Biomaterial Scaffolds for Improving Vascularization During Skin Flap Regeneration

作     者：Yunkun PEI Liucheng ZHANG Xiyuan MAO Zhimo LIU Wenguo CUI Xiaoming SUN Yuguang ZHANG Yunkun PEI;Liucheng ZHANG;Xiyuan MAO;Zhimo LIU;Wenguo CUI;Xiaoming SUN;Yuguang ZHANG

作者机构：Department of Plastic and Reconstructive SurgeryShanghai Ninth People’s HospitalShanghai Jiaotong University School of Medicine639 Zhi Zao Ju RoadShanghai 200011China 

出 版 物：《Chinese Journal of Plastic and Reconstructive Surgery》 (Chinese Journal of Plastic and Reconstructive Surgery)

年 卷 期：2020年第2卷第2期

页      面：109-119页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 10[医学] 

基　　金：Yunkun Pei and Liucheng Zhang contributed equally to this work.This work was supported,in part,by the National Natural Science Foundation of China(81772099,81701907,81801928,and 81772087) Shanghai Sailing Program(18YF1412400) Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support(20171906) Shanghai talent development fund(2018099) Shanghai Municipal Health and Family Planning Commission(201840027) and Shanghai Jiao Tong University“Medical and Research”Program(ZH2018ZDA04) 

主　　题：skin flap vascularization biomaterial 

摘      要：Over the past few decades,biomaterials have made rapid advances in tissue *** particular,there have been several studies on vascularization during skin flap regeneration for plastic *** the perspective of function,the biomaterials used to improve the vascularization of skin flaps are primarily classified into two types:(1)electrospun nanofibrous membranes as porous scaffolds,and(2)hydrogels as cell or cytokine *** on their source,various natural,synthetic,and semi-synthetic biomaterials have been developed with respective *** the ischemic environment of the flap tissue,the therapeutic effect of the combination of biomaterials was better than that of drugs,cytokines,and cells *** could improve cell migration,prolong the efficacy of cytokines,and provide an advantageous survival environment to transplanted cells.