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Skeletal interoception:an emerging area for musculoskeletal research

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Biomaterials Translational 2022年第4期3卷 237-239页

作者： zhidao xia Institute of Life Science Swansea University Medical SchoolSwanseaUK

Little is known about the relationship between bone and brain;however,accumulated clinical and experimental evidence suggests that there is crosstalk and a bilateral dependence between the two organs.1 A recent review article published in Cell Metabolism highlights the importance of skeletal interoception and signifies a new era for musculoskeletal research.

关键词： skeletal organs clinical

The emergence of AI tools in scientific writing and research

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Biomaterials Translational 2023年第1期4卷 1-2页

作者： zhidao xia Qian Wang Institute of Life Science Swansea University Medical SchoolSwanseaUK Department of Chemistry and Biochemistry University of South CarolinaColumbiaSCUSA

Biomaterials Translational is now in its third year since its *** March 19,the first virtual forums in 2023 on‘Advanced Technology for Biomaterial Research’hosted by Biomaterials Translational received a great *** forum covered topics including angiogenesis of biomaterials presented by Professor Jake Barralet,McGill University,Canada,and a new lasermicrotome technology from *** Rechter,LLS ROWIAK LaserLabSolutions,*** and its related platform are expected to have wide applications for histology,pathology,and tissue/biomaterial interfaces,as shown in the cover art.

关键词： Canada pathology histology

Additive manufacturing innovation for musculoskeletal tissue repair and regeneration:from bench to bedside

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Biomaterials Translational 2022年第2期3卷 99-101页

作者： Chaozong Liu zhidao xia Institute of Orthopaedic&Musculoskeletal Science University College LondonRoyal National Orthopaedic HospitalLondonUK Centre for Nanohealth Institute of Life ScienceSwansea University Medical SchoolFaculty of MedicineHealth and Life ScienceSwanseaUK

Additive manufacturing(AM)or three-dimensional(3D)printing is a technique that builds the 3D objects from a 3D digital model(either by a computer-aided design or by scanning the object)in a layer-by-layer *** are seven categories of AM process as defined in the ISO/ASTM 52900:2021,1 based on their working *** include vat photopolymerization,powder bed fusion,material extrusion,binder jetting,directed energy deposition,material jetting,and sheet lamination.1 Over the past decades,AM technology has been exploited in many fields such as the medical,automotive,aerospace and industries.

关键词： Additive computer printing

Three-dimensional biofabrication of an aragoniteenriched self-hardening bone graft substitute and assessment of its osteogenicity in vitro and in vivo

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Biomaterials Translational 2020年第1期1卷 69-81页

作者： Yunsong Shi Ruijun He xiangyu Deng Zengwu Shao Davide Deganello Chunze Yan zhidao xia Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology WuhanHubei ProvinceChina Centre for Nanohealth Swansea University Medical SchoolSwanseaUK Centre for Nanohealth Faculty of Science and EngineeringSwansea UniversitySwanseaUK State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhanHubei ProvinceChina

A self-hardening three-dimensional(3D)-porous composite bone graft consisting of 65 wt%hydroxyapatite(HA)and 35 wt%aragonite was fabricated using a 3D-Bioplotter®.New tetracalcium phosphate and dicalcium phosphate anhydrous/aragonite/gelatine paste formulae were developed to overcome the phase separation of the liquid and solid *** mechanical properties,porosity,height and width stability of the end products were optimised through a systematic analysis of the fabrication processing parameters including printing pressure,printing speed and distance between *** resulting 3D-printed bone graft was confirmed to be a mixture of HA and aragonite by X-ray diffraction,Fourier transform infrared spectroscopy and energy dispersive X-ray *** compression strength of HA/aragonite was between 0.56 and 2.49 *** was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay in *** osteogenicity of HA/aragonite was evaluated in vitro by alkaline phosphatase assay using human umbilical cord matrix mesenchymal stem cells,and in vivo by juxtapositional implantation between the tibia and the anterior tibialis muscle in *** results showed that the scaffold was not toxic and supported osteogenic differentiation in ***/aragonite stimulated new bone formation that bridged host bone and intramuscular implants in *** conclude that HA/aragonite is a biodegradable and conductive bone formation biomaterial that stimulates bone *** this material is formed near 37°C,it will have great potential for incorporating bioactive molecules to suit personalised application;however,further study of its biodegradation and osteogenic capacity is *** study was approved by the Animal Ethical Committee at Tongji Medical School,Huazhong University of Science and Technology(IACUC No.738)on October 1,2017.

