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Ginsenoside Rk3 modulates gut microbiota and regulates immune response of group 3 innate lymphoid cells to against colorectal tumorigenesis

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Journal of Pharmaceutical Analysis 2024年第2期14卷 259-275页

作者： Xue Bai Rongzhan Fu Yannan Liu Jianjun Deng Qiang Fei zhiguang duan Chenhui Zhu Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials School of Chemical EngineeringNorthwest UniversityXi'an710069China Biotech&Biomed Research Institute Northwest UniversityXi'an710069China School of Chemical Engineering and Technology Xi'an Jiaotong UniversityXi'an710069China

The gut microbiota plays a pivotal role in the immunomodulatory and protumorigenic microenvironment of colorectal cancer(CRC).However,the effect of ginsenoside Rk3(Rk3)on CRC and gut microbiota remains ***,the purpose of this study is to explore the potential effect of Rk3 on CRC from the perspective of gut microbiota and immune *** results reveal that treatment with Rk3 significantly suppresses the formation of colon tumors,repairs intestinal barrier damage,and regulates the gut microbiota imbalance caused by CRC,including enrichment of probiotics such as Akkermansia muciniphila and Barnesiella intestinihominis,and clearance of pathogenic *** metabolomics data demonstrate that Rk3 can modulate the metabolism of amino acids and bile acids,particularly by upregulating glutamine,which has the potential to regulate the immune ***,we elucidate the regulatory effects of Rk3 on chemokines and inflammatory factors associated with group 3 innate lymphoid cells(ILC3s)and T helper 17(Th17)signaling pathways,which inhibits the hyperactivation of the Janus kinase-signal transducer and activator of transcription 3(JAK-STAT3)signaling *** results indicate that Rk3 modulates gut microbiota,regulates ILC3s immune response,and inhibits the JAK-STAT3 signaling pathway to suppress the development of colon *** importantly,the results of fecal microbiota transplantation suggest that the inhibitory effect of Rk3 on colon tumors and its regulation of ILC3 immune responses are mediated by the gut *** summary,these findings emphasize that Rk3 can be utilized as a regulator of the gut microbiota for the prevention and treatment of CRC.

关键词： Colorectal cancer Ginsenoside Immune cells Gut microbiota

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基于文献计量分析的护理人文教育视域思考

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中华护理教育 2024年第6期21卷 645-652页

作者：石嫣段志光山西医科大学人文社会科学学院太原市030001 山西医科大学医学健康人文研究中心、医学教育研究中心太原市030001

目的梳理护理人文教育文献的现状与发展趋势,思考护理人文教育视域变化。方法以中国知网和Web of Science数据库中的护理人文教育文献为对象,应用VOSviewer和Pajek软件对中英文文献的关键词聚类、发展趋势进行分析并比较。结果从聚类结... 详细信息

目的梳理护理人文教育文献的现状与发展趋势,思考护理人文教育视域变化。方法以中国知网和Web of Science数据库中的护理人文教育文献为对象,应用VOSviewer和Pajek软件对中英文文献的关键词聚类、发展趋势进行分析并比较。结果从聚类结果来看,“优质人文护理”“护理人才培养”是护理人文教育中英文文献的共同主题,但两者侧重点不同。从发展趋势来看,在2010年之前,中英文文献关注的领域都比较分散;2010年之后,关注范围逐步拓宽,关注点开始聚集。中英文文献涉及的广度和深度有所不同,英文文献视角更宽,拓展到“卫生保健”“临终关怀”“公共卫生”等领域,但时间跨度较短;中文文献很大程度上仍侧重以“疾病”为导向,基本局限于医学人文范畴。结论护理人文教育面临新的问题与挑战,其视域需向健康人文和大健康人文拓展,这有赖于护理人文教育改革的不断深化。

