endoscopic lumbar discectomy(PELD). Mechanistically, we demonstrated that injected fibroblasts not only proliferated but also induced NP cells to adopt a fibrotic phenotype via the secretion of TGF-β.Finally, to better mimic human conditions, the efficacy of autologous fibroblast injection in the treatment of IDD was further examined in a nonhuman primate cynomolgus monkey model due to their capacity for upright posture. We showed that the injection of fibroblasts could maintain the IVD height and rescue IVD signals in cynomolgus monkeys. Taken together, the results of our study reveal that autologous fibroblast injection can enhance the natural process of fibrosis during acute and subacute stages of stress-induced IDD. Fibrotic IVDs can maintain the stability, biological activity, and mechanical properties of the intervertebral space, thus providing a new direction for the treatment of intervertebral space-derived lumbar degenerative diseases.

关键词： intervertebral degenerative degeneration

LiBH4 for hydrogen storage-New perspectives

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Nano Materials Science 2020年第2期2卷 109-119页

作者： Zhao Ding Shaoyuan Li Yang Zhou zhiqian chen Weijie Yang Wenhui Ma Leon Shaw Department of Mechanical Materials and Aerospace EngineeringIllinois Institute of TechnologyChicagoIL60616USA Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming650091China School of Photovoltaic and Renewable Energy Engineering University of New South WalesSydneyNSW2052Australia School of Textile Science and Engineering State Key Laboratory of New Textile Materials and Advanced Processing TechnologyWuhan Textile UniversityWuhan430200China Department of Computer Science Virginia TechFalls ChurchVA22043USA School of Energy and Power Engineering North China Electric Power UniversityBaoding071003China

Hydrogen energy has been recognized as“Ultimate Power Source”in the 21st century.It is a boon in these days of energy crunches and concerns about climate change because of the characterized advantages,such as high energy density,large calorific value,abundant resource,zero pollution,zero carbon emission,storable and renewable.State-of-the-art perspectives on tuning the stable thermodynamics and sluggish kinetics of dehydrogenation and re-hydrogenation of LiBH4,which has been regarded as a promising hydrogen storage alternative for onboard energy carrier applications have been discussed.Five major technological approaches are involved,including nanoengineering,catalyst modification,ions substitution,reactant destabilization and a novel process termed as high-energy ball milling with in-situ aerosol spraying(BMAS).It is worth noting that BMAS has the potential to help overcome the kinetic barriers for thermodynamically favorable systems like LiBH4 t MgH2 mixture and provide thermodynamic driving force to enhance hydrogen release at a lower temperature.

关键词： Hydrogen storage materials LiBH4 Nanoengineering MgH2 BMAS

基于RDBN深度学习算法的窃电监测系统设计

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电器与能效管理技术 2024年第5期 67-74页

作者：陈志谦鲍光海方艳东福州大学电气工程与自动化学院福建福州350108 浙江天正电气股份有限公司浙江乐清528300

窃电行为不仅会造成电网非技术性损耗增加,而且可能因操作不当影响电网设备的运行安全和窃电者的人身安全。针对当前电网在窃电检测方面存在的稽查难度大、检测效率低等问题,设计了窃电监测系统。配套监测装置可灵活安装在供电线路上,... 详细信息

窃电行为不仅会造成电网非技术性损耗增加,而且可能因操作不当影响电网设备的运行安全和窃电者的人身安全。针对当前电网在窃电检测方面存在的稽查难度大、检测效率低等问题,设计了窃电监测系统。配套监测装置可灵活安装在供电线路上,使用电流互感器取能,实时采集线路电流,利用4G模块将数据传输至云服务器,在上位机软件中采用实值深度置信网络(RDBN)算法对数据进行分析。仿真和实验测试表明,RDBN算法对窃电状态的识别准确率达到98.15%,监测系统能实时获取并分析监测数据,标记可疑窃电线路,降低稽查难度,提高检测效率。

关键词：非技术性损耗窃电检测电流互感器取能实值深度置信网络

甘油三酯葡萄糖指数与心血管疾病相关性的研究进展

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中华老年多器官疾病杂志 2024年第4期23卷 307-310页

作者：陈芷倩龚开政赵培扬州大学附属医院心血管内科江苏扬州225000 扬州大学附属医院全科医学科江苏扬州225000 大连医科大学研究生院辽宁大连116000

胰岛素抵抗是心血管疾病的危险因素之一,目前用于评价胰岛素抵抗的传统方法大多较为复杂且价格昂贵,临床应用较为局限。甘油三酯葡萄糖指数是一种新兴反映胰岛素抵抗水平的指标,被大量实验证实与心血管疾病相关。本文就胰岛素抵抗在心... 详细信息

胰岛素抵抗是心血管疾病的危险因素之一,目前用于评价胰岛素抵抗的传统方法大多较为复杂且价格昂贵,临床应用较为局限。甘油三酯葡萄糖指数是一种新兴反映胰岛素抵抗水平的指标,被大量实验证实与心血管疾病相关。本文就胰岛素抵抗在心血管疾病中的作用机制以及甘油三酯葡萄糖指数与心血管疾病相关性的研究进展展开综述,旨在为早期发现和预防心血管疾病提供有力的指导。

关键词：胰岛素抵抗甘油三酯葡萄糖指数心血管疾病

城市人防工程与地下空间融合发展策略思考——以江苏为例

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现代城市研究 2024年第1期39卷 70-75页

作者：陈智乾邱长浩冒旭海王华伟缪刚江苏省城镇与乡村规划设计院有限公司

在城市建设由“增量扩张”转变为“存量更新”的大背景下,文章梳理了江苏省人防工程与地下空间融合发展存在规划编制各自为政、空间融合综合效益不高、平战转换困难、管理体制和法规标准支撑不够等问题,针对以上问题在借鉴国内外经验的... 详细信息