关键词： biofabrication cytotoxicity hydroxyapatite/aragonite osteogenesis

Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model

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Medicine in Novel Technology and Devices 2023年第2期18卷 267-271页

作者： Husham Ahmed Matthew Bedding-Tyrrell Davide Deganello zhidao xia Yi Xiong Feihu Zhao Zienkiewicz Centre for Computational Engineering and Department of Biomedical Engineering Faculty of Science&EngineeringSwansea UniversitySwanseaSA18ENUK Welsh Centre for Printing and Coating Faculty of Science and EngineeringSwansea UniversitySwanseaSA18ENUK Centre for Nanohealth Swansea University Medical School and Faculty of MedicineHealth and Life ScienceSwansea UniversitySwanseaSA35AUUK School of System Design and Intelligent Manufacturing Southern University of Science and TechnologyShenzhen518055China

Mechanical stimulation,such as fluid-induced wall shear stress(WSS),is known that can influence the cellular ***,in some tissue engineering experiments in vitro,mechanical stimulation is applied via bioreactors to the cells in cell culturing to study cell physiology and *** 3D cell culturing,porous scaffolds are used for housing the *** is known that the scaffold porous geometries can influence the scaffold permeability and internal WSS in a bioreactor(such as perfusion bioreactor).To calculate the WSS generated on cells within scaffolds,usually computational fluid dynamics(CFD)simulation is ***,the limitations of the computational method for WSS calculation are:(i)the high time cost of the CFD simulation(in particular for the highly irregular geometries);(ii)accessibility to the CFD model for some cell culturing experimentalists due to the knowledge *** address these limitations,this study aims to develop an empirical model for calculating the WSS based on scaffold *** model can allow the tissue engineers to efficiently calculate the WSS generated within the scaffold and/or determine the bioreactor loading without performing the computational simulations.

关键词： Wall shear stress Permeability Empirical model Tissue engineering scaffold Bioreactor

Role of hypoxia inducible factor 1α in cobalt nanoparticle induced cytotoxicity of human THP-1 macrophages

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Biomaterials Translational 2021年第2期2卷 143-150页

作者： Wendy Rachel Francis Zhao Liu Sian E Owens xiao Wang Huaming Xue Alex Lord Venkateswarlu Kanamarlapudi zhidao xia Centre for Nanohealth Swansea University Medical SchoolSwanseaUK Department of Orthopaedic Surgery Orthopaedic InstituteThe First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Department of Orthopaedic Surgery Johns Hopkins School of MedicineBaltimoreMDUSA Department of Orthopaedics Yangpu Hospital affiliated to Tongji University School of MedicineShanghaiChina.

Cobalt is one of the main components of metal hip prostheses and cobalt nanoparticles(CoNPs)produced from wear cause inflammation,bone lyses and cytotoxicity at high *** ions mimic hypoxia in the presence of normal oxygen levels,and activate hypoxic signalling by stabilising hypoxia inducible transcription factor 1α(HIF1α).This study aimed to assess in vitro the functional role of HIF1αin CoNP induced cellular ***1α,lysosomal pH,tumour necrosis factorαand interleukin 1βexpression were analysed in THP-1 macrophages treated with CoNP(0,10 and 100μg/mL).HIF1αknock out assays were performed using small interfering RNA to assess the role of HIF1αin CoNP-induced *** CoNP concentration increased lysosomal activity and acidity in THP-1 *** doses of CoNP significantly reduced cell viability,stimulated caspase 3 activity and *** HIF1αactivity increased the pro-inflammatory activity of tumour necrosis factorαand interleukin 1β,but had no significant impact on cellular *** suggests that whilst CoNP promotes cytotoxicity and cellular inflammation,the apoptotic mechanism is not dependent on HIF1α.

