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Characterization, preparation, and reuse of metallic powders for laser powder bed fusion: a review

International Journal of Extreme Manufacturing 2024年第1期6卷 52-91页

作者： Xiaoyu Sun Minan Chen Tingting Liu Kai Zhang Huiliang Wei zhiguang zhu Wenhe Liao School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094People’s Republic of China

Laser powder bed fusion(L-PBF) has attracted significant attention in both the industry and academic fields since its inception, providing unprecedented advantages to fabricate complex-shaped metallic components. The printing quality and performance of L-PBF alloys are infuenced by numerous variables consisting of feedstock powders, manufacturing process,and post-treatment. As the starting materials, metallic powders play a critical role in infuencing the fabrication cost, printing consistency, and properties. Given their deterministic roles, the present review aims to retrospect the recent progress on metallic powders for L-PBF including characterization, preparation, and reuse. The powder characterization mainly serves for printing consistency while powder preparation and reuse are introduced to reduce the fabrication *** powder characterization and preparation methods are presented in the beginning by analyzing the measurement principles, advantages, and limitations. Subsequently, the effect of powder reuse on the powder characteristics and mechanical performance of L-PBF parts is analyzed, focusing on steels, nickel-based superalloys, titanium and titanium alloys, and aluminum alloys. The evolution trends of powders and L-PBF parts vary depending on specific alloy systems, which makes the proposal of a unified reuse protocol infeasible. Finally,perspectives are presented to cater to the increased applications of L-PBF technologies for future investigations. The present state-of-the-art work can pave the way for the broad industrial applications of L-PBF by enhancing printing consistency and reducing the total costs from the perspective of powders.

关键词： laser powder bed fusion powder characterization powder preparation powder reuse

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Multienzyme co-immobilization-based bioelectrode:Design of principles and bioelectrochemical applications

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Chinese Journal of Chemical Engineering 2020年第8期28卷 2037-2050页

作者： Ranran Wu Haiyan Song Yuanming Wang LeiWang zhiguang zhu Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences32West Seventh AvenueTianjin Airport Economic AreaTianjin 300308China University of Chinese Academy of Sciences 19A Yuquan RoadShijingshan DistrictBeijing 100049China National Human Genetic Resource Center 12 Dahuisi RoadHaidian DistrictBeijing 100081China

Enzyme cascade reactions play significant roles in bioelectrochemical processes because they permit more complex reactions. Co-immobilization of multienzyme on the electrode could help to facilitate substrate/intermediate transfer among different enzymes and electron transfer from enzyme active sites to the electrode with high stability and retrievability. Different co-immobilization strategies to construct multienzyme bioelectrodes have been widely reported, however, up to now, they have barely been reviewed. In this review, we focus on recent state-of-the-art techniques for constructing co-immobilized multienzyme electrodes including random and positional co-immobilization. Particular attention is given to strategies such as multienzyme complex and surface display. Cofactor co-immobilization on the electrode is also crucial for the enhancement of catalytic reaction and electron transfer, yet, few studies have been reported. The up-to-date advances in bioelectrochemical applications of multienzyme bioelectrodes are also presented. Finally, key challenges and future perspectives are discussed.

关键词： Multienzyme co-immobilization Bioelectrode Bioelectrochemical system Cascade reaction

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Crack-free and high-strength AA2024 alloy obtained by additive manufacturing with controlled columnar-equiaxed-transition

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Journal of Materials Science & Technology 2023年第25期156卷 183-196页

作者： Xing zhu zhiguang zhu Tingting Liu Wenhe Liao Yulei Du Huiliang Wei School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China

