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低分子肝素与普通肝素用于冠脉内支架置入术患者疗效比较

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中国药师 2006年第2期9卷 108-110页

作者：张建华张素贞刘东亮董敬远陶志敏漯河市中心医院河南漯河462003

目的:观察冠脉内支架置入术后低分子肝素和普通肝素的临床疗效。方法:将研究对象49例分为普通肝素组22例及低分子肝素组27例。观察两组急性、亚急性支架内血栓形成发生例数及术后半个月内严重心脏事件的发生情况。统计两组出血副作用的... 详细信息

目的:观察冠脉内支架置入术后低分子肝素和普通肝素的临床疗效。方法:将研究对象49例分为普通肝素组22例及低分子肝素组27例。观察两组急性、亚急性支架内血栓形成发生例数及术后半个月内严重心脏事件的发生情况。统计两组出血副作用的发生例数。结果:低分子肝素组发生急性、亚急性支架内血栓形成及术后半个月内心脏严重事件的发生例数均低于普通肝素组,但无统计学差异(P>0．05)。低分子肝素组出血发生率明显低于普通肝素组(P<0．05)。结论:低分子肝素抗凝疗效与普通肝素相似,而出血事件明显少于普通肝素,且无需监测,值得推广应用。

关键词：低分子肝素肝素支架植入支架内血栓形成

Magma mixing of granites at Lianghe:In-situ zircon analysis for trace elements, U-Pb ages and Hf isotopes

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Science China Earth Sciences 2011年第9期54卷 1346-1359页

作者： CONG Feng LIN ShiLiang ZOU GuangFu LI ZaiHui XIE tao PENG zhimin LIANG Ting Chengdu Center of China Geological Survey Chengdu 610081 China State Key Laboratory of Geological Processes and Mineral Resources China University ofGeosciences Wuhan 430074 China

In this paper, we report an integrated study of trace element, U-Pb age and Hf isotopic composition of zircons from alkali feldspar granites, granodiorites and diorite enclaves in a recently discovered ring complex at Lianghe in western Yunnan, Chi na. The granitoids showed identical U-Pb ages of 127, 115 and 122 Ma, from felsic to mafic, but had different zircon trace el ements and Hf isotopic compositions. Trace element content decreased with a gradual increase in εHf(t) values of ?9.1 to ?5.4, ?4.5 to 0, and 3.6 to 6.2, respectively. Results indicate that changes in zircon trace elements generally correlate with changes in Hf isotope signatures within single samples and among various granitoids. These relationships reflect the mixing of felsic and mafic magmas. Evidence indicates that depleted mantle-derived mafic magma underplating caused ancient crustal melting, and then formed large-scale granites in Lianghe during the Early Cretaceous. These granodiorites were formed mainly by the mix ing of mafic magma and granitic magma.

关键词： Lianghe zircon trace element U-Pb age Hf isotope magma mixing

Controllable synthesis of titania/reduced graphite oxide nanocomposites with various titania phase compositions and their photocatalytic performance

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Science China Chemistry 2012年第7期55卷 1294-1302页

作者： ZHAO YanFei XIE Yun SUN ZhenYu ZHANG HongYe tao RanTing HUANG ChangLiang LIU zhimin Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing 100080China

A facile method is presented for preparing TiO2/reduced graphite oxide （RGO） nanocomposites with phase-controlled TiO2 nanoparticles via redox reaction between the reductive titanium （III） precursor and graphite oxide （GO）, and a series of TiO2/RGO composites with various TiO2 phase compositions were obtained. In all the titania/RGO composites, the TiO2 nanoparticles were uniformly distributed on the surface of the RGO. The TiO2 consisted of anatase phase particles in the form of square-plates with edges less than 10 nm and the rutile phase nanorods in diameters less than 10 nm. The performances of the as-prepared TiO2/RGO composites were investigated on catalytically degrading phenol under visible light irradiation. The TiO2/RGO composites can effectively degrade phenol under visible light irradiation, and the phase composition of TiO2 in the composites significantly influences the activities of these catalysts.

关键词： titania phase control reduced graphite oxide composite

Classification of Transmission Line Ground Short Circuit Fault Based on Convolutional Neural Network

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Energy Engineering 2022年第3期119卷 985-996页

作者： tao Guo Gang Tian zhimin Ao Xi Fang Lili Wei Fei Li Tongren Power Supply Bureau of Guizhou Power Grid Co. Ltd.Tongren554300China

Ground short circuit faults in current transmission lines are common in the power *** order to prevent the power system from aggravating the accident caused by short-circuit faults of transmission lines,a novel convolutional neural network(CNN)model is constructed to identify the short-circuit fault of the transmission line in the power *** CNN model is mainly consisted of five convolutional layers,three max-pooling layers,one concatenate layer,one dropout layer,one fully connected layer,and a Softmax *** method uses a fixed time window to intercept system short-circuit fault data,extracts the deep features of these data from the training samples,and then corresponds the extracted features to labels ***,in PSCAD/EMTDC,the new England 10 machine 39 nodes are taken as an example to realize the *** experimental results show that the CNN model can quickly and accurately identify the short-circuit fault types,and the optimal model accuracy rate reaches 99.95%.The results of this manuscript-have positive effect on enhancing the disaster prevention capability and the operation stability of transmission lines.