关键词： cobalt nanoparticle cytotoxicity hypoxia inducible factor macrophages TNFα

Celebrating the 2^(nd)anniversary of Biomaterials Translational

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Biomaterials Translational 2022年第4期3卷 235-236页

作者： zhidao xia Qian Wang Institute of Life Science Swansea University Medical SchoolSwanseaUK Department of Chemistry and Biochemistry University of South CarolinaColumbiaSCUSA

December 2022 marks the 2^(nd)anniversary of the foundation of Biomaterials *** birth of our journal occurred in the middle of the coronavirus disease 2019(COVID-19)*** the enormous disruption of human life and global interactions,the launch of Biomaterials Translational has drawn great attention from peers in the research fields of biomaterials science and translational *** the past 2 years,Biomaterials Translational has published nine issues with a total of 71 articles,including 17 research papers,39 literature reviews,15 view-point essays and *** website can be visited at http://***/,with 17,205 views of articles and 32,207 downloads(up to December 21,2022).Both citations and journal website visits have increased significantly since Biomaterials Translational was first included in PubMed in July 2022.

关键词： journal anniversary spite

优化底物酶及冻存剂组成对软骨细胞增殖力及活力的影响

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中国矫形外科杂志 2012年第13期20卷 1222-1225页

作者：涂意辉 zhidao xia 薛华明马童刘晓东蔡珉巍张长青上海同济大学附属杨浦医院骨科上海200090 Nuffield Department of Orthopaedics Oxford University Oxford OX3 7LD UK 上海交通大学附属第六人民医院骨科上海200233

[目的]本文研究的目的在于找到软骨细胞分离的合适方法及优化冰冻保存软骨组织的配方。[方法]来源于骨关节炎膝关节置换术的软骨标本被用于本次试验,采用300或400 u/ml II型胶原酶(CTII-1或2)进行软骨细胞体外分离,保存在不同组成的冷... 详细信息

[目的]本文研究的目的在于找到软骨细胞分离的合适方法及优化冰冻保存软骨组织的配方。[方法]来源于骨关节炎膝关节置换术的软骨标本被用于本次试验,采用300或400 u/ml II型胶原酶(CTII-1或2)进行软骨细胞体外分离,保存在不同组成的冷冻剂中,进行梯度冷却并保存在液氮中48 h,随后进行软骨细胞活力及增殖潜力的测定。[结果]CTII-1较CTII-2更能分离出高活力的软骨细胞(P<0.05),并且300或400 u/ml的底物酶浓度比较合适。10%DMSO+90%FCS是一种比较合适的冰冻保护剂,能够最大程度保留软骨细胞的增殖潜力与活力,并且毒副作用小。[结论]通过相关的优化措施诸如软骨细胞体外分离底物酶以及冰冻保护剂的组成,从关节软骨组织中分离具有高增殖潜力的活力软骨细胞是一种可行的方法。

关键词：人关节软骨底物酶冷冻保护剂增殖力活力

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Invitation

中国生物工程杂志 2008年第7期 148-148页

作者： zhidao xia,PhD Chairman,Organising CommitteeThe 14～(th) CLSS-UK Meeting,Oxford,2008 Standing Committee Member,CLSS-UK

Dear Sir/Madam,The 14th Annual Meeting of the Chinese Life Scientists Society in the UK will be held in St Anne’s College, University of Oxford, 13-14 September, 2008. On behalf of the Organising Committee, I am writ... 详细信息

关键词： UK St Invitation