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Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retrospective analyses of the POPLAR/OAK and CHOICE-01 trial

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Science China Life Sciences 2025年第1期 249-262页

作者： Jinliang wang Wenyong Zhou Yu Xu Jianchun Duan Qiaoxia Zhou Guoqiang wang Leo Li Chunwei Xu Wenxian wang Shangli Cai zhijie wang Jie wang Department of Oncology The Fifth Medical Center of Chinese PLA General Hospital Department of Thoracic Surgery Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong University Burning Rock Biotech CAMS Key Laboratory of Translational Research on Lung Cancer State Key Laboratory of Molecular OncologyDepartment of Medical OncologyNational Cancer Center/National Clinical Research Center for ancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences Department of Clinical Trial The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)

In non-small cell lung cancers,the non-squamous and squamous subtypes（nsqNSCLC and sqNSCLC） exhibit disparities in pathophysiology,tumor immunology,and potential genomic correlates affecting responses to immune checkpoint inhibitor（ICI）-based *** our inhouse training cohort（n=85）,the presence of the LRP1B deleterious mutation（LRP1B-del） was associated with longer and shorter progression-free survival（PFS） on ICIs alone in nsqNSCLCs and sqNSCLCs,respectively(Pinteraction=0.008).These results were validated using a larger public ICI cohort(n=208,Pinteraction<0.001).Multiplex immunofluorescence staining revealed an association between LRP1B-del and increased and decreased numbers of tumor-infiltrating CD8+T cells in nsqNSCLCs（P=0.040） and sqNSCLCs（P=0.014）,*** the POPLAR/OAK cohort,nsqNSCLCs with LRP1B-del demonstrated improved PFS benefits from atezolizumab over docetaxel(hazard ratio（HR）=0.70,P=0.046),whereas this benefit was negligible in those without LRP1B-del（HR=1.05,P=0.64）.Conversely,sqNSCLCs without LRP1B-del benefited more from atezolizumab（HR=0.60,P=0.002） than those with LRP1B-del（HR=1.30,P=0.31）.Consistent results were observed in the in-house CHOICE-01 cohort,in which nsqNSCLCs with LRP1B-del and sqNSCLCs without LRP1B-del benefited more from toripalimab plus chemotherapy than from chemotherapy alone(Pinteraction=0.008).This multi-cohort study delineates the antithetical impacts of LRP1B-del in nsqNSCLCs and sqNSCLCs on predicting the benefits from ICI alone or with chemotherapy over chemotherapy *** findings highlight the distinct clinical utility of LRP1B-del in guiding treatment choices for nsqNSCLCs and sqNSCLCs,emphasizing the necessity for a detailed analysis based on pathological subtypes when investigating biomarkers for cancer therapeutics.

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Stability of Rotation Relations of Three Unitaries with the Flip Action in C^(*)-Algebras

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Chinese Annals of Mathematics,Series B 2023年第4期44卷 577-598页

作者： zhijie wang Junyun HU Jiajie HUA College of Data Science Jiaxing UniversityJiaxing 314001ZhejiangChina

The authors show that ifΘ=(θ_(jk))is a 3×3 totally irrational real skewsymmetric matrix,whereθ_(jk)∈[0,1)for j,k=1,2,3,then for anyε>0,there existsδ>0 satisfying the following:For any unital C^(*)-algebra A with the cancellation property,strict comparison and nonempty tracial state space,any four unitaries u1,u2,u3,w∈A such that(1)■,wujw-1=uj-1,w2=1A for j,k=1,2,3;(2)τ(aw)=0 and■for all n∈N,all a∈C^(*)(u1,u2,u3),j,k=1,2,3 and all tracial statesτon A,where C^(*)(u1,u2,u3)is the C^(*)-subalgebra generated by u1,u2 and u3,there exists a 4-tuple of unitaries■in A such that■and■for j,k=1,2,*** above conclusion is also called that the rotation relations of three unitaries with the flip action is stable under the above conditions.

关键词： C*-Algebras Stability Rotation relation Unitary Flip action

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Traveling chimera states in locally coupled memristive Hindmarsh-Rose neuronal networks and circuit simulation

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Science China(Technological Sciences) 2022年第7期65卷 1445-1455页

作者： YUAN YuanYuan YANG Hao HAN Fang wang zhijie College of Information Science and Technology Donghua UniversityShanghai 201620China

Chimera states have been found in many physiology systems as well as nervous systems and may relate to neural information processing. The present work investigates the traveling chimera states in memristive neuronal networks of locally coupled Hindmarsh-Rose neurons, with both excitation and inhibition considered. Various traveling chimera patterns and firing modes are found to exist in the networks. Particularly, for excitatory connection, two kinds of traveling chimera states appear in opposite directions. Besides, a new type of chimera state composed of traveling chimera state and incoherent state is observed, named the semi-traveling chimera state. Multi-head traveling chimera states with several incoherent groups are also observed. For excitatory-inhibitory connection, the network is observed to exhibit an imperfect coherent state under the synergistic effect of strong excitatory and weak inhibitory coupling. Moreover, a firing pattern named mixed-amplitude bursting state is witnessed,consisting of two bursts of different amplitudes in a time sequence. Furthermore, an electric circuit is designed and built on Multisim to realize the above phenomena, suggesting that traveling chimera states could be generated in real circuits. Our findings can deepen the understanding of the electromagnetic induction effect in regulating the dynamics of neuronal networks and may provide useful clues for constructing artificial neural systems.

