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Membrane-coated nanoparticles as a biomimetic targeted delivery system for tumour therapy

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Biomaterials Translational 2024年第1期5卷 33-45页

作者： Haoyu Guo Mingke Guo zhidao xia Zengwu Shao Department of Orthopaedic Beijing Jishuitan HospitalCapital Medical UniversityBeijingChina Department of Orthopaedic Beijing Jishuitan HospitalFourth Medical College of Peking UniversityBeijingChina National Center for Orthopaedics BeijingChina Department of Orthopaedics Affiliated Hospital of NCO School of Army Medical UniversityShijiazhuangHebei ProvinceChina Centre for Nanohealth ILS2Medical SchoolSwansea UniversitySwanseaUK Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Drug therapy towards tumours often causes adverse effects because of their non-specific ***-coated technology and membrane-coated nanoparticles provide an advanced and promising platform of targeted and safe *** camouflaging the nanoparticles with natural derived or artificially modified cell membranes,the nano-payloads are bestowed with properties from cell membranes such as longer circulation,tumour or inflammation-targeting,immune stimulation,augmenting the performance of traditional *** this review,we review the development of membrane coating technology,and summarise the technical details,physicochemical properties,and research status of membrane-coated nanoparticles from different sources in tumour ***,we also look forward to the prospects and challenges of transforming membrane coating technology from experiment into clinical *** together,membrane-coated nanoparticles are bound to become one of the most potential anti-tumour strategies in the future.

关键词： biomimetic targeted delivery system membrane-coated nanoparticles membrane-coated technology tumour therapy

Skeletal interoception:an emerging area for musculoskeletal research

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Biomaterials Translational 2022年第4期3卷 237-239页

作者： zhidao xia Institute of Life Science Swansea University Medical SchoolSwanseaUK

Little is known about the relationship between bone and brain;however,accumulated clinical and experimental evidence suggests that there is crosstalk and a bilateral dependence between the two organs.1 A recent review article published in Cell Metabolism highlights the importance of skeletal interoception and signifies a new era for musculoskeletal research.

关键词： skeletal organs clinical

Three-dimensional biofabrication of an aragoniteenriched self-hardening bone graft substitute and assessment of its osteogenicity in vitro and in vivo

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Biomaterials Translational 2020年第1期1卷 69-81页

作者： Yunsong Shi Ruijun He xiangyu Deng Zengwu Shao Davide Deganello Chunze Yan zhidao xia Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology WuhanHubei ProvinceChina Centre for Nanohealth Swansea University Medical SchoolSwanseaUK Centre for Nanohealth Faculty of Science and EngineeringSwansea UniversitySwanseaUK State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhanHubei ProvinceChina

A self-hardening three-dimensional(3D)-porous composite bone graft consisting of 65 wt%hydroxyapatite(HA)and 35 wt%aragonite was fabricated using a 3D-Bioplotter®.New tetracalcium phosphate and dicalcium phosphate anhydrous/aragonite/gelatine paste formulae were developed to overcome the phase separation of the liquid and solid *** mechanical properties,porosity,height and width stability of the end products were optimised through a systematic analysis of the fabrication processing parameters including printing pressure,printing speed and distance between *** resulting 3D-printed bone graft was confirmed to be a mixture of HA and aragonite by X-ray diffraction,Fourier transform infrared spectroscopy and energy dispersive X-ray *** compression strength of HA/aragonite was between 0.56 and 2.49 *** was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay in *** osteogenicity of HA/aragonite was evaluated in vitro by alkaline phosphatase assay using human umbilical cord matrix mesenchymal stem cells,and in vivo by juxtapositional implantation between the tibia and the anterior tibialis muscle in *** results showed that the scaffold was not toxic and supported osteogenic differentiation in ***/aragonite stimulated new bone formation that bridged host bone and intramuscular implants in *** conclude that HA/aragonite is a biodegradable and conductive bone formation biomaterial that stimulates bone *** this material is formed near 37°C,it will have great potential for incorporating bioactive molecules to suit personalised application;however,further study of its biodegradation and osteogenic capacity is *** study was approved by the Animal Ethical Committee at Tongji Medical School,Huazhong University of Science and Technology(IACUC No.738)on October 1,2017.

