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Regulated extravascular microenvironment via reversible thermosensitive hydrogel for inhibiting calcium influx and vasospasm

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Bioactive Materials 2023年第3期21卷 422-435页

作者： Binfan Zhao Yaping Zhuang zhimo liu Jiayi Mao Shutong Qian Qiuyu Zhao Bolun Lu Xiyuan Mao liucheng Zhang Yuguang Zhang Wenguo Cui Xiaoming Sun Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s Hospital Shanghai JiaoTong University School of Medicine 639 Zhi Zao Ju RoadShanghai200011PR China Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine197 Ruijin 2nd RoadShanghai200025PR China

Arterial vasospasm after microsurgery can cause severe obstruction of blood flow manifested as low tissue temperature,leading to tissue *** timely discovery and synchronized treatment become *** this study,a reversible,intelligent,responsive thermosensitive hydrogel system is constructed employing both the gel–sol transition and the sol–gel ***“reversible thermosensitive(RTS)”hydrogel loaded with verapamil hydrochloride is designed to dynamically and continuously regulate the extravascular microenvi-ronment by inhibiting extracellular calcium *** accurate implantation and following in situ gelation,the RTS hydrogel reverses to the sol state causing massive drug release to inhibit vasospasm when the tissue tem-perature drops to the predetermined transition *** restoration of the blood supply allevi-ates further tissue *** the temperature drops,the RTS hydrogel maintains the gel state as a sustained-release reservoir to prevent *** inhibition of calcium influx and vasospasm in vitro and in vivo is demonstrated using vascular smooth muscle cells,mice mesenteric arterial rings,and vascular ultrasonic Doppler *** animal experiments demonstrate that RTS hydrogel can promote tissue survival and alleviate tissue injury responding to temperature ***,this RTS hydrogel holds therapeutic po-tential for diseases requiring timely detection of temperature change.

关键词： Reversible thermosensitive hydrogel Low temperature response Calcium influx Vasospasm Vascular

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Conditioned medium-electrospun fiber biomaterials for skin regeneration

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Bioactive Materials 2021年第9期6卷 361-374页

作者： Lu Chen Liying Cheng Zhen Wang Jianming Zhang Xiyuan Mao zhimo liu Yuguang Zhang Wenguo Cui Xiaoming Sun Department of Plastic and Reconstructive Surgery Shanghai Ninth People's HospitalShanghai Jiao Tong University School of Medicine639 Zhi Zao Ju RoadShanghai200011PR China Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of Medicine197 Ruijin 2nd RoadShanghai200025PR China National Research Center for Translational Medicine Ruijin HospitalShanghai JiaoTong University School of MedicineShanghaiPR China

Conditioned medium(CM)contains variety of factors secreted by cells,which directly regulate cellular processes,showing tremendous potential in regenerative ***,for the first time,we proposed a novel regenerative therapy mediated by biodegradable micro-nano electrospun fibers loaded with highly active conditioned medium of adipose-derived stem cells(ADSC-CM).ADSC-CM was successfully loaded into the nanofibers with biological protection and controllable sustained-release properties by emulsion electrospinning and protein freeze-drying *** vitro,ADSC-CM released by the fibers accelerated the migration rate of fibroblasts;inhibited the over proliferation of fibroblasts by inducing apoptosis and damaging cell membrane;in addition,ADSC-CM inhibited the transformation of fibroblasts into myofibroblasts and suppressed excessive production of extracellular matrix(ECM).In vivo,the application of CM-biomaterials significantly accelerated wound closure and improved regeneration outcome,showing superior pro-regenerative *** study pioneered the application of CM-biomaterials in regenerative medicine,and confirmed the practicability and significant biological effects of this innovative biomaterials.

关键词： Conditioned medium Biomaterials Regenerative medicine Skin regeneration Electrospun fiber

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ANALYSING FAULT EQUIVALENCE IN LOGIC NETWORKS WITH STATE VARIABLE STAR ALGORITHM

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Acta Mathematica Scientia 1983年第3期3卷 343-356页

作者：刘志模袁由光 Wanzhong Maehinary Plant Wuhan Digital Engineering Institute

In this paper the State Variable Star Algoritnm(SVSALG) is briefly introduced. The identification of equivalent faults in logic networks is treated with the *** is shown that SVSALG is an efficient means to analyse fault equivalence. Based on the algorithm, the conception on a particular type of equivalence fault classes, the strongly connectivé equivalence fault class, is presented. The properties of the. equivalence class and its importance for multiple fault analysis are discussed in detail.

关键词： ANALYSING FAULT EQUIVALENCE IN LOGIC NETWORKS WITH STATE VARIABLE STAR ALGORITHM line Star

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STYLISTIC EQUIVALENCE IN TRANSLATION

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外语研究 1989年第3期6卷 38-46页

作者：刘志谟张亚非

An important component part of translation theory and practice is the reprodue-tion of the style characteristic of the source language(SL)in the target language(TL).Since the stylistic features of a language are systematically related to non-stylistic aspects—social,aesthetic,scientific,etc.,they form into a special field *** the emergence of stylistic study and its rapid development haveinfluenced the science of translation,and set new tasks and created new problemsfor researchers in the field.