关键词： memristive neuronal network traveling chimera state firing pattern electric circuit

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Sequence memory based on an oscillatory neural network

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Science China(Information Sciences) 2014年第7期57卷 235-246页

作者： XIA Min WENG LiGuo wang zhijie FANG JianAn College of Information and Control Science Nanjing University of Information Science and Technology College of Information Science and Technology Donghua University

In the brain,the discrete elements in a temporal order is encoded as a sequence *** the neural level,the reproducible sequence order of neural activity is very crucial for many *** this paper,a mechanism for oscillation in the network has been proposed to realize the sequence *** mechanism for oscillation in the network that cooperates with hetero-association can help the network oscillate between the stored patterns,leading to the sequence *** to the oscillatory mechanism,the firing history will not be sampled,the stability of the sequence is increased,and the evolvement of neurons’states only depends on the current *** simulation results show that neural network can effectively achieve sequence memory with our proposed model.

关键词： neural network hetero-association sequence memory oscillation Hebbian rule

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Changes in sediment discharge in a sediment-rich region of the Yellow River from 1955 to 2010: implications for further soil erosion control

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Journal of Arid Land 2014年第5期6卷 540-549页

作者： JuYing JIAO zhijie wang GuangJu ZHAO WanZhong wang XingMin MU Institute of Soil and Water Conservation Northwest A&F University Institute of Soil and Water Conservation Chinese Academy of Sciences and Ministry of Water Resources

The well-documented decrease in the discharge of sediment into the Yellow River has attracted considerable attention in recent years. The present study analyzed the spatial and temporal variation of sediment yield based on data from 46 hydrological stations in the sediment-rich region of the Yellow River from 1955 to 2010. The results showed that since 1970 sediment yield in the region has clearly decreased at different rates in the 45 sub-areas controlled by hydrological stations. The decrease in sediment yield was closely related to the intensity and extent of soil erosion control measures and rainstorms that occurred in different periods and sub-areas. The average sediment delivery modulus（SDM） in the study area decreased from 7,767.4 t/（km^2·a） in 1951–1969 to 980.5 t/（km^2·a） in 2000–2010. Our study suggested that 65.5% of the study area with the SDM below 1,000 t/（km^2·a） is still necessary to control soil deterioration caused by erosion, and soil erosion control measures should be further strengthened in the areas with the SDM above 1,000 t/（km^2·a）.

关键词： sediment delivery modulus(SDM) Yellow River hydrological station(s)-controlled sub-area soil and water conservation

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Layered vanadium oxides:Promising cathode materials for calcium-ion batteries

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Chinese Journal of Structural Chemistry 2024年第5期43卷 5-7页

作者： Yuhan Wu Qing Zhao zhijie wang School of Environmental and Chemical Engineering Shenyang University of TechnologyShenyang110870China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin300071China Key Laboratory of Semiconductor Materials Science Beijing Key Laboratory of Low Dimensional Semiconductor Materials and DevicesInstitute of SemiconductorsChinese Academy of SciencesBeijing100083China

Electric vehicles powered by lithium-ion batteries(LIBs)have been regarded as an effective way to reduce CO_(2)emissions,which is known as one of the main causes of global *** share of electric ve-hicles in total sales has increased rapidly,from around 4%in 2020 to 14%in 2022[1].In this case,LIBs have been mass-produced and consumed in the past few *** is estimated that LIBs will account for 65%of total lithium consumption by 2025[2].

关键词： lithium vanadium powered

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An in-depth understanding of photophysics in organic photocatalysts

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Journal of Semiconductors 2023年第3期44卷 9-12页

作者： Mengmeng Ma zhijie wang Yong Lei Key Laboratory of Semiconductor Materials Science Beijing Key Laboratory of Low Dimensional Semiconductor Materials and DevicesInstitute of SemiconductorsChinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Fachgebiet Angewandte Nanophysik Institut für Physik&IMN MacroNanoTechnische Universität IlmenauIlmenau 98693Germany

The urgent need to replace conventional fossil fuels with clean energy has stimulated a large number of research efforts on photocatalytic hydrogen evolution[1−4].Alternatively,organic semiconductors with tunable light absorption,well-positioned band edges,and excellent charge separation are highly expected[5−8].Conventionally,a semiconductor material with a wide band gap has a larger exciton binding energy,while a semiconductor material with a narrow band gap has a smaller exciton binding energy[9].Since smaller exciton binding energies are favorable for exciton separation,choosing a semiconductor with a suitable bandgap seems to be the first step toward high solar-to-hydrogen *** tunable light-harvesting ability determines the advantage and potential of organic semiconductors as ***,the insufficient external quantum efficiency(EQE)and the un-derlying photophysical mechanism remain restricting the orientation toward industrialization[10].