在城市建设由“增量扩张”转变为“存量更新”的大背景下,文章梳理了江苏省人防工程与地下空间融合发展存在规划编制各自为政、空间融合综合效益不高、平战转换困难、管理体制和法规标准支撑不够等问题,针对以上问题在借鉴国内外经验的基础上,从规划、空间及管理3个维度提出以下对策,包括在总体规划、专项规划、详细规划3个阶段做好流程融合和内容衔接;落实“基于城市功能需求,引导人防工程综合利用”“结合便民惠民工程,补老城区人防工程不足”“统一平时战时功能,减轻减少平战转换工作”等6方面空间融合策略;从“优化管理体制,将人防纳入地下空间一张图”“加快推进各级规划编制,引导空间融合建设”“健全法律法规体系,弥补相关技术标准空白”3方面做好管理融合工作。

关键词：人防工程地下空间平战结合融合发展

The Properties of Elasticity, Thermology, and Anisotropy in Pd-Based Alloys

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Journal of Materials Science and Chemical Engineering 2017年第3期5卷 17-34页

作者： Kuankuan chen Meng Hu Chunmei Li Guannan Li zhiqian chen Faculty of Materials and Energy Southwest University Chongqing China

This work is devoted to investigate the elasticity, anisotropy, plastic properties, and thermal conductivity of PdSnYb, PdSn2Yb and Heusler alloy Pd2SnYb via employing the first-principles. The magnetic properties of Pd2SnYb, PdSnYb and PdSn2Yb are obtained by the geometry optimization combining with spin polarization. And the stability of these three kinds of materials is ensured by comparing with the enthalpy of formation and binding energy. The Fermi energy has same trend with stability. The details of bulk and Young’s modulus are demonstrated in 3D plots, embodied the elastic anisotropies of PdSnYb, PdSn2Yb, and Pd2SnYb. The calculations of plastic properties are also anisotropic. And the minimum thermal conductivities are small enough for these three materials to be used as thermal barrier coatings.

关键词： First-Principles Pd-Based Alloys Elasticity Thermal Conductivity Anisotropy

Sources appointment and health risks of PM_(2.5)-bound trace elements in a coastal city of southeastern China

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Journal of Environmental Sciences 2024年第4期138卷 561-571页

作者： Ziyi Lin Xiaolong Fan Gaojie chen Youwei Hong Mengren Li Lingling Xu Baoye Hu chen Yang Yanting chen zhiqian Shao Jinsheng chen Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Key Lab of Urban Environment and Health Institute of Urban EnvironmentChinese Academy ofSciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China Minnan Normal University Zhangzhou 363000China

To gain a comprehensive understanding of sources and health risks of trace elements in an area of China with high population densities and low PM_(2.5)concentrations,15 trace elements(Al,K,Ca,Ti,V,Cr,Mn,Fe,Ni,Cu,Zn,As,Sn,Ba,Pb)in PM_(2.5)were monitored from December 2020 to November 2021 in a representative city,Xiamen.The concentrations of trace elements in Xiamen displayed an obvious seasonal variation and were dominated by K,Fe,Al,Ca and Zn.Based on Positive Matrix Factorization analysis,source appointment revealed that the major sources of trace elements in Xiamen were traffic,dust,biomass and firework combustion,industrial manufacture and shipping emission.According to health risk assessment combined with the source appointment results,it indicated that the average noncarcinogenic risk was below the threshold and cancer risk of four hazardous metals(Cr,Ni,As,Pb)exceeded the threshold(10^(-6)).Traffic-related source had almost half amount of contribution to the health risk induced by PM_(2.5)-bound trace elements.During the dust transport period or Spring Festival period,the health risks exceeded an acceptable threshold even an order of magnitude higher,suggesting that the serious health risks still existed in low PM_(2.5)environment at certain times.Health risk assessment reminded that the health risk reduction in PM_(2.5)at southeastern China should prioritize traffic-related hazardous trace elements and highlighted the importance of controlling vehicles emissions in the future.

关键词： PM_(2.5)-bound trace elements Seasonal variations Source appointment Health risks Traffic-related source

Intermetallic phase formation and evolution during homogenization and solution in Al-Zn-Mg-Cu alloys

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Science China(Technological Sciences) 2013年第11期56卷 2827-2838页

作者： LI ChunMei chen zhiqian ZENG SuMin chenG NanPu chen TianXiao School of Materials Science and Engineering Central South University School of Materials Science and Engineering Southwest University

The effects of major alloy element contents of Zn,Mg,Cu in Al-Zn-Mg-Cu alloys on the formation and evolution of intermetallic phases during casting,homogenization and solution treatment have been investigated through using X-ray diffraction,scanning electron microscopy and differential scanning calorimetry.Experimental results showed that a relatively higher Zn content with lower Mg and Cu contents was beneficial to the formation of MgZn2phase instead of the Al2CuMg phase,which resulted in the unicity of the intermetallics in the Al matrix,and that the MgZn2phase was easier for diffusion and dissolution during homogenization and solution than the Al2CuMg phase.Additionally,the results of the first-principles calculations gave support for explaining the experimental phenomena.A larger absolute value of formation enthalpy and a smaller value of binding energy of the MgZn2phase,as compared with the Al2CuMg phase,give it priority to precipitate during casting and make it easier to re-dissolve during homogenization and solution treatment.What’s more,higher elastic constants with severe anisotropy of Young’s modulus make undissolved blocks of Al2CuMg phase act as crack initiation,which degrade the performance of the materials.

关键词： Al-Zn-Mg-Cu系合金金属间相同质化演化 X-射线衍射仪差示扫描量热法扫描电子显微镜固溶化处理