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An Industrial Intrusion Detection Method Based on Hybrid Convolutional Neural Networks with Improved TCN

Computers, Materials & Continua 2024年第1期78卷 411-433页

作者： zhihua liu Shengquan liu Jian Zhang College of Computer Science and Technology Xinjiang UniversityXinjiang Uygur Autonomous RegoinUrumqi830000China

Network intrusion detection systems(NIDS)based on deep learning have continued to make significant advances.However,the following challenges remain:on the one hand,simply applying only Temporal Convolutional Networks(TCNs)can lead to models that ignore the impact of network traffic features at different scales on the detection performance.On the other hand,some intrusion detection methods considermulti-scale information of traffic data,but considering only forward network traffic information can lead to deficiencies in capturing multi-scale temporal features.To address both of these issues,we propose a hybrid Convolutional Neural Network that supports a multi-output strategy(BONUS)for industrial internet intrusion detection.First,we create a multiscale Temporal Convolutional Network by stacking TCN of different scales to capture the multiscale information of network traffic.Meanwhile,we propose a bi-directional structure and dynamically set the weights to fuse the forward and backward contextual information of network traffic at each scale to enhance the model’s performance in capturing the multi-scale temporal features of network traffic.In addition,we introduce a gated network for each of the two branches in the proposed method to assist the model in learning the feature representation of each branch.Extensive experiments reveal the effectiveness of the proposed approach on two publicly available traffic intrusion detection datasets named UNSW-NB15 and NSL-KDD with F1 score of 85.03% and 99.31%,respectively,which also validates the effectiveness of enhancing the model’s ability to capture multi-scale temporal features of traffic data on detection performance.

关键词： Intrusion detection industrial internet channel spatial attention multiscale features dynamic fusion multi-output learning strategy

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Stability and bifurcation analysis of a size-stage-structured cooperation model

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International Journal of Biomathematics 2024年第1期17卷 61-80页

作者： Yajing Li zhihua liu Laboratory of Mathematics and Compler Systems(Ministry of Education)School of Mathematical Sciences Beijing Normal University Beijing 100875 P.R.China

In this paper,we propose a size-stage-structured cooperation model which has two distinct life stages in facultative cooperator.The primary feature of this model is to consider size structure,stage structure and obligate and facultative symbiosis at the same time in a cooperation system.We use the method of characteristic to show that this new model can be reduced to a threshold delay equations(TDEs)model,which can be further transformed into a functional differential equations(FDEs)model by a simple change of variables.Such simplification allows us to apply the classical theory of FDEs and establish a set of sufficient conditions to investigate the qualitative analysis of solutions of the FDEs model,including the global existence and uniqueness,positivity and boundedness.What's more,we use the geometric criteria to get the conclusions about stability and Hopf bifurcation of positive equilibrium because the coefficients of the characteristic equation depend on the bifurcation parameter.Finally,numerical simulations are carried out as supporting evidences of our analytical results.Our results show that the presence of size structure and stage structure plays an important role in the dynamic behavior of the model.

关键词： Cooperation model size-structured threshold-type delay stability bifurcation

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Severe Global Environmental Issues Caused by Canada’s Record-Breaking Wildfires in 2023

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Advances in Atmospheric Sciences 2024年第4期41卷 565-571页

作者： Zhe WANG Zifa WANG Zhiyin ZOU Xueshun CHEN Huangjian WU Wending WANG Hang SU Fang LI Wenru XU zhihua liu Jiaojun ZHU State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Institute of Applied Ecology Chinese Academy of SciencesShenyang 110016China

Due to the record-breaking wildfires that occurred in Canada in 2023,unprecedented quantities of air pollutants and greenhouse gases were released into the atmosphere.The wildfires had emitted more than 1.3 Pg CO_(2)and 0.14 Pg CO_(2)equivalent of other greenhouse gases(GHG)including CH4 and N_(2)O as of 31 August.The wildfire-related GHG emissions constituted more than doubled Canada’s planned cumulative anthropogenic emissions reductions in 10 years,which represents a significant challenge to climate mitigation efforts.The model simulations showed that the Canadian wildfires impacted not only the local air quality but also that of most areas in the northern hemisphere due to long-range transport,causing severe PM_(2.5)pollution in the northeastern United States and increasing daily mean PM_(2.5)concentration in northwestern China by up to 2μg m-3.The observed maximum daily mean PM_(2.5)concentration in New York City reached 148.3μg m-3,which was their worst air quality in more than 50 years,nearly 10 times that of the air quality guideline(i.e.,15μg m-3)issued by the World Health Organization(WHO).Aside from the direct emissions from forest fires,the peat fires beneath the surface might smolder for several months or even longer and release substantial amounts of CO_(2).The substantial amounts of greenhouse gases from forest and peat fires might contribute to the positive feedback to the climate,potentially accelerating global warming.To better understand the comprehensive environmental effects of wildfires and their interactions with the climate system,more detailed research based on advanced observations and Earth System Models is essential.