Laser powder bed fusion(LPBF)of high-strength Al alloys is challenging due to the formation of both hot and cold *** the present work,highly dense and crack-free AA2024 samples could be additively manufactured via inoculation treatment of Zr-based metallic glass(MG)*** columnar grains in the LPBF-fabricated AA2024 alloy were significantly refined and almost completely transformed to the equiaxed grains with a bimodal grain size distribution consisting of ultrafine grains with a size smaller than 1μm and relatively coarser *** grain refinement can be associated with the formation of Al3Zr particles,serving as the heterogeneous nucleation sites for theα-Al *** routes for columnar-equiaxed-transition(CET)have been revealed by tailoring the concentration of nucleation particles and solidification *** occurs both at the melt pool boundary due to the sufficiently high concentration of Al3Zr particles and at the topmost of the melt pool due to the heterogeneous nucleation driven by constitutional *** these two regions,columnar grains epitaxially grow with orientations determined by the thermal *** as-built Zr-based MG inoculated AA2024 specimens are robust in healing hot cracks due to a more tortuous propagation path of cracks for equiaxed *** as-fabricated AA2024/5%MG specimens exhibit a high ultimate tensile strength of 531 MPa due to crack elimination and grain refinement,surpassing most of the reported values for the LPBF-fabricated AA2024 alloy inoculated with other inoculated *** present work could provide a novel inoculation agent to fabricate high-strength Al alloys and the CET can be used to precisely control the grain morphology.

关键词： Laser powder bed fusion Aluminum alloy Solidification parameters Columnar-equiaxed-transition Hot cracking Grain refinement

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Protein engineering of oxidoreductases utilizing nicotinamide-based coenzymes,with applications in synthetic biology

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Synthetic and Systems Biotechnology 2017年第3期2卷 208-218页

作者： Chun You Rui Huang Xinlei Wei zhiguang zhu Yi-Heng Percival Zhang Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences32 West 7th AvenueTianjin Airport Economic AreaTianjin300308People's Republic of China Biological Systems Engineering Department Virginia Tech304 Seitz HallBlacksburgVA 24061USA

Two natural nicotinamide-based coenzymes(NAD and NADP)are indispensably required by the vast majority of oxidoreductases for catabolism and anabolism,*** NAD(P)-dependent oxidoreductases prefer one coenzyme as an electron acceptor or donor to the other depending on their different metabolic *** coenzyme preference associated with coenzyme imbalance presents some challenges for the construction of high-efficiency in vivo and in vitro synthetic biology *** the coenzyme preference of NAD(P)-dependent oxidoreductases is an important area of protein engineering,which is closely related to product-oriented synthetic biology *** review focuses on the methodology of nicotinamide-based coenzyme engineering,with its application in improving product yields and decreasing production *** nicotinamide-containing coenzymes have been proposed to replace natural coenzymes because they are more stable and less costly than natural *** advances in the switching of coenzyme preference from natural to biomimetic coenzymes are also covered in this *** coenzyme preferences from natural to biomimetic coenzymes has become an important direction for coenzyme engineering,especially for in vitro synthetic pathways and in vivo bioorthogonal redox pathways.

关键词： Coenzyme engineering Nicotinamide-based coenzymes NAD NADP Protein engineering Synthetic biology Biomimetic coenzymes

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Stoichiometric Conversion of Maltose for Biomanufacturing by In Vitro Synthetic Enzymatic Biosystems

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BioDesign Research 2022年第1期2022卷 217-227页

作者： Guowei Li Xinlei Wei Ranran Wu Wei Zhou Yunjie Li zhiguang zhu Chun You Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences32 West 7th AvenueTianjin Airport Economic AreaTianjin 300308China College of Biotechnology Tianjin University of Science and Technology1038 Dagu NanluHexi DistrictTianjin 300457China National Technology Innovation Center of Synthetic Biology Tianjin 300308China

Maltose is a natural α-(1,4)-linked disaccharide with wide applications in food industries and microbial fermentation. However,maltose has scarcely been used for in vitro biosynthesis, possibly because its phosphorylation by maltose phosphorylase (MP)yields β-glucose 1-phosphate (β-G1P) that cannot be utilized by α-phosphoglucomutase (α-PGM) commonly found in in vitrosynthetic enzymatic biosystems previously constructed by our group. Herein, we designed an in vitro synthetic enzymaticreaction module comprised of MP, β-phosphoglucomutase (β-PGM), and polyphosphate glucokinase (PPGK) for thestoichiometric conversion of each maltose molecule to two glucose 6-phosphate (G6P) molecules. Based on this syntheticmodule, we further constructed two in vitro synthetic biosystems to produce bioelectricity and fructose 1,6-diphosphate (FDP),respectively. The 14-enzyme biobattery achieved a Faraday efficiency of 96.4% and a maximal power density of 0.6mW/cm^(2),whereas the 5-enzyme in vitro FDP-producing biosystem yielded 187.0mM FDP from 50 g/L (139mM) maltose by adopting afed-batch substrate feeding strategy. Our study not only suggests new application scenarios for maltose but also provides novelstrategies for the high-efficient production of bioelectricity and value-added biochemicals.