关键词： biofabrication cytotoxicity hydroxyapatite/aragonite osteogenesis

The emergence of AI tools in scientific writing and research

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Biomaterials Translational 2023年第1期4卷 1-2页

作者： zhidao xia Qian Wang Institute of Life Science Swansea University Medical SchoolSwanseaUK Department of Chemistry and Biochemistry University of South CarolinaColumbiaSCUSA

Biomaterials Translational is now in its third year since its *** March 19,the first virtual forums in 2023 on‘Advanced Technology for Biomaterial Research’hosted by Biomaterials Translational received a great *** forum covered topics including angiogenesis of biomaterials presented by Professor Jake Barralet,McGill University,Canada,and a new lasermicrotome technology from *** Rechter,LLS ROWIAK LaserLabSolutions,*** and its related platform are expected to have wide applications for histology,pathology,and tissue/biomaterial interfaces,as shown in the cover art.

关键词： Canada pathology histology

Celebrating the 2^(nd)anniversary of Biomaterials Translational

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Biomaterials Translational 2022年第4期3卷 235-236页

作者： zhidao xia Qian Wang Institute of Life Science Swansea University Medical SchoolSwanseaUK Department of Chemistry and Biochemistry University of South CarolinaColumbiaSCUSA

December 2022 marks the 2^(nd)anniversary of the foundation of Biomaterials *** birth of our journal occurred in the middle of the coronavirus disease 2019(COVID-19)*** the enormous disruption of human life and global interactions,the launch of Biomaterials Translational has drawn great attention from peers in the research fields of biomaterials science and translational *** the past 2 years,Biomaterials Translational has published nine issues with a total of 71 articles,including 17 research papers,39 literature reviews,15 view-point essays and *** website can be visited at http://***/,with 17,205 views of articles and 32,207 downloads(up to December 21,2022).Both citations and journal website visits have increased significantly since Biomaterials Translational was first included in PubMed in July 2022.

关键词： journal anniversary spite

Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model

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Medicine in Novel Technology and Devices 2023年第2期18卷 267-271页

作者： Husham Ahmed Matthew Bedding-Tyrrell Davide Deganello zhidao xia Yi Xiong Feihu Zhao Zienkiewicz Centre for Computational Engineering and Department of Biomedical Engineering Faculty of Science&EngineeringSwansea UniversitySwanseaSA18ENUK Welsh Centre for Printing and Coating Faculty of Science and EngineeringSwansea UniversitySwanseaSA18ENUK Centre for Nanohealth Swansea University Medical School and Faculty of MedicineHealth and Life ScienceSwansea UniversitySwanseaSA35AUUK School of System Design and Intelligent Manufacturing Southern University of Science and TechnologyShenzhen518055China

Mechanical stimulation,such as fluid-induced wall shear stress(WSS),is known that can influence the cellular ***,in some tissue engineering experiments in vitro,mechanical stimulation is applied via bioreactors to the cells in cell culturing to study cell physiology and *** 3D cell culturing,porous scaffolds are used for housing the *** is known that the scaffold porous geometries can influence the scaffold permeability and internal WSS in a bioreactor(such as perfusion bioreactor).To calculate the WSS generated on cells within scaffolds,usually computational fluid dynamics(CFD)simulation is ***,the limitations of the computational method for WSS calculation are:(i)the high time cost of the CFD simulation(in particular for the highly irregular geometries);(ii)accessibility to the CFD model for some cell culturing experimentalists due to the knowledge *** address these limitations,this study aims to develop an empirical model for calculating the WSS based on scaffold *** model can allow the tissue engineers to efficiently calculate the WSS generated within the scaffold and/or determine the bioreactor loading without performing the computational simulations.