关键词：教育,护理护理人文教育视域文献计量分析

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南丁格尔奖在我国护士和护生中的声誉度调查

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护理研究 2024年第3期38卷 562-564页

作者：王倩段志光山西医科大学护理学院山西030001

目的:探讨南丁格尔奖在我国护士和护生中的声誉度,以更好地传承和弘扬南丁格尔精神。方法:采用便利抽样法和滚雪球抽样法对我国护士和护生进行南丁格尔奖声誉度抽样调查。结果:共调查1 557名护理人员,90.11%的调查者认为南丁格尔奖能对... 详细信息

目的:探讨南丁格尔奖在我国护士和护生中的声誉度,以更好地传承和弘扬南丁格尔精神。方法:采用便利抽样法和滚雪球抽样法对我国护士和护生进行南丁格尔奖声誉度抽样调查。结果:共调查1 557名护理人员,90.11%的调查者认为南丁格尔奖能对她从事的护理工作起到激励作用;93.26%的调查者会将南丁格尔精神作为职业信仰;93.71%的调查者愿意将南丁格尔奖获得者作为职业榜样。不同年龄、护龄、职称、学历护士和不同年级护生的南丁格尔奖声誉度不同(P<0.05)。结论:在职业范围内南丁格尔奖声誉度高。低年资、本科学历护士和本科一年级护生对南丁格尔奖声誉度的总体评价稍低,高年资护士和研究生的总体评价高。新时代南丁格尔精神传承中应重点关注低年资本科护士群体和本科一年级护生。

关键词：南丁格尔奖声誉度护士护生调查研究

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恶性肿瘤病人人文护理质量评价体系的构建

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护理研究 2024年第10期38卷 1827-1832页

作者：张贝贝段志光山西医科大学健康人文科研中心山西030001

目的:构建恶性肿瘤病人人文护理质量评价体系。方法:通过查阅文献,结合文献筛选结果及专家小组讨论结果形成恶性肿瘤病人人文护理质量评价体系初稿,采用改良后的德尔菲法对初稿内容进行修订并形成恶性肿瘤病人人文护理质量评价体系终稿... 详细信息

目的:构建恶性肿瘤病人人文护理质量评价体系。方法:通过查阅文献,结合文献筛选结果及专家小组讨论结果形成恶性肿瘤病人人文护理质量评价体系初稿,采用改良后的德尔菲法对初稿内容进行修订并形成恶性肿瘤病人人文护理质量评价体系终稿,运用层次分析法进行一致性检验。结果:2轮专家函询问卷回收率分别为76%和97%,专家权威系数为0.893,2轮专家函询肯德尔和谐系数为0.090~0.095(P<0.05),第1轮专家函询重要性均分为4.21~4.92分,变异系数为0.05~0.20,满分比为42%~92%。第2轮专家函询重要性均分为4.30~4.92分,变异系数为0.06~0.18,满分比为43%~92%。最终形成包括4个一级指标、17个二级指标、67个三级指标的恶性肿瘤病人人文护理质量评价体系,层次分析结果表明各层次指标矩阵均通过一致性检验。结论:恶性肿瘤病人人文护理质量评价体系的构建具有科学性,为提高恶性肿瘤病人人文护理质量,需强化非技术性人文关怀技能,建立家庭友好型长期护理保险制度,倡导病人自我护理,突出政府责任。

关键词：恶性肿瘤病人人文护理德尔菲法层次分析法质量评价

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地塞米松植入剂联合康柏西普治疗视网膜静脉分枝阻塞继发黄斑水肿的临床研究

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大理大学学报 2024年第4期9卷 46-51页

作者：刘腾段直光大理大学云南大理671000 大理大学第三附属医院云南大理671000 大理白族自治州人民医院云南大理671000

目的:评价地塞米松植入剂(Ozurdex)联合康柏西普治疗视网膜静脉分枝阻塞继发黄斑水肿(BRVO-ME)的临床疗效。方法:将168例BRVO-ME患者按治疗方案分为康柏西普组、Ozurdex组和联合组,分析比较3组患者治疗后的最佳矫正视力(BCVA)、黄斑容积... 详细信息

