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不同类型的慢性血栓栓塞性肺动脉高压肺血管病变的介入治疗策略

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中国循环杂志 2025年第2期40卷 190-196页

作者：李欣杨涛张毅罗勤赵青曾绮娴章思铖赵智慧柳志红中国医学科学院、北京协和医学院、国家心血管病中心、阜外医院呼吸与肺血管疾病诊治中心北京100037 电子科技大学四川省人民医院重症医学中心成都610072

慢性血栓栓塞性肺动脉高压(CTEPH)是一类慢性进展性疾病,其特征是机化的血栓阻塞肺动脉,伴随非阻塞部位的小血管病变,可导致右心衰竭和死亡。肺动脉内膜剥脱术(PEA)是CTEPH患者的根治性手术,但约40%的患者不能接受PEA或术后残留肺动脉... 详细信息

慢性血栓栓塞性肺动脉高压(CTEPH)是一类慢性进展性疾病,其特征是机化的血栓阻塞肺动脉,伴随非阻塞部位的小血管病变,可导致右心衰竭和死亡。肺动脉内膜剥脱术(PEA)是CTEPH患者的根治性手术,但约40%的患者不能接受PEA或术后残留肺动脉高压。对于这些患者,球囊肺动脉成形术(BPA)是有效的治疗方法,可显著改善患者的血液动力学、运动耐力和预后。随着BPA证据的积累,2022年欧洲心脏病学会/欧洲呼吸学会发布的肺动脉高压指南推荐将其作为不适合PEA或术后残留肺动脉高压患者的替代治疗。但不同类型CTEPH病变的特征存在差异,相应的BPA治疗策略和器械有所不同,BPA治疗成功率和并发症发生率差异也较大。本文旨在总结当前不同类型CTEPH病变的BPA治疗策略及相关并发症处理方法,为临床医师提供指导。

关键词：肺动脉高压介入治疗慢性血栓栓塞性肺动脉高压球囊肺动脉成形术策略

钻孔灌注桩废弃泥浆快速絮凝脱水技术与机理研究

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建筑施工 2025年第1期47卷 6-11页

作者：陈祎刘明昊赵智慧无锡大诚建设有限公司江苏无锡214000 扬州大学建筑科学与工程学院江苏扬州225127

钻孔灌注桩废弃泥浆由于具有稠度大、含水率高、流动性大等特点,导致难以自然沉降且对环境造成污染。因此,利用无机絮凝剂FC剂和FS剂、高分子有机絮凝剂FM剂、无机-有机复合絮凝剂FC-FM,通过沉降柱曲线、比阻、浊度等试验,对钻孔灌注桩... 详细信息

钻孔灌注桩废弃泥浆由于具有稠度大、含水率高、流动性大等特点,导致难以自然沉降且对环境造成污染。因此,利用无机絮凝剂FC剂和FS剂、高分子有机絮凝剂FM剂、无机-有机复合絮凝剂FC-FM,通过沉降柱曲线、比阻、浊度等试验,对钻孔灌注桩工程施工过程中产生的废弃泥浆进行快速絮凝脱水研究。结果表明:FS剂的絮凝效果最优质量浓度为0.05 g/mL,最优掺量为泥浆体积的10%;FM剂的最优质量浓度为0.005 g/mL,最优掺量为泥浆体积的15%;FC-FM剂的效果优于二者单掺效果,其中FC最优掺量为10 mL、FM最优掺量为15 mL,此时,液相体积为28 mL,1 d后为35.5 mL,脱水后泥饼质量最低为41.4 g,泥水能够实现快速分离,且其去浊的效果最优,去浊率达45.1%。在最优絮凝脱水组合方案下,利用固化剂S剂可高效固化下层的泥浆,当固化剂掺量从3%增加到7%时,土体的28 d抗压强度从1.08 MPa增长到1.92 MPa,钻孔灌注桩废弃泥浆实现快速处理的同时,节约了1/3的经济成本,可对类似废弃钻孔泥浆的处理提供借鉴。

关键词：钻孔灌注桩废弃泥浆絮凝脱水无机-有机复合絮凝剂固化剂

Asymmetric Synthesis of Novel Axially Chiral 2,2＇-Bipyridine N,N＇-Dioxides Bearing α-Amino Acid Residues and Their Applications in Enantioselective Allylation of Aromatic Aldehydes with Allyltrichlorosilane

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Chinese Journal of Chemistry 2013年第4期31卷 485-493页