关键词：人行道神仙电话簿普通话白话文警察恐怖不知疲倦拥挤光流

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孩子放学后的未来——日本小学课后服务发展制度、模式及特征探析

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比较教育研究 2024年第2期46卷 83-92页

作者：首新熊致墨刘杨重庆师范大学科技教育与传播研究中心重庆401331 西南大学教育学部重庆400715 陕西师范大学生命科学学院陕西西安710062

面对双职工家庭数量增加、“少子化”现象加剧、儿童放学后安全保障不足以及国际学业测评结果不理想等问题,日本自20世纪40年代末开始逐步推进课后服务。日本小学课后服务历经三个阶段:法制化阶段,将课后服务纳入基本法律体系,并逐渐形... 详细信息

面对双职工家庭数量增加、“少子化”现象加剧、儿童放学后安全保障不足以及国际学业测评结果不理想等问题,日本自20世纪40年代末开始逐步推进课后服务。日本小学课后服务历经三个阶段:法制化阶段,将课后服务纳入基本法律体系,并逐渐形成课后服务福利事业;普及化阶段,一体化推进课后服务面向所有适龄儿童;“五年计划”阶段,将小学课后服务建设成为与正式教育平行共生的普及化教育事业,实现常态化。通过对日本“放学后儿童俱乐部”和“放学后儿童教室”两大类项目课后服务模式的分析,发现日本课后服务趋于稳定和完备,在多元化和一体化之间实现稳态发展,体现出支援制度依法健全化、联合“家校社”一体化、双重评价机制走向可持续化、师资专业且多样的课后服务特征。

关键词：日本课后服务放学后儿童小学教育

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English Infinitives In Active Forms Used In Passive Sense

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外国语(上海外国语学院学报) 1985年第5期 47-50+75页

作者：刘志谟南京大学外文系英语副教授

In most English grammar books, the active form of the infinitive in the passive sense is labelledas a grammatical phenomenon in old English, which has been handed down through generationsto the present day and is alive only in such stock phrase as 'The house is to let'. But the factis that it is widely used in Modern English, and more so orally than in writing.

关键词： English Infinitives In Active Forms Used In Passive Sense

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Paraphrase and Chomsky’s Deep Structure Theory

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外国语(上海外国语学院学报) 1987年第4期 69-72页

作者：刘志谟

As defined in DICTIONARY OF LANGUAGE AND LINGUISTICS, paraphrase is 'the process or result of rewording an utterance from one level or variety of a language into another without altering the meaning, as opposed to metaphrase or translation which converts the utterance into a different language. Some types of language teaching make use of both expressing the same meaning in a number of different ways.' This ’defini

关键词： Paraphrase and Chomsky’s Deep Structure Theory test

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Biomaterial Scaffolds for Improving Vascularization During Skin Flap Regeneration

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Chinese Journal Of Plastic and Reconstructive Surgery 2020年第2期2卷 109-119页

作者： Yunkun PEI liucheng ZHANG Xiyuan MAO zhimo liu Wenguo CUI Xiaoming SUN Yuguang ZHANG Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiaotong University School of Medicine639 Zhi Zao Ju RoadShanghai 200011China

Over the past few decades,biomaterials have made rapid advances in tissue *** particular,there have been several studies on vascularization during skin flap regeneration for plastic *** the perspective of function,the biomaterials used to improve the vascularization of skin flaps are primarily classified into two types:(1)electrospun nanofibrous membranes as porous scaffolds,and(2)hydrogels as cell or cytokine *** on their source,various natural,synthetic,and semi-synthetic biomaterials have been developed with respective *** the ischemic environment of the flap tissue,the therapeutic effect of the combination of biomaterials was better than that of drugs,cytokines,and cells *** could improve cell migration,prolong the efficacy of cytokines,and provide an advantageous survival environment to transplanted cells.

关键词： skin flap vascularization biomaterial

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一种生成冗余组合线路单故障完全测试集的算法

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重庆大学学报(自然科学版) 1985年第S1期 103-109页

作者：刘志模万众机器厂

本文以星算法的故障屏蔽分析方法为工具,提出了一种对冗余组合线路中可测单故障生成完全测试集的算法,所生成的测试集完全排除了不可测故障对检测的影响。

关键词：单故障测试集故障屏蔽可测性交运算最小化问题定期测试数字系统输入线输出线

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状态变量星算法及其应用

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计算机学报 1984年第2期 135-145页

作者：刘志模重庆大学

本文运用四值布尔代数的方法对Poage的线状态方程进行了分析,导出了星算法中诸分量的线递推公式,从而将星算法与线状态方法结合起来。文中在此基础上推出的全故障星展式算法全面地反映了逻辑网络中可能发生的故障与网络输入、输出三者... 详细信息

本文运用四值布尔代数的方法对Poage的线状态方程进行了分析,导出了星算法中诸分量的线递推公式,从而将星算法与线状态方法结合起来。文中在此基础上推出的全故障星展式算法全面地反映了逻辑网络中可能发生的故障与网络输入、输出三者之间的因果关系,它使得故障诊断中的很多问题能够更方便、更系统地描述和处理。文中最后讨论了该方法在一些方面的应用。

关键词：状态变量定理递推公式分量算法

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