Polyphenol based hybrid nano-aggregates modified collagen fibers of biological valve leaflets to achieve enhanced mechanical,anticoagulation and anti-calcification properties

作     者：Shufen Li Shiying Lang Zhiqian Chen Jingruo Chen Weihua Zhuang Yangrui Du Yawen Yao Gongyan Liu Mao Chen Shufen Li;Shiying Lang;Zhiqian Chen;Jingruo Chen;Weihua Zhuang;Yangrui Du;Yawen Yao;Gongyan Liu;Mao Chen

作者机构：Laboratory of Heart Valve DiseaseWest China HospitalSichuan University37 Guoxue AlleyChengdu 610041China The Key Laboratory of Leather Chemistry and Engineering of Ministry of EducationCollege of Biomass Science and EngineeringSichuan UniversityChengdu 610065China University of California Davis1 Shields AveDavisCA 95616USA Faculty of Science and EngineeringAachen-Maastricht Institute for Biobased Materials(AMIBM)Maastricht UniversityBrightlands Chemelot Campus6167 RD GeleenThe Netherlands Department of CardiologyWest China HospitalSichuan University37 Guoxue AlleyChengdu 610041China Regenerative Medicine Research CenterWest China HospitalSichuan University37 Guoxue AlleyChengdu 610041China 

出 版 物：《Journal of Leather Science and Engineering》 (皮革科学与工程（英文）)

年 卷 期：2022年第4卷第4期

页      面：394-408页

学科分类：08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：the National Natural Science Foundation of China(81970325 and 82170375) Key Research and Develop-ment Support Project of Science&Technology Department of Chengdu(2021-YF08-00121-GX) Post-Doctor Research Project,West China Hospital,Sichuan University(Grant No.20HXBH164 and 20HXBH105) Chinese Medical Association Cardiovascular Branch(CSC)Clinical Research Special Fund Project(CSCF2020B04) West China Hospital“1·3·5”Discipline of Excellence Project-“Percutaneous transcatheter aortic valve implantation”and“Mechanisms of aortic stenosis and the clinical applications”(ZYGD20002) 

主　　题：Tannic acid Bioprosthetic heart valve Antibacterial and anti-calcification 

摘      要：Glutaraldehyde(Glut)-crosslinked porcine pericardium and bovine pericardium are mainly consisted of collagen and widely used for the preparation of heterogenous bioprosthetic heart valves(BHV),which play an important role in the replacement therapy of severe valvular heart disease,while their durability is limited by degeneration due to calcification,thrombus,endothelialization difficulty and prosthetic valve ***,we develop a novel BHV,namely,TPly-BP,based on natural tannic acid and polylysine to improve the durability of Glut crosslinked bovine pericardium(Glut-BP).Impressively,tannic acid and polylysine could form nanoaggregates via multiple hydrogen bonds and covalent bonds,and the introduction of nanoaggregates not only improved the mechanical properties and collagen stability but also endowed TPly-BP with good biocompatibility and *** to Glut-BP,TPly-BP showed significantly reduced cytotoxicity,improved endothelial cell adhesion,a low hemolysis ratio and obviously reduced platelet ***,TPly-BP exhibited great antibacterial and in vivo anti-calcification ability,which was expected to improve the in vivo durability of *** results suggested that TPly-BP would be a potential candidate for BHV.