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Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

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Neural Regeneration Research 2025年第3期20卷 900-912页

作者： Baoqi Hu Rui Wang Hanyue zhang Xiou Wang Sijia Zhou Bo Ma Yan Luan Xin Wang Xinlin Chen zhichao zhang Qianyan Kang Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Institute of Neurobiology Xi’an Jiaotong University Health Science CenterXi’anShaanxi ProvinceChina

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development studies.Thus,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo retina.In this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in vivo.Initially,we used SOX2 and PAX6 immunostaining to identify retinal progenitor cells.We then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,respectively.Ki-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between groups.Additionally,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,respectively.The timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant retinas.Our study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina development.The findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

关键词： bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells

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N-Heterocyclic carbene-catalyzed enantioselective(dynamic) kinetic resolutions and desymmetrizations

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Science China Chemistry 2024年第2期67卷 482-511页

作者： Yi zhang Hui Cai Xiuhai Gan zhichao Jin National Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityHuaxi DistrictGuiyang550025China

N-heterocyclic carbene-catalyzed enantioselective kinetic resolutions,dynamic kinetic resolutions,and desymmetrization reactions are systematically reviewed.The content is organized according to the activation modes involved in these transformations.Future advances within this highly active research field are discussed from our perspectives on the topic.

关键词： N-heterocyclic carbene kinetic resolution dynamic kinetic resolution desymmetrization organocatalysis

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Graphene enables equiatomic FeNiCrCoCu high-entropy alloy with improved TWIP and TRIP effects under shock compression

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Journal of Materials Science & Technology 2024年第3期170卷 186-199页

作者： Hongcai Xie zhichao Ma Wei zhang Hongwei Zhao Luquan Ren School of Mechanical and Aerospace Engineering Jilin UniversityChangchun 130025China Key Laboratory of CNC Equipment Reliability Ministry of Education Jilin UniversityChangchun 130025China Key Laboratory of Bionic Engineering Ministry of Education Jilin UniversityChangchun 130025China Weihai Institute for Bionics-Jilin University Weihai 264400China Institute of Structured and Architected Materials Liaoning Academy of MaterialsShenyang 110167China

Graphene(Gr)reinforced high-entropy alloy(HEA)matrix composites are expected as potential candidates for next-generation structural applications in light of outstanding mechanical properties.A deep comprehension of the underlying deformation mechanisms under extreme shock loading is of paramount importance,however,remains lacking due to experimentally technical limitations in existence.In the present study,by means of nonequilibrium molecular dynamics simulations,dynamic deformation behaviors and corresponding mechanisms in equiatomic FeNiCrCoCu HEA/Gr composite systems were investigated in terms of various shock velocities.The resistance to dislocation propagation imparted by Gr was corroborated to encourage the elevated local stress level by increasing the likelihood of dislocation interplays,which facilitated the onset of twins and hexagonal close-packed(HCP)martensite laths.Meanwhile,the advent of Gr was demonstrated to endow the HEA with an additional twinning pathway that induced a structural conversion from HCP to parent face-centered cubic(FCC)inside HCP martensite laths,different from the classical one that necessitated undergoing the intermediate procedure of extrinsic stacking fault(ESF)evolution.More than that,by virtue of an increase in flow stress,the transformation-induced plasticity(TRIP)effect was validated to be additionally evoked as the predominant strain accommodation mechanism at higher strains on the one hand,but which only assisted plasticity in pure systems,and on the other hand,can also act as an auxiliary regulation mode together with the twinning-induced plasticity(TWIP)effect under intermediate strains,but with enhanced contributions relative to pure systems.One may expect that TRIP and TWIP effects promoted by introducing Gr would considerably inspire a synergistic effect between strength and ductility,contributing to the exceptional shock-resistant performance of FeNiCrCoCu HEAs under extreme regimes.