目的:评价地塞米松植入剂(Ozurdex)联合康柏西普治疗视网膜静脉分枝阻塞继发黄斑水肿(BRVO-ME)的临床疗效。方法:将168例BRVO-ME患者按治疗方案分为康柏西普组、Ozurdex组和联合组,分析比较3组患者治疗后的最佳矫正视力(BCVA)、黄斑容积(MV)、黄斑中心凹厚度(CFT)及视网膜中央厚度(CRT)、眼内压(IOP)及并发症发生情况等。结果:3组患者在治疗后各时间点的BCVA、CFT、MV、CRT均显著优于治疗前,差异有统计学意义(P<0.05);3组患者在治疗后各时间点的IOP均较为稳定,Ozurdex组和联合组患者在治疗后均出现IOP较治疗前升高的情况。结论:Ozurdex联合康柏西普治疗BRVO-ME,可以用相对较少的注射次数使患者在视力和解剖学获益,其治疗效果明显好于单药治疗。

关键词：视网膜静脉分枝阻塞黄斑水肿地塞米松植入剂康柏西普

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Construction of multifunctional hydrogel based on the tannic acid-metal coating decorated MoS2 dual nanozyme for bacteria-infected wound healing

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Bioactive Materials 2022年第3期7卷 461-474页

作者： Yang Li Rongzhan Fu zhiguang duan Chenhui Zhu Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials School of Chemical EngineeringNorthwest UniversityXi’an710069ShaanxiChina Shaanxi R&D Center of Biomaterials and Fermentation Engineering School of Chemical EngineeringNorthwest UniversityXi’an710069ShaanxiChina Biotech.&Biomed.Research Institute Northwest UniversityXi’an710069ShaanxiChina

Bacterial infection,tissue hypoxia and inflammatory response can hinder the infected wound repair *** mitigate the above issues,tannic acid-chelated Fe-decorated molybdenum disulfide nanosheets(MoS2@TA/Fe NSs)with dual enzyme activities were developed and anchored to a multifunctional *** hydrogel exhibited excellent antibacterial ability owing to the combined effects of photothermal therapy(PTT),glutathione(GSH)loss,and the peroxidase(POD)-like activity(catalyse H2O_(2)into⋅OH under acid condition)of MoS2@TA/Fe *** from the catalase(CAT)-like activity,the hydrogel could decompose H2O_(2)into O_(2)at neutral pH to relieve hypoxia and supply adequate O_(2).POD-like activity was mainly attributed to MoS2 NSs,while CAT-like activity was primarily due to TA/Fe ***,MoS2@TA/Fe NSs endowed the hydrogel with outstanding anti-oxidant ability to scavenge redundant reactive oxygen species(ROS)and reactive nitrogen species(RNS)under neutral environment to maintain the balance of antioxidant systems and prevent *** addition,the hydrogel could inhibit the release of inflammatory factors for the anti-inflammatory property of *** retained partial phenolic hydroxyl groups,which cross-linked the nanosheets to the network structure of the hydrogel and promoted the adhesion of *** to the dynamic boron ester bonds between polyvinyl alcohol(PVA),dextran(Dex),MoS2@TA/Fe,and borax,the hydrogel demonstrated fast self-healing and rapid shape *** shape-adaptable adhesive hydrogel could fill the whole wound and closely contact the wound,ensuring that it achieved its functions with maximum *** MoS2@TA/Fe nanozyme-anchored multifunctional hydrogel showed high potential for bacteria-infected wound healing.