关键词： Canada forest fire greenhouse gases PM_(2.5) transboundary air pollution

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Analysis on Typical Spatio-temporal Characteristics of Open-cast Mining and Its Countermeasures

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Asian Agricultural Research 2024年第5期16卷 20-24页

作者： Qingyou AO Qiang FU zhihua liu Yu XUN Lin LIN State Power Investment Corporation Inner Mongolia Energy Co. Ltd.Tongliao 029200China Huolinhe South Surface Mine of Inner Mongolia Power Investment Energy Co. Ltd.Tongliao 029200China Huolinhe North Surface Mine of Inner Mongolia Power Investment Energy Co. Ltd.Tongliao 029200China CCTEG Shenyang Engineering Company Shenyang 110015China

In order to deal with the special spatio-temporal environmental changes encountered in the process of open-cast mining,taking Huolinhe No.1 Open-cast Mine as the research object,this paper studied its typical problems in river reconstruction and cultural relics protection.The study focused on eight key core aspects,including the design optimization of the spatial layout of the mining area,the accurate estimation of the mineral resources reserves,the scientific theoretical demonstration of the mining scale,the fine analysis and calculation of the stripping ratio,the comprehensive consideration of the transport distance and efficiency,the accurate judgment of the best time for the implementation of the transformation,the analysis and evaluation of the slope stability,and the overall planning of the production system.The results show that the extracted problem-solving strategies and scheme system for special mining conditions can not only provide specific and practical guidance for Huolinhe No.1 Open-cast Mine,but also serve as a valuable reference and practical reference for other open-cast mine enterprises facing similar challenges.

关键词： Open-cast mining in the mining area Typical space-time environment River reconstruction Cultural relics protection Spatial layout

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Reflections on the withdrawal of medical articles and the development of writing and publishing standards

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Cancer Biology & Medicine 2022年第9期19卷 1283-1289页

作者： Lidong Wang zhihua liu Research Integrity Construction Office(RICO) National Natural Science Foundation of ChinaBeijing 100085China The Supervisory Committee National Natural Science Foundation of ChinaBeijing 100085China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

In recent years,the withdrawal of several batches of articles from international academic journals has negatively affected Chinese scholars.The Chinese government,the scientific community,and many scientific researchers have made substantial efforts to rectify this problem.This Editorial reviews the mass withdrawal events as a whole;identifies their causes;and systematically investigates China’s policy adjustments,institutional arrangements,and regulatory mechanisms in response.We hope that,in addition to reminding authors to pay greater attention to avoiding withdrawals,this Editorial will provide guidance to help them conduct scientific research and present their achievements in a more standardized manner.

关键词： withdrawal arrangement batch

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GNA12 regulates C5a-induced migration by downregulating C5aR1-PLCβ2-PI3K-AKT-ERK1/2 signaling

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Biophysics Reports 2023年第1期9卷 33-44页

作者： Haonan Yu zhihua liu Key Laboratory of Infection and Immunity Institute of Biophysics Chinese Academy of Sciences University of Chinese Academy of Sciences Institute for Immunology Tsinghua University Tsinghua-Peking Center for Life Sciences

Gna12 has been identified as one of the reported inflammatory bowel disease(IBD) susceptibility genes in genome-wide association studies(GWAS). However, the function of GNA12 in intestinal homeostasis remains unknown. Here we report that GNA12, a G-protein α subunit, regulates C5a-induced migration in macrophages. Deficiency of GNA12 results in enhanced migration induced by C5a in macrophages.Mechanistically, GNA12 suppresses C5a-induced migration by downregulating the C5aR1-PLCβ2-PI3K-AKT-ERK1/2 signaling. Therefore, our study reveals that GNA12 is an anti-inflammatory factor, which might alleviate the development of inflammation by inhibiting the excessive chemotactic migration of macrophages.

关键词： Inflammatory bowel disease GNA12 Macrophages Chemotactic migration

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Deep proteome profiling promotes whole proteome characterization and drug discovery for esophageal squamous cell carcinoma

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Cancer Biology & Medicine 2022年第3期19卷 273-277页

作者： Wei liu Yongping Cui Wen liu zhihua liu Liyan Xu Enmin Li College of Science Heilongjiang Institute of TechnologyHarbin 150050China Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology the Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan AreaShantou University Medical CollegeShantou 515041China Department of Pathology Key Laboratory of Cellular Physiology(Shanxi Medical University)Ministry of EducationTaiyuan 030001China Fujian Provincial Key Laboratory of Innovative Drug Target Research School of Pharmaceutical SciencesXiamen UniversityXiamen 361005China State Key Lab of Molecular Oncology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Proteins are key players in various cellular processes.As the ultimate executors of cellular processes,they play essential roles in linking genotypes to phenotypes.Abnormalities in protein expression and post-translational modifications(PTMs)are closely associated with the initiation and development of cancer,and they carry biological information inaccessible to genomics and transcriptomics1.Proteomics complements genomic and transcriptomic data,thus enabling comprehensive analysis of cancer pathogenesis and accelerating biomedical research2.

