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The combined therapeutic effects of ^(131)iodinelabeled multifunctional copper sulfide-loaded microspheres in treating breast cancer

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Acta Pharmaceutica Sinica B 2018年第3期8卷 371-380页

作者： Qiufang Liu Yuyi Qian Panli Li Sihang Zhang Zerong Wang Jianjun Liu Xiaoguang Sun Michael Fulham Dagan Feng zhigang chen Shaoli Song Wei Lu Gang Huang Department of Nuclear Medicine Ren Ji Hospital School of Medicine Shanghai Jiao Tong University SJTU-USYD Joint Research Alliance for Translational Medicine Shanghai Jiao Tong University Institute of Clinical Nuclear Medicine Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Department of Pharmaceutics School of Pharmacy Key Laboratory of Smart Drug Delivery Ministry of Education & State Key Laboratory of Molecular Engineering of Polymers Fudan University Shanghai Gezhi Middle School Department of Molecular Imaging Royal Prince Alfred Hospital Australia and Sydney Medical School University of Sydney Biomedical and Multimedia Information Technology Research Group School of Information Technologies University of Sydney Centre for Future Materials University of Southern Queensland Department of Biomedical and Pharmaceutical Sciences College of Pharmacy the University of Rhode Island Shanghai Key Laboratory for Molecular Imaging Shanghai University of Medicine and Health Sciences

Compared to conventional cancer treatment, combination therapy based on well-designed nanoscale platforms may offer an opportunity to eliminate tumors and reduce recurrence and *** this study, we prepared multifunctional microspheres loading ^(131)I-labeled hollow copper sulfide nanoparticles and paclitaxel( ^(131)I-HCu SNPs-MS-PTX) for imaging and therapeutics of W256/B breast tumors in rats.18 F-fluordeoxyglucose(18 F-FDG) positron emission tomography/computed tomography(PET/CT) imaging detected that the expansion of the tumor volume was delayed(Po0.05) following intra-tumoral(i.t.) injection with ^(131)I-HCu SNPs-MS-PTX plus near-infrared(NIR) irradiation. The immunohistochemical analysis further confirmed the anti-tumor effect. The single photon emission computed tomography(SPECT)/photoacoustic imaging mediated by ^(131)I-HCu SNPs-MS-PTX demonstrated that microspheres were mainly distributed in the tumors with a relatively low distribution in other organs. Our results revealed that ^(131)I-HCu SNPs-MS-PTX offered combined photothermal, chemo-and radio-therapies, eliminating tumors at a relatively low dose, as well as allowing SPECT/CT and photoacoustic imaging monitoring of distribution of the injected agents non-invasively. The copper sulfide-loaded microspheres, ^(131)I-HCu SNPs-MS-PTX, can serve as a versatile theranostic agent in an orthotopic breast cancer model.

关键词： Microspheres Theranostics Combination therapy Single photon emission computed tomography/computed tomography(SPECT/CT) Photoacoustic imaging

Temporospatial changes of carbon footprint based on energy consumption in China

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Journal of Geographical Sciences 2012年第1期22卷 110-124页

作者： CHUAI Xiaowei LAI Li HUANG Xianjin ZHAO Rongqin WANG Wanjing chen zhigang School of Geographic ＆ Oceanic Science Nanjing University Jiangsu Information Center Land Development and Consolidation Technology Engineering Center of Jiangsu Province

Study on regional carbon emission is one of the hot topics under the background of global climate change and low-carbon economic development, and also help to establish different low-carbon strategies for different regions. On the basis of energy consumption and land use data of different regions in China from 1999 to 2008, this paper established carbon emission and carbon footprint models based on total energy consumption, and calculated the amount of carbon emissions and carbon footprint in different regions of China from 1999 to 2008. The author also analyzed carbon emission density and per unit area carbon footprint for each region. Finally, advices for decreasing carbon footprint were put forward. The main conclusions are as follows：（1） Carbon emissions from total energy consumption increased 129% from 1999 to 2008 in China, but its spatial distribution pattern among different regions just slightly changed, the sorting of carbon emission amount was： Eastern China Northern China Central and Southern China Southwest China Northwest China. （2） The sorting of carbon emission density was： Eastern China Northeast China Central and Southern China Northern China Southwest China Northwest China from 1999 to 2003, but from 2004 Central and Southern China began to have higher carbon emission density than Northeast China, the order of other regions did not change. （3） Carbon footprint increased significantly since the rapid increasing of carbon emissions and less increasing area of pro-ductive land in different regions of China from 1999 to 2008. Northern China had the largest carbon footprint, and Northwest China, Eastern China, Northern China, Central and Southern China followed in turn, while Southwest China presented the lowest area of carbon footprint and the highest percentage of carbon absorption. （4） Mainly influenced by regional land area, Northern China presented the highest per unit area carbon footprint and followed by Eastern China, and Northeast China; Centr