关键词： MoS2@TA/Fe nanozyme Multifunctional hydrogel POD-Like CAT-Like Anti-inflammation

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Glucose and MMP-9 dual-responsive hydrogel with temperature sensitive self-adaptive shape and controlled drug release accelerates diabetic wound healing

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Bioactive Materials 2022年第11期7卷 1-17页

作者： Wanyi Zhou zhiguang duan Jing Zhao Rongzhan Fu Chenhui Zhu Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials School of Chemical EngineeringNorthwest UniversityXi’an710069ShaanxiChina Shaanxi R&D Center of Biomaterials and Fermentation Engineering School of Chemical EngineeringNorthwest UniversityXi’an710069ShaanxiChina Biotech.&Biomed.Research Institute Northwest UniversityXi’an710069ShaanxiChina

Chronic diabetic wounds are an important healthcare challenge. High concentration glucose, high level of matrix metalloproteinase-9 (MMP-9), and long-term inflammation constitute the special wound environment of diabetic wounds. Tissue necrosis aggravates the formation of irregular wounds. All the above factors hinder the healing of chronic diabetic wounds. To solve these issues, a glucose and MMP-9 dual-response temperature-sensitive shape self-adaptive hydrogel (CBP/GMs@Cel&INS) was designed and constructed with polyvinyl alcohol (PVA) and chitosan grafted with phenylboric acid (CS-BA) by encapsulating insulin (INS) and gelatin microspheres con-taining celecoxib (GMs@Cel). Temperature-sensitive self-adaptive CBP/GMs@Cel&INS provides a new way to balance the fluid-like mobility (self-adapt to deep wounds quickly, approximately 37 ◦C) and solid-like elasticity (protect wounds against external forces, approximately 25 ◦C) of self-adaptive hydrogels, while simultaneously releasing insulin and celecoxib on-demand in the environment of high-level glucose and MMP-9. Moreover, CBP/ GMs@Cel&INS exhibits remodeling and self-healing properties, enhanced adhesion strength (39.65 ± 6.58 kPa), down-regulates MMP-9, and promotes cell proliferation, migration, and glucose consumption. In diabetic full-thickness skin defect models, CBP/GMs@Cel&INS significantly alleviates inflammation and regulates the local high-level glucose and MMP-9 in the wounds, and promotes wound healing effectively through the synergistic effect of temperature-sensitive shape-adaptive character and the dual-responsive system.

关键词： Dual-responsive Temperature-sensitive Shape self-adaptive hydrogels Diabetic wound healing

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A biomimetic bi-layered tissue engineering scaffolds for osteochondral defects repair

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Science China(Technological Sciences) 2021年第4期64卷 793-805页

作者： LIU KaiQiang LIU YanNan duan zhiguang MA XiaoXuan FAN DaiDi Shaanxi Key Laboratory of Degradable Biomedical Materials School of Chemical EngineeringNorthwest UniversityXi'an 710069China Shaanxi R&D Center of Biomaterials and Fermentation Engineering School of Chemical EngineeringNorthwest UniversityXi'an 710069China Biotech&Biomed Research Institute Northwest UniversityXi'an 710069China

Osteochondral defects are most commonly characterized by damages to both cartilage and underlying subchondral bone tissues,thus developing bi-layered scaffold that can concurrently regenerate these two specific lineages becomes *** this study,the highly biomimetic bi-layered scaffolds were successfully prepared using human-like-collagen(HLC),hyaluronan(HA)and nano hydroxyapatite(HAP)particles,combined with"liquid phase synthesis"technology,freeze-drying and chemical crosslinking techniques,which was simulated the composition of natural extracellular matrix to repair osteochondral *** novel bilayer osteochondral graft had a seamlessly integrated layer structure,suitable pore size,high levels of porosity,and excellent mechanical *** vitro cell experiments of the bilayer scaffold indicated that the scaffold could promote the proliferation and adhesion of human bone marrow mesenchymal stem *** vivo osteochondral defects and micro-CT experiment revealed that bilayer scaffolds showed complete closure of the *** confirmed collagen and glycosaminoglycans were deposited in the new matrix of hyaline cartilage and bone in the bilayer scaffold ***,the developed bionic bilayer scaffold enhanced the regeneration of hyaline cartilage through subchondral bone formation and lateral host-tissue *** conclusion,this bilayer scaffold based on HLC could be used as the desired strategy for osteochondral defects regeneration.