关键词： esophageal linking carry

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An mRNA vaccine encoding Chikungunya virus E2-E1 protein elicits robust neutralizing antibody responses and CTL immune responses

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Virologica Sinica 2022年第2期37卷 266-276页

作者： Ningning Ge Jin Sun zhihua liu Jiayi Shu Huimin Yan zhihua Kou Yu Wei Xia Jin CAS Key Laboratory of Molecular Virology and Immunology Institut Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China Shanghai Public Health Clinical Center Fudan UniversityShanghai 200540China Wuhan Institute of Virology Chinese Academy of SciencesWuhan 430071China

Arthropod-borne chikungunya virus(CHIKV)infection can cause a debilitating arthritic disease in human.However,there are no specific antiviral drugs and effective licensed vaccines against CHIKV available for clinical use.Here,we developed an m RNA-lipid nanoparticle(m RNA-LNP)vaccine expressing CHIKV E2-E1 antigen,and compared its immunogenicity with soluble recombinant protein s E2-E1 antigen expressed in S2 cells.For comparison,we first showed that recombinant protein antigens mixed with aluminum adjuvant elicit strong antigenspecific humoral immune response and a moderate cellular immune response in C57BL/6 mice.Moreover,s E2-E1vaccine stimulated 12-23 folds more neutralizing antibodies than s E1 vaccine and s E2 vaccine.Significantly,when E2-E1 gene was delivered by an m RNA-LNP vaccine,not only the better magnitude of neutralizing antibody responses was induced,but also greater cellular immune responses were generated,especially for CD8+T cell responses.Moreover,E2-E1-LNP induced CD8~+T cells can perform cytotoxic effect in vivo.Considering its better immunogenicity and convenience of preparation,we suggest that more attention should be placed to develop CHIKV E2-E1-LNP m RNA vaccine.

关键词： Chikungunya virus(CHIKV) mRNA vaccine Neutralizing antibody Cytotoxic T-lymphocytes(CTL)

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The disease resistance potential of Trichoderma asperellum T-Pa2 isolated from Phellodendron amurense rhizosphere soil

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Journal of Forestry Research 2022年第1期33卷 321-331页

作者： Zeyang Yu zhihua liu Yuzhou Zhang Zhiying Wang School of Forestry Northeast Forestry University26 Hexing RoadHarbin 150040People’s Republic of China General Station of Forest and Grassland Pest Management National Forestry and Grassland AdministrationShenyang 110034People’s Republic of China College of Forestry Shenyang Agricultural UniversityShenyang 110866People’s Republic of China

To promote the application of Trichoderma,many countries have collected Trichoderma resources.In the present study,nine isolates were isolated from a rhizosphere soil of Phellodendron amurense and were identified as three species:Trichoderma brevicompactum(one isolate),T.asperellum(two isolates),T.atroviride(six isolates).Dual culture experiments showed that T.asperellum T-Pa2 grew fast and produced the best inhibition rates against six tested pathogens(80.25–91.65%)via competition and mycoparasitism.Populus davidiana×P.alba var.pyramidalis Louche(PdPap poplar)was treated with T-Pa2,which increased the catalase activity,nitrate reductase activity,and content of osmosis molecules significantly(P<0.05).Meanwhile,induction by T-Pa2 increased the resistance of PdPap poplar against Alternaria alternata via modulating the expression of salicylic acid,jasmonic acid,and auxin transduction pathway genes.The results will form the basis for the collection and application of biocontrol agents in forestry.

关键词： Biological control Trichoderma identification Antifungal property Enzyme activity

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Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis

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Frontiers of Medicine 2023年第5期17卷 924-938页

作者： Pengfei Zhao Yating Wang Xiao Yu Yabing Nan Shi liu Bin Li Zhumei Cui zhihua liu State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100021China Department of Gynecological Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100021China Department of Obstetrics and Gynecology The Affiliated Hospital of Qingdao UniversityQingdao266000China

Long noncoding RNAs(lncRNAs)play a crucial regulatory role in the development and progression of multiple cancers.However,the potential mechanism by which lncRNAs affect the recurrence and metastasis of ovarian cancer remains unclear.In the current study,the lncRNA LOC646029 was markedly downregulated in metastatic ovarian tumors compared with primary tumors.Gain-and loss-of-function assays demonstrated that LOC646029 inhibits the proliferation,invasiveness,and metastasis of ovarian cancer cells in vivo and in vitro.Moreover,the downregulation of LOC646029 in metastatic ovarian tumors was strongly correlated with poor prognosis.Mechanistically,LOC646029 served as a miR-627-3p sponge to promote the expression of Sprouty-related EVH1 domain-containing protein 1,which is necessary for suppressing tumor metastasis and inhibiting KRAS signaling.Collectively,our results demonstrated that LOC646029 is involved in the progression and metastasis of ovarian cancer,which may be a potential prognostic biomarker.

关键词： 0varian cancer lncRNA LOC646029 metastasis microRNA 627-3p SPRED1

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