关键词： Convolutional neural networks transmission line fault classification

Geochronology and Petrogenesis for the Protolith of Biotite Plagioclase Gneiss at Lianghe,Western Yunnan

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Acta Geologica Sinica(English Edition) 2011年第4期85卷 870-880页

作者： CONG Feng LIN Shiliang ZOU Guangfu XIE tao LI Zaihui TANG Fawei PENG zhimin Chengdu Center of China Geological Survey Chengdu 610081China

In this paper,we report an integrated study of U-Pb age and Hf isotope compositions of zircons from biotite plagioclase gneiss at Lianghe in western *** zircons preserved inherited core and rim *** zircon grains and rims yielded a weighted mean ^（206）Pb/^（238）U age of 120.4±1.7 Ma,theirε_（Hf）（120 Ma）values were mainly negative ranging from-13.9 to-10.7,with Hf model ages between 1.9 Ga and 2.0 Ga,some zircons had positiveε_（Hf）（120 Ma）values ranging from 0.2 to *** inherited cores showed the wide variations in the U-Pb age of 375-1315 *** of them showed theε_（Hf）（506 Ma）value of-4.2,it was similar to the gray gneiss of old crust,whichε_（Hf）（500 Ma） values were negative ranging from-4.5 *** geological feature and geochemical data,we concluded that the protolith of biotite plagioclase gneiss was old crust-derived tonalitic magma during the early Cretaceous.

关键词： zircon U-Pb age Hf isotope Lianghe western Yunnan

PTPN11基因突变急性髓系白血病患者临床特征及预后分析

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安徽医科大学学报 2024年第8期59卷 1483-1488,1494页

作者：陶千山薛婉莹谢蓓蓓张青王会平翟志敏秦慧董毅安徽医科大学第二附属医院血液内科合肥230601

目的探讨PTPN11基因突变急性髓系白血病(AML)患者的临床特征及预后情况。方法选取经医院初次诊断、治疗并行二代测序(NGS)检测的成人AML患者115例,收集包括疾病特征、治疗效果、长期预后、免疫细胞亚群以及白血病干细胞等数据,分析PTP... 详细信息

目的探讨PTPN11基因突变急性髓系白血病(AML)患者的临床特征及预后情况。方法选取经医院初次诊断、治疗并行二代测序(NGS)检测的成人AML患者115例,收集包括疾病特征、治疗效果、长期预后、免疫细胞亚群以及白血病干细胞等数据,分析PTPN11基因突变AML患者的临床特征及预后情况。结果初诊成人AML中PTPN11基因突变率为9.57%,突变位点主要发生在3号外显子区域,突变类型均为点突变。与PTPN11基因野生型组相比,PTPN11基因突变组首次诱导治疗期间早期病死率高(18.18%vs 4.00%,P=0.048),完全缓解率低(33.33%vs 67.71%,P=0.039),复发率高(83.33%vs 42.31%,P=0.043),中位总生存时间短(9月vs 20月,P=0.026),效应性T细胞比例低[(1.39±0.12)%vs(3.56±0.46)%,P=0.038],白血病干细胞比例高[(13.82±3.66)%vs(3.87±1.40)%,P=0.021]。结论 PTPN11基因突变是AML的不良预后标志物,该类患者早期病死率高、完全缓解率低、复发率高、中位总生存时间短,且体内效应性T细胞比例低、白血病干细胞比例高。

关键词：急性髓系白血病基因突变 PTPN11 预后

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真实感材质外观的表示和高效渲染技术研究现状及展望

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计算机辅助设计与图形学学报 2024年第8期36卷 1131-1154页

作者：陶成之孙奇过洁袁军平周辰熙何雪滟范之闽史鹏程郭延文计算机软件新技术全国重点实验室(南京大学) 南京210033

在虚拟场景的组成中,除了三维几何模型之外最重要的要素就是物体表面的材质外观,对材质进行基于物理的建模和真实感绘制是保证虚拟场景真实感的重要手段.然而,由于现实世界材质外观本身的多样性和复杂性,迄今为止对真实感材质的研究一... 详细信息