关键词： carbon emissions carbon sink carbon footprint temporospatial changes China

Guiding and routing of a weak signal via a reconfigurable gravity-like potential

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Photonics Research 2019年第9期7卷 1087-1093页

作者： ZHILI LI PING ZHANG XUE MU PENGBO JIA YI HU zhigang chen JINGJUN XU MOE Key Laboratory of Weak-Light Nonlinear Photonics TEDA Applied Physics Institute and School of PhysicsNankai UniversityTianjin 300457China Department of Physics and Astronomy San Francisco State UniversitySan FranciscoCalifornia 94132USA

We demonstrate both experimentally and theoretically the trapping and guiding of a weak signal pulse via a selfaccelerating Airy pulse. This is achieved by launching the Airy pulse in the anomalous dispersion regime of an optical fiber, thereby inducing a gravity-like potential that can compel the signal pulse in the normal dispersion regime to undergo co-acceleration. Such guiding pulse by pulse can be controlled at ease simply by altering the acceleration conditions of the Airy pulse. Furthermore, the guided signal can be featured with either single or double peaks, which is explained by using the theory of fundamental and second-order quasi-modes associated with the gravity-like potential. Our work represents, to our knowledge, the first demonstration of pulse guiding in the anomalous dispersion regime of any self-accelerating pulse.

关键词： simulation Guiding and routing of a weak signal via a reconfigurable gravity-like potential

Formation Mechanism of the Slice and Rod-like Cerium Dioxide Precursor Particles

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Formation Mechanism of the Slice and Rod-like Cerium Dioxide...

Optical force-induced nonlinearity and self-guiding of light in human red blood cell suspensions

中国材料大会2012

作者： Jianqing chen zhigang chen Yong Wei College of Materials Science and Technology Hohai University Suzhou University of Science and Technology

ISBN: (纸本)9783037856062;3037856068

Ultra-fine cerium dioxide precursor particles was prepared with cerium （Ⅲ） nitrate hexahydrate （Ce（NO3）36H2O） and urea （CO（NH2）2） at 85 ℃ by homogenous precipitation method. Effects of reaction and ageing time on the morphology of the precursor particles were studied, the morphology of precursor particles was characterized by scan electronic microscope and the crystallinity of the precursors was studied by X-ray diffraction. The result showed that the mono-dispersed spherical particles turned into flower and bundle-like particles as reaction time increasing, the particles turned into slice and rod-like particles as the ageing time increasing, the transition process occurred in ageing process was later than that in the reaction process, the spherical particles were less crystallization and the slice and the rod-like particles were at a state of fine crystallization.

关键词： Ultra-fine cerium dioxide Precursor particles Homogenous precipitation Crstallinity.

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Light(Science & Applications) 2019年第1期8卷 927-935页

