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Nano Research 2025年第1期18卷 100-106页

作者： Ri Feng Jiuyi Hu Liangjun Wang Jiayu xu Jiajia Li Zeeshan Ahmad Shaohui Zheng Muhammad Farhan Farid Wenjing Liu Faisal Saleem Key Laboratory of Flexible Electronics(KLOFE) Institute of Advanced Materials(IAM)and School of Flexible Electronics(Future Technologies)Nanjing Tech UniversityNanjing 211816China

Nanozymes,which possess enzyme-like catalytic activity,are attractive alternatives to natural *** activity is largely dependent on the structure of the ***,challenges remain in optimizing the structure-activity *** work explores the synthesis and utilization of PtCu nanostructures(NSs),focusing on their peroxidase(POD)-like properties and their potential as antibacterial *** developed PtCu dendrites that transform into unique dendroframe octahedrons(DFOs)and subsequently stabilize into solid octahedrons with unusual growth *** intermediate DFO,showed higher POD-like activity in comparison to other shapes of PtCu *** DFOs also have the better ability to consume glutathione,thus enhancing their sterilization ***,we demonstrate the effectiveness of these PtCu DFOs as powerful antibacterial *** work provides valuable information on shape dependent activities of PtCu NSs in the field of biomedicine.

关键词： nanozymes antibacterials peroxidase PtCu dendroframe octahedrons dendrites

Negative efficacy of antidepressants in pharmacotherapy of child and adolescent depression

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World Journal of Psychiatry 2025年第1期15卷 32-36页

作者： Min xu Hai-Ying Jin Feng-Li Sun Wei-Dong Jin Department of Psychiatry Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Psychiatry Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Department of Psychiatry Zhejiang Provincial Mental Health CenterHangzhou 311122Zhejiang ProvinceChina

Antidepressants are the main drugs used to treat depression,but they have not been shown to be effective in the treatment of child and adolescent ***,many adolescent depression treatment guidelines still recommend the use of antidepressants,especially specific serotonin re-uptake *** studies have suggested that antidepressants have little therapeutic effect but many side effects,such as switching to mania,suicide,and non-suicidal self injury(NSSI),in the treatment of child and adolescent *** the process of developing guidelines,drug recommendations should not only focus on impro-ving symptoms,but they should also consider potential side *** review discusses the serious side effects of antidepressants,including switching to mania,suicide,and NSSI.

关键词： Child depression Adolescent depression Antidepressant Switch Suicide Non-suicidal self injury

Study on the COVID-19 epidemic in China's Mainland between November 2022 and January 2023,with prediction of its tendency

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Journal of Biosafety and Biosecurity 2023年第1期5卷 39-44页

作者： Yao Bai zhihang Peng Fengying Wei Zhen Jin Jinjie Wang Ximing xu Xinyan Zhang Jun xu Zixiong Ren Bulai Lu Zhaojun Wang Jianguo xu Senzhong Huang Xi’an Center for Disease Control and Prevention Xi’an 710054ShaanxiChina Department of Biostatistics School of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina School of Mathematics and Statistics Fuzhou UniversityFuzhou 350116FujianChina Complex Systems Research Center Key Discipline of Computer Science and Technology of“Double-First-Class”Project of Shanxi ProvinceShanxi UniversityTaiyuan 030006ShanxiChina Nankai Institute of Economics Binhai Development InstituteNankai UniversityTianjin 300071China Children’s Hospital of Chongqing Medical University Chongqing 400010China Jinzhou Center for Disease Control and Prevention Jinzhou 121000LiaoningChina School of Statistics and Data Science Nankai UniversityTianjin 300071China Suzhou Center for Disease Control and Prevention Suzhou 215004JiangsuChina State Key Laboratory of Communicable Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Institute of Public Health Nankai UniversityTianjin 300071China School of Statistics and Data Science ZhiYing Research Center for Health DataNankai UniversityTianjin 300071China

The prediction system EpiSIX was used to study the COVID-19 epidemic in China's Mainland between November 2022 and January 2023,based on reported data from December 9,2022,to January 30,2023,released by The Chinese Center for Disease Control and Prevention on February 1,*** kinds of reported data were used for model fitting:the daily numbers of positive nucleic acid tests and deaths,and the daily number of hospital beds taken by COVID-19 *** was estimated that the overall infection rate was 87.54%and the overall case fatality rate was 0.078%–0.116%(median 0.100%).Assuming that a new COVID-19 epidemic outbreak would start in March or April of 2023,induced by a slightly more infectious mutant strain,we predicted a possible large rebound between September and October 2023,with a peak demand of between 800,000 and 900,000 inpatient *** no such new outbreak was induced by other variants,then the current COVID-19 epidemic course in China's Mainland would remain under control until the end of ***,it is suggested that the necessary medical resources be prepared to manage possible COVID-19 epidemic emergencies in the near future,especially for the period between September and October 2023.