关键词： human-like collagen bi-layered scaffold osteochondral repair

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Recent advances in systemic and local delivery of ginsenosides using nanoparticles and nanofibers

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Chinese Journal of Chemical Engineering 2021年第2期34卷 291-300页

作者： Jing Zhao zhiguang duan Xiaoxuan Ma Yannan Liu Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials School of Chemical EngineeringNorthwest UniversityXi’an 710069China Shaanxi R&D Center of Biomaterials and Fermentation Engineering School of Chemical EngineeringNorthwest UniversityXi’an 710069China Biotech.&Biomed.Research Institute Northwest UniversityXi’an 710069China

Ginsenosides are the main pharmacologically active constituents of ginseng which have been used in East Asian countries for centuries to modulate blood pressure,metabolism and immune *** the technological advances in isolation,purification and mass production,their mechanisms of action are gradually elucidated,providing solid basis for clinical *** extracts(total ginsenosides)and ginsenoside Rg3,CK,Rd have been marketed or entered clinical trials as drugs or dietary *** the proven safety and efficacy of some ginsenosides,their applications are hindered by inferior pharmacokinetics such as low solubility,poor membrane permeability and metabolic *** formulation of drugs and implantable drug depots are effective strategies to improve the pharmacokinetics of therapeutic agents by enhancing solubility,providing protection,facilitating intracellular transport,and enabling sustained and controlled *** mini-review summarizes the recent advances in systemic delivery of ginsenosides using liposomes,micelles,albumin-based nanoparticles,and inorganic nanoparticles,as well as local delivery of ginsenosides by electronspun fibrous membranes and hydrogels.

关键词： Ginsenosides Nanoparticles Nanofibers Drug delivery

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High efficiency production of ginsenoside compound K by catalyzing ginsenoside Rb1 using snailase

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Chinese Journal of Chemical Engineering 2018年第7期26卷 1591-1597页

作者： zhiguang duan Chenhui Zhu Jingjing Shi Daidi Fan Jianjun Deng Rongzhan Fu Rong Huang Cuiying Fan Shaanxi Key Laboratory of Degradable Biomedical Materials School of Chemical EngineeringNorthwest UniversityTaibai North Road 229Xi'an 710069China Shanxi R&D Center of Biomaterials and Fermentation Engineering School of Chemical Engineering Northwest University Taibai North Road 229Xi'an 710069China

The rare ginsenoside Compound K （C-K） is attracting more attention because of its good physiological activity and urgent need. There are many pathways to obtain ginsenoside C-K, including chemical and biological methods. Among these, the conversion of PPD-type ginsenosides by enzymatic hydrolysis is a trend due to its high efficiency and mild conditions. For effectively extracting from the other panaxadiol saponins, the conversion process for ginsenoside C-K was investigated using snailases in this study. The univariate experimental design and response surface methodology were used to determine the optimal hydrolysis conditions for the conversion of ginsenoside Rbl into ginsenoside C-K by snailases. The optimum conditions were as follows： pH 5,12, temperature 51 ℃, ratio of snailase/substrate 0.21, and reaction time 48 h. On the basis of these parameters, the addition of 1.0 mmol· L- 1 ferric ion was found to significantly improve the enzymolysis ofsnailases for the first time. With the above conditions, the maximum conversion rate reached 89.7%, suggesting that the process can obviously increase the yield of ginsenoside C-K. The bioassay tests indicated that the ginsenoside C-K showed anti-tumor activity in a series of tumor cell lines. Based on these results, we can conclude that the process of rare ginsenoside C- K production by enzymolysis with snailase is feasible, efficient, and suitable for the industrial production and application.

关键词： Ginsenoside Rb1 Ginsenoside Compound K Snailase Enzymolysis

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