作者： Rekha Gautam Yinxiao Xiang Josh Lamstein Yi Liang Anna Bezryadina Guo Liang Tobias Hansson Benjamin Wetzel Daryl Preece Adam White Matthew Silverman Susan Kazarian Jingjun Xu Roberto Morandotti zhigang chen Department of Physics and Astronomy San Francisco State UniversitySan FranciscoCA 94132USA Department of Biomedical Engineering Vanderbilt UniversityNashvilleTN 37240USA MOE Key Lab of Weak-Light Nonlinear Photonics TEDA Applied Physics Institute and School of PhysicsNankai UniversityTianjin 300457China Guangxi Key Lab for Relativistic Astrophysics Guangxi Colleges and Universities Key Lab of Novel Energy Materials and Related TechnologySchool of Physical Science and TechnologyGuangxi UniversityNanningGuangxi 530004China Department of Physics and Astronomy California State University NorthridgeNorthridgeCA 91330USA Institut National de la Recherche Scientifique Universite du QuebecVarennesQC J3X 1S2Canada Department of Physics Chemistry and BiologyLinkoping UniversityLinkoping SE-58183Sweden School of Mathematical and Physical Sciences University of SussexSussex HouseFalmerBrighton BN19RHUK Department of Biomedical Engineering University of California IrvineIrvineCAUSA Clinical Laboratory Science Program San Francisco State UniversitySan FranciscoCA 94132USA Institute of Fundamental and Frontier Sciences University of Electronic Science and Tech.of ChinaChengdu 610054China ITMO University Saint Petersburg 197101Russia

Osmotic conditions play an important role in the cell properties of human red blood cells(RBCs),which are crucial for the pathological analysis of some blood diseases such as *** the past decades,numerous efforts have mainly focused on the study of the RBC biomechanical properties that arise from the unique deformability of ***,we demonstrate nonlinear optical effects from human RBCs suspended in different osmotic ***,we observe self-trapping and scattering-resistant nonlinear propagation of a laser beam through RBC suspensions under all three osmotic conditions,where the strength of the optical nonlinearity increases with osmotic pressure on the *** tunable nonlinearity is attributed to optical forces,particularly the forward-scattering and gradient ***,in aged blood samples(with lysed cells),a notably different nonlinear behavior is observed due to the presence of free *** use a theoretical model with an optical force-mediated nonlocal nonlinearity to explain the experimental *** work on light self-guiding through scattering biosoft-matter may introduce new photonic tools for noninvasive biomedical imaging and medical diagnosis.

关键词： nonlinearity suspensions nonlinear

MnO_(2)/Poly-L-lysine Co-decorated Carbon Fiber Cloth with Decreased Evaporation Enthalpy and Enhanced Photoabsorption/Antibacterial Performance for Solar-Enabled Anti-fouling Seawater Desalination

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Advanced Fiber Materials 2024年第5期6卷 1569-1582页

作者： Xinxing Song Xiaolong Li Bo Zhu Songmei Sun zhigang chen Lisha Zhang State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Environmental Science and EngineeringDonghua UniversityShanghai 201620China College of Materials Science and Engineering Donghua UniversityShanghai 201620China

Solar-driven seawater evaporation is a potential strategy for mitigating global freshwater shortage,but its application is hindered by the photothermal membranes with high evaporation enthalpy,unsatisfactory photoabsorption,and easy contamination by *** solve these problems,herein we reported the design of manganese oxide/poly-L-lysine co-decorated carbon-fiber cloth(CFC)with decreased evaporation enthalpy and enhanced photoabsorption/antibacterial *** oxide(MnO_(2))nanosheets(thickness:10-30 nm,diameter:400-450 nm)were grown in situ on the CFC surface by a hydrothermal method,and then the nanosheet surface was further decorated with poly-L-lysine(PLL)by the electrostatic ***-decoration of MnO_(2)/PLL confers the conversion of hydrophobic CFC to superhydro-philic CFC/MnO_(2)/PLL,accompanied by the reduction of the evaporation enthalpy of bulk water to 2132.34 kJ kg-1 for CFC/MnO_(2)/PLL *** CFC/MnO_(2)/PLL exhibits a strong photoabsorption in wide range(280-2500 nm)with an absorption efficiency of 97.8%,due to the light-trapping effects from hierarchical ***,CFC/MnO_(2)/PLL has excellent antibacterial performance toward ***(99.1±0.2%)and ***(98.2±0.5%)within 60 min in the dark,due to the electrostatic interaction between the bacterial cell membrane and ***,CFC/MnO_(2)/PLL was hung between the seawater tank and empty tank to construct a hanging *** 1.0 kW m^(-2)light irradiation,CFC/MnO_(2)/PLL shows a preeminent evaporation rate of 2.20 kg m^(-2)h^(-1).Importantly,when germy NaCl solution is evaporated,there is no solid-salt accumulation and bacteria contamination on CFC/MnO_(2)/PLL surface during the long-time test(12 h),conferring long-term anti-fouling seawater ***,this work provides new possibilities in the rational design of photothermal fabrics for solar-enabled efficient anti-fouling seawater desalination.

