The zinc finger protein ZBTB20 regulates transcription of fructose-1,6-Bis phosphatase 1 and β-Cell function
作者单位：Department of PathophysiologySecond Military Medical University Center for Obesity & Diabetes Research and InnovationSecond Military Medical University
会议名称：《生命的分子机器及其调控网络——2012年全国生物化学与...》
会议日期：2012年
学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种]
摘 要：The glucose metabolic pathway is critical forβcell ***-1,6-bisphosphatase(FBP)-1 is a gluconeogenic enzyme capable of regulating glucose metabolism and insulin secretion inβcells,but its transcription regulatory mechanism is poorly *** previous study identified a potential role of the zinc finger protein ZBTB20 in glucose *** we show that ZBTB20 is a transcription repressor of Fbp1 gene,and plays an important role in regulating glucose-stimulated insulin secretion(GSIS) inβ*** found that ZBTB20 was abundantly