在虚拟场景的组成中,除了三维几何模型之外最重要的要素就是物体表面的材质外观,对材质进行基于物理的建模和真实感绘制是保证虚拟场景真实感的重要手段.然而,由于现实世界材质外观本身的多样性和复杂性,迄今为止对真实感材质的研究一直是计算机图形学领域的热点和难点.文中总结了材质外观的近期相关工作,从材质的表示建模和材质的真实感绘制2大方向展开讨论;进一步,将材质模型分为表达范围广的通用材质模型和针对毛发及布料等材质的特殊材质模型2大类;并将材质绘制方法分为用于离线渲染的点采样优化和用于实时渲染的材质预过滤2种;最后指出材质研究可能的3个发展方向:神经网络材质、波动光学材质和材质的统一标准,为未来该领域的研究提供思路.

关键词：真实感绘制材质表面微结构毛发渲染皮肤渲染布料渲染重要性采样纹理预过滤

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SENEX gene promotes cell proliferation by activating RB/E2F pathway in diffuse large B-cell lymphoma cells

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BIOCELL 2021年第4期45卷 933-942页

作者： JIYU WANG YING PAN YANG WAN ZHIXIANG WANYAN ZHItao WANG QIANSHAN tao zhimin ZHAI Department of Hematology The Second Hospital of Anhui Medical UniversityHefei230601China

The present study aimed to clarify the role of SENEX in malignant cell proliferation in diffuse large B-cell lymphoma(DLBCL).22 DLBCL patients(6 newly diagnosed cases,7 cases at complete remission,and 9 relapsed cases)were included in the *** results indicated that both SENEX gene and protein were significantly increased in peripheral blood mononuclear cells(PBMCs)and tumor cells of relapsed DLBCL patients,accompanied by overexpression of p21,p16,and phosphorylated retinoblastoma(Rb).Silencing the SENEX gene in a DLBCL cell line caused a significant decrease in cell proliferation and inhibited cell cycle progression in the G1 *** Rb and E2F1 were also decreased,and activation of the Rb/E2F1 pathway was obviously *** conclude,the SENEX gene promotes proliferation in PBMC and tumor cells of DLBCL patients by activating the Rb/E2F1 pathway,in a manner suggesting that increased SENEX expression affects the relapse of DLBCL and may serve as an important target for DLBCL therapy.

关键词： SENEX DLBCL Cell proliferation Rb E2F

An efficient chemical reduction-induced assembly of Fe_(3)O_(4)@graphene fiber for wire-shaped supercapacitors with ultrahigh volumetric energy density

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Science China(Technological Sciences) 2021年第10期64卷 2246-2254页

作者： XIAO Peng SHI MinJie XU Li tao FengBo LI Yu ZHU HangTian LIU YuTing LI zhimin ZHOU YunPeng FENG Wei State Grid Jiangsu Electric Power Co.Ltd.Research Institute Nanjing 211103China School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China State Key Laboratory of Advanced Transmission Technology Global Energy Interconnection Research Institute Co.Ltd.Beijing 102211China School of Materials Science and Engineering Tianjin UniversityTianjin 300354China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215213China

Benefiting from high flexibility and weavability,the wire-shaped supercapacitors(SCs)arouse tremendous interests for the applications in wearable/portable *** fiber(GF)is considered as a promising linear electrode for wire-shaped ***,the bottleneck is how to develop the GF-based linear electrode with facile fabrication process while wellmaintaining satisfactory electrochemical ***,a novel Fe_(3)O_(4)@GF composite linear electrode is proposed via a chemical reduction-induced assembly approach,in which the GO and Fe_(3)O_(4) nanoparticles(NPs)realize the efficient selfassembly owing to the electrostatic and van der Waals interactions,as well as the sufficient reduction of GO during the preparation *** resultant fiber-shaped architecture shows boosted charge-transfer kinetics,high flexibility and structural *** Fe_(3)O_(4)@GF linear electrode exhibits excellent electrochemical behaviors including a large volumetric specific capacitance(~250.75 F cm^(−3)),remarkable rate capability and favorable electrochemical kinetics in aqueous electrolyte,superior than previously reported GF-based linear *** real application,a high-performance wire-shaped SC with excellent flexibility and weavability is fabricated based on such Fe_(3)O_(4)@GF linear electrode and gel electrolyte,demonstrating ultrahigh volumetric energy density(18.8 mWh cm^(−3)),power density(4000 mW cm^(−3))and strong durability(~93.5%retention after 10000 cycles).Prospectively,the fabricated wire-shaped SC can maintain reliable electrochemical behaviors in various deformation states,showing its potentials in future portable and wearable devices.

关键词： wire-shaped supercapacitors self-assembly graphene fiber high energy density wearable electronics