关键词： Molecular dynamics High-entropy alloy Graphene TRIP TWIP Shock

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A near-zero quiescent power breeze wake-up anemometer based on a rolling-bearing triboelectric nanogenerator

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Microsystems & Nanoengineering 2024年第2期10卷 241-249页

作者： Xianpeng Fu zhichao Jiang Jie Cao Zefang Dong Guoxu Liu Meiling Zhu Chi zhang CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing101400China School of Nanoscience and Engineering University of Chinese Academy of SciencesBeijing100049China Center on Nanoenergy Research Guangxi Colleges and Universities Key Laboratory of Blue Energy and Systems IntegrationSchool of Physical Science&TechnologyGuangxi UniversityNanning530004China Institute of Intelligent Flexible Mechatronics Jiangsu UniversityZhenjiang212013China College of Engineering Mathematics and Physical ScienceUniversity of ExeterExeterEX44QFUK

Wind sensors have always played an irreplaceable role in environmental information monitoring and are expected to operate with lower power consumption to extend service lifetime.Here,we propose a breeze wake-up anemometer(B-WA)based on a rolling-bearing triboelectric nanogenerator(RB-TENG)with extremely low static power.The B-WA consists of two RB-TENGs,a self-waking-up module(SWM),a signal processing module(SPM),and a wireless transmission unit.The two RB-TENGs are employed for system activation and wind-speed sensing.Once the ambient wind-speed exceeds 2 m/s,the wake TENG(W-TENG)and the SWM can wake up the system within 0.96 s.At the same time,the SPM starts to calculate the signal frequency from the measured TENG(M-TENG)to monitor the wind speed with a sensitivity of 9.45 Hz/(m/s).After the wind stops,the SWM can switch off the B-WA within 0.52 s to decrease the system energy loss.In quiescent on-duty mode,the operating power of the B-WA is less than 30 nW,which can greatly extend the service lifetime of the B-WA.By integrating triboelectric devices and rolling bearings,this work has realized an ultralow quiescent power and self-waked-up wireless wind-speed monitoring system,which has foreseeable applications in remote weather monitoring,IoT nodes,and so on.

关键词： generator power service

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Study of poly-disperse aerosols deposition in turbulent flow with different Reynolds numbers

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Particuology 2024年第6期89卷 32-43页

作者： zhichao Gao Yongzheng Chen Dandi zhang Peng Chen Lili Tong Xuewu Cao School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai200240China China Nuclear Power Technology Research Institute Co. Ltd.Shenzhen518000China

The turbulent deposition mechanism is one of the main mechanisms of aerosol deposition in nuclear power plant tubes.An experimental study of poly-disperse aerosol deposition in a horizontal tube is conducted,where the nominal Reynolds number(Re)is in a range of 3600–200,000.The aerosol deposition velocity first increases and then decreases with the increase of Res,and at high Re,particle rebound occurs during aerosol deposition in the tube.When the Re is low,the aerosol deposition velocity increases with the increase of aerosol diameter.When the Re is greater than 60,000,the deposition velocity first increases and then decreases with the increase of aerosol diameter due to particle surface rebound.A new aerosol deposition model has been developed by establishing the energy conservation equation of the rebounded particles in the viscous sublayer.The calculated results of the new model are in good agreement with these experimental results,and the error between the aerosol deposition velocity calculated by the model and experimental results is between−60%and 150%.

关键词： Aerosol Turbulent deposition Rebound High Reynolds number

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A 16-bit 18-MSPS flash-assisted SAR ADC with hybrid synchronous and asynchronous control logic

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Journal of Semiconductors 2024年第6期45卷 3-12页

作者： Junyao Ji Xinao Ji Ziyu Zhou zhichao Dai Xuhui Chen Jie zhang Zheng Jiang Hong zhang School of Microelectronics Xi'an Jiaotong UniversityXi'an 710049China Qingdao Hi-image Tech.Co.Ltd. Qingdao 266100China