关键词： Manganese oxide Poly-L-lysine Carbon fiber cloth Anti-fouling Solar-driven evaporation

各向异性半空间中浅埋孔洞对地表反平面运动的影响

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地震学报 2015年第4期37卷 617-628,711页

作者：陈志刚暨南大学力学与土木工程系中国广州510632 暨南大学重大工程灾害与控制教育部重点实验室中国广州510632

本文采用复变函数方法研究了稳态水平剪切波(SH波)在各向异性弹性半空间中任意形状孔洞上的散射及其对地面运动的影响.在变换空间中构造出自动满足各向异性半空间水平表面上应力为零的散射波函数,并根据孔洞表面应力为零的边界条件,采... 详细信息

本文采用复变函数方法研究了稳态水平剪切波(SH波)在各向异性弹性半空间中任意形状孔洞上的散射及其对地面运动的影响.在变换空间中构造出自动满足各向异性半空间水平表面上应力为零的散射波函数,并根据孔洞表面应力为零的边界条件,采用最小二乘法求解散射波函数的系数.用介质的各向异性性质来模拟地质条件,给出了SH波作用下含圆孔、椭圆孔和方孔的各向异性半空间表面位移幅值的数值结果,并分析了介质特性、孔洞的形状、埋深、入射波波数及入射角度等因素对地面运动的影响规律.数值结果表明:介质的各向异性对含有孔洞的半空间表面的地表位移具有显著的影响;沿一定角度的入射波在某一频段内所引起的地表位移幅值比各向同性介质的可能要大,且随着孔洞埋深的增加,地表位移的幅值逐渐减小.

关键词：各向异性半空间 SH 波散射孔洞地面运动复变函数

Nonlinear topological valley Hall edge states arising from type-Ⅱ Dirac cones

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Advanced Photonics 2021年第5期3卷 44-51页

作者： Hua Zhong Shiqi Xia Yiqi Zhang Yongdong Li Daohong Song Chunliang Liu zhigang chen Xi’an Jiaotong University School of Electronic Science and EngineeringKey Laboratory for Physical Electronics and Devices of the Ministry of Education&Shaanxi Key Lab of Information Photonic TechniqueFaculty of Electronic and Information EngineeringXi’anChina Nankai University TEDA Applied Physics Institute and School of PhysicsMOE Key Laboratory of Weak-Light Nonlinear PhotonicsTianjinChina San Francisco State University Department of Physics and AstronomySan FranciscoCaliforniaUSA

A Dirac point is a linear band crossing point originally used to describe unusual transport properties of materials like *** recent years,there has been a surge of exploration of type-II Dirac/Weyl points using various engineered platforms including photonic crystals,waveguide arrays,metasurfaces,magnetized plasma and polariton micropillars,aiming toward relativistic quantum emulation and understanding of exotic topological *** endeavors,however,have focused mainly on linear topological states in real or synthetic Dirac/Weyl *** propose and demonstrate nonlinear valley Hall edge(VHE)states in laserwritten anisotropic photonic lattices hosting innately the type-Ⅱ Dirac *** self-trapped VHE states,manifested as topological gap quasi-solitons that can move along a domain wall unidirectionally without changing their profiles,are independent of external magnetic fields or complex longitudinal modulations,and thus are superior in comparison with previously reported topological edge *** finding may provide a route for understanding nonlinear phenomena in systems with type-Ⅱ Dirac points that violate the Lorentz invariance and may bring about possibilities for subsequent technological development in light field manipulation and photonic devices.

关键词： photonic topological insulator type-ⅡDirac cone valley Hall edge soliton

Biotemplate Synthesis of Porous Ceria Fiber and Study on Its Catalytic Performance

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Biotemplate Synthesis of Porous Ceria Fiber and Study on Its...