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检索条件"作者=Zhifang Xie Ye Zhang Hai Zhang guangdi zhou Yu Du Weiping Zhang Department of Pathophysiology,Second Military Medical University,800 Xiangyin Road,Shanghai 200433,China"

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Tissue-specific Ablation of Zinc Finger Protein Gene DPZF in Pancreatic βcells Leads to the Defects of Glucose Sensing and Insulin Secretion

Tissue-specific Ablation of Zinc Finger Protein Gene DPZF in...

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中国遗传学会“发育、遗传和疾病”研讨会

作者： zhifang xie ye zhang hai zhang guangdi zhou yu du weiping zhang department of pathophysiology,second military medical university,800 xiangyin road,shanghai 200433,china

Cell dysfunction is a central component of the pathogenesis of type 2 *** glucose-sensing pathway plays important roles in cell dysfunction,but its regulatory network is still poorly *** we show that novel transcription factor DPZF is highly expressed by pancreatic cells and acts as a critical regulator for the glucose-sensing and insulin secretion of *** gene was specifically ablated in cells by LoxP/Cre approach,and the cell-specific DPZF knockout mice exhibit hyperglycemia, impaired glucose tolerance,and the loss of first-phase insulin secretion after glucose *** isolated islets from the cell-specific DPZF knockout mice display defective glucose-stimulated insulin release in ***,the cell mass,total insulin content in cells,or the KCl-stimulated insulin release doesn't differ between the knockouts and control *** expression patterns of the genes which are potentially involved in glucose-sensing of cells are carefully *** together,these data suggest an important role for DPZF in cell function and a therapeutic target for diabetes.

关键词： Tissue-specific Ablation of Zinc Finger Protein Gene DPZF in Pancreatic cells Leads to the Defects of Glucose Sensing and Insulin Secretion

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Fructose-1,6-Bisphosphatase Regulates Glucose-Stimulated Insulin Secretion Of Mouse Pancreatic Beta Cells

Fructose-1,6-Bisphosphatase Regulates Glucose-Stimulated Ins...

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中国病理生理学会受体、肿瘤和免疫专业委员会联合学术会议

作者： ye zhang,zhifang xie,guangdi zhou,hai zhang,Jian Lu,weiping J.zhang department of pathophysiology,second military medical university

Pancreaticβcells can precisely sense glucose stimulation and accordingly adjust their insulin ***-1,6-bisphosphatase(FBPase) is a gluconeogenic enzyme,but its physiological significance inβcells is not *** we determined its physiological role in regulating glucose sensing and insulin secretion ofβ*** FBPase was detected in normal mouse islets andβcell *** of FBP1 in MIN6 cells by siRNA led to enhanced glucose stimulated insulin secretion(GSIS),while FBP1-overexpressing MIN6 cells exhibited decreased *** of FBPase activity by specific inhibitor MB05032 significantly increased cellular ATP/ADP ratio,and enhanced GSIS both in vitro and in ***,FBPase is an important regulator of isletβcells controlling glucose sensing and insulin secretion,and serves a promising target for diabetes treatment.

关键词： Fructose-1,6-Bisphosphatase Mouse Pancreatic Beta Cells

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The zinc finger protein ZBTB20 regulates transcription of fructose-1,6-Bis phosphatase 1 and β-Cell function

The zinc finger protein ZBTB20 regulates transcription of fr...

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生命的分子机器及其调控网络——2012年全国生物化学与...

作者： ye zhang zhifang xie Luting zhou Ling Li hai zhang guangdi zhou Xianhua Ma weiping J.zhang department of pathophysiology Second Military Medical University Center for Obesity & Diabetes Research and Innovation Second Military Medical University

The glucose metabolic pathway is critical forβcell ***-1,6-bisphosphatase(FBP)-1 is a gluconeogenic enzyme capable of regulating glucose metabolism and insulin secretion inβcells,but its transcription regulatory mechanism is poorly *** previous study identified a potential role of the zinc finger protein ZBTB20 in glucose *** we show that ZBTB20 is a transcription repressor of Fbp1 gene,and plays an important role in regulating glucose-stimulated insulin secretion(GSIS) inβ*** found that ZBTB20 was abundantly

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