关键词： COVID-19 Epidemic Infection rate Case fatality rate Prediction

Profile of Dr. Tao xu

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Science China(Life Sciences) 2018年第11期61卷 1310-1311页

作者： xu Tao

*** xu is an outstanding biophysicist on membrane trafficking and super-resolution *** has mainly focused on two aspects:one is to identify key proteins and molecular regulatory mechanisms involved in the docking,priming and fusion of different secretory vesicles such as DCVs and GSVs dense core vesicles (DCVs)and GLUT4 storage vesicles(GSVs).

关键词： vesicles DCVs outstanding biophysicist membrane

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Bullous pemphigoid associated with acquired hemophilia A: A case report

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World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： Su-Ye Hu Meng-Can Li Zi-Jia Hao xu-Ya Chai Pei-Sai Li Yang Liu Li-Xia Liu Ying xu Pan-Pan Yang Ling-E Li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (< 1.0%). Furthermore, the FⅧ inhibitor titer had greatlyincreased (59.2 Bethesda units). Therefore, the patient was diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 *** AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

A Flexible Smart Healthcare Platform Conjugated with Artificial Epidermis Assembled by Three‑Dimensionally Conductive MOF Network for Gas and Pressure Sensing

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Nano-Micro Letters 2025年第2期17卷 601-620页

作者： Qingqing Zhou Qihang Ding Zixun Geng Chencheng Hu Long Yang Zitong Kan Biao Dong Miae Won Hongwei Song Lin xu Jong Seung Kim State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea TheranoChem Incorporation Seoul 02856Republic of Korea

The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine *** building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external ***,realistic mimesis,both in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities,remains a challenging yet vital need for simplifying the design of flexible logic ***,we construct an artificial epidermal device by in situ growing Cu_(3)(HHTP)_(2) particles onto the hollow spherical Ti_(3)C_(2)T_(x) surface,aiming to concurrently emulate the spinous and granular layers of the skin’s *** bionic Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2) exhibits independent NO_(2) and pressure response,as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message ***,a wearable alarming system with a mobile application terminal is self-developed by integrating the bimodular senor into flexible printed *** system can assess risk factors related with asthmatic,such as stimulation of external NO_(2) gas,abnormal expiratory behavior and exertion degrees of fingers,achieving a recognition accuracy of 97.6%as assisted by a machine learning *** work provides a feasible routine to develop intelligent multifunctional healthcare equipment for burgeoning transformative telemedicine diagnosis.

关键词： Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2)composites NO_(2)/pressure flexible sensors Health-monitoring Machine learning

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Enantio-divergent C–H borylation with two different ligands from a single chiral source

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Science China Chemistry 2025年第1期 226-232页

作者： Rongrong Du Senmiao xu State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics Chinese Academy of Sciences College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of Education Hangzhou Normal University University of Chinese Academy of Sciences

Reported here is an iridium-catalyzed enantio-divergent C（sp3）–H borylation of α-gem-dimethyl groups of trifluoromethyl ketone-derived hydrazones to construct a series of acyclic all-carbon quaternary stereocenters with a high level of chiral induction. Two different chiral bidentate boryl ligands from a common chiral source not only can switch the enantioselectivity but also are complementary in terms of the substrate scope.

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基于RUSLE和地理探测器的皖南地区土壤侵蚀时空分异及定量归因

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水土保持研究 2025年第1期32卷 21-29页

作者：许长安王乃举合肥大学生物食品与环境学院合肥大学旅游与会展学院

[目的]揭示皖南地区土壤侵蚀时空分异特征及成因可为该区域的土壤侵蚀防治提供科学依据。[方法]基于RUSLE模型和地理探测器，结合多源遥感数据，探查皖南地区土壤侵蚀时空分布及其影响因素。[结果](1) 2002—2022年该地区土壤侵蚀空间... 详细信息

[目的]揭示皖南地区土壤侵蚀时空分异特征及成因可为该区域的土壤侵蚀防治提供科学依据。[方法]基于RUSLE模型和地理探测器，结合多源遥感数据，探查皖南地区土壤侵蚀时空分布及其影响因素。[结果](1) 2002—2022年该地区土壤侵蚀空间分布差异显著。安庆市北部大别山区、安庆市东南部大别山余脉大龙山片、铜陵市东部与芜湖市中西部狮子山片、池州市与宣城市南部、黄山市内黄山山区和周边齐云山及白际山等地区系主要侵蚀区；而皖江诸市沿江平原及其他诸河河谷平原土壤侵蚀较小。(2) 2002—2022年该地区的土壤侵蚀总体呈“下降—上升—下降”趋势。其中，2002年总侵蚀量为2 231.41万t/a, 2007年降至2 118.05万t/a,而2012年增至2 452.36万t/a,之后持续下降至2022年的2 060.67万t/a。(3)因子探测器的各因子解释力结果显示：土地覆盖类型、坡度、海拔、降雨是该地区的主要影响因素。(4) 2002年、2017年、2022年土地覆盖类型与其他因子共同作用对土壤侵蚀的解释力大于其他因子，而2007年、2012年为植被覆盖度与其他因子共同作用对土壤侵蚀的解释力较为突出。(5)基于2022年的土壤侵蚀数据及因子数据所识别的高风险区域为植被覆盖度63.96°、海拔1 056～1 819 m、年均温度10.46～11.3℃的灌丛。[结论]皖南地区在过去20年中土壤侵蚀状况有所改善，但坡度大、植被覆盖度低、降雨强度高及不合理土地利用的山地丘陵区仍然是高侵蚀风险区域，未来的防治工作应针对这些重点区域。

关键词：土壤侵蚀 RUSLE模型地理探测器皖南地区

Clinicopathological differences between patients with schistosomal appendicitis and non schistosomal appendicitis:A retrospectively study of past ten years

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World Journal of Clinical Cases 2025年第2期13卷 24-32页

作者： Xiao-Yi Wang Yao Hao Zi-Jian Wang Xiu-Liang xu Jiang-Hua Yang Department of Infectious Diseases The First Affiliated of Wannan Medical CollegeWuhu 241001Anhui ProvinceChina

BACKGROUND Chronic schistosomiasis causes multiple organ and multiple system diseases,especially the digestive *** eggs are mainly deposited in the stomach,liver and colorectal,but a few eggs are deposited in the appendix and cause *** present,there are few studies on schistosomal *** To explore the differences in epidemiological,clinical and pathological characteristics between schistosomal appendicitis and non-schistosomal appendicitis over the past decade in order to assess the impact of schistosomiasis on *** The differences of general data,clinical data and laboratory examination data of patients with appendicitis from October 2013 to October 2023 were retrospectively *** patients were divided into two groups for *** were 136 patients in schistosomal appendicitis group and 5418 patients in non-schistosomal appendicitis *** Schistosomal appendicitis accounted for 2.45%of all patients with appendicitis,and the annual proportion in the past decade was 2.2%,2.9%,1.8%,1.9%,3.4%,3.1%,1.9%,1.6%,3%,2.6%,*** prevalence of schistosomal appendicitis was middle-aged and elderly males,with an average age of 61.73±15.335 *** main population of non-schistosomal appendicitis was middle-aged men,with an average age of 35.8±24.013 years(P<0.001).The distribution of pathological types of appendicitis was different between the two groups(P<0.001).The incidence of acute suppurative appendicitis in non-schistosomal appendicitis was higher than that in schistosomal appendicitis[odds ratio(OR)=0.504;95%confidence interval(CI):0.349-0.728;P<0.001].The proportion of acute attack of chronic appendicitis in schistosomal appendicitis was higher than that in non-schistosomal appendicitis(OR=2.614;95%CI:1.815-3.763;P<0.001).The proportion of schistosomal appendicitis patients complicated with colorectal cancer was higher than that of nonschistosomal appendicitis patients(OR=5.087;95%CI:1.427-

关键词： Schistosomal appendicitis Schistosomiasis Appendix Colorectal cancer Clinicopathological characteristics

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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