关键词： separation semiconductors replace

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Pattern dynamics of network-organized system with cross-diffusion

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Chinese Physics B 2017年第2期26卷 80-85页

作者： Qianqian Zheng zhijie wang Jianwei Shen College of Information Science and Technology Donghua University Shanghai 201620 China Institute of Applied Mathematics Xuchang University Xuchang 461000 China

Cross-diffusion is a ubiquitous phenomenon in complex networks, but it is often neglected in the study of reaction–diffusion networks. In fact, network connections are often random. In this paper, we investigate pattern dynamics of random networks with cross-diffusion by using the method of network analysis and obtain a condition under which the network loses stability and Turing bifurcation occurs. In addition, we also derive the amplitude equation for the network and prove the stability of the amplitude equation which is also an effective tool to investigate pattern dynamics of the random network with cross diffusion. In the meantime, the pattern formation consistently matches the stability of the system and the amplitude equation is verified by simulations. A novel approach to the investigation of specific real systems was presented in this paper. Finally, the example and simulation used in this paper validate our theoretical results.

关键词： cross diffusion random network Turing instability amplitude equation

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Hybrid solar cells constructed of macroporous n-type GaP coated with PEDOT:PSS

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Chinese Chemical Letters 2015年第4期26卷 469-473页

作者： zhijie wang Elizabeth S.Brown Stephen Maldonado Department of Chemistry University of Michigan Program in Applied Physics University of Michigan

Hybrid organic-inorganic solar cell devices were fabricated utilizing macroporous n-type GaP and poly（3,4-ethylenedioxythiophene）：poly（4-styrene sulfonate）（PEDOT：PSS）. The high-aspect ratio structures of the macroporous GaP resulted in higher photocurrent and external quantum yield as a function of wavelength. Photocurrent-voltage measurements as a function of light intensity revealed information on the dependence of short-circuit current （Jsc） and open-circuit voltage （Voc） on light intensity. Under 1.0 Sun illumination, hybrid macroporous GaPJPEDOT：PSS devices showed Jsc of 2.34 mA cm 2, Voc of 0.95 V, fill factor of 0.54, and overall efficiency of 1.21%. The extent of the influence of dopant density of GaP on hybrid device performance was probed with current density-voltage measurements. The addition of a gold nanoparticle coating on macroporous GaP prior to PEDOT：PSS coating showed increased device performance, with overall efficiency of 1.81%. Gold-modified planar GaPJPEDOT：PSS showed decreased Jsc and Voc values and lower external quantum yield over all wavelengths,

关键词： Gallium phosphideOrganic-inorganic solar cellMacroporous

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Recent progress and future prospect of novel multi-ion storage devices

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Journal of Semiconductors 2023年第4期44卷 1-5页

作者： Shijiang He Zidong wang zhijie wang Yong Lei Institute of Nanochemistry and Nanobiology School of Environmental and Chemical EngineeringShanghai UniversityShanghai 200444China Fachgebiet Angewandte Nanophysik Institut für Physik&IMN MacroNanoTechnische Universität IlmenauIlmenau98693Germany Key Laboratory of Semiconductor Materials Science Beijing Key Laboratory of Low Dimensional Semiconductor Materials and DevicesInstitute of SemiconductorsChinese Academy of SciencesBeijing 100083China

Rechargeable batteries,especially lithium-ion batteries(LIBs),have made rapid development since the 21st century,greatly facilitating people's lives[1−6].Based on considerations of cost and existing problems(such as safety issues due to LIBs stacking strategy and unsatisfactory performance for various applications),researchers have explored alternative technologies to LIBs to meet the needs for wide application scenarios[5].Among them,multi-ion storage devices such as dual-ion batteries(DIBs)and metal-ion hybrid capacitors(MIHCs)are considered promising alternative energy storage devices of LIBs due to their unique multi-ion storage *** a multi-ion storage device,cations and anions carry charges back and forth between the electrolyte and the electrodes at the same time,unlike the rocking chair mechanism of LIBs[7].Generally,the anodes of DIBs and MIHCs work in a similar mechanism to LIBs,storing charge through redox *** main difference among them is the mechanism of the cathodes during charging and discharging[8].In DIBs,the battery-type cathode stores anions through the Faraday reaction.

关键词： mechanism reaction electrolyte

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