关键词： Wall shear stress Permeability Empirical model Tissue engineering scaffold Bioreactor

Additive manufacturing innovation for musculoskeletal tissue repair and regeneration:from bench to bedside

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Biomaterials Translational 2022年第2期3卷 99-101页

作者： Chaozong Liu zhidao xia Institute of Orthopaedic&Musculoskeletal Science University College LondonRoyal National Orthopaedic HospitalLondonUK Centre for Nanohealth Institute of Life ScienceSwansea University Medical SchoolFaculty of MedicineHealth and Life ScienceSwanseaUK

Additive manufacturing(AM)or three-dimensional(3D)printing is a technique that builds the 3D objects from a 3D digital model(either by a computer-aided design or by scanning the object)in a layer-by-layer *** are seven categories of AM process as defined in the ISO/ASTM 52900:2021,1 based on their working *** include vat photopolymerization,powder bed fusion,material extrusion,binder jetting,directed energy deposition,material jetting,and sheet lamination.1 Over the past decades,AM technology has been exploited in many fields such as the medical,automotive,aerospace and industries.

关键词： Additive computer printing

Role of hypoxia inducible factor 1α in cobalt nanoparticle induced cytotoxicity of human THP-1 macrophages

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Biomaterials Translational 2021年第2期2卷 143-150页

作者： Wendy Rachel Francis Zhao Liu Sian E Owens xiao Wang Huaming Xue Alex Lord Venkateswarlu Kanamarlapudi zhidao xia Centre for Nanohealth Swansea University Medical SchoolSwanseaUK Department of Orthopaedic Surgery Orthopaedic InstituteThe First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Department of Orthopaedic Surgery Johns Hopkins School of MedicineBaltimoreMDUSA Department of Orthopaedics Yangpu Hospital affiliated to Tongji University School of MedicineShanghaiChina.

Cobalt is one of the main components of metal hip prostheses and cobalt nanoparticles(CoNPs)produced from wear cause inflammation,bone lyses and cytotoxicity at high *** ions mimic hypoxia in the presence of normal oxygen levels,and activate hypoxic signalling by stabilising hypoxia inducible transcription factor 1α(HIF1α).This study aimed to assess in vitro the functional role of HIF1αin CoNP induced cellular ***1α,lysosomal pH,tumour necrosis factorαand interleukin 1βexpression were analysed in THP-1 macrophages treated with CoNP(0,10 and 100μg/mL).HIF1αknock out assays were performed using small interfering RNA to assess the role of HIF1αin CoNP-induced *** CoNP concentration increased lysosomal activity and acidity in THP-1 *** doses of CoNP significantly reduced cell viability,stimulated caspase 3 activity and *** HIF1αactivity increased the pro-inflammatory activity of tumour necrosis factorαand interleukin 1β,but had no significant impact on cellular *** suggests that whilst CoNP promotes cytotoxicity and cellular inflammation,the apoptotic mechanism is not dependent on HIF1α.

关键词： cobalt nanoparticle cytotoxicity hypoxia inducible factor macrophages TNFα

Organoids:the future of disease modelling and therapeutics

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Biomaterials Translational 2024年第4期5卷 335-336页

作者： Dongyang Zhou zhidao xia Jiacan Su Organoid Research Center Institute of Translational MedicineShanghai UniversityShanghaiChina Department of Orthopedics Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina National Center for Translational Medicine(Shanghai)SHU Branch Shanghai UniversityShanghaiChina Centre for Nanohealth Swansea University Medical SchoolSwansea UniversitySwanseaUK

In the rapidly advancing field of biomedical research,organoid technology has been a groundbreaking ***-three-dimensional structures derived from stem cells that replicate key structural and functional features of human tissues-have transformed approaches to disease modelling,1 drug discovery,2 and regenerative medicine.3 With the ability to mimic human organs more accurately than traditional cell cultures or animal models,organoids offer tremendous potential for advancing precision medicine and personalised therapies.

关键词： organs development. breaking