作者： Hongwu zhao Yuanyuan Yue Hailong Li zhihui Sheng zhao Yang Wei Meng College of Life Science and Bio-engineering Beijing University of Technology Beijing 100124 China

A series of novel axially chiral 2,2＇-bipyridine N,N＇-dioxides bearing C1 or C2-symmetry have been synthesized by the use of enantiopure a-amino acids as chiral sources. The absolute stereochemistry of the axial chirality of these organocatalysts has been clearly assigned by means of CD measurements together with literature protocols. The reactivities and enantioselectivities of these organocatalysts have been examined in the reactions of aromatic aldehydes with allyltrichlorosilane, thus providing the desired products with moderate yields and enantioselectivies.

关键词： 2,2'-bipyridine N,N'-dioxide organocatalyst asymmetric catalysis enantioselective allylation allyl-trichlorosilane

基于细胞培养基中血清水平优化探索赭曲霉毒素A对HK-2细胞的毒性作用

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南京农业大学学报 2025年第1期48卷 220-229页

作者：董芳张志岐聂冬霞范楷娄秀萍朱雪婷韩铮赵志辉上海海洋大学食品学院上海201306 上海市农业科学院农产品质量标准与检测技术研究所上海201403

[目的]本文旨在探讨细胞培养基中添加不同水平血清对赭曲霉毒素A(ochratoxin A,OTA)毒性的影响,以期更深入了解OTA的毒性,同时为其他OTA体外毒性研究提供重要参考。[方法]测定OTA对人肾皮质近曲小管上皮细胞(human proximal tubule-deri... 详细信息

[目的]本文旨在探讨细胞培养基中添加不同水平血清对赭曲霉毒素A(ochratoxin A,OTA)毒性的影响,以期更深入了解OTA的毒性,同时为其他OTA体外毒性研究提供重要参考。[方法]测定OTA对人肾皮质近曲小管上皮细胞(human proximal tubule-derived epithelial cells,HK-2)细胞活力的影响,同时利用超高效液相色谱-串联质谱技术检测细胞上清液中OTA浓度以间接反应细胞对OTA的摄入量,分析培养基中不同水平血清对OTA毒性的影响。[结果]细胞培养基中添加5%的血清在48 h内不会影响细胞活力,可以作为细胞正常培养条件;添加2%的血清在36 h不会影响细胞活力,可以作为配制OTA工作液的细胞处理条件。基于优化的细胞培养及处理条件,OTA对HK-2细胞活力的影响结果表明,OTA抑制细胞活力呈现时间和剂量依赖性,OTA处理HK-2细胞12、24、36 h的IC50分别为39.29、6.28和2.72 μmol·L^(-1)。同时OTA可以时间依赖性极显著提高细胞释放乳酸脱氢酶水平,并损伤细胞膜的完整性(P<0.01)。[结论]细胞培养基中添加不同水平的血清会影响OTA的毒性,且血清水平越高,对OTA毒性影响越大。当使用2%血清的培养基配制OTA工作液时,可在不影响细胞活力的前提下最大限度降低血清水平对OTA毒性的影响。

关键词：赭曲霉毒素A 血清水平 HK-2细胞超高效液相色谱-串联质谱技术

Review of the research on the development and utilization of clay-type lithium resources

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Particuology 2024年第4期87卷 46-53页

作者： Ruiqi Xie zhihui zhao Xiong Tong Xian Xie Qiang Song Peiqiang Fan Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunming650093China Yunnan Engineering Research Center for Metal Tailings Resource Utilization Kunming650093China

Since the demands for lithium have been in explosive growth recently and several great clay lithium resources were founded in China,the development and utilization of clay-type lithium resources become a hot *** order to provide a guidance for the concentration and extracting lithium of clay-type lithium resources,this review systematically summarized the main types and characteristics of clay-type lithium resources and the research status of lithium extraction from clay lithium ***,the flotation research status of the main mineral of clay lithium ore was also ***,we discussed the difficulties in the development and utilization of clay-type lithium ore and put forward the subsequent research *** paper can provide a guidance for the con-centration and extracting lithium of clay-type lithium resources in the future.