This paper presents a 16-bit,18-MSPS(million samples per second)flash-assisted successive-approximation-register(SAR)analog-to-digital converter(ADC)utilizing hybrid synchronous and asynchronous(HYSAS)timing control logic based on an on-chip delay-locked loop(DLL).The HYSAS scheme can provide a longer settling time for the capacitive digital-to-analog converter(CDAC)than the synchronous and asynchronous SAR ADC.Therefore,the issue of incomplete settling or ringing in the DAC voltage for cases of either on-chip or off-chip reference voltage can be solved to a large extent.In addition,the fore-ground calibration of the CDAC’s mismatch is performed with a finite-impulse-response bandpass filter(FIR-BPF)based least-mean-square(LMS)algorithm in an off-chip FPGA(field programmable gate array).Fabricated in 40-nm CMOS process,the proto-type ADC achieves 94.02-dB spurious-free dynamic range(SFDR),and 75.98-dB signal-to-noise-and-distortion ratio(SNDR)for a 2.88-MHz input under 18-MSPS sampling rate.

关键词： SAR ADC control logic reference ringing DAC incomplete settling

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Independent and Combined Associations of Sleep Duration, Bedtime, and Polygenic Risk Score with the Risk of Hearing Loss among Middle-Aged and Old Chinese: The Dongfeng–Tongji Cohort Study

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Research 2024年第1期2023卷 721-733页

作者： Miao Liu Haiqing zhang zhichao Wang Tingting Mo Xuefeng Lai Yaling He Minghui Jiang Meian He Weijia Kong Tangchun Wu Xiaomin zhang Department of Occupational and Environmental Health Ministry of Education Key Laboratory of Environment and Healthand State Key Laboratory of Environmental Health(Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Otorhinolaryngology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina

Evidence available on the independent and combined associations of sleep duration,bedtime,and genetic predisposition with hearing loss was lacking.The present study included 15,827 participants from the Dongfeng–Tongji cohort study.Genetic risk was characterized by polygenic risk score(PRS)based on 37 genetic loci related to hearing loss.We conducted multivariate logistic regression models to assess the odds ratio(OR)for hearing loss with sleep duration and bedtime,as well as the joint association and interaction with PRS.Results showed that hearing loss was independently associated with sleeping≥9 h/night compared to the recommended 7 to9:00 p.***.to 10:00 p.***.compared to those with bedtime>10:00 p.***.to 11:00 p.m.,with estimated ORs of 1.25,1.27,and 1.16,respectively.

关键词： Middle hearing fen

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Micro/nanosystems for controllable drug delivery to the brain

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The Innovation 2024年第1期5卷 139-157页

作者： Mingzhen Tian zhichao Ma Guang-Zhong Yang Institute of Medical Robotics School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Drug delivery to the brain is crucial in the treatment for central nervous system disorders.While significant progress has been made in recent years,there are still major challenges in achieving controllable drug delivery to the brain.Unmet clinical needs arise from various factors,including controlled drug transport,handling large drug doses,methods for crossing biological barriers,the use of imaging guidance,and effective models for analyzing drug delivery.Recent advances in micro/nanosystems have shown promise in addressing some of these challenges.These include the utilization of microfluidic platforms to test and validate the drug delivery process in a controlled and biomimetic setting,the development of novel micro/nanocarriers for large drug loads across the blood-brain barrier,and the implementation of micro-intervention systems for delivering drugs through intraparenchymal or peripheral routes.In this article,we present a review of the latest developments in micro/nanosystems for controllable drug delivery to the brain.We also delve into the relevant diseases,biological barriers,and conventional methods.In addition,we discuss future prospects and the development of emerging robotic micro/nanosystems equipped with directed transportation,real-time image guidance,and closed-loop control.

关键词： equipped doses barriers

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Optimizing 3d spin polarization of CoOOH by in situ Mo doping for efficient oxygen evolution reaction

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Carbon Energy 2024年第1期6卷 236-244页

作者： zhichao Jia Yang Yuan Yanxing zhang Xiang Lyu Chenhong Liu Xiaoli Yang Zhengyu Bai Haijiang Wang Lin Yang Key Laboratory of Green Chemical Media and Reactions School of Chemistry and Chemical EngineeringCollaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsMinistry of EducationHenan Normal UniversityXinxiangHenanChina School of Physics Henan Normal UniversityXinxiangHenanChina Oak Ridge National Laboratory Electrification and Energy Infrastructures DivisionOak RidgeTennesseeUSA Department of Mechanical and Energy Engineering Key Laboratory of Energy Conversion and Storage TechnologiesSouthern University of Science and TechnologyShenzhenGuangdongChina

Transition-metal oxyhydroxides are attractive catalysts for oxygen evolution reactions(OERs).Further studies for developing transition-metal oxyhydroxide catalysts and understanding their catalytic mechanisms will benefit their quick transition to the next catalysts.Herein,Mo-doped CoOOH was designed as a high-performance model electrocatalyst with durability for 20 h at 10 mAcm−2.Additionally,it had an overpotential of 260 mV(glassy carbon)or 215 mV(nickel foam),which was 78 mV lower than that of IrO_(2)(338 mV).In situ,Raman spectroscopy revealed the transformation process of CoOOH.Calculations using the density functional theory showed that during OER,doped Mo increased the spin-up density of states and shrank the spin-down bandgap of the 3d orbits in the reconstructed CoOOH under the electrochemical activation process,which simultaneously optimized the adsorption and electron conduction of oxygen-related intermediates on Co sites and lowered the OER overpotentials.Our research provides new insights into the methodical planning of the creation of transition-metal oxyhydroxide OER catalysts.

关键词： electrocatalyst in situ Raman Mo-doped CoOOH oxygen evolution reaction

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Decoding the inconsistency of six cropland maps in China

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The Crop Journal 2024年第1期12卷 281-294页

作者： Yifeng Cui Ronggao Liu zhichao Li Chao zhang Xiao-Peng Song Jilin Yang Le Yu Mengxi Chen Jinwei Dong Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Department of Geographical Sciences University of MarylandCollege ParkMD 20740USA College of Grassland Science and Technology China Agricultural UniversityBeijing 100193China Ministry of Education Ecological Field Station for East Asian Migratory Birds Department of Earth System ScienceInstitute for Global Change StudiesTsinghua UniversityBeijing 100084China Ministry of Education Ecological Field Station for East Asian Migratory Birds Beijing 100084China Tsinghua University(Department of Earth System Science)-Xi’an Institute of Surveying and Mapping Joint Research Center for Next-Generation Smart Mapping Beijing 100084China Institute of Remote Sensing and Geographic Information System Peking UniversityBeijing 100871China Department of Forest and Conservation Sciences University of British ColumbiaVancouverBCV6T 1Z4Canada

Accurate cropland information is critical for agricultural planning and production,especially in foodstressed countries like China.Although widely used medium-to-high-resolution satellite-based cropland maps have been developed from various remotely sensed data sources over the past few decades,considerable discrepancies exist among these products both in total area and in spatial distribution of croplands,impeding further applications of these datasets.The factors influencing their inconsistency are also unknown.In this study,we evaluated the consistency and accuracy of six cropland maps widely used in China in circa 2020,including three state-of-the-art 10-m products(i.e.,Google Dynamic World,ESRI Land Cover,and ESA WorldCover)and three 30-m ones(i.e.,GLC_FCS30,GlobeLand 30,and CLCD).We also investigated the effects of landscape fragmentation,climate,and agricultural management.Validation using a ground-truth sample revealed that the 10-m-resolution WorldCover provided the highest accuracy(92.3%).These maps collectively overestimated Chinese cropland area by up to 56%.Up to 37%of the land showed spatial inconsistency among the maps,concentrated mainly in mountainous regions and attributed to the varying accuracy of cropland maps,cropland fragmentation and management practices such as irrigation.Our work shed light on the promotion of future cropland mapping efforts,especially in highly inconsistent regions.

关键词： Consistency and accuracy 10-and 30 m Cropland mapping Agricultural management China

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