关键词： enzymatic utilized maximal

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Ginsenoside Rk3 modulates gut microbiota and regulates immune response of group 3 innate lymphoid cells to against colorectal tumorigenesis

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Journal of Pharmaceutical Analysis 2024年第2期14卷 259-275页

作者： Xue Bai Rongzhan Fu Yannan Liu Jianjun Deng Qiang Fei zhiguang Duan Chenhui zhu Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials School of Chemical EngineeringNorthwest UniversityXi'an710069China Biotech&Biomed Research Institute Northwest UniversityXi'an710069China School of Chemical Engineering and Technology Xi'an Jiaotong UniversityXi'an710069China

The gut microbiota plays a pivotal role in the immunomodulatory and protumorigenic microenvironment of colorectal cancer(CRC).However,the effect of ginsenoside Rk3(Rk3)on CRC and gut microbiota remains ***,the purpose of this study is to explore the potential effect of Rk3 on CRC from the perspective of gut microbiota and immune *** results reveal that treatment with Rk3 significantly suppresses the formation of colon tumors,repairs intestinal barrier damage,and regulates the gut microbiota imbalance caused by CRC,including enrichment of probiotics such as Akkermansia muciniphila and Barnesiella intestinihominis,and clearance of pathogenic *** metabolomics data demonstrate that Rk3 can modulate the metabolism of amino acids and bile acids,particularly by upregulating glutamine,which has the potential to regulate the immune ***,we elucidate the regulatory effects of Rk3 on chemokines and inflammatory factors associated with group 3 innate lymphoid cells(ILC3s)and T helper 17(Th17)signaling pathways,which inhibits the hyperactivation of the Janus kinase-signal transducer and activator of transcription 3(JAK-STAT3)signaling *** results indicate that Rk3 modulates gut microbiota,regulates ILC3s immune response,and inhibits the JAK-STAT3 signaling pathway to suppress the development of colon *** importantly,the results of fecal microbiota transplantation suggest that the inhibitory effect of Rk3 on colon tumors and its regulation of ILC3 immune responses are mediated by the gut *** summary,these findings emphasize that Rk3 can be utilized as a regulator of the gut microbiota for the prevention and treatment of CRC.

关键词： Colorectal cancer Ginsenoside Immune cells Gut microbiota

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Establishment of NaLuF_(4):15%Tb-based low dose X-PDT agent and its application on efficient antitumor therapy

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 599-610页

作者： Yi Tian zhiguang Fu Xiaosheng zhu Chunjing Zhan Jinwei Hu Li Fan Chaojun Song Qian Yang Yu Wang Mei Shi Department of Radiation Oncology Xijing HospitalThe Fourth Military Medical UniversityXi’an 710032China Department of Oncology Air Force Medical CenterPLAThe Fourth Military Medical UniversityBeijing 100142China Department of Tumor Radiotherapy Air Force Medical CenterPLAThe Fourth Military Medical UniversityBeijing 100142China Department of Gastroenterology Air Force Hospital of Southern Theater CommandGuangzhou 510062China Department of Pharmaceutical Chemistry and Analysis School of PharmacyThe Fourth Military Medical UniversityXi’an 710032China School of Life Sciences Northwestern Polytechnical UniversityXi’an 710072China Institue of Materia Medica School of PharmacyThe Fourth Military Medical UniversityXi’an 710032China

X-ray excited photodynamic therapy(X-PDT)is the bravo answer of photodynamic therapy(PDT)for deep-seated tumors,as it employs X-ray as the irradiation source to overcome the limitation of light penetration ***,high X-ray irradiation dose caused organ lesions and side effects became the major barrier to X-PDT *** address this issue,this work employed a classic-al co-precipitation reaction to synthesize NaLuF_(4):15%Tb^(3+)(NLF)with an average particle size of(23.48±0.91)nm,which was then coupled with the photosensitizer merocyanine 540(MC540)to form the X-PDT system NLF-MC540 with high production of singlet *** system could induce antitumor efficacy to about 24%in relative low dose X-ray irradiation range(0.1-0.3 Gy).In vivo,when NLF-MC540 irradiated by 0.1 Gy X-ray,the tumor inhibition percentage reached 89.5%±5.7%.The therapeutic mechanism of low dose X-PDT was found.A significant increase of neutrophils in serum was found on the third day after *** immunohistochemical staining of tumor sections,the Ly6G^(+),CD8^(+),and CD11c^(+)cells infiltrated in the tumor microenvironment were *** the bilat-eral tumor model,the NLF-MC540 with 0.1 Gy X-ray irradiation could inhibit both the primary tumor and the distant tumor ***-tected by enzyme linked immunosorbent assay(ELISA),two cytokines IFN-γand TNF-αin serum were upregulated 7 and 6 times than negative control,*** by enzyme linked immune spot assay(ELISPOT),the number of immune cells attributable to the IFN-γand TNF-αlevels in the group of low dose X-PDT were 14 and 6 times greater than that in the negative control group,***,it conclude that low dose X-PDT system could successfully upregulate the levels of immune cells,stimulate the secretion of cy-tokines(especially IFN-γand TNF-α),activate antitumor immunity,and finally inhibit colon tumor growth.

关键词： X-ray excited photodynamic therapy singlet oxygen low dose X-Ray irradiation efficient antitumor therapy anti-tumor immunity

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In Situ Analysis of Tobacco Leaves Based on Microwave Plasma Torch Desorption Ionization Mass Spectrometry

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Journal of Analysis and Testing 2024年第1期8卷 9-15页

作者： He Tang Yonggang Zhang zhiguang Reng Junchen zhu Yue Xie Xiaobin Zhang Hongru Feng Kailong Yuan Yuanjiang Pan Department of Chemistry Zhejiang UniversityHangzhou 310027China Zhejiang China Tobacco Industrial Co. Ltd.Hangzhou310008China

Tobacco is an important economic crop *** leaves contain a large number of natural ***,the analysis of tobacco composition is crucial for the control of tobacco safety and quality *** plasma torch desorption ionization mass spectrometry(MPT-MS) is an emerging ambient mass spectrometry(AMS) technique that can be used for rapid real-time analysis of s amples without *** work focuses on the chemical composition analysis of tobacco using MPT-MS,and 14 compounds were detected in green flue-cured tobacco leaves,while 30 compounds were detected in cured flue-cured tobacco leaves,which confirms that curing can enhance the flavor of ***,we successfully in situ identified characteristic fragment ions of α/β-CBD(α/β-cembranoids),an important aroma compound in tobacco by *** results demonstrate the capability of MPT-MS for in situ analysis of tobacco components and its potential for evaluating tobacco quality.

关键词： Microwave plasma torch Ambient mass spectrometry Tobacco α/β-Cembranoids

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Study on two-stage fractional order gradient descend method

Study on two-stage fractional order gradient descend method

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第40届中国控制会议

作者： zhiguang zhu Ang LI Yong WANG Department of Automation University of Science and Technology of China

In this paper, a new kind of gradient descent method with global search capability is proposed. This method is superior to the conventional gradient method in two aspects. On the one hand, the particle swarm optimization algorithm is used to obtain the initial value near the global optimal solution. On the other hand, the fractional order gradient is used instead of the first order in the iteration. For the characteristics of the fractional calculus, the method can quickly escape the saddle point to accelerate the convergence process. We test the efficiency of the algorithm on a multi extremum function and a medium scale convolution neural network, and compare it with other conventional algorithms. Finally, conclusions and some suggestions for future work are given.

关键词： Global optimization Fractional calculus Gradient descent method Neural network

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3 - 7 Stability Study of PAN-PEO based Quasi-solid DSSC

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IMP & HIRFL Annual Report 2010年第1期 97-98页

作者： Ma Yizhun Wang zhiguang zhu Yabin Pang Lilong Shen Tielong

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