关键词： Clay lithium Clay mineral flotation Lithium extraction Leaching

Extract lithium from clay-type lithium ore by mixed acid and its mechanism Author links open overlay panel

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Particuology 2024年第8期91卷 323-332页

作者： Wuchang Zhou Ruiqi Xie Xiong Tong Xian Xie Yang Liu zhihui zhao Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunming650093China Technology Innovation Center for Comprehensive Utilization of Strategic Mineral Resources Ministry of Natural ResourcesChengdu610041China National&Regional Engineering Research Center for Green comprehensive Utilization of Tailing Resources from Metal Minerals Kunming650093China

A roasting-leaching test was carried out for the efficient utilization of clay-type lithium ore in the central region of Yunnan *** test used the mixed acid of sulfuric acid and phosphoric acid as the leaching *** the conditions of roasting temperature of 600℃,roasting time of 1 h,liquid-solid ratio of 5:1,volume ratio of H_(2)SO_(4)solution to H_(3)PO_(4)solution of 45:5,leaching time of 2 h and leaching temperature of 80℃,the leaching rate of lithium was as high as 97.83%.The leaching mechanism was studied by SEM,pore property analysis,XRD and *** was found that the morphology of the ore changed obviously after roasting and leaching,and a certain degree of collapse and fragmentation occurred,which provided favorable spatial conditions for the leaching of *** porosity,total intrusion volume and total pore area also increased after roasting and leaching,thus promoting the leaching of Li^(+).The results showed that chemical reaction taken placed during the roasting and *** phase of the sample changed from chlorite,kaolinite and diaspore(boehmite)mainly to corundum,hematite,periclase and quartz after ***,after leaching,no new phase was produced in the ore sample,and no S and P elements were found on the surface of the ore sample,indicating that the leaching mechanism of lithium might be the ion exchange between H^(+)and Li^(+).

关键词： Clay-type lithium ore Lithium extraction Roasting Leaching

A Bio-inspired Climbing Robot with Flexible Pads and Claws

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Journal of Bionic Engineering 2018年第2期15卷 368-378页

作者： Aihong Ji zhihui zhao Poramate Manoonpong Wei Wang Guangming Chen Zhendong Dai Institute of Bio-inspired Structure and Surface Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 China CBR Embodied AI & Neurorobotics Lab The McerskMc-Kinney Moller Institute University of Southern Denmark Odense M Denmark

Many animals exhibit strong mechanical interlocking in order to achieve efficient climbing against rough surfaces by using their claws in the pads. To maximally use the mechanical interlocking, an innovative robot which utilizes flexible pad with claws is designed. The mechanism for attachments of the claws against rough surfaces is further revealed according to the theoretical analysis. Moreover, the effects of the key parameters on the performances of the climbing robots are obtained. It indicates that decreasing the size of the tip of the claws while maintaining its stiffness unchanged can effectively improve the attachment ability. Furthermore, the structure of robot body and two foot trajectories are proposed and the new robot is presented. Using experimental tests, it demonstrates that this robot has high stability and adaptability while climbing on vertical rough surfaces up to a speed of 4.6 cm.s^-1.

关键词： bionic climbing robot mechanical interlocking claw rough surface

Expression profiles of genes and enzymes related to ascorbic acid metabolism in fruits of Ziziphus jujuba Mill.‘Jinsixiaozao’

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Frontiers of Agricultural Science and Engineering 2016年第2期3卷 131-136页

作者： Yingying CHEN zhihui zhao Jin zhao Mengjun LIU Research Center of Chinese Jujube Agricultural University of Hebei College of Life Science Agricultural University of Hebei

The fruit of Chinese jujube(Ziziphus jujuba)possesses extremely high concentrations of ascorbic acid(As A).The accumulation of As A,the expression patterns of the nine genes related to As A metabolism as well as the activities of five enzymes involved in As A synthesis,oxidation and recycling were investigated during fruit development in *** Mill.‘Jinsixiaozao'.The results showed that the high level of As A accumulation in jujube fruit is due to a contribution from both As A biosynthesis and As A *** is suggested that L-galactono-1,4-lactone dehydrogenase,ascorbate peroxidase and monodehydro-ascorbate reductase are the crucial genes/enzymes of jujube As A synthesis,oxidization and recycling,*** results provide useful new insights into the regulatory mechanisms of As A accumulation in Chinese jujube.

关键词： Chinese jujube ascorbic acid metabolism gene enzyme

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浅谈反例在概率论教学中的意义

高等数学研究 2025年第1期28卷 95-98,112页

作者：王亚林赵志辉方晓峰火箭军工程大学基础部陕西西安710025

本文针对概率论中的一些重要知识构造了相应的反例,以期深化学生对重要知识的理解,提升学生的思维能力,达到预期的教学目标.

关键词：概率论